Medscape InDiscussion: Psoriasis

What drives patients with psoriasis to seek care? Dr Steven Feldman and Professor Andrew Finlay, inventor of the Dermatology Life Quality Index, explore what matters most to patients. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965160). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals. Resources How is the severity of psoriatic arthritis and psoriasis usually assessed? https://www.medscape.com/answers/2196539-155443/how-is-the-severity-of-psoriatic-arthritis-and-psoriasis-is-usually-assessed Dermatology Life Quality Index (DLQI) https://www.bad.org.uk/shared/get-file.ashx?id=1653&itemtype=document Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2230.1994.tb01167.x Determining the Minimal Clinically Important Difference and Responsiveness of the Dermatology Life Quality Index (DLQI): Further Data https://www.karger.com/Article/FullText/365390 A Changed Life: The Life Experiences of Patients With Psoriasis Receiving Biological Treatment https://onlinelibrary.wiley.com/doi/10.1111/bjd.18876 Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): The Correlation Between Disease Severity and Psychological Burden in Patients Treated With Biological Therapies https://pubmed.ncbi.nlm.nih.gov/23425140/

What's the best way to screen for common comorbidities in patients with psoriasis, and how do the experts respond when clues of systemic disease show up? Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965161). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals. Resources Psoriasis https://emedicine.medscape.com/article/1943419-overview#a6 Axial Psoriatic Arthritis: An Update for Dermatologists https://www.jaad.org/article/S0190-9622(20)30959-2/fulltext Psoriatic Arthritis https://emedicine.medscape.com/article/2196539-overview Psoriatic Arthritis: State of the Art Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297592/pdf/clinmed-17-1-65.pdf Joint American Academy of Dermatology–National Psoriasis Foundation Guidelines of Care for the Management of Psoriasis With Systemic Nonbiologic Therapies https://www.jaad.org/article/S0190-9622(20)30284-X/fulltext Axial Spondyloarthritis https://ard.bmj.com/content/80/12/1511.long Use of IL-23 Inhibitors for the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727454/pdf/40257_2020_Article_578.pdf Risankizumab, an IL-23 inhibitor, for Ankylosing Spondylitis: Results of a Randomized, Double-blind, Placebo-Controlled, Proof-of-concept, Dose-Finding Phase 2 Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104676/pdf/annrheumdis-2018-213328.pdf Axial Involvement in Psoriatic Arthritis Cohort (AXIS): The Protocol of a Joint Project of the Assessment of SpondyloArthritis International Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721378/pdf/10.1177_1759720X211057975.pdf Three Multicenter, Randomized, Double-blind, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis https://onlinelibrary.wiley.com/doi/10.1002/art.40728 Efficacy of Guselkumab on Axial Involvement in Patients With Active Psoriatic Arthritis and Sacroiliitis: A Post-Hoc Analysis of the Phase 3 DISCOVER-1 and DISCOVER-2 Studies https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(21)00105-3/fulltext Efficacy and Safety of Ustekinumab in Psoriatic Arthritis Patients With Peripheral Arthritis and Physician-Reported Spondylitis: Post-hoc Analyses From Two Phase III, Multicentre, Double-blind, Placebo-Controlled Studies (PSUMMIT-1/PSUMMIT-2) https://ard.bmj.com/content/75/11/1984.long BASDAI Calculator https://qxmd.com/calculate/calculator_299/basdai Effectiveness, Costs and Cost-effectiveness of Chiropractic Care and Physiotherapy Compared With Information and Advice in the Treatment of Non-specific Chronic Low Back Pain: Study Protocol for a Randomised Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741874/pdf/13063_2017_Article_2351.pdf Axial Involvement in Psoriatic Arthritis: An Update for Rheumatologists https://www.sciencedirect.com/science/article/pii/S0049017221001190?via%3Dihub Dactylitis: A Hallmark of Psoriatic Arthritis https://www.sciencedirect.com/science/article/pii/S0049017217306261?via%3Dihub Psoriasis Workup https://emedicine.medscape.com/article/1943419-workup#c2 Treatment Guidelines in Psoriatic Arthritis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065461/pdf/kez383.pdf Risk of Myocardial Infarction in Patients With Psoriasis https://jamanetwork.com/journals/jama/fullarticle/203598 Cardiovascular Disease Prevention for Psoriasis and Psoriatic Arthritis (CP3) https://www.med.upenn.edu/gelfand/research.html Primary Care-Based Screening for Cardiovascular Risk Factors in Patients With Psoriasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113692/pdf/BJD-175-348.pdf Psoriasis: Comorbidities https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252780/pdf/JDE-48-732.pdf Changing Health Behaviours in Rheumatology: An Introduction to Behavioural Economics https://www.nature.com/articles/s41584-019-0336-1 The Influence of Body Weight of Patients With Chronic Plaque Psoriasis on Biological Treatment Response https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262805/

Dermatologists Steven Feldman and Melinda Gooderham share expert advice and go-to options for topical use in patients with psoriasis. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965162). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Joint AAD–NPF Guidelines of Care for the Management and Treatment of Psoriasis With Topical Therapy and Alternative Medicine Modalities for Psoriasis Severity Measures https://www.jaad.org/article/S0190-9622(20)32288-X/fulltext#secsectitle0050 Does the Vehicle Matter? Real-World Evidence on Adherence to Topical Treatment in Psoriasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539972/ Optimizing the Use of Topical Agents in Psoriasis https://www.scmsjournal.com/wp-content/uploads/2017/02/v33i2s-Optimizing-the-use-of-Topical-Agents.pdf

Dr Joel Gelfand talks with host Dr Steven Feldman about why phototherapy is a great tool for treating psoriasis. He shares insights on who can benefit and how to approach patients about it. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965163). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Plaque Psoriasis Treatment & Management https://emedicine.medscape.com/article/1108072-treatment#d11 Effect of UV-B Phototherapy on Plasma HIV Type 1 RNA Viral Level: A Self-Controlled Prospective Study https://jamanetwork.com/journals/jamadermatology/fullarticle/189280 Effect of Two Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991103/

This podcast has the goods on what oral therapy to recommend for almost any circumstance, even weddings. Drs Steven Feldman and Bruce Strober share a treasure trove of practical wisdom. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/965165). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Acitretin Revisited in the Era of Biologics https://pubmed.ncbi.nlm.nih.gov/20673152/ Combining Biologic Therapies With Other Systemic Treatments in Psoriasis: Evidence-Based, Best-Practice Recommendations From the Medical Board of the National Psoriasis Foundation https://jamanetwork.com/journals/jamadermatology/article-abstract/2019961 Joint American Academy of Dermatology–National Psoriasis Foundation Guidelines of Care for the Management of Psoriasis with Systemic Nonbiologic Therapies https://www.jaad.org/article/S0190-9622(20)30284-X/fulltext

Host Dr Steven Feldman unpacks years of accrued knowledge on managing psoriasis using biologic therapy, with our special guest Dr Craig Leonardi. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/965167). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Joint AAD-NPF Guidelines of Care for the Management and Treatment of Psoriasis With Biologics https://www.jaad.org/article/S0190-9622(18)33001-9/fulltext Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review https://pubmed.ncbi.nlm.nih.gov/32121574/ Biologic Treatments of Psoriasis: An Update for the Clinician https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896737/

Dr Steven Feldman and Leah Howard, National Psoriasis Foundation President and CEO, discuss how an unseen and unheard patient population has begun to step out and speak up — at the US Capitol and beyond. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986130). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources National Psoriasis Foundation (NPF) https://www.psoriasis.org/ Management of Psoriasis as a Systemic Disease: What Is the Evidence? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187293/ Psoriasis: Classical and Emerging Comorbidities https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323693/

Dr Steve Feldman speaks with Drs Mehta, Ritchlin, and Fried who share an exciting new roadmap for calming key psoriasis comorbidities. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986151). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Treatment of Psoriasis With Biologic Therapy Is Associated With Improvement of Coronary Artery Plaque Lipid-rich Necrotic Core: Results From a Prospective, Observational Study https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.120.011199 Treating the Skin With Biologics in Patients With Psoriasis Decreases the Incidence of Psoriatic Arthritis https://pubmed.ncbi.nlm.nih.gov/34281904/ The Patient Health Questionnaire-2: Validity of a Two-Item Depression Screener https://pubmed.ncbi.nlm.nih.gov/14583691/

Drs Steven R. Feldman and Kim A. Papp discuss the expanding universe of opportunities and advances for halting limited psoriasis. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986152). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Trial of Roflumilast Cream for Chronic Plaque Psoriasis https://pubmed.ncbi.nlm.nih.gov/32668113/ Psoriasis in Special Localizations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330687/ Vitamin D Analogs in the Treatment of Psoriasis: Where Are We Standing and Where Will We Be Going? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219168/

Dr Steven R. Feldman and nurse practitioner Lakshi M. Aldredge discuss systemic therapy for psoriasis and how nurse practitioners and physician associates fill an important gap. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986153). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199465/?report=reader Tumor Necrosis Factor Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK482425/ Deucravacitinib for the Treatment of Psoriatic Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372960/

Drs Steve Feldman and Andrew Blauvelt have a fascinating chat about contrasts and similarities between biologics and biosimilars, covering pharmacoeconomic and legal differences between the US and Europe. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986154). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Biosimilar Drugs for Psoriasis: Principles, Present, and Near Future https://pubmed.ncbi.nlm.nih.gov/29549597/ International Psoriasis Council https://psoriasiscouncil.org/ Biosimilars for Psoriasis: Clinical Studies to Determine Similarity https://pubmed.ncbi.nlm.nih.gov/27639072/ Safety, Efficacy and Drug Survival of Biologics and Biosimilars for Moderate-to-severe Plaque Psoriasis https://pubmed.ncbi.nlm.nih.gov/29094341/

Drs Steve Feldman and Megan Noe fill in the gaps about pustular psoriasis, a relatively rare but serious condition that can be tough to diagnose. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986155). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Palmoplantar Pustulosis: Current Understanding of Disease Definition and Pathomechanism https://pubmed.ncbi.nlm.nih.gov/32201085/ Evaluation of a Case Series of Patients With Generalized Pustular Psoriasis in the United States https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655659/ Pathophysiology of Generalized Pustular Psoriasis https://pubmed.ncbi.nlm.nih.gov/36779688/ Trial of Spesolimab for Generalized Pustular Psoriasis https://pubmed.ncbi.nlm.nih.gov/34936739/