In World War II, the U.S. government embraced a radical idea: putting scientists and technologists in charge of building advanced weapons. The rest, as we say, is history. What are the radical ideas we need today? And what can we learn from the history of Silicon Valley? This week, we talk with Steve Blank — serial entrepreneur, Stanford professor, and influential author who created concepts that define today's innovation ecosystem. After serving in the Air Force during the Vietnam War, Steve landed his first job at William Perry's now-famous Electromagnetic Systems Laboratory. He went on to launch several companies, from taking on Intel in microprocessor manufacturing to building early versions of CRM. His book, "Four Steps to the Epiphany," is credited as the intellectual backbone of the lean startup movement. He has also studied the Pentagon for decades, served on the Defense Business Board, and co-founded Stanford's Gordian Knot Center. We start with Steve's entrepreneurial journey and the evolution of Silicon Valley over the past 50 years, from helping end the Cold War to pioneering the computer and internet age. We also examine the devolution of government and its decline from the engine of technology and research in the 20th century to today's slow, bloated bureaucracy. Steve outlines his bold ideas for reforming the Pentagon and outpacing China in the technology race; he also breaks down the difference between execution and innovation and how the best organizations, like SpaceX, can manage both simultaneously. Finally, we discuss why Steve had called for a pause in AI research and, given his concerns over China, if we can afford to pause. 00:00 Episode Intro01:40 "Bill Perry was my first boss" 7:43 The Secret History of Silicon Valley12:14 How US govt fell behind SV17:05 SpaceX vs NASA22:00 Radical ideas for Pentagon 26:28 Execution vs Innovation31:13 Lean startup vs fat startup 40:11 Does industrial policy work? 43:40 Why did Steve call for AI pause? This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
What does political courage look like in action? What does it mean to stand up to special interests? And what are the fights we must take on — and win — to keep America free and prosperous? I recently interviewed Oklahoma Governor Kevin Stitt at the Cicero Institute's 2024 Courage Awards, where we recognized him and other bold leaders from across the country for taking on cronyism and corruption in the face of great opposition. Stitt considers himself a businessman governor: he started Gateway Mortage with $1,000 and a computer before scaling it into a national company. He never sought public office before running for governor, and since he's taken charge, he's run it like a business: balancing budget shortfalls, streamlining permitting, and slashing regulations. More impressively, he's demonstrated real courage in standing up to powerful special interests, like the homelessness industrial complex, and others you might not expect, like the police union. Learn how he succeeded in getting real help to the homeless and mentally ill, and why he vetoed a pension increase for police officers. Stitt also explains how woke nonsense and cronyism manifest even in a deep red state — and how to fight it; why politics shouldn't be a career profession; and how he succeeded in passing one of the boldest school choice programs in the nation. Oklahoma has become one of the nation's fastest-growing states under his leadership, and you'll see why. 00:00 Episode Intro01:58 Entrepreneur to governor05:29 Passing school choice8:33 Taking on the homeless industrial complex12:20 Vetoing police pension increase15:45 Slashing regulations19:05 Fixing the nursing shortfall / workforce readiness22:13 Limiting the growth of government This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
For Episode 100, we have a special conversation with Elad Gil, one of Silicon Valley's great thinkers, builders, and investors. Elad has been involved with many of the leading technology companies of the past 20 years — and likely the next 20 years. Learn how he's backed dozens of unicorns, why he thinks AI is underhyped, and where he sees investment opportunities amid this new wave of disruption. An early leader at Google, Elad helped build the initial mobile team, before founding MixerLabs, which was acquired by Twitter in 2009. Elad stayed on as VP of Corporate Strategy and became a key "fixer" during Twitter's hypergrowth phase. Later, he co-founded Color Health, a genetic testing company specializing in cancer detection. Over the past decade, he's backed nearly 40 unicorns, including Airbnb, Coinbase, Figma, Instacart, and Stripe. He's also invested in Harvey, Mistral, Perplexity, Pika, and other leading AI startups. In this episode, Elad takes us behind the scenes of the early days of Google and Twitter, and how Silicon Valley culture has evolved. He explains his three categories of exceptional founders and how he positioned himself to become one of the top angel investors. We also dive deep into AI, from the trajectory of LLMs to frameworks for investing in the AI value stack. Finally, we discuss AI's impact on education and the most exciting possibilities for the decade ahead. 00:00 Episode intro01:16 Building Google’s mobile team06:01 Early days at Twitter11:37 Building Color Health 15:57 How he’s backed dozens of unicorns 21:52 How small clusters of talent change the world25:20 Where are the young people in government?27:25 Where are the young startup founders?30:17 Why AI is underhyped36:40 Will LLMs get exponentially better? 39:10 Investing in the AI value stack41:33 AI and the future of education This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
The rich are getting richer, the poor are getting poorer. The wealthiest among us don't pay their fair share in taxes. The American Dream is disappearing... Are these claims true? What data are they based upon? And does it stand up to scrutiny? This week, we analyze the debate over income inequality and mobility in America with economist and former U.S. Senator Phil Gramm. In his book, "The Myth of American Inequality" (winner of the 2024 Hayek Prize), Gramm lays out the oft-cited data for widening inequality and exposes where it falls short. According to the U.S. Census Bureau, the top 20% of earners possess 16.7 times the income of the bottom 20%. However, Gramm reveals that this data excludes nearly all government transfer payments to the poor, like food stamps, and fails to subtract the high taxes paid by top earners. Adjusting for these factors, inequality drops from 16.7X to 4X! Gramm also points out that benefits to the poor have increased from $9,700 per household in 1967 (adjusted for inflation) to nearly $50,000 today. He argues that we suffer, not from extreme inequality, but from welfare-driven equality that encourages huge numbers of low-and-middle income Americans to drop out of the workforce. Senator Phil Gramm served in Washington D.C. for 25 years, first as a Congressman and later as a three-term Senator from Texas. He's an economist by training who taught at Texas A&M before entering public service. His book is a must-read for understanding the inequality debate, the truth about the super-rich, and the state of the American Dream. 00:00 Episode intro 03:32 Is inequality extreme and growing? 10:45 Elon Musk and the super-rich16:19 Is Warren Buffet cheating the government? 22:55 Industrial Revolution — setting the record straight 29:35 Do billionaires pay their fair share? 33:40 Is the American Dream dying? This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Founded in 1913, the Anti-Defamation League has played an important role in protecting the Jewish community and fighting for civil rights. But in recent years, many believe it has lurched too Left and promoted content that ends up harming Jews. I sat down with its CEO, Jonathan Greenblatt, to discuss what the ADL has gotten right and debate where it's gone wrong.Jonathan started his career in President Clinton's administration before finding success as an entrepreneur and later returning to the Obama White House. We don't align on politics, but we have mutual respect and I visited him at the White House during Obama's tenure to discuss policy issues. Many of the ADL's core activities are noble: report illegal threats against Jews, push back aggressively on anti-Semitism, and provide legal assistance for Jewish students harmed or threatened on college campuses. But recently, many on the Center and Right have taken serious issue with some of the ADL's actions, including its pressure campaigns against social media platforms and embrace of progressive politics that may be making Jews more vulnerable.In our candid discussion, I challenged Greenblatt on ADL's Left-wing stances and its promotion of critical race theory and Ta-Nehisi Coates' earlier work. I was encouraged to hear about the ADL's aggressive actions against Harvard, Penn, and other institutions after October 7; his agreement that oppressor vs oppressed frameworks foment hate against Jews; and his call for regime change in Iran, not appeasement.I’d like to see the ADL stop demonizing many on the Right and promoting woke nonsense on their site, distracting from its core purpose of fighting the actual enemies of Jews. But Jonathan and I agree that the ADL is an organization with a storied history and a valuable role to continue to play, especially given the pressing need to combat antisemitism today.00:00 Episode Intro 02:15 Jonathan's background 05:14 ADL's History 08:39 Lessons from October 7 15:33 Have things improved on college campuses? 17:20 Iran funding antisemitism in the US 20:20 Has ADL gone hard Left? Does ADL teach CRT? 24:00 Will ADL stop promoting Ta-Nehisi Coates? 28:36 How wokeness causes antisemitism This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
At 19 years old, Jimmy John Liautaud dropped out of college to start his own sandwich shop. He spent 10 years perfecting his first 10 stores, before franchising his model and scaling to nearly 3,000 Jimmy John's locations nationwide. Then the government almost destroyed it. This week, we sit down with the billionaire sandwich king to discuss his remarkable journey, the impact of government policy, and the consequences of elections. We dive into the business model that made Jimmy John's a national success, and how the Department of Labor under President Obama changed the regulations, sued his stores, and eventually caused him to sell the business. He now encourages business leaders to stand up and speak out, and explains why he's backing President Trump in the upcoming election. He shares a wealth of lessons learned, including the qualities he looks for in managers and how he can tell if a restaurant will succeed or fail by looking at the front door. Along with his personal success, he's also created hundreds of millionaires within the company, including many who started as sandwich makers, and he donates millions to wildlife preservation and scholarships for disadvantaged youth. Jimmy loves his country, his family, and his community; he's a true American success story and you'll see why.00:00 Episode Intro01:40 The first Jimmy John's store05:05 How Jimmy scaled nationwide07:03 How government almost ruined his business13:17 Why every election matters18:39 Want to win? Nail the details21:10 Turning around failing stores23:59 Minimum wage & AI + robots29:49 Final advice for entrepreneurs This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Roland Fryer is a profile in courage; the Harvard economist follows the data where it leads, no matter the outcome. He studied the impact of paying kids for positive behaviors. He demonstrated how charter school best practices can transform even the worst public schools. And most controversially, he conducted a comprehensive study of police use of force, finding that racial discrimination exists at low levels of force but not in shootings. His colleagues at Harvard pressured him to shelve the study; he received death threats. Learn why he didn't cave and why says he would do it again tomorrow. Roland is not only a leading public intellectual but also a builder. In 2020, he co-founded Sigma Squared, which uses data science and new AI tools to help employers find the best talent for the job, or as he says, supercharge meritocracy. His goal: bring HR into the AI age and take the hiring process from a well-educated guess to a precise science.Roland's accomplishments are even more impressive considering his upbringing: his father went to prison and his mother walked out. Yet, he fell in love with economics and worked his way through college — including stints at McDonald's and Golden Corral — to become the youngest tenured black professor in Harvard's history! Roland personifies American optimism, and you'll see why. Learn more about Roland's research and read his study on charter school best practices here. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
The U.S. Navy dominated in World War II, not because we had the most advanced ships, but because our industrial capacity was unmatched. When we lost a ship in battle, we could instantly replace it with two or three new ones. Our enemies couldn't keep pace. But today, our shipbuilding is a shell of its former self. In 1943, we built over 18,000 ships. Last year, we built eight (and retired 12). China, on the other hand, is producing hundreds of ships and now boasts 250 times the U.S. shipbuilding capacity! How can the U.S. Navy maintain deterrence? One answer is autonomous surface vehicles (ASVs) and harnessing new possibilities in AI to field and simultaneously coordinate hundreds or thousands of unmanned vessels. That's why Dino Mavrookas and his team are building Saronic Technologies — the leading ASV manufacturer. Saronic is the only company engineering the hardware, software, and AI to create modular platforms that can be produced economically at scale. They currently offer three classes of vehicles that can be fitted with various sensors and weapons (including the possibility of torpedoes!). Dino believes the push into unmanned, attritable systems is our generation's space race. He served 11 years as a Navy SEAL with eight combat tours before working as a private equity technology investor. He partnered with 8VC through its Build program to launch Saronic in 2022, and it has quickly become one of the fastest-growing defense technology companies. Saronic recently closed a $175 million Series B, making it the newest defense unicorn. Its advisors include former admirals and other naval leaders, and did we mention it's being built right here in Austin, Texas! This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Wilbur Ross is one of the great turnaround artists in modern finance. Dubbed the "King of Bankruptcy," he restructured over $400 billion of assets, saving companies — and jobs — in distressed industries like steel, coal, and textiles. In 2016, he went to Washington as U.S. Commerce Secretary to take on a similar mission and defend American companies and workers in high-stakes trade negotiations, particularly with China.We were privileged to host Wilbur for a conversation about his storied career and new book: “Risks and Returns: Creating Success in Business and Life." We began with his investment philosophy and how he reshaped Wall Street, including his close relationship with Mike Milken and the inception of leveraged buyouts. Wilbur also recalls going head-to-head with Donald Trump during the bankruptcy negotiations for the Taj Mahal Casino in Atlantic City, and explains how that interaction led him to become one of the first Wall Street leaders to support Trump's candidacy for president. Next, we dive into his tenure as Commerce Secretary and the ongoing debates over U.S. trade policy. He shares his favorite Trump story — an early interaction with Chinese President Xi Jinping — as well as the accomplishments he's most proud of, like regulatory relief, and what he wishes the administration had done differently: act faster and more boldly! Wilbur is a patriot and leader we can all learn from, and hope you'll check out his new book. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
He predicted Vladimir Putin would attack Ukraine months before it happened. Now he believes similar signals foreshadow China invading Taiwan. What similarities does he see? When and how would a Chinese incursion unfold? And what can the U.S. do to deter this conflict?This week, we're joined by Dmitri Alperovitch, co-founder of web security giant CrowdStrike, who departed the firm several years ago to focus on the intersection of technology, national security, and global competition as the Chairman of the Silverado Policy Accelerator. He's the author of an important new book: "World on the Brink: How America Can Beat China in the Race for the Twenty-First Century."We begin with Dmitri's entrepreneurial journey, from building a multi-billion dollar cyber security firm to lessons learned on the front lines of Chinese and Russian cyber attacks. Next, we discuss Dmitri's new book, his Cold War II thesis, and the comparative strengths and weaknesses between China and the U.S. He lays out Putin's rationale for attacking Ukraine and the similarities he sees with Xi Jinping and Taiwan — and even predicts the date China might invade! Finally, he explains the four key technologies where the U.S. must remain ahead of China to prevent a Cold War from turning hot. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Electronic shields are iconic elements of Star Trek, Star Wars, and other great American sci-fi. Once a fantasy, we are now building versions of these in real life! And they're a vital solution to a new type of threat confounding our legacy defense industry. This real-life force field alternative is called directed high-power microwave (HPM), and it's an answer to drone swarms and the proliferation of autonomous, attritable threats. Founded out of 8VC Build in 2018, Epirus is building the world's most advanced HPM systems, capable of disabling hordes of drones and other electronic devices up to miles away — and it only costs pennies to fire! This week, we talk with Epirus CEO Andy Lowery about the science behind HPM and why the Army, Navy, Marines, Air Force, and Space Force are all pursuing Epirus' technology. We begin with the changing nature of warfare and why harnessing — and defending against — autonomous, attributable systems is essential for any future conflict. Next, we dive into HPM technology and its myriad applications, from taking out drones, missiles, boats, and other vehicles to defending satellites in space. We also discuss the rise of "neo-primes" like SpaceX, Palantir, and Anduril and a new model for getting the best technology into the hands of our warfighters as quickly as possible. Finally, we discuss the importance of fusing Silicon Valley's AI and big data expertise with the U.S. defense-industrial base's advanced hardware experience in order to maintain our technological advantages over China and other adversaries. Learn more about Epirus’ approach to electronic warfare, and follow Epirus on Social: YouTube, LinkedIn, X This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Ken Langone's father was a plumber and his mother a cafeteria worker — neither made it past 8th grade — yet Ken became a multi-billionaire investor, builder, and philanthropist. And he did so as an outspoken patriot, defender of capitalism, and man of honor, famously taking on one of the most corrupt politicians of our time — and winning! In our conversation, we begin with Ken's investment philosophy, including how he became the largest shareholder in Eli Lilly. Next, we dive into leadership lessons and how he co-founded and grew Home Depot into an American icon valued at over $400 billion. But Ken is most proud of the fact that 3,000 associates who began pushing carts in the parking lot have gone on to become multi-millionaires within the company — a feat only possible under capitalism he says. In the 2000s, Ken had a front-page showdown with then-NY Attorney General Eliot Spitzer. Most of the Wall Street bigwigs in Spitzer's crosshairs cowered and ran, but not Ken. He fought back and won, exposing Spitzer's abuse of power. Ken hilariously recounts his epic battles and demonstrates the importance of fighting for justice and defending the honor of your colleagues, no matter the cost. Finally, we discuss the impact of Ken's prolific philanthropy, such as his recent $200 million donation to help make NYU Medical School tuition-free. For decades, he's also been a leader in education reform, including one of the greatest urban success stories: Harlem Children's Zone. They have proven that kids from the most difficult areas and family backgrounds can succeed, and have revealed the failings of the teachers' unions and education establishment. I'm fortunate to call Ken a friend and mentor. There will never be another quite like him, but we should do our best to follow his lead! This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Is greatness a choice? If so, why doesn't everyone choose greatness? And more broadly, what are the prerequisites for a great society? This week, I'm joined by Ethan Penner, author of the new book "Greatness Is a Choice" and one of the most influential figures in modern real estate. In his early 30s, Ethan pioneered the creation of commercial mortgage-backed securities and helped build a new market at a critical moment in history. We discuss his journey from the streets of Yonkers to the heights of Wall Street and what he learned from industry greats like Sam Zell. Ethan is also a student of history, religion, and philosophy who cares deeply about advancing freedom and helping others find purpose in life. His new book argues that most people misunderstand greatness and equate it to the top one percent of society. Rather, he believes that greatness is a daily decision to choose excellence, and by deliberately choosing excellence we can bring newfound meaning and fulfillment to our daily lives. Through concise and pointed chapters, like "The Debilitating Effects of the Victim Mentality" and “Equality Is Not the Point," Ethan diagnoses where our modern culture has gone awry and offers an antidote that can inspire us all to pursue greatness. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
At Columbia University's freshman orientation, Coleman Hughes and his classmates were separated into groups by skin color to discuss the effects of racism, with minorities portrayed as victims and white students as beneficiaries. Why have exercises like this become commonplace in elite institutions? How did this neo-racism take hold? And what are the counter-arguments and better approaches to race and diversity? These questions are at the heart of Coleman's new book: "The End of Race Politics: Arguments for a Colorblind America." A talented, rising public intellectual, Coleman was one of the first courageous voices pushing back against the "anti-racist" pablum popularized by Ibram Kendi and Robin DiAngelo. He's a contributor to The Free Press, analyst at CNN, and host of the popular podcast "Conversations with Coleman." In this episode, Coleman argues for a return to colorblindness and the ethics of MLK — not that we pretend we can't see race, but that we strive to move beyond it and focus on character, culture, and merit instead. He makes the case that socioeconomic factors, not race, are more accurate proxies for helping the most disadvantaged in society, and our public policy should be oriented as such. He also exposes the lazy thinking and platitudes that permeate conversations about race, along with some of the worst ideas done in the name of diversity, such as rejecting standardized tests. Finally, we discuss a better way to acknowledge America's past sins while moving forward in a way that unites our country. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Dr. Clarence Jones is a giant of the civil rights movement. As the personal attorney and speechwriter for Dr. Martin Luther King Jr., he risked everything to help save the soul of America, including smuggling scraps of papers in and out of Birmingham prison that would become Dr. King's Letter from Birmingham Jail. In fact, Dr. Jones never thought he'd live to see the age of 50. Today, he's 93 years old, and one of the last living civil rights icons. In this episode, we trace the journey of an American hero — the son of domestic servants who became valedictorian of his high school and studied at Juilliard before becoming a successful entertainment lawyer. That is until Dr. King showed up at his California home asking for legal assistance. After initially turning him away, he went to hear Dr. King preach, and his life — and the direction of our country — changed forever. We discuss the key moments in his fight for justice, the significance of the black-Jewish alliance, and the legacy of Dr. King, including his thoughts on today's debate over DEI, Critical Race Theory, and colorblindness. He also shares his powerful approach to radical non-violence and his advice for young people today: pursue excellence. Dr. Jones has lived an extraordinary life, and his wisdom on issues of race should be heeded over many of the voices in popular culture today. SHOW NOTES: Dr. Jones was recently awarded the Presidential Medal of Freedom, the Nation's highest civilian honor. Last year, Dr. Jones released his memoir, "Last of the Lions." Learn more about Dr. Jones' work through his foundation and as Chair of the Spill the Honey Foundation, which continues the legacy of the Black-Jewish Alliance. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Are government programs and interventions superior to market corrections? According to Dr. Cliff Winston, the evidence to support such a claim doesn’t exist. Many economists obsess over market failures but seldom point the microscope in the direction of government, despite its many failures. And worse, the bureaucracy doesn't hold itself accountable. This week, we examine some of the flaws of modern economic theories with Dr. Winston, a microeconomist and Senior Fellow at the Brookings Institution, with a B.A. and Ph.D. in economics from UC Berkeley, and Masters from the London School of Economics. He is the author of numerous books and papers, including, most recently, “Indispensable: Market corrections in a U.S. economy beset by government failures.” From antitrust to welfare programs and tax incentives, most Americans assume government interventions are preferable to allowing the market to correct itself, but as Cliff explains, we don't have scholarly evidence to back that up. He explains why we need government retrospectives and more widespread experiments to test what does or doesn't work. When has government been effective? Ironically, Cliff says, when it gets out of the way: deregulation. We talk about the benefits of airline deregulation, for example, and Cliff makes the case for deregulating the legal profession and other areas that require occupational licensure. Finally, we discuss scenarios where government involvement could be beneficial, such as setting adoption standards for autonomous vehicles. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
STEM (science, technology, engineering & math) education is the backbone of the innovation economy. Yet at many schools, it's become stodgy and irrelevant to solving real-world problems. Not surprisingly, many of the best minds forgo college or drop out. What would it look like to design a STEM program that is inspiring, cutting-edge, and grounded in timeless truths? And how do you educate the next generation of great entrepreneurs who are also citizens of virtue? This week, we discuss a better model for STEM with Dr. David Ruth, Dean of the Center for STEM at the University of Austin (UATX). Dr. Ruth is a retired U.S. Navy Captain who worked on a nuclear attack submarine, an aircraft carrier, and as a war planner in Asia, before teaching advanced mathematics at the U.S. Naval Academy for 13 years. In this episode, Dr. Ruth lays out UATX's approach to 21st-century STEM: a curriculum that balances first principles with practical application and unparalleled industry engagement. (We're already partnering with The Boring Company and other leading companies in Texas!) Many STEM programs bog down students in unnecessary tasks; UATX is taking a different approach with "computation-enabled thinking" that combines what humans do best (abstracting, modeling, and interpreting) with what computers do best (computation). We also discuss how to safeguard science and math from identity politics, and the importance of making STEM exciting and challenging through innovative games and challenges. If you're a student pursuing a STEM education, we hope you'll check out what we're building at UATX. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
In 1979, Crown Prince of Iran Reza Pahlavi was attending fighter pilot school in Lubbock, Texas when the Islamic Revolution overthrew his father's reign. A radical theocracy seized power and began extinguishing freedoms, persecuting minorities, and taking a pro-Western Iran back to the Middle Ages. Since then, the Crown Prince has lived in exile as a leading voice for a secular and democratic Iran. What is his view of the Revolution? Why does he believe regime change is possible today? And how should the U.S. and the West deal with Iran? Given Iran's recent attack on Israel, we get a rare and timely perspective on the power dynamics within Iran and why the current regime is more fragile than we realize. The Crown Prince paints a picture of his homeland pre-and-post Revolution, and explains why many governments misunderstand the fanatical leadership of Iran. He lays out his strategy of "maximum support" and how combining sanctions and external pressure with internal support, such as internet access and financial resources for protestors, could someday topple the regime. And if it does, he details a post-regime strategy to transition the government toward a secular democracy. We also discuss the longstanding history between the Persian and Jewish people, and how, with the right leadership, the region could once again become dynamic and prosperous. [NOTE: this conversation was recorded shortly before Iran launched hundreds of missiles and drones at Israel.] This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
India’s tech ecosystem has hit an indisputable inflection point in recent years. For decades, American corporations outsourced basic services to India, while India outsourced its top talent to Silicon Valley. But today, India’s tech economy boasts homegrown software giants and a flourishing startup scene.This week, we get a front-row look into India’s startup evolution with one of its top talents: Sri Ganesan, Founder and CEO of Rocketlane. His first company, Konotor, was acquired into Freshworks, which went public in 2021 for $10 billion and became one of India's biggest wins. Now, Sri is building Rocketlane into a leading solution for SaaS deployment and professional services automation, with teams in the U.S. and India. By combining American know-how with Indian talent, Rocketlane represents an important dynamic for the future of tech and expanding key partnerships around the world. In this episode, we dive into the lessons learned from Freshworks's success and how it paved the way for greater entrepreneurial risk within India. We also explore Sri's journey in scaling Rocketlane, from finding product-market fit to positioning the company to take advantage of the AI wave. We discuss what India’s rise to become one of the world's most important economies means for the future of tech and global talent distribution, along with the cultural differences between India and the US, and what it's like building on two continents simultaneously. Finally, Sri guides us through the various tech hubs in India, from Mumbai to Bangalore and Chennai, even down to his favorite restaurant and must-visit destinations for anyone heading to India soon. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
Every year, more than 20,000 Americans receive a bone marrow transplant — a Nobel prize-winning procedure that saves many lives but also carries great risk. For leukemia patients, it's a choice of last resort, as nearly 20% die from the transplant. Ivan Dimov, co-founder & CEO of Orca Bio, and his team have created a novel cell therapy alternative that has already saved over 400 lives in clinical trials with virtually zero rejection!This week, we dive into Ivan's journey, the science behind Orca's cancer breakthrough, and the potential of cell therapies to cure a host of other diseases. By discovering new, high-precision methods to manipulate cells, Orca is able to provide leukemia patients with a designer immune system that attacks the cancer while nearly eliminating rejection. By safely rebooting the immune system, Ivan and his team believe Orca also has the potential to cure autoimmune diseases like Crohn’s disease and multiple sclerosis, and impact the lives of millions of Americans.Orca is currently seeking the first-ever FDA approval in this space, and since it's a unique one-time curative therapy, they are also commercializing the drug in-house — a rare move in biopharma. Ivan walks us through the path to bringing Orca's products to market, from collaborating with regulators to negotiating with insurance companies and scaling up its manufacturing. Though many challenges remain, you'll see why we're incredibly bullish on Ivan's leadership and Orca's potential to transform the future of medicine. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit blog.joelonsdale.com
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