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Mind & Matter
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Mind & Matter

Author: Nick Jikomes

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Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
313 Episodes
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Send us Fan Mail Nick talks with Prof. Gary Lewin (Max Delbrück Center, Berlin) about naked mole-rats, which in lab tests survived 18 minutes in pure nitrogen by shutting down brain activity, keeping the heart beating, and switching to fructose for fuel. TOPICS DISCUSSED: • From Pain Research to Mole-Rats: The work began when the animals turned out not to feel the burn of capsaicin. • Ecology & Eusociality: Colonies with a queen, one breeding male, workers, and soldiers, spread across sem...
Send us Fan Mail Nick talks with Prof. Lutz Schomburg about selenium biology in the endocrine system: selenoprotein P as the liver’s selenium transport protein and status biomarker, autoantibodies that can impair delivery despite normal blood selenium, thyroid autoimmunity (Hashimoto’s and Graves’), diabetes, aging, and what selenium supplementation trials show. TOPICS DISCUSSED: • Selenoprotein P: Liver-made transport protein that delivers selenium to tissues and serves as a status biomarker...
Send us Fan Mail Controlled human feeding trials show added fructose raises liver fat, triglycerides, uric acid, and insulin resistance at real-world doses. TOPICS DISCUSSED: Glucose vs Fructose in the Liver: Glucose and fructose are handled by the liver in distinct ways.Natural Sugars vs Processed Sugars: Whole fruit is mostly water, fiber, and micronutrients at modest sugar density; cookies and sodas pack far more sugar per weight and are easier to overconsume.HFCS on Store Shelves: Industr...
Send us Fan Mail How genomics is used to study what makes a human brain, and how genetically damaged neurons get removed. TOPICS DISCUSSED: Scale & Size: A human brain is about three times a chimpanzee brain by mass, but the larger change is extra association cortex and extra upper-layer circuits that talk mostly to other cortex.When Development Ends: Most cortical neurons are born before birth. Myelin and other glia keep forming into the twenties. Synapses keep changing after that.Broken...
Send us Fan Mail The biology of endogenous cannabinoids & history of cannabinoid-based therapeutics TOPICS DISCUSSED: Anandamide vs 2-AG: The two major endocannabinoids with a shared arachidonic acid backbone but distinct head groups biological roles.On-demand production: Calcium-dependent enzymes release cannabinoids from membranes in response to neuronal activity patterns.Trafficking: Fatty acid binding proteins and extracellular microvesicles traffic endocannabinoids within and between...
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