Today's episode is about excitation-inhibition with specific attention with an inhibitory neuron called parvalbumin interneurons (PVINs). The discussion covers the medial prefrontal cortex, insular cortex, and salience network, linking their dysfunction to autistic traits like sensory over-responsiveness and social deficits. We cover two articles, alongside the CNTNAP2 protein’s role in neural circuit organization and its implications for Autism.The episode also critiques the 1985 theory of mind framework, emphasizing autistic strengths in interoception and intuition, which suggest a sensory-social trade-off that enhances learning and information processing. PVIN hypofunction is connected to social deficits and rigid thinking, supported by a 2017 post-mortem study showing a 38-70% reduction in prefrontal PVINs. The discussion integrates prior research on salience network hyper-connectivity and emotional processing deficits in autism.Daylight Computer Companyuse "autism" for $50 off athttps://buy.daylightcomputer.com/autismChroma Light Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 - Parvalbumin InterneuronsFujima et al., social familiarity, emotion recognition, graphical abstract.02:03 - Neuron InteractionsPVIN activity, social interactions, familiar/stressed peers, pyramidal neurons, excitation-inhibition balance.04:10 - Daylight Computer use "autism" for $50 discount06:38 - Chroma Light Devices use "autism" for 10% discount09:46 - Medial Prefrontal Cortex in AutismDecision-making, social cognition, self-referential thinking, anterior cingulate cortex12:38 - Insular Cortex and Salience NetworkInsular cortex, anterior insula, salience network, emotional states, bodily signals, social cues, autistic intuition.15:06 - Parvalbumin InterneuronsPVINs, GABAergic, fast-spiking, cortex/hippocampus/basal ganglia, inhibition, neural synchronization, social/emotional processing.17:08 - Fujima et al. Study Methodology and Behavioral EffectsMicroendoscopic calcium imaging, chemogenetic manipulation, mice, social familiarity, emotional recognition, context-dependent behaviors, pyramidal modulation.21:22 - Tsang et al. Study on Infant Salience Networksix-week-old infants, salience network, sensorimotor/prefrontal connectivity, sensory over-responsiveness, social attention, autism likelihood.25:22 - Salience Network and Autism ResearchSalience network hyper-connectivity, sensory processing, alexithymia, anterior insula, emotional processing deficits, autism studies (2013, 2016, 2024).27:44 - CNTNAP2 and PVIN DysfunctionNeural circuits, synaptic function, dendritic arborization, PVIN reduction, social deficits, 2017 post-mortem study.32:00 - Autistic Interoception and Theory of MindIntuition, sensory-social trade-off, theory of mind, learning/information processing.34:00 - ClosingX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
My guest today is Tristan Scott, an electrical engineer and head of operations at Daylight Computer Company. Tristan delivers a dynamic discussion on redefining technology for human health, blending personal anecdotes with technical insights. His expertise on electromagnetic fields (EMFs) and blue light’s impact drives the conversation, illuminating Daylight’s mission to create human-friendly technology.The episode explores the harmful effects of modern screens, particularly on children, with Tristan sharing data on developmental delays and technology’s addictive design, akin to a casino’s flashing lights. He highlights Daylight’s DC1 computer, explaining its flicker-free and blue-light-free design, which reduces eye strain and fosters a less addictive digital experience. In addition, we will discuss some issues with Autism's sensory-processing phenomena and the benefits of the DC1 computer from Daylight. The episode wraps up with an inspiring discussion on Daylight’s Kids initiative, a hopeful vision for a healthier tech future, making this episode a must-listen for anyone concerned about technology’s impact on well-being.Daylight Computer Company https://daylightcomputer.comKids Daylight (!) https://kids.daylightcomputer.comDaylight Computer Company Instagram https://www.instagram.com/daylightco/?hl=enDaylight Kids Facebook https://www.facebook.com/groups/1300308801490853Daylight Computer Company X https://x.com/daylightcoTristan Scott Instagram https://www.instagram.com/tristan_health/?hl=enTristan Scott X https://x.com/bitcoinand_beefTristan's Book https://www.amazon.com/Bitcoin-Beef-Criticisms-Similarities-Decentralization/dp/B09W799F5FDaylight Computer Companyuse "autism" for $50 off athttps://buy.daylightcomputer.com/autismChroma Light Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Tristan Scott1:09 Tristan's path into holistic health, electrical engineering, & Daylight Computer Company; EMF Harms10:35 Daylight's Mission and DC1 Computer; Importance of Natural Light14:10 The Future of Tech (is already here with Daylight) & Children & Human Health16:54 Daylight's unique approach to Tech20:19 The Role of Tech in Modern Life; Tech Designed for Humans, not Against Humans23:10 Technology and Casinos (Same Trap); Dopamine Trap; Addictive and Maladaptive Behaviors33:25 Creating Synergy between Humans and Tech36:34 Understanding Sensory Processing & Autism42:32 Dangers of Light Flicker & The Harms for the Nervous System52:52 Daylight's Kids Initiative; Tech Designed for Humans & Kids01:02:35 Daylight's Future in Technology and Beyond
My guest today is Dr. Nirosha Murugan, a Tier II Canada Research Chair in Biophysics and Assistant Professor at Wilfrid Laurier University. Dr. Murugan explores how physics shapes biological processes, with pioneering research into biophotons—ultraweak photon emissions that reveal the hidden interplay between physics, biology, and life.By the end of this episode, listeners will understand how biophotons contribute to cellular communication, regeneration, and health. Dr. Murugan’s insights highlight the emerging field of quantum biology and how it connects physics to life, offering transformative potential for medical diagnostics and a deeper understanding of living systems.This episode explores the future of medicine through the lens of life’s physical foundations.The Murugan Lab https://themuruganlab.comPublications https://themuruganlab.com/publications/X https://x.com/msahsorinCause of Autism: https://youtu.be/0onzTNYyrmI?si=4cah8YtY8J1dlh0YAutism & Mitochondria: Biophysics meets Biochemistry https://youtu.be/-wXJI719L5s?si=XAMqQ0f1xMDlPqlsNeurulation, Neuroepitheial Cells, & Mesencephalon https://youtu.be/ZPkb1Fp7EIc?si=OSfUJP9uZIjGe3ZM0:00 Dr. Nirosha Murugan2:16 Daylight Computer Company, use "autism" for $50 discount6:34 Chroma Light Devices, use "autism" for a 10% discount9:45 Path into Quantum Biology & Biophysics role on organisms; Bioelectricity13:13 Opsins versus Chromophores; Proteins; Photoreceptors & Light17:37 The Body Glows & Emits Light (biophotons); Photomultipliers & Measuring Biophotons20:37 The Role of Light & Development21:04 Seed Germination & Human Development (neurodevelopment) Analogy23:54 Environmental Light & Impact on Health; Light Patterns, Spectrums, & Wavelengths25:34 Mother's of the original Autistic kids from Leo Kanner26:46 Light type exposure & Autism29:50 Mitochondria, Light, & Energy31:28 Neurocognitive (Dementias) rates & Aging; Reactive Oxygen Species (ROS), Electrons35:35 Microtubules & Cell Function; Reverse Engineer Oxidative Phosphorylation- ATPase, Electron Transport Chain & TCA Cycle37:14 Cytochrome C Oxidase, Water, Energy, Four Red Light Chromophores- Heme a, a3, CuA, & CuB, vitamin D receptors, Red light & UV Light42:11 Tryptophan, Tublin, Microtubules46:49 The Role of Water & Energy in Cells48:59 Nature's Impact on Health; Get Outside (!), Oxygen51:46 Midbrain (mesencephalon), Dopamine, Norepinephrine; Serotonin and Raphe53:36 Serotonin & Development (remember the sensory map !)55:11 Biophotons & Seasonal changes; Depression, Pale Autistics58:02 Cancer & Biophoton Signals59:50 Human connection, Biophotons & Quantum Coherence, Energy, & Molecular Signals01:01:53 Psychedelics, Depression, Anxiety, Consciousness01:05:20 Mitochondria, Memory & Information: What is Information?01:09:54 Intersection of Light & Information01:12:27 Future Direction in Quantum Biology and Medicine; Silos01:13:36 Ryan's journey into Quantum Biology & Practices, Reversing Autoimmune Diseases
My guest today is Dr. Kenda Rigdon. Dr. Rigdon is a microbiologist with a PhD in microbiology and virology from the University of Alabama at Birmingham. Drawing from her expertise, she explores how the gut’s microbial ecosystem—comprising bacteria, yeast like Candida and Malassezia, and other microbes—interacts with genetic and epigenetic factors to influence Autism. Dr. Rigdon highlights the critical role of the birthing process, particularly how vaginal delivery seeds a newborn’s gut with beneficial microbes like lactobacillus, setting the stage for healthy development in the first three years. She also delves into how yeast overgrowth, nutrient competition (e.g., for tryptophan), and environmental factors like manganese and glyphosate exposure can disrupt this delicate ecosystem, potentially exacerbating autism-related symptoms.Dr. Rigdon shares insights into the surprising links between melanin, Neanderthal DNA, and Autism. She discusses how specific genetic mutations, such as MTHFR and PAI1, can intersect with Autism. Additionally, she connects melanin production—potentially influenced by gut yeast like Malassezia—to neurological health, drawing parallels with conditions like Parkinson’s. By viewing the gut as a dynamic ecosystem shaped by birth, diet, and early development, this episode offers a fresh perspective on Autism’s microbial roots and practical implications for health, urging listeners to reconsider modern birthing practices and dietary choices in fostering a balanced gut microbiome.Dr. Rigdon X https://x.com/KendaRigdonDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Dr. Kenda Rigdon1:14 Journey into Microbiology4:08 The Gut's Ecosystem8:21 Genetics, Autism, & The Microbial Connection13:08 MTHFR & PAI1: Homocysteine, Methionine, Folate20:21 The Role of Yeast in Health & Disease; Serotonin, Candida26:39 The Fight for Tryptophan31:14 Impact of Birthing Method on Gut Health (!)33:13 Modern versus Evolutionary Births, Breastfeeding; Oxygen, Acidity, PH37:15 Melanin, Cell Protection, Neanderthal DNA, Autism40:46 Neuromelanin; Biological Energy, Melanocytes43:20 Neanderthal's & Modern Disease & Environments47:23 Microbes in the Brain53:21 Manganese & Gut Health58:22 Gut-Brain Connection & Microbial Balance01:03:19 Early Gut Health & Development; Modern Insults01:07:21 Future Direction in Gut Health & Kenda's Passion & LoveX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Su study: https://www.nature.com/articles/s41564-024-01739-1Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/postsDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems(6:22) POMC; HPA; Stress example(8:19) Common Autism problems in the GI(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation(14:09) Melanin/POMC; Clock-Timing; Omentum(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut(19:04) Vitamin D Receptors and more Clock-Timing(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids(24:33) Avoiding UV Light implications(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD(38:27) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAEmail: info.fromthespectrum@gmail.com
For today's episode, we will cover B2 (insistence on sameness, inflexible routines, and ritualized behaviors) and B3 (highly restricted, fixated interests with abnormal intensity). It emphasizes the preference for an internal world, where repetition and self-directed learning thrive, contrasting this with societal misunderstandings that label such behaviors as abnormal. The episode critiques societal pressures to conform to broad knowledge expectations, highlighting how Autistics find comfort in their self-driven focus, supported by neurobiological insights like the role of the mesencephalon in attention and environmental interaction.Further, the episode addresses the challenges Autistics face with external disruptions, like unpredictable social interactions or changes to routines, which can feel debilitating due to the brain’s predictive nature and metabolic energy demands. The discussion ties these struggles to the medial prefrontal cortex’s role in adaptive responses, explaining why Autistics may resist environmental changes to maintain their internal homeostasis. The episode underscores the unique learning style of Autistics, advocating for self-directed interests over externally imposed norms.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Daylight Computer Company, use "autism" for $25 discount02:24 Autism DSM Criteria B, Autism phenotypes, DSM criteria B, restricted repetitive behaviors, focus on B2 and B3, prior episodes (1, 2, 6, 7).04:42 B2: Insistence on Sameness, DSM B2, insistence on sameness, inflexible routines, distress at small changes, rigid thinking05:24 B3: Fixated Interests and Autistic Intelligence, DSM B3, Kenner/Asperger kids, autistic intelligence, societal mislabeling.07:15 Autism and Societal Misunderstandings, Autos (self), societal confusion, discomfort with complexity, Autistics’ comfort in self, internal state shifts.09:19 Autistic Learning, Love, & Internal World, Autistic intelligence, learning, repetition, professing, self-directed learning, societal pressure.11:40 Path, Meaning, & Love; “Daimon”14:42 Neurobiology and Environmental Interaction, Mesencephalon (midbrain), motor movement, sensory integration, attention bias, lack of environmental orientation, social implications, embryogenesis, Autistic resistance to external changes.17:34 Chroma Light Devices, use "autism" for 10% discount20:43 Routines, Social Challenges, and Adaptive Responses, B2 routines, external insults, brain as prediction machine, metabolic energy, social interactions, Autistic efficiency, frustration with unpredictability, medial prefrontal cortex, adaptive responses25:21 Reviews/Ratings & Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons.Jack Kruse https://www.patreon.com/DrJackKruse/postsGlycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/#:~:text=Glycolysis%20is%20a%20central%20metabolic,use%20in%20other%20metabolic%20pathways.Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycleOxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylationDr. Richard Frye, MD, PhD: Understanding the Roles and Sensitivity of Mitochondrial Functioning: https://www.youtube.com/watch?v=_wsDkv-dkEU&t=13sDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO)6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS)8:25 Glycolysis10:03 Citric Acid cycle12:02 OXPHOS13:51 Cytochrome I15:07 Cytochrome II16:08 Cytochrome III17:10 Cytochrome IV and creating water19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism29:20 Cytochrome V and ATPase; Chromophores33:56 Evolution and losing electrons; Autism and modern health complications37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies40:23 Reviews/Ratings and contact infoX: https://twitter.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In this episode, we explore the concept of supplementing relationships in Autism, focusing on the vivid internal dialogues and imaginative "movies" that feel profoundly real. These self-directed monologues and conversations with imagination create a safe, predictable space for social engagement, contrasting with the chaotic external world. We dive into Kanner’s and Asperger’s insights on self-directed speech, used for self-soothing or processing thoughts, not communication. Kanner observed children muttering during solitary play, while Asperger noted lecture-like monologues reflecting autistic intelligence.I will share personal experiences of vivid internal dialogues emerging soon after waking, free of external speech issues but disrupted by real-world interactions. These internal relationships, as frequent as an extrovert’s, pose challenges when balancing with social expectations, offering a predictable haven for exploring restricted interestsSupplementing Relationships with Visual Thinking https://youtu.be/lglEGQ7pSlc?si=TgwuMMFGRPmAcCwkDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for 10% discount03:11 Supplementing Relationships and Autism: Supplementing relationships, autism, internal dialogue, monologue, imagination, vivid movies, real-like, accelerator.04:14 Historical Context of Autism Start Time: Autism history, autos, self, dreamlike states, Eugen Bleuler, 1900s, schizophrenia, late 1950s.05:14 Shared Phenotypes and Kanner/Asperger Contributions: Autism, schizophrenia, phenotypes, speech, language, motor control, intensity, Kanner, Asperger, self-directed communication.05:55 Autism, Isolation, and Speech/Language Challenges: Isolation, chaotic world, speech issues, language issues, biology, socialness, negative experiences.07:12 Kanner’s Observations on Self-Directed Speech: Kanner, self-directed speech, internal needs, self-soothing, narrating thoughts, solitary play, no listener, repetitive activities.09:33 Asperger’s Insights on Monologues and Autistic Intelligence: Asperger, monologues, obsessions, academic style, self-satisfaction, autistic intelligence, accelerated learning, solitary activities.12:23 Personal Experience with Internal Dialogues and Disruptions: Personal experience, internal dialogues, vivid movies, waking fixation, motor movements, silent speaking, listening dissonance, medial prefrontal cortex.15:00 Internal Socialness, Supplementing Relationships, and Real-World Challenges: Internal socialness, extrovert comparison, no speech issues, supplementing relationships, vivid imagination, real-world social challenges, predictability, restricted interests, early memories.19:08 Reviews/Ratings & Contact Info19:50 Daylight Computer Company, use "autism" for $25 discountX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
My guest today is Samantha Fox. Sam is a Speech-Language Pathologist with a Master’s from Kent State University and the founder of, Beyond Speech Therapy Center, where they focus on personalized therapy and building meaningful connections with clients. As a registered Spelling to Communicate practitioner with deep expertise in Early Intervention, Sam brings a unique perspective to supporting non-speaking and minimally speaking individuals with Autism, Apraxia, and speech sound disorders. Today’s episode is all about Speech-Language Pathology and Spelling to Communicate interventions. By the end, you’ll have a deeper understanding of these powerful protocols.Sam Fox https://www.beyondspeechtherapycenter.com/our-teamBeyond Speech Therapy Center https://www.beyondspeechtherapycenter.com/homeFacebook https://www.facebook.com/BeyondSpeechI-ASC https://i-asc.orgOther episodes: Dr. Reza Shadmehr: Computational Motor Control & The Cerebellum https://youtu.be/LoklISzlXK8?si=AoVKbHRZ0hDDtdY0Katie Asher: Understanding Communication, Telepathy, and Spiritual Existence https://youtu.be/7FJ52cyfShg?si=gmf7PxrCajcXHkUSDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Sam Fox2:15 Learning about Spellers; Kaden8:55 Beyond Speech Therapy Center; Spelling 2 Communicate; I-ASC18:06 Non-Verbal, Motor Control, Apraxia, & Communication23:03 Presuming Competence in Non Speaking Individuals31:10 Impact of Communication on Behavior; The use of Spelling; Self-Injurious Behaviors40:08 Understanding Apraxia43:56 The Process of Spelling 2 Communicate50:40 Building Motor Skills for Communication57:27 Overcoming Barriers in Spelling1:02:29 The Importance of Consistency, Practice, Reasonable Expectations & Patience; Insurance Coverage1:11:58 The Leap of Faith in Spelling1:16:56 The Future of Spelling 2 CommunicateX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
For today's episode, we will expand on Autism & Relationships and introduce a very fascinating phenomena of "Supplementing" relationships. We will cover what Autism means, intense, "dream" like states, visual thinking & seeing movies. This might be hard for you to understand and you cannot verify any of this. In addition, you cannot see this thinking style, you can only guess. See previous episodes: Autism and RelationshipsUnderstanding the Rates of Autism Part 1 Origins of Autism: The Kanner Kids & Part 2 Origins of Autism: Asperger's "little professors"JD BarkerAutism and Neurulation (two episodes)Part 2: Autism & Sensory Processing Temple Grandin books https://www.templegrandin.com/templegrandinbooks.htmlDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma3:10 Relationships, Supplementing Relationships & Visual Thinking4:49 Kids of Kanner and Asperger's primary concerns6:02 What Autism means; Schizophrenia & Autism8:15 Attention to the environment & Mesencephalon roles; Neuroplasticity10:18 Social Norms11:52 Supplementing Relationships; Visual Thinking; JD Barker13:42 Temple Grandin material14:32 Visual Thinking & Processing Information/Sensations; The How of Supplementing Relationships18:17 Reviews/Ratings19:04 Daylight Computer CompanyX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
Relationships are challenging.In this episode, we explore some of the Autistic phenotype challenges in relationships. We discuss symptoms from criteria A are external and criteria B are internal, and how criteria B complicates the symptoms in criteria A. In addition, Autism is a comparison to social-norms, and this is a problem. Some environments/relationships discussed include peer-to-peer, romantic, and parent-child. To begin, we explain the mechanisms behind the speaker-receiver and the use of conveying speech in socialness.Before we begin, we cover a brief explanation of Speaker-Receiver and human communication.Dr. Theresa Regan episode https://youtu.be/aUhIreFd5swAutism and Adaptive Responses https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000658438095What is Autism: Criteria A https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000651048705The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273(0:00) Intro; Speaker-Receiver explanation when conveying speech(3:55) Unpredicableness in socialness; black and white thinking and context-dependent and adaptive responses; Metabolic energy/resources; Oxytocin and Serotonin(7:10) Biology that gives us Autism gives us complications to socialness and relationships; Sex-differences and socialness(8:40) Criteria A is external, Criteria B is internal; Sensory-Processing(10:32) B.2 and B.3 implicates socialness(16:58) Direct social interactions(22:26) Autism versus social norms; Romantic relationships(26:51) Do Autistics outgrow Autism?(28:04) Parenting(31:30) Cohabitating(32:28) Wrap Up(32:45) Reviews/Ratings and contact infoLinks: hopp.bio/fromthespectrumX: https://twitter.com/rps47586Email: info.fromthespectrum@gmail.com
For today's episode, John Coates from RF Safe returns to provide valuable and needed information about the harms of Radio Frequency Radiation and our modern environments.John Coates Episode 1 https://youtu.be/KgLj0X4AJh4?si=QS8KM6FUfASqpzTsRF Safe https://www.rfsafe.comJohn's X https://x.com/rfsafeSection 704 https://www.rfsafe.com/section-704-and-fcc-guidelines-cemented-a-dangerous-wireless-monopoly-at-the-expense-of-health-and-innovation/FCC https://www.fcc.gov/engineering-technology/electromagnetic-compatibility-division/radio-frequency-safety/faq/rf-safetyPublic Law 90-602 https://www.congress.gov/90/statute/STATUTE-82/STATUTE-82-Pg1173.pdfDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 John Coates1:17 Trump Phone4:29 Impact of 600 MHz on Health7:27 Antenna History & Safety10:15 WIFI vs. LIFI, The Future of Wireless13:07 Public Awareness16:25 Historical Context of RF Regulation; Public Law 90-602, Section 70419:07 Cellular Communication & Health22:31 The Need for Wireless Change39:46 Public Law 90-602, Health Trends, FCC49:21 Radiation & Regulation51:14 LIFI Technology; Infrared Light53:57 Microwave Cartel, Control, & Lack of Safety57:51 Government's Role1:01:30 The Future of Data Transfer & Bandwidth1:05:48 The Need for Unified Action & Change1:11:50 Light & Health1:14:54 Approaching the Government for ChangeX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In this episode we explore spindle neurons, also known as von Economo neurons (VENs), discovered by Constantine von Economo in the 1920s. These large, cylinder-shaped cells, found in the anterior cingulate cortex (ACC), anterior (or called frontoinsula) insula, and rarely the dorsolateral prefrontal cortex (DLPFC), are crucial for rapid communication in social behaviors. Three key points stand out: first, spindle neurons are located exclusively in the ACC and insula, the core hubs of the salience network, which is disrupted in autism as early as six weeks of age, as shown in a UCLA study. Second, these neurons are primarily involved in social behaviors, underpinning complex interactions in humans and other social species. Third, they are rare, found only in highly social animals like great apes, cetaceans, and possibly elephants, highlighting their evolutionary significance. In autism, increased spindle neuron density in the insula of children aged 4–14 is linked to early brain overgrowth, though this normalizes in adulthood due to pruning.The salience network, driven by the ACC and anterior insula, relies on spindle neurons to process relevant stimuli, integrate sensory data, and guide social-emotional responses. In autism, hyper-connectivity between the insula and sensory regions causes sensory hypersensitivity, while hypo-connectivity with prefrontal areas, including the DLPFC, impairs social cognition and adaptive behaviors. This disrupts the network’s ability to switch between the default mode network and executive functions, often trapping autistic individuals in an internal world. Spindle neurons are also linked to disorders like frontotemporal dementia, schizophrenia, Alzheimer’s, and emotional dysregulation.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for 10% discount3:10 Spindle Neurons; Interesting Point #1: Salience Network6:03 Interesting Point #2: Rapid Communication & Social Behaviors7:11 "rediscovery" of Spindle Neurons in 1990s by John Allman8:30 Interesting Point #3: Highly Social Species10:57 Neuropeptide Y & Monoamine- Dopamine & Serotonin11:45 Morphology of Spindle Neurons & In Utero-Children; Social Learning12:54 Species with Spindle Neurons14:47 Small Clusters within the dlPFC15:08 Salience Network, ACC, Anterior Insula; Fulcrum for Default Mode and Executive Networks22:48 Daylight Computer Company, use "autism" for $25 discount27:08 Diseases/Conditions associated with Spindle Neurons29:26 The Autistic Phenotype (!!) -- The Whole Reason for the Podcast32:25 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems.https://www.semel.ucla.edu/autism/team/catherine-lord-phdhttps://childmind.org/bio/catherine-lord-phd/https://labs.dgsom.ucla.edu/lord/pages/our_teamAutism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Intro(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum(11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments(16:36) Gaps in the Autism Assessment(23:15) The Challenges with Understanding the Spectrum of Autism(29:32) Updates on the Lancet Commission and Profound Autism(35:19) Barriers with Autism and the Medical Field(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests)(44:25) The Future of Autism and Helping Autistics Across the Life Span(51:03) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In this episode, we explore the impact of tech use and blue light on circadian biology, exploring how melanopsin and chromophores regulate physiology, mood, and cell functioning. The discussion highlights the leptin-melanocortin pathway, its role in placental physiology, and how ultra-weak biophotons from placental mitochondrial DNA influence fetal development, emphasizing the critical interplay of light and dark cycles in health.We further examine fetal brain development, focusing on mitochondria, neurogenesis, and the effects of UV light and nitric oxide on the thalamus and sensory integration. The episode connects BH4, tryptophan, and melanin deficits to Autism, discussing how environmental light and electromagnetic fields disrupt biological energy, contributing to neurodevelopmental problems and the Autistic phenotype.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Daylight Computer Company, use "autism" for $25 discount04:17 leptin-melanocortin pathway, biophotons, mitochondria, POMC, nitric oxide, BH4, fetal, placental physiology, fertility, ultra-weak biophotons, maternal blood, quantum biology, melanin, UV08:00 endocannabinoid, UV light, 380 nanometer, melanopsin, photo switch, brain development, leptin, mTOR, mitochondria, thalamus, sensory integration center, neurogenesis, fetal thalamus12:00 nitric oxide, autism, BH4, fetal ATP production, tryptophan, cellular redox, BPA, fluoride, deuterium absorption, electromagnetic fields, semiconduction, brain growth, biological energy16:03 Chroma Lights for Humans, use "autism" for 10% discount20:04 leptin-melanocortin pathway, leptin, adipose tissue, melanopsin, hypothalamus, POMC, placental physiology, ultra-weak biophotons, melanin, semiconductor, antioxidant, maternal physiology, brain volume24:23 biophotons, living cells, mitochondrial activity, cellular communication, electromagnetic waves, UV light wavelengths, energy, mitochondria, reactive oxygen species, TCA cycle, placental efficiency, thalamic timing28:29 mitochondrial DNA, retrograde signaling, gene expression, environmental cues, autism, heteroplasmy, biophoton coherence, calcium release, acetyl coenzyme A, fetal thalamus, neurogenesis, environmental light32:29 leptin-melanocortin pathway, neurodevelopmental problems, biophotons, somnathogenesis, circadian abnormalities, melanin, neural semiconduction, hyper excitability, hyper connectivity, salience network, attention, autistic phenotype36:34 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
My guest today is a special Mother's Day edition with Katie Asher. Katie is a devoted mother of five and founder of Asher House, who shares her inspiring journey of raising her son Houston, who has severe autism. Katie discusses the challenges of navigating trauma, loss, and an abusive past, all while advocating for Houston’s voice through groundbreaking communication methods like letter boards. She recounts the transformative moment when Houston, previously nonverbal, began spelling to communicate, revealing his profound intelligence and telepathic abilities, which reshaped her worldview and deepened their spiritual connection. Their story, detailed in their co-authored book The Book of Heaven, highlights resilience, faith, and the fight for recognition and inclusion for non-speaking individuals.Katie also critiques systemic failures in education and healthcare, exposing how institutions often dismiss the capabilities of those with autism, prioritizing profit over humanity. She passionately advocates for presuming competence, emphasizing the need for trust, love, and proper motor coaching to unlock communication. Through her experiences, Katie calls for a societal shift toward kindness, truth, and justice, urging listeners to value every soul and embrace the spiritual abundance that fosters unity and hope. Join us for an emotional and thought-provoking conversation that challenges assumptions and celebrates the power of connection.Katie Asher X https://x.com/KTAsher5Katie Asher Instagram https://www.instagram.com/asherhousehope/p/DHrUwDtv2R_/?img_index=1Asher House https://www.asher.houseThe Book of Heaven https://www.amazon.com/dp/1737898608DTP Hib https://en.wikipedia.org/wiki/DPT-Hib_vaccineImmune Thrombocytopenic Purpura (ITP) https://en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura0:00 Katie Asher1:33 Katie's Intro into Autism7;24 Challenges with the medical paradigm; Profits over Humanity13:35 Understanding Intelligence & Communication; Telepathy & Sensory Processing25:18 Spelling 2 Communicate31:24 Houston Pops In37:26 Building Trust & Communication Skills46:19 The Instinctual Desire to be Known48:00 Understanding Non-Verbal Communication50:26 The Abundance Mindset51:30 Unity through Truth & Justice52:42 The Struggles of Parents of Autistic Children54:10 The Role of Technology in Communication56:36 The Challenges of Motor Control1:00:00 Eloping & Self-Injurious Behavior; Being drawn to Water1:02:05 The Connection to Water1:03:50 Energy & Spiritual Connection1:05:46 The Role of Humanity in Nature1:07:31 The War between Nature & Machine1:08:35 Telepathy & Communication1:11:43 The Impact of Thoughts on Life1:15:50 Trusting God in Doubt; Contact InformationX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
My guest today is John Coates. John is the founder of RFsafe, and he is on a mission from a personal commitment to understand and educate the harms of non-native Electromagnetic Fields. John takes us through a passionate and personal story and educates us on many topics around these modern products. We explore cell phones, microwaves, routers, WIFI, computers, towers, and more. John also educates us about regulation changes such as Section 704 that prevents questioning the health factors related to our modern man-made environment. In addition, John offers a solution to the harms of WIFI by telling us about LIFI, or light fidelity. By the end of this episode, we hope you understand more about health implications related to these non-native EMFs.RF safe https://www.rfsafe.comSection 704 https://www.rfsafe.com/section-704-and-fcc-guidelines-cemented-a-dangerous-wireless-monopoly-at-the-expense-of-health-and-innovation/FCC https://www.fcc.gov/engineering-technology/electromagnetic-compatibility-division/radio-frequency-safety/faq/rf-safetyDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 John Coates02:20 Personal Mission & Commitment08:14 A fight for change; Policy & Tech11:29 Hidden Dangers of nnEMF14:19 Unconstitutional Laws & Public Health; Protecting Big Tech17:12 The Need for Safer Tech; Section 70420:34 LiFI, Light Fidelity23:20 Environment Emergency in Schools39:37 Evolution of nnEMF & Human Health42:31 nnEMF & Autoimmune Diseases51:45 Bioelectric Dissonance & Development01:03:42 The Role of Natural Environment & Health01:12:48 The Illusion of Safety in Tech01:16:50 Demanding Safer Tech for Children01:21:18 Bioelectric & DNA connection theory01:32:22 The Future of Personalized Health Solutions01:41:00 Scams of SRA; Cancer ratesX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
For today's episode we learn about the cerebellum with Dr. Reza Shadmehr. Dr. Shadmehr is a trailblazing neuroscientist whose groundbreaking work has reshaped our understanding of how the brain controls movement. With a rich academic journey—from a bachelor’s in electrical engineering to a PhD in robotics and computer science, followed by a postdoctoral fellowship at MIT—Dr. Shadmehr now leads the Shadmehr Lab at Johns Hopkins University. We dive into his pioneering theories, including motor memory consolidation, state space theory, and the neural encoding of action by the cerebellum’s Purkinje cells. The conversation explores the physics of motor movement, prediction, error correction, and the often-overlooked power of the cerebellum—a brain region Dr. Shadmehr calls an “underrated yet powerful” player in our daily lives.Dr. Shadmehr shares his personal path into neuroscience, sparked by a childhood fascination with the brain. This curiosity led him to blend engineering principles with biology, culminating in a lifelong mission to decode how the brain builds internal models for movement. We unpack the cerebellum’s critical role in fine-tuning actions—like stopping the tongue precisely or ensuring eye movements hit their mark, to cutting-edge research with marmosets. The episode also touches on the interplay between reward, effort, and cerebellar function, revealing surprising discoveries about how this brain region cancels noise to keep our movements smooth and purposeful. Shadmehr Lab: http://shadmehrlab.orgPublications: http://shadmehrlab.org/publicationsYT Videos (Very Good !): https://www.youtube.com/@shadmehrlab1352Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Reza Shadmehr02:26 Daylight Computer Company, use "autism" for $25 discount06:45 Chroma Light Devices- Lights Designed for Humans, use "autism" for 10% discount9:54 Reza's journey into Biomedical Engineering & Neuroscience16:26 Understanding the Cerebellum; 3 primary functions22:07 Neuronal Communication & Purkinje Cells; Sensory and Interneurons25:41 Cerebellum, eyes, and Autistic phenotype; Mesencephalon & other connections28:13 Excitation/Inhibition (E/I) balance; Video examples & Movement deficiencies 29:29 Layers of the Cerebellum34:08 E/I & Brain function36:30 Learning & Memory in the Cerebellum39:54 Dysfunction & Brain Compensation41:57 Basal Ganglia and Cerebellum43:48 Internal Calculators & Prediction49:42 Reward & Movement & Accuracy52:52 Movement control; Eye movements55:56 Purkinje Cells & Tongue movements; deceleration 59:47 Understanding Language of the Cerebellum 1:01:58 Future of Cerebellar Technology X: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In this episode, we explore the critical role of serotonin in shaping sensory maps within the brain, a process vital for interpreting sensory input and navigating the world. Serotonin, a neurotransmitter and neuromodulator synthesized from the aromatic amino acid tryptophan, influences brain development by fine-tuning sensory systems. It modulates neuronal growth, synaptic connections, and plasticity, which are essential for creating accurate sensory maps in regions like the somatosensory cortex, visual cortex, and auditory cortex. These maps serve as blueprints for processing touch, vision, and sound, with serotonin regulating the pruning of connections in the thalamus and cortex to ensure precise sensory wiring.The episode also explores the broader biological implications of serotonin, emphasizing its role in both prenatal and postnatal development. Maternally derived serotonin, supplied via the placenta from the peripheral and enteric nervous systems, significantly influences fetal brain development, affecting proliferation, differentiation, and neuronal migration in sensory regions. Postnatally, serotonin continues to support sensory integration and mood regulation, working alongside oxytocin to facilitate bonding and stress buffering. We explore environmental factors, such as stress and modern lighting, on serotonin synthesis and the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol release. Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for a 10% discount03:12, Sensory Map Introduction and Serotonin’s Role, The episode introduces sensory maps, neural blueprints that help the brain interpret sensory inputs like touch, vision, and sound, 04:30, Serotonin’s Developmental Impact, Serotonin fine-tunes sensory systems by modulating neuronal growth, synaptic connections, and plasticity, creating precise sensory maps in the somatosensory, visual, and auditory cortices,06:04, Serotonin and Sensory Processing (Visual), Serotonin, sensory processing in the visual cortex08:29, Critical Periods and Neuroplasticity, sensory neurons and connections, pruning10:00, Brain Regions and Serotonin’s Mechanisms, Serotonin, axonal guidance, neurogenesis, and migration via microtubules, brain-derived neurotrophic factor (BDNF), glutamate and GABA12:55, Serotonin and Sensory Processing (Somatosensory),13:51, Serotonin and Sensory Processing (Auditory),14:52, Stress and the HPA Axis, Cortisol, circadian rhythms and cortisol spikes, modern environments,16:16 Daylight Computer Company, use "autism" for a $25 discount20:38, Maternal Serotonin and Prenatal Influence; Postnatal Serotonin and Oxytocin; Tryptophan Metabolism and Neurodevelopment, placenta, fetal brain development, proliferation, differentiation, and neuronal migration, serotonin, oxytocin & bonding and stress buffering, TPH1 and TPH2, kynurenine pathwayX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction. Antipsychotics https://www.marketresearchfuture.com/reports/antipsychotic-drugs-market-2784#:~:text=The%20antipsychotic%20drugs%20market%20size,period%20(2023%20%2D%202030). Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618 Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/ Thinking in Pictures https://www.grandin.com/inc/visual.thinking.html Autism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s (0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment (7:00) The Prescription Era; Medication first Paradigm (10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning; (13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not? (13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism; (14:39) Subject Switching and Criteria B conflict (17:14) If you have met one child with Autism, you have met one child with Autism (17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience; (23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics; (27:00) Art was fine, other subjects were not fine; Details to General versus General to Details; (27:58) High School personal experiences; Pathway to Success ＞ General Education; (29:52) Did I graduate, or Not? (31:56) SAT (32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses) (36:34) Education Arrangement; Taking Notes is challenging (39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information