Longevity Matters Podcast with Dr. James Meschino: Live Longer, Live Better and Thrive

In  part 2 of the health and anti-aging benefits of CoQ10, Dr. Meschino explains the human studies using CoQ10 to prevent and manage cardiovascular conditions, such as congestive heart failure and high blood pressure. He also explains the human studies using CoQ10 in the management of COPD, recovery from pneumonia, cancer and cancer recurrence prevention, asthma and other conditions. He also explains dosages of CoQ10 recommended for anti-aging, longevity and healthy life expectancy, the form of Co10 to use and how to best absorb it from the intestinal tract. Some Key Scientific References: Mantle D. Pharmacology of coenzyme Q10: Relevance to cardiovascular and other disorders. Nurse Prescribing. 2013. 11(12):602-607 http://www.magonlinelibrary.com/doi/abs/10.12968/npre.2013.11.12.602 •Alehagan U, Johansson P, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiology, 2013, 167(5):1860-1866 http://www.internationaljournalofcardiology.com/article/S0167-5273(12)00593-1/abstract Mantle D and Dybring A. BIoavailability of coenzyme Q10: AN overview of the absorption process and subsequent metabolism. J Antioxidants (Basel). 2020; 9(5): 386.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278738/ Zoxina V.I. Coenzyme Q10 in COPD: An unexplored opportunity? Journal of Chronic Obstructive Pulmonary Disease. 2020; 18)1): 114-122 https://www.tandfonline.com/doi/full/10.1080/15412555.2020.1849084  References for CoQ10 and Immune System and Cancer: •https://www.ncbi.nlm.nih.gov/books/NBK65890/ •https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736082/ •https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840161/ •https://jdc.jefferson.edu/cgi/viewcontent.cgi?referer=https://www.google.com/&httpsredir=1&article=1009&context=jmbcim •Alpha Lipoic acid and CoQ10 reduces Cisplatin Nephrotoxicity - https://www.hindawi.com/journals/iji/2020/5369797/ Some Additional References of Significance: •https://www.walshmedicalmedia.com/open-access/the-breakthroughs-of-karl-folkers-in-biochemistry-and-human-nutrition-2161-0509-1000213.pdf •https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482328/ •https://pubmed.ncbi.nlm.nih.gov/27345130/ 

In this episode Dr. Meschino explains how Coenzyme Q10 was discovered and the extensive research undertaken on CoQ10 by renowned  researcher Dr. Karl Folkers - the father of CoQ10 research. He explains its role in the heart health, with implications for the prevention and management of congestive heart failure and high blood pressure and he touches on other studies involving HIV infection and cancer. Dr. Meschino explains how cells in the body use CoQ10 for energy production and as a key fat-soluble antioxidant and immune-modifying agent. Some Key Scientific References: http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/folkers-karl.pdf https://pubmed.ncbi.nlm.nih.gov/27345130/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131403/

In this episode Dr. Meschino explains the specific ways that vitamin C influences individual immune cells, helping to enhance their ability to prevent and fight many infections as well as cancer. He explains ideal vitamin C blood levels, vitamin C requirements under changing conditions, and factors known to deplete vitamin C from the body. He also reviews clinical studies showing the value of vitamin C in fighting specific types of infections, and cautions people with certain health conditions about precautions they should exercise regarding vitamin C supplementation. Dr. James Meschino is an associate professor in the division of physiology and biochemistry at the Canadian Memorial Chiropractic College, where he has taught nutrition and biochemistry since 1984. He has also been a faculty member at the Canadian College of Naturopathic Medicine, the American Academy of Anti-Aging Medicine and the American Council on Exercise (ACE). He is the author of four nutrition/wellness/anti-aging books. He also teaches Advanced Nutritional Medicine for the Global Integrative Medicine Academy (www.gim-academy.com). Dr. Meschino has lectured extensively throughout North America and is the formulator for Adeeva supplements – a professional supplement line (www.adeevainfo.com). Key References: https://jlb.onlinelibrary.wiley.com/doi/pdfdirect/10.1189/jlb.0806541 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/ https://www.medpagetoday.com/casestudies/infectiousdisease/87976 http://rs.yiigle.com/yufabiao/1189815.htm https://www.pharmacistsmb.ca/files/2014/winnipeg_freepress/winnipeg_free_press_-_vitamin_c_a_legitimate_weapo.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872359/ https://www.mdpi.com/2072-6643/12/8/2447 https://www.acpjournals.org/doi/10.7326/0003-4819-140-7-200404060-00010 https://lpi.oregonstate.edu/mic/vitamins/vitamin-C https://www.acpjournals.org/doi/10.7326/0003-4819-140-7-200404060-00010 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400679/#:~:text=High%20dietary%20fat%20and%20sugar,vitamin%20C%20intake%20and%20status.&text=Staple%20foods%20such%20as%20grains,lower%20overall%20vitamin%20C%20intake