In this episode, Lauren & Matt speak with Neguine Rezaii, MD, an Assistant Professor of Neurology at Harvard Medical School and a Board-Certified Neuropsychiatrist at Mass General Hospital. Dr. Rezaii’s research focuses on using natural language processing and artificial intelligence to improve the detection and classification of neurodegenerative disorders.Dr. Rezaii talks about her recent study, “Voiceprints of Cognitive Impairment: Analyzing Digital Voice for Early Detection of Alzheimer’s and Related Dementias,” which explores how artificial intelligence can analyze short speech samples to identify subtle signs of cognitive impairment. The study used speech recordings from 120 individuals and found that features such as pauses, word choice and the specificity of language can help distinguish cognitive impairment and Alzheimer’s disease.The conversation also explores how a simple 30-second speech test could potentially be used in clinical settings to support earlier detection and monitoring of cognitive impairment, as well as the challenges and ethical considerations that come with using AI to analyze something as personal as a person’s voice.The transcript for this episode can be found here.Article Discussed in the Episode:Rezaii, N., Wong, B., Aisen, P. et al. Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias. npj Dement. 1, 35 (2025). https://doi.org/10.1038/s44400-025-00040-0 DOI; npj Dementia volume 1, Article number: 35 (2025)You can listen on the Michigan Medicine podcasting network and other podcasting platforms such as Apple Podcasts and Spotify. This episode is also available on our CAPRA website. Hosted on Acast. See acast.com/privacy for more information.
In this episode, Lauren & Matt speak with Neil Mehta, PhD who is the associate dean for research and a professor in the Department of Epidemiology at the University of Texas Medical Branch in Galveston. Dr. Mehta’s research focuses on US life expectancy trends, the effects of obesity on disability and mortality, the sources of socioeconomic status disparities in mortality, and patterns of health in the United States and Europe. Dr. Mehta talks about a recent manuscript from the NIA-funded TRENDS study called “Trends in Memory Function and Memory Impairment Among Older Adults in the United States and Europe, 1996 to 2018.”, which looks at data from several sources to compare trends in memory function across 13 different countries. The transcript for this episode can be found here. Neil Mehta, PhD Faculty Profile Article Discussed in the Episode: Myrskylä M, Hale JM, Schneider DC, Mehta NK. Trends in Memory Function and Memory Impairment Among Older Adults in the United States and Europe, 1996-2018. J Gerontol A Biol Sci Med Sci. 2024 Nov 7;79(21 Suppl 11):S11-S21. doi: 10.1093/gerona/glae154. PMID: 38953519; PMCID: PMC11542220. You can listen on the Michigan Medicine podcasting network and other podcasting platforms such as Apple Podcasts and Spotify. This episode is also available on our CAPRA website. Hosted on Acast. See acast.com/privacy for more information.
Welcome back to Season 6 of Minding Memory! In this episode, Lauren & Matt speak with Dr. Katherine (Kate) Possin, who holds the John Douglas French Alzheimer’s Foundation Professorship at the University of California, San Francisco Fein Memory & Aging Center. Dr. Possin talks about the Care Ecosystem, a telephone and web-based model that provides ongoing education, support, care planning, and coordination for people living with dementia and their care partners. They’ll dig into how the Care Ecosystem was developed, and what studies have shown about its impact on people living with dementia. The transcript for this episode can be found here.Katherine Possin, PhD Faculty ProfileThe Care Ecosystem at the UCSF Fein Memory & Aging Center Article Discussed in the Episode: Atkins KJ, Kahn JG, Possin KL. Cost-effectiveness and impact at Scale of Collaborative Care and Lecanemab for Alzheimer's Disease. Alzheimer's Dement. 2026; 2:e70054. https://doi.org/10.1002/bsa3.70054 You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.
In this episode, Matt & Lauren build off their previous conversation with Ashwin Kotwal about social isolation by speaking with Eve Lefkowitz, the Executive Director of the non-profit organization, A Conversation to Remember, which connects older adults – including those who live with cognitive decline – with young adult college students to combat the epidemic of social isolation and loneliness. Lauren & Matt learn about the populations this non-profit serve as well as perspectives on how to address social isolation with older adults. Episode TranscriptResources:c2r.chat: Conversations to RememberYou can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.
In this episode we're going to discuss a topic that's increasingly recognized as central to cognitive health and social connection. We'll define what it is and what happens when it's missing. Social isolation and loneliness are now widely discussed as public health concerns, and evidence has really mounted that social disconnection has profound effects on health, including cognitive decline and dementia risk. To help us think through this, we're joined by Dr. Ashwin Kotwal, a geriatrician and health services researcher at UCSF and the director of the Social Connections and Aging Lab. His work examines how social relationships shape aging related outcomes, including cognitive health, disability, and mortality. The transcript for this episode can be found here.Additional Links: Ashwin Kotwal Faculty Profile Social Connections & Aging Lab @ UCSF Relevant Articles: Kotwal AA, Cenzer IS, Yaffe K, Perissinotto C, Smith AK. End-of-life health care use among socially isolated and cognitively impaired older adults. J Am Geriatr Soc. 2023 Mar;71(3):880-887. doi: 10.1111/jgs.18131. Epub 2022 Nov 23. PMID: 36420540; PMCID: PMC10023302. Kotwal AA, Allison TA, Halim M, Garrett SB, Perissinotto CM, Ritchie CS, Smith AK, Harrison KL. "Relationships, Very Quickly, Turn to Nothing": Loneliness, Social Isolation, and Adaptation to Changing Social Lives Among Persons Living With Dementia and Care Partners. Gerontologist. 2024 Apr 1;64(4):gnae014. doi: 10.1093/geront/gnae014. PMID: 38499400; PMCID: PMC10948338. Kotwal AA, Cenzer I, Hunt LJ, Ankuda C, Torres JM, Smith AK, Aldridge M, Harrison KL. Psychosocial distress among spouses of persons with dementia before and after their partner's death. J Am Geriatric Soc. 2024 Aug;72(8):2336-2346. doi: 10.1111/jgs.19030. Epub 2024 Jun 1. PMID: 38822746; PMCID: PMC11323186. You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.