Multiple Myeloma Hub

During the 23rd International Myeloma Society (IMS) Annual Meeting and Exposition, September 23–26, 2026, Glasgow, UK, the Multiple Myeloma Hub spoke with María-Victoria Mateos, University Hospital of Salamanca, ES. We asked about the long-term outcomes with ciltacabtagene autoleucel (cilta-cel) in patients with relapsed/refractory multiple myeloma (RRMM) in Cohort A of the CARTITUDE-2 trial. In this interview, Mateos discusses the ≥5-year findings from Cohort A of the phase II CARTITUDE-2 trial (NCT04133636), which evaluated a single cilta-cel infusion in patients with RRMM after 1–3 prior lines of therapy who were exposed to a proteasome inhibitor and are lenalidomide-refractory. Mateos reviews long-term remission and survival outcomes, characteristics associated with prolonged disease control, immune correlates of durable response, and long-term safety findings. Mateos also discusses these findings in the context of cilta-cel use in earlier lines of therapy. Hosted on Acast. See acast.com/privacy for more information.

During the 23rd International Myeloma Society (IMS) Annual Meeting and Exposition, September 23–26, 2026, Glasgow, UK, the Multiple Myeloma Hub spoke with Rakesh Popat, University College Hospital, London, UK. We asked about interim results from Arm D of the UKMRA ProMMise trial in patients with relapsed/refractory multiple myeloma (RRMM). In this interview, Popat discusses interim results from Arm D of the ProMMise trial, which is evaluating a vision-related anamnestic tool (VRAT) to assess ocular symptoms and function, and guide belantamab mafodotin dosing in patients with RRMM receiving belantamab mafodotin + bortezomib + dexamethasone (BVd). Popat reviews interim results from Stage 1, including the correlation between VRAT and ocular assessments, and outlines the planned evaluation of VRAT-guided dosing without mandated ocular examinations in Stage 2. Intended for healthcare professionals. This educational resource is independently supported by GSK. All content is developed by SES in collaboration with an expert steering committee. Funders are allowed no influence. Hosted on Acast. See acast.com/privacy for more information.

The Multiple Myeloma Hub spoke with Rakesh Popat, UCL Hospitals NHS Foundation Trust, London, UK. We asked how to optimize outpatient delivery of bispecific antibody therapy for multiple myeloma (MM). In this interview, Popat discusses practical strategies to support the outpatient delivery of bispecific antibody therapy, including patient selection, caregiver support, and access to timely medical care if needed. Popat also outlines approaches that could facilitate step-up dosing in the outpatient setting, such as strategies to reduce the risk of cytokine release syndrome (CRS) and the potential use of wearable technology and remote monitoring. Intended for healthcare professionals. This educational resource is independently supported by Johnson & Johnson. All content is developed by SES in collaboration with an expert steering committee. Funders are allowed no influence. Hosted on Acast. See acast.com/privacy for more information.

The Multiple Myeloma Hub spoke with Christoph Renner, University of Basel, Basel, CH. We asked about the use of belantamab mafodotin-based combination therapy for relapsed/refractory multiple myeloma (RRMM). During this interview, Renner provides an overview of pivotal clinical data from the DREAMM-7 and DREAMM-8 trials that supported regulatory approvals of belantamab mafodotin-based combinations in RRMM and outlines practical considerations for their use in clinical practice. Renner discusses patient selection and treatment sequencing alongside other BCMA-directed therapies, as well as the monitoring and management of associated ocular toxicities. Renner draws on his experience in Switzerland and highlights the importance of multidisciplinary collaboration, particularly between hematology and ophthalmology, to support the management of ocular toxicities and inform treatment decisions. Intended for healthcare professionals. This educational resource is independently supported by GSK. All content is developed by SES in collaboration with an expert steering committee. Funders are allowed no influence. Hosted on Acast. See acast.com/privacy for more information.

The Multiple Myeloma Hub spoke with María-Victoria Mateos, University Hospital of Salamanca, ES. We asked about the management of toxicities associated with bispecific antibody therapy for multiple myeloma (MM) in community practice. In this interview, Mateos discusses practical considerations for the management of adverse events (AEs) associated with bispecific antibodies in MM. Mateos outlines how to recognize and manage cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), as well as strategies to mitigate infection risk. Mateos also discusses the management of skin, nail, and oral toxicities associated with G-protein coupled receptor family C group 5 member D (GPRC5D)-directed bispecific antibodies. Intended for healthcare professionals. This educational resource is independently supported by Johnson & Johnson. All content is developed by SES in collaboration with an expert steering committee. Funders are allowed no influence. Hosted on Acast. See acast.com/privacy for more information.