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Two critical care guys walk into a recording studio and breakdown intensive care trials both old and new! We'll also do deep dives on specific topics important to practicing intensive care medicine and have special guests talking about their area of expertise! This podcast is made for educational purposes. The content provided in this podcast, and in any linked materials, is not intended and should not be construed as medical advice and should not be used to diagnose or treat any medical condition. We try to stay away from opinions but all opinions represent our own and not of any entity we work for. Please keep this in mind as you enjoy the podcast!
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Send us a Text Message (please include your email so we can respond!) Back by popular demand, year in review! Or probably better titled "Our Favorite Articles of the Year" but I kept the title from last year. A smattering of papers and topics in this one ranging from avalanche survival, to intubation, to cardiac resuscitation and more. Happy New Year everyone! We will see you in 2026, thanks for listening and spending sometime with us. If you enjoy the show be sure to like and subscri...
Send us a Text Message (please include your email so we can respond!) Episode 81! In this episode we talk to Yonathan Fruend the senior author on the MODS study looking at a single questions approach to ruling out pulmonary embolism in the emergency department. This is not our typical patient population but this is a good episode, don't miss this one! MODS: https://pubmed.ncbi.nlm.nih.gov/41135553/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follo...
Send us a Text Message (please include your email so we can respond!) We start our Critical Care Reviews Down Under coverage with RSI talking with the first author of the "Ketamine versus Etomidate for Adults Receiving Emergency Endotrachael Intubation", Jonathan Casey! We will pick up the rest of our CCR Down Under Coverage after the holiday break! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated fig...
Send us a Text Message (please include your email so we can respond!) Episode 79! We talk all about perfusion with arterial lines in EVERDAC and personalized resuscitation with ANDROMEDA SHOCK 2! EVERDAC: https://pubmed.ncbi.nlm.nih.gov/41159885/ EVERDAC (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2502136 ANDROMEDA SHOCK 2: https://pubmed.ncbi.nlm.nih.gov/41159835/ ANDROMEDA SHOCK 2(JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840823 If you enjoy the show be sure to like...
Send us a Text Message (please include your email so we can respond!) Episode 78! We start our discussion of the trials that drop with ESICM with the much anticipated BICAR-ICU 2! Then we talk briefly about some changes to the SOFA score with the new SOFA-2 score. BICAR-ICU2: https://pubmed.ncbi.nlm.nih.gov/41159812/ BICAR-ICU 2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840824 SOFA-2: https://pubmed.ncbi.nlm.nih.gov/41159833/ SOFA-2 (JAMA): https://jamanetwork.com/journ...
Send us a Text Message (please include your email so we can respond!) Episode 77! We will start on ESICM coverage next episode. In this episode we talk about WFIT or "A Randomized Controlled Trial of a Post-ICU Telehealth Care Model" by Bakhru et al published in the blue journal September 2025! A long discussion but a good one! WFIT: https://pubmed.ncbi.nlm.nih.gov/40532205/ Editorial: https://pubmed.ncbi.nlm.nih.gov/40700738/ ICU Recovery Pilot: https://pubmed.ncbi.nlm.nih.gov/31385881/ If y...
Send us a Text Message (please include your email so we can respond!) We were LIVE from the CHEST Annual Meeting 2025! Thanks to everyone who came out and stuck around to chat afterwards. We cover a lot of ground including some conference and Chicago related banter (~8 minutes if you wanted to skip to the learning!) High frequency oscillation: https://pubmed.ncbi.nlm.nih.gov/40983167/ MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/ Continuous glucose monitoring: https://pubmed.ncbi.nlm.nih....
Send us a Text Message (please include your email so we can respond!) Episode 75! We talk about melatonin! We highlight MELLOW because it has the best acronym (by Burry et al in CHEST 2025). Then we dive into our mailbag! MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/ DEMEL: https://pubmed.ncbi.nlm.nih.gov/40608082/ Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/40662882/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icuc...
Send us a Text Message (please include your email so we can respond!) Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM. SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/ SBT (NEJM): https://www.nejm.org/doi/10.1056/NEJM199612193352502 SBT Timing: https://pubmed.ncbi.nlm.nih.gov/40393063/ SBT Timin...
Send us a Text Message (please include your email so we can respond!) We are (were) LIVE at ACNP Critical Care Bootcamp 2025! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the PIC trial or "Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia" by Lemiale et al published in the Lancet Respiratory Medicine September 2025 PIC (pubmed): https://pubmed.ncbi.nlm.ni...
Send us a Text Message (please include your email so we can respond!) Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018. UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/ UK-RO...
Send us a Text Message (please include your email so we can respond!) Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018. FLUID: https://pubmed.ncbi.nlm.nih.gov/405...
Send us a Text Message (please include your email so we can respond!) Episode 70! In this episode we have a special guest, Wes Ely, join us to talk about A2B or "Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients" by Walsh et al published in JAMA May of 2025. A long discussion but a good one, don't miss this one! Pubmed: https://pubmed.ncbi.nlm.nih.gov/40388916/ JAMA: https://jamanetwork.com/journals/jama/article-abstract/2834276 Editorial: https:...
Send us a Text Message (please include your email so we can respond!) Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation" by Bosma et al in NEJM. RESCUE-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/40498082/ PROMIZING (pubmed): h...
Send us a Text Message (please include your email so we can respond!) Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial". Disclaimer, this is stated in the episode but Todd and I are authors on this paper. Please keep that in mind as you enjoy the episode! Pubmed: https://pubmed.ncbi.nlm.nih...
Send us a Text Message (please include your email so we can respond!) Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon...
Send us a Text Message (please include your email so we can respond!) Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/ AJRCCM: https://www.atsj...
Send us a Text Message (please include your email so we can respond!) Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding! Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/ Transfusion threshold: https://pubmed.ncbi.nlm.nih.gov/23281973/ Transfusion threshold (NEJM): htt...
Send us a Text Message (please include your email so we can respond!) Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be su...
Send us a Text Message (please include your email so we can respond!) Episode 63! We talk about intermediate risk PE in "Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism" by Jaber et al published in Circulation in February 2025. Then we talk about "Fibrinolysis for patients with intermediate-risk pulmonary embolism" by Meter et al in NEJM 2014. PEERLESS: https://pubmed.ncbi.nlm.nih.gov/39470698/ PEITHO: https://...
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