In this program, Dr. Jeffrey Gordon, Director of the Edison Family Center for Genome Sciences & Systems Biology at Washington University and the Scripps Institution of Oceanography's 2024 recipient of the Nierenberg Prize for Science in the Public Interest, discusses his research into the microbiome. Gordon is credited with founding the field of gut microbiome research. His transformative studies have demonstrated that human health and disease are shaped by the communities of microbes that live in the human gut. His body of work has opened up the vast new therapeutic potential for the microbiome, exemplified by his identification of ways to repair the gut microbiomes of children with malnutrition and restore their healthy growth. Series: "Science in the Public Interest" [Health and Medicine] [Show ID: 40154]
Madeline Oudin, Ph.D., is a scientist and mother on a groundbreaking mission to help her daughter, Margot, who has two de novo mutations in the SCN8A gene, which causes epilepsy. Margot's condition causes frequent seizures and developmental challenges. Determined to make a difference, Madeleine and her team are pioneering a cutting-edge genetic therapy that could one day transform treatment for Margot and others like her. In this heartfelt talk, Madeleine shares how her scientific expertise and personal journey intersect, revealing the highs and lows of developing life-changing treatments. From innovative approaches using Antisense Oligonucleotides (ASOs) to the unexpected success of a ketogenic diet, this story is about resilience, hope, and the power of community. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 40210]
Gloria Yiu, M.D., Ph.D., delves into the transformative potential of genetic editing technologies in addressing rare immune disorders, with a focus on CD3δ severe combined immunodeficiency (SCID)—a condition characterized by impaired T-cell development and severely compromised immune function. Leveraging her expertise as a physician-scientist, Yiu explores how CRISPR and other precision gene-editing tools can correct genetic mutations at the cellular level, potentially restoring T-cell production and immune resilience in patients with CD3δ SCID. Her presentation underscores the challenges and breakthroughs in treating such life-threatening conditions, emphasizing the role of interdisciplinary research, clinical innovation, and ethical considerations in advancing the frontiers of personalized medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40245]
The infections disease landscape is constantly changing - challenging our standard treatments. Can new - as well as ancient - therapies be the answer? Hear from experts on the cutting edge of phage therapy, HIV/AIDS research and cancer care about what is on the horizon to improve human health. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39982]
Examine how what we eat and how we live can promote wellness, enhance immunity, combat age-related diseases, and promote longevity. Gordon Saxe, M.D., Ph.D., and Anthony Lim, M.D., J.D., share a timeless perspective, supported by their own research and clinical experience, on how optimal nourishment, purposeful reflection, health movement, and generosity of spirit can improve age-related conditions and slow the aging process. They present evidence-based recommendations for diet and lifestyle, as well as a practical and simple framework to help foster extending healthy aging behavioral changes. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40049]
John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]
How can a healthy microbiome prevent disease? In this program, Dr. Sean Spencer talks about the vast microbial world that lives within our guts — known as the gut microbiome — and how it supports our health. He discusses the current evidence about how to nourish your microbiome to prevent and treat disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40074]
Catriona Jamieson, M.D., Ph.D., discusses pioneering research on cancer and aging in space environments, highlighting how microgravity accelerates cancer cell growth and leads to stem cell exhaustion, genomic instability, and “dark genome” activation. Using innovative tools like nano-bioreactors and artificial intelligence, her team simulates these effects and tracks cellular changes, uncovering how space’s unique conditions drive mutations and alter cellular behavior. They find that stem cells rapidly proliferate but then become exhausted in space, a process tied to telomere shortening and mitochondrial stress, impacting cell longevity and regenerative potential. Through collaborations with NASA and industry partners, Jamieson’s research aims to develop therapies to counter these effects, offering potential insights for cancer treatment and stem cell health on Earth. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39948]
Through the UniversityLink Medical Science Program (ULMSP), college students from underrepresented and disadvantaged backgrounds who aspire to become future health science professionals develop essential academic and professional skills, benefit from long-term mentoring, and build lasting social and professional networks. Dr. Ramón A. Hernandez highlights how the program fosters family support, instills a culture of academic excellence, and emphasizes the importance of community service, showing how ULMSP helps pave the way for these students' success in the health sciences. Series: "Education Channel" [Health and Medicine] [Education] [Show ID: 37921]
What's the secret to supporting a sharp mind at any age? In this program, Dr. Nancy Isenberg discusses the latest science-based practices to promote brain health and resiliency as we age. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40073]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Dennis O. Clegg, Ph.D., discusses treatments for age-related macular degeneration (AMD), a condition that causes vision loss. Clegg explains that while patients often report improved vision after receiving implants, objective tests don't always confirm this. He explores the potential differences in patients' responses based on genetics and disease progression. There is also an ongoing challenge in finding the best ways to reduce immune rejection of these treatments. New trials are underway to test implants in earlier stages of the disease, and researchers are looking at different strategies like localized immunosuppression. Additionally, some studies suggest that secretions from retinal cells may help preserve vision. Overall, there are many open questions, but advances in the field offer hope for better AMD treatments. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39459]
The risk for many chronic diseases is directly linked to metabolic changes in the body and loss of muscle mass often associated with aging. In this program, Dr. Natalie Marshall focuses on the central importance of movement, strength training, and body composition to improve metabolic fitness and tips to help you get started “building muscle for life." Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40071]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
UCSF Neurosurgeon Ethan Winkler, MD, PhD, summarizes the surgical treatment options for patients with brain aneurysms and describes the decision-making process for choosing the best treatment for each individual. Series: "UC San Francisco News" [Health and Medicine] [Show ID: 40238]
Mind-body medicine (MBM) is an integrative approach that helps people build awareness and develop tools for stress resilience. MBM focuses on the interactions between the mind, body, and behavior to promote health and well-being. Dr. Kavita K. Mishra discusses how MBM interventions have shown beneficial short and long-term impact on physical, mental, social-emotional, and interpersonal well-being. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40072]
Explore the captivating realm of brain research at UC San Diego with Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A. Furnari and Khalessi delve into groundbreaking efforts to find new treatments for neurological conditions such as brain tumors, stroke, and brain injuries, bringing hope to patients and their families. Emphasizing ethics, innovation, and patient care, Furnari and Khalessi shed light on the challenges and successes in their quest to unravel the mysteries of the mind. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39723]
Colin Depp delves into the critical role of social connections in our well-being, particularly in the context of aging. Depp explores the impacts of digital versus in-person interactions, the influence of cultural differences on social needs, and the potential health benefits of both deep and superficial connections. Depp also discusses the challenges of loneliness, the effects of grief, and offers practical daily practices to strengthen social ties. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39388]
A Neuroprosthesis for Speech Decoding and Avatar Control Series: "UC San Francisco News" [Health and Medicine] [Show ID: 40235]
Perpetual stress runs us down. But a truly restorative state that alters our bodies at the cellular level can counter this deterioration. Series: "UC San Francisco News" [Health and Medicine] [Show ID: 40226]
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