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The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. Show notes and video CHAPTERS: 06:04 - Introduction 08:12 - Atherosclerosis 13:49 - Brain 16:07 - Circulating LPS and behavior 19:05 - Toll-like receptors and inflammation 24:00 - Factors that affect intestinal permeability 30:10 - Alcohol 32:07 - Gluten 35:21 - Butyrate and dietary fiber 37:48 - Dietary fat 42:21 - Biomarkers of intestinal permeability 43:11 - Omega-3 fatty acids 50:02 - Q&A LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier Learn about intestinal permeability Learn about toll-like receptors Learn about cerebral small vessel disease SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of the FoundMyFitness platform. Become a member
Dr. Dominic ("Dom") D'Agostino is an expert on a wide range of topics related to metabolic health, ketosis, and ketogenic diets. As one of the world's foremost experts on the ketogenic diet, Dom has personally practiced some variation of ketogenic diet for over a decade, bringing a substantial amount of practical experience along with his anecdotes from human and animal research. In this episode, we discuss: 00:04:59 - What is "keto” (and what it is not) 00:08:42 - Types of ketogenic diets 00:15:27 - Lifestyle Ketogenic Diet 00:26:36 - Biomarkers and hyperlipidemia 00:29:41 - Micronutrients and Supplementation 00:33:40 - Exogenous Ketones 00:55:48 - Optimal blood concentration of ketones (Dom's pick) 01:13:31 - Exercise performance and anti-catabolic effects 01:34:37 - Brain and Memory 01:42:39 - Intermittent Fasting 01:51:43 - Neurodegenerative Diseases 01:58:05 - Migraines 02:04:17 - Autoimmune diseases 02:06:15 - Cancer 02:22:03 - Carnivore diet 02:28:22 - Dom's lifestyle habits 02:31:46 - Measuring ketones Watch this episode on YouTube: https://www.youtube.com/watch?v=RWkv9ad7zvc If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/dominic-dagostino-2 Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
This episode features a discussion with MedCram co-founder Kyle Allred on the effects of sauna. I had the pleasure of being interviewed by Kyle on all things sauna science and we're posting that discussion for you here. As an exercise mimetic, sauna use has anti-inflammatory, mood-elevating, and detoxifying properties that research increasingly shows may deliver cardiovascular and brain benefits. The science of sauna use has been a research interest of mine for many years and this discussion is by far one of the most well-rounded discussions I've had on the subject. Thanks to Kyle and MedCram for having me for his interview. In this episode, we'll discuss: 00:00:00 - Introduction 00:02:46 - Summary of sauna benefits 00:10:47 - Heat as an aerobic exercise mimetic 00:14:45 - Effects of heat acclimation on endurance 00:17:37 - Why heat shock proteins may protect against dementia 00:23:20 - The stress-relieving effects of sauna use (personal anecdote) 00:27:43 - Investigating sauna for depression 00:30:32 - Brain-derived neurotrophic factor (BDNF) and endorphins response 00:34:51 - Cellular repair mechanisms elicited by sauna use 00:40:05 - Prevention of muscle atrophy 00:42:45 - Detoxification of heavy metals  00:44:50 - Heart rate variability, a measure of stress resilience 00:46:40 - The synergy of sauna use and exercise 00:52:13 - Cross-cultural and historical prevalence of heat therapy 00:56:12 - Infrared sauna vs. traditional saunas 00:58:31 - Rhonda's personal sauna protocol: duration, temperature, humidity, and frequency 01:03:22 - How jacuzzi, hot baths, and hot showers compare to sauna use 01:06:19 - Hydration, cold therapy, and sauna safety  01:11:18 - Who should not use saunas? 01:15:21 - Does sauna use increase blood sugar levels? 01:17:16 - Limitations of current sauna research and hopes for future research MedCram is a YouTube channel created by Kyle Allred, PA-C and Roger Sehuelt, MD, master educators of health and medical science. Their videos cover important topics such as immunity, metabolism, and vitamin D in an authoritative, but approachable way. Visit the MedCram YouTube channel for more efficient, engaging, fun, and lasting way to learn and review medical topics. Watch this episode on MedCram:https://www.youtube.com/watch?v=RWkv9ad7zvc If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/medcram-sauna Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging. Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks.  In this episode, Dr. Levine and I discuss:  00:01:19 - What is aging and why does it matter to scientists? 00:04:45 - Hallmarks of aging 00:08:59 - The advantage of epigenetic clocks in research 00:19:05 - Epigenetic age acceleration 00:36:40 - Are epigenetic changes in aging a cause or consequence? 00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques 00:49:27 - Therapeutic plasma exchange in aging and pro-aging factors in blood  00:56:01 - Lifestyle factors that accelerate epigenetic age 01:03:23 - Reliability of consumer epigenetic aging tests 01:06:12 - Construct validity of epigenetic clocks 01:12:06 - Thoughts on most exciting research in aging field  01:13:44 - Dr. Levine's lifestyle habits Get the show notes: foundmyfitness.com/episodes/morgan-levine Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Try thirty days of our FoundMyFitness premium member to get access to exclusive episodes, emails, a live Q+A with Rhonda and more: https://www.foundmyfitness.com/trial
Dr. Peter Diamandis is a serial entrepreneur and founder of XPRIZE, a non-profit organization that designs and conducts global competitions that incentivize the development of technological breakthroughs that propel humanity toward a better future.    Tony Robbins is an entrepreneur, bestselling author, philanthropist, and business strategist. He provides business and life coaching to millions of people worldwide through his audio programs, educational videos, and live seminars.    Diamandis and Robbins are a dynamic duo, having paired up with co-author Dr. Robert Hariri to write Life Force, a best-selling book that describes breakthroughs in precision medicine and health technologies that can help people live longer, healthier, more fulfilling lives – in the very near future.   In this episode, Tony Robbins, Peter Diamandis and I discuss… 00:07:09 - How Tony Robbins and Peter Diamandis met  00:18:08 - Tony and Peter discuss their lifestyle habits 00:29:32 - GRAIL cancer screening blood test 00:30:16 - Cleerly AI-driven coronary CT scan  00:36:13 - The role of DNA damage in aging 00:37:25 - Epigenetics, NAD+, and sirtuins 00:44:33 - Interrupted cellular reprogramming 00:52:15 - Longevity escape velocity 00:57:50 - What do we do after longevity is "solved?"  01:04:19 - Space travel, gene therapy, and organogenesis 01:21:48 - Promises and challenges of future technologies 01:26:10 - How mRNA vaccine technology may impact aging Get the show notes: https://www.foundmyfitness.com/episodes/robbins-diamandis Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Try thirty days of our FoundMyFitness premium member to get access to exclusive episodes, emails, a live Q+A with Rhonda and more: https://www.foundmyfitness.com/trial
Eran Elinav, MD, PhD, is a professor of immunology and principal investigator at the Weizmann Institute of Science in Tel Aviv, Israel, where he co-directs the Personalized Nutrition Project. Dr. Elinav is also a principal investigator at the German Cancer Research Center in Heidelberg, Germany. His research focuses on understanding the complex interactions between humans and the bacteria that reside in their gut and how these interactions shape human health and disease. In this episode, Dr. Elinav and I discuss... 00:06:38 - Circadian rhythm of the microbiome 00:17:17 - Lessons from Hunter-gatherers 00:24:44 - Nurturing the microbiome in children 00:35:16 - Triglycerides and cholesterol 00:38:58 - Saturated fat 00:40:25 - Effect of artificial sweeteners on the microbiome 00:56:10 - What causes recurrent obesity 00:58:17 - Impact of caloric restriction 00:59:26 - Intestinal permeability (gut leakiness) 01:19:54 - Bacteriophage therapy and precision probiotics 01:34:44 - Bacterial role in TMAO risk 01:40:33 - Weight gain from smoking cessation 01:41:53 - Tips for diet personalization Get the show notes: https://www.foundmyfitness.com/episodes/eran-elinav Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Try thirty days of our FoundMyFitness premium member to get access to exclusive episodes, emails, a live Q+A with Rhonda and more: https://www.foundmyfitness.com/trial
In this nearly 2.5-hour episode, Dr. Rhonda Patrick and Dr. Roger Seheult and Kyle Allred of MedCram make a thoughtful, merit-based, and truly comprehensive discussion of COVID-19 vaccination. In addition to being a co-founder of MedCram Medical Lectures, Dr. Roger Seheult is, as you will find out in the conversation, a boots on the ground, critical care pulmonologist. For Dr. Seheult, COVID-19 is not just theory. He sees real sick people and for that reason brings a very special context to this conversation. Furthermore, Dr. Seheult is also an academic and educator. He is an Associate Clinical Professor at the University of California, Riverside School of Medicine and an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple-board certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine and Sleep Medicine through the American Board of Internal Medicine. In this episode, we discuss: 00:00:00 - Introduction 00:06:58 - Vaccination in the young and healthy 00:12:25 - Risk of myocarditis from COVID-19 is greater than for vaccination 00:16:18 - Long-haul COVID is often preceded by mild infection 00:25:36 - The spike protein generated from vaccination is not the same as the viral one 00:34:16 - Biodistribution of vaccine particles 00:41:17 - COVID-19 Vaccine Adverse Event Reporting System (VAERS) 01:06:55 - Antibody-dependent enhancement isn't a concern for the SARS-CoV-2 vaccine 01:14:54 - Do the COVID-19 vaccines damage human fertility? 01:19:51 - Can mRNA vaccines alter human DNA? 01:28:10 - Current ivermectin evidence 01:47:40 - Delta-variant and breakthrough infections 02:01:42 - Viral evolution (virulence vs. immune escape) 02:10:45 - T-cell immunity vs. antibody immunity Watch the annotated video: https://www.youtube.com/watch?v=pp-nPZETLTo Subscribe to MedCram on Apple Podcasts: https://podcasts.apple.com/us/podcast/medcram/id1564795918 Subscribe to MedCram on YouTube: https://www.youtube.com/channel/UCG-iSMVtWbbwDDXgXXypARQ
Dr. William ("Bill") Harris is one of the world's preeminent experts in the field of omega-3 fatty acid research. His work has focused on the roles that fatty acids in play in cardiovascular and neurocognitive health. The author of more than 300 scientific papers on fatty acids and health, Dr. Harris is a professor in the Department of Medicine in the Sanford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute. In this episode, Dr. Harris and I discuss… 00:00:00 - Introduction 00:06:36 - Early studies on omega-3s, dietary fats, and cholesterol  00:14:44 - Omega-3s may normalize bleeding times  00:20:33 - Plant-based omega-3s are not equivalent in power to marine omega-3s  00:25:23 - Genetic engineering of plants is needed for sustainable omega-3s in the future 00:27:18 - The omega-3 index reveals individual variations in omega-3 needs 00:32:13 - Red blood cell concentration of omega-3s better reflect long-term omega-3 status 00:36:41 - Genetic variants influence omega-3 dietary needs 00:54:20 - The omega-3 index may predict life expectancy 01:05:03 - How metabolites of omega-3 reduce and resolve inflammation 01:17:11 - High omega-3 concentrations halve the risk of COVID-19 death 01:20:10 - DHA may help keep the SARS-CoV-2 spike protein from entering cells 01:22:50 - Concerns over the omega-6/omega-3 ratio may be unfounded Looking for more?  Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Dr. Ashley Mason is a clinical psychologist and director of the Sleep, Eating, and Affect Laboratory at the Osher Center for Integrative Medicine at UCSF. Her research centers on nonpharmacological approaches for treating depression, insomnia, and overeating. In this episode, we discuss: 00:00:00 - Introduction 00:08:10 - Whole-body hyperthermia (WBH) and sauna use differ 00:17:06 - Depression causes thermoregulatory dysfunction – but sauna use may correct it 00:21:12 - WBH and sauna use may reduce symptoms of depression 00:33:22 - Heating the body slowly may improve heat tolerance and increase WBH effectiveness 00:39:35 - Sauna use may benefit people with depression and cardiovascular disease – which often coincide 00:40:18 - Dr. Mason and Rhonda are collaborating on new research on depression and WBH 00:44:19 - Sauna bathing and similar practices often provide opportunities for people to connect socially 00:53:12 - Common causes of insomnia 01:01:26 - Cognitive behavioral therapy, sleep hygiene, stimulus control, and sleep restriction for treating insomnia Looking for more?  Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Dr. Mark Mattson Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature. Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting. In this episode, we discuss... 00:3:31 - Hormetic stressors drive adaptation and prevent physiological complacency 00:13:00 - Intermittent fasting improves health by promoting metabolic switching 00:16:49 - Daily time-restricted eating vs 5:2 weekly fasting  00:27:44 - A ketogenic diet and intermittent fasting differ in terms of brain effects 00:34:23 - Exercising while intermittent fasting exerts additive effects 00:52:32 - Plant-based bioactive compounds induce hormetic stress 01:10:48 - Severe caloric restriction may compromise muscle mass 01:26:25 - Intermittent fasting in young vs. old and in men vs. in women 01:35:20 - The effects of cortisol differ during a fast versus chronic stress 01:53:36 - Fasting-mimetics like resveratrol and spermidine vs actual fasting 02:08:44 - How ketone supplementation may improve brain health Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Dr. Satchin Panda Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies.  Dr. Panda’s work focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches. He is an expert on circadian rhythms and a pioneer in the field of time-restricted eating. A priority for Dr. Panda when designing his studies is to identify strategies that positively impact public health. In this episode, Dr. Panda and I discuss... 00:00:00 - Introduction 00:04:29 - How circadian rhythms influence human health 00:12:30 - Seeking bright light in the morning and avoiding it in the evening improves sleep 00:20:40 - Supplemental melatonin may counteract evening bright light exposure 00:26:16 - The relationship between melatonin and insulin secretion  00:33:15 - Shift work, jet lag, and modern life contribute to circadian dysfunction 00:45:10 - Naps might aid with afternoon sleepiness and sleep loss 00:47:05 - Indoor lighting can be used to promote healthy circadian rhythms 00:51:20 - Time-restricted eating strengthens circadian biology 01:02:13 - Dr. Panda’s ongoing study uses a smartphone app to track diet 01:03:41 - Most people are unaware of their eating patterns 01:07:58 - How Dr. Panda incorporates his research findings into his own life 01:16:21 - Our circadian rhythms dictate when we should exercise If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/satchin-panda-3 Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Michael Snyder Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics. In this episode, we discuss: 00:00:00 - Introduction 00:12:51 - Continuous glucose monitor use in people without diabetes 00:31:04 - A smartwatch helped diagnose Dr. Snyder's Lyme disease 00:34:00 - Predicting other illnesses with smartwatches 00:40:41 - Detecting airborne pollutants in the exosome  00:51:04 - Genetics and metabolism tell us our Ageotypes 00:58:05 - Exercise is most important for longevity 01:03:11 - Dr. Snyder's lifestyle habits If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/michael-snyder Join over 300,000 people and get the latest distilled information on personalized medicine straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Dr. Roger Seheult Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity.   What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic. In this episode, we discuss: 00:00:00 - Introduction 00:06:20 - How MedCram Videos got started  00:09:37 - Using evidence to make COVID-19 treatment decisions 00:12:46 - The differences in treating early vs late-stage COVID-19  00:14:40 - How doctors would've treated COVID-19 one-hundred years ago 00:18:13 - Increasing ventilation reduces SARS-CoV-2 transmission  00:20:28 - Masks are virtually universally beneficial regardless of type 00:21:32 - Vitamin D and COVID-19 00:22:22 - Steroid chemical structure of vitamin D  00:23:24 - The vitamin D RDA is likely too low 00:24:23 - Vitamin D is more like a hormone than vitamin 00:26:21 - The overlap between COVID-19 and vitamin D deficiency 00:30:27 - How Mendelian randomization studies helped solve the vitamin D puzzle 00:34:20 - The gene regulatory effects of vitamin D  00:35:49 - Vitamin D and the ACE2/renin-angiontensin system 00:42:00 - Daily doses of vitamin D are more effective  00:43:23 - A prescription-only form of vitamin D (calcifediol) may be best for COVID-19 00:47:06 - Skin synthesis of vitamin D from sunlight can be unreliable  00:53:43 - The safest dose range for vitamin D 01:06:15 - The beneficial circadian effect of early morning sunlight 01:07:38 - Sleep deprivation impairs vital immunity 01:12:08 - Dr. Seheult's suggestions for the best sleep 01:19:18 - A Spanish flu era treatment boosts interferon by ten times 01:22:38 - Why interferon is so important for the viral response 01:26:43 - Treating the symptoms of fever during the Spanish flu harmed patients 01:31:58 - Dr. Seheult's ongoing research of hot hydrotherapy  01:47:00 - COVID-19 Vaccines   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/roger-seheult Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Steve Horvath Steve Horvath, PhD, is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. In this episode, we discuss: 00:00 - Introduction and overview 20:24 - Horvath Aging Clocks 26:36 - Heredity determines aging 35:49 - DNAm PhenoAge vs GrimAge 45:58 - Slowing the epigenetic clock 01:10:43 - Epigenetics: Cause or consequence of aging? 01:16:43 - Vitamin D reverses epigenetic age 01:19:07 - Omega-3 slows GrimAge clock 01:24:19 - Ongoing research If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/steve-horvath Join over 300,000 people and get the latest distilled information on aging straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Dr. Jed Fahey In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants. In this episode, we discuss:  00:00:00 - Introduction 00:07:19 - The minimum daily dose of sulforaphane  00:12:04 - Gauging sulforaphane content of foods is challenging 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods 00:23:38 - How often to consume broccoli sprouts and how long their effects last 00:39:28 - The effects of sulforaphane on glutathione production in the brain 00:43:12 - The effects of sulforaphane on cancer 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends) 01:33:08 - Safety concerns regarding sulforaphane If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/jed-fahey-q-a Join over 300,000 people and get the latest distilled information  straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Giselle Petzinger Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease. Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure. In this episode, we discuss: 00:00:00 - Introduction 00:06:57 - What is Parkinson’s disease? 00:11:57 - When symptoms of Parkinson’s disease appear  00:14:57 - Circuits in the brain can compensate for  substantia nigra dysfunction 00:18:37 - Hereditary risk factors of Parkinson’s disease 00:21:25 - Parkinson’s disease is associated with pesticide and pollutant exposure 00:26:57 - Exercise can lower the risk of developing Parkinson’s disease 00:35:38 - How skill-based exercise such as boxing reduces disease symptoms  00:47:49 - Treadmill exercise increased BDNF and brain health 00:58:33 - Exercise at 80 percent of maximum heart rate slowed Parkinson’s disease progression  01:01:31 - Why exercise may not fully replace medications  01:09:58 - DHA reduces motor symptoms and dyskinesia  01:12:12 - Patients with Parkinson’s disease have higher levels of inflammatory biomarkers If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/giselle-petzinger Join over 300,000 people and get the latest distilled information on parkinson's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor  
Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed. In this previous, you'll learn: 00:01:48 - Fasting supports a healthy gut microbiome and reduces autoimmunity 00:08:28 - Increasing autophagy with fasting  00:13:26 - Reducing protein acetylation with fasting mimetics 00:18:17 - Fasted exercise, water fasting, and a fasting-mimicking diet Learn more about our premium podcast feed The Aliquot by clicking here. Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed. In this episode, you'll learn: 00:01:41 - Evidence supporting sauna use for health 00:04:09 - How Finnish humid saunas can reduce viral illness 00:08:40 - Sauna and hot bath use during the COVID-19 pandemic 00:15:07 - Rhonda's sauna routine Learn more about our premium podcast feed The Aliquot by clicking here. Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed. This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As. In this episode, you'll hear: 00:00:00 - Introducing "The Aliquot" 00:02:43 - Omega-3s for babies and toddlers to maximize brain development 00:07:02 - Common nutrient deficiencies in children and how to prevent them 00:11:42 - Evidence to support omega-3 supplementation in children 00:20:58 - Fasting considerations and restrictions for women Learn more about our premium podcast feed The Aliquot by clicking here. Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
This episode aims to be the most comprehensive video compendium on the biology of breast milk ever recorded. In this episode, you'll discover: 00:00:00 - Introduction 00:07:11 - Breast milk production and composition 00:09:59 - Human milk oligosaccharides help establish the infant gut microbiome 00:16:32 - Omega-3s in breast milk boost brain development 00:18:15 - Vitamins and minerals in breast milk 00:22:05 - Breast milk stem cells and multi-organ microchimerism 00:22:54 - Harmful substances transferred to infants via breast milk 00:28:05 - Breastfeeding boosts the infant's immune system 00:31:17 - Effects on intelligence 00:34:36 - Breastfeeding as a benefit to maternal health If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/breast-milk Join over 300,000 people and get the latest distilled information on the biology of breast milk straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
Comments (44)

Irish G

pity they didn't address Vax injuries like Maddie De Garay

Jan 11th
Reply

Jennifer Lamon

so disappointed that you use this as a teaser to get people onto the paid platform.. I do love your work but this seems a bit commercial.

May 15th
Reply

Dingfod Fodding

omg really? probably the worst content ever from a guest

Mar 13th
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Aaron Cartridge

Is there crossover in the research to other degenerative diseases? Such as Huntington's?

Jan 8th
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michael pawluk

Moringa powder is some of the grossest shit I've ever tasted.

Dec 24th
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Robs

Just the best! Thank you so much for all the great information! Going through all the JRE podcasts now and they all are so interesting... All the information I have gained from you has helped me so much. Now it is just fun to try to be as healthy as possible after learning so much stuff from you. Keep up the podcasts! 🤟

Oct 1st
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jewel

it's tough to breast feed when you're a full time teacher who's only oppurtunity to pump is on her twenty minute break in the janitor closet. Thiis makes me feel sad for my baby i switched to formula at three months. i feel like a bad mom.

Sep 29th
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Ollie W

Disappointing, not the info - that was interesting - although obviously aimed to be a cliffhanger/ trailer to having to paying for a premium version. Real disappointment comes from the scaremongering in SEPTEMBER 2020 (I might understand if it was in April) speaking paranoia about exercising outside & avoiding the apartment's sauna. This is reactive and not science-based, in fact there's gathering evidence that locking down & social distancing for the vast majority of the population, when there are so few serious cases or deaths (despite the case-demic) is clearly counter-productive & both has & will lead to more deaths. Get out in the sun Rhonda, stop being paranoid & help build yours & others immunity.

Sep 24th
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Not About The Clicks

Excellent preview discussion about heat stress proteins. One thing about baths, to get the full effect it needs to be in the 110°F range but baths seem to be more adverse in health to reproductive organs in males mainly? Is this avoidable?

Sep 4th
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rupexo

bloody hell, great podcast but felt like i had to be a third scientist myself listening in to this! majorly technical at points

Aug 13th
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CHYNA HOPKINS

I was once a herpes patient, but now I have finally got rid of it with the help of Dr Edes herbal remedies. you can also get your self cured with this same remedy. Please feel free to share Your problems with him and don’t forget to tell him I did refer you to Him. Thanks. Dr Edes deals with (1)Alzheimer virus (2)Cancer (3)HIV (4)Herpes (5)Genital warts (6)ALS (7)Virginal infection (8)HPV (9)Hepatitis (10)Asthma Email him on dredeshome@gmail.com https://dredesherbalhome.weebly.com

Aug 11th
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Josh Er

awesome thanks Rhonda

Jun 4th
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P. Dutra

i miss your podcasts. Hope everything is alright and that you guys can post more soon. it's really great material.

Mar 9th
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Sebastian Andersson

What do you think of n Acetyl Cysteine ​​vs sulforafan in broccoli sprouts regarding activation of glutathione? //Sebastian in Sweden

Jan 8th
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damian ferr

thanks, for explaining the difference between trans, and regular.

Jan 3rd
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Tom Foolery

Smartest human on optimal health. The ability to research and remember these studies; then apply their information is uncanny. I wish you were in charge of public health. The world would be a better place. Not that it isn't already because of you and the people that you introduce us to in this. Thanks so much!

Dec 22nd
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Rich Frissen

“I want to know what’s right, not who’s right” https://m.facebook.com/groups/553235201434948/

Dec 8th
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Blunt

I've been eagerly waiting so long for this!

Nov 7th
Reply (1)

Vali Florea

Is just me who thinks this is on fast speach?

Aug 14th
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Juan Reyna

🤘

Jun 18th
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