My Path to Success

What It Takes is a podcast series featuring intimate, revealing conversations with towering figures in almost every field: music, science, sports, politics, film, technology, literature, the military and social justice. These rare interviews have been recorded over the past 25 years by The Academy of Achievement. They offer the life stories and reflections of people who have had a huge impact on the world, and insights you can apply to your own life. Subscribe to the What It Takes podcast series at iTunes.com/WhatItTakes

Hailed as the greatest active playwright in the English-speaking world, South Africa's Athol Fugard has won international praise for creating theater of "power, glory, and majestic language." In more than 20 plays, written over six decades, he has chronicled the struggles of men and women of all races for dignity and human fulfillment. Born and raised in the Eastern Cape, he founded a multiracial theater company in the 1950s in defiance of the South African government's apartheid system. When he and a black colleague appeared as mixed-race brothers in his play The Blood Knot, it was closed after a single performance. In the 1960s, his work found an audience in other English-speaking countries, but after he appeared in The Blood Knot on BBC Television, the government seized his passport. Since the downfall of the apartheid system, Fugard has been honored by his country's government and by critics and audiences the world over. An Honorary Fellow of Britain's Royal Society of Literature, in 2001 he received Broadway's Tony Award for Lifetime Achievement. His novel Tsotsi was adapted into the film of the same name, which won the Oscar for Best Foreign Film of 2006. He has appeared as an actor in the feature films Gandhi and The Killing Fields. In 2014, he returned to the stage for the first time in 15 years to act in his play Shadow of the Hummingbird at the Long Wharf Theatre in New Haven, Connecticut. In this podcast, recorded at the 2014 International Achievement Summit in San Francisco, he speaks of his youth in South Africa and his early adventures as a merchant seaman. Rather than dwelling on the persecution he suffered as an advocate of racial equality in his country, he focuses on the most basic and satisfying emotions that have informed his life, including the love of other human beings and of nature.

Frances Arnold's techniques of "directed evolution" have revolutionized the science of chemistry by creating new organisms and enzymes for use in medicine, agriculture, manufacturing and alternative energy. She came to her profoundly original research by an equally original career path, one that led her from undergraduate studies in aerospace engineering at Princeton’Ůand an early career in alternative energy in the United States and Brazil’Ůto postdoctoral chemistry studies at Berkeley and an endowed chair at Caltech, where she directs the Rosen Bioengineering Center. A co-founder of the bio-fuel company GEVO, last year she founded a second firm, Provivi Labs, to develop green biocatalytic processes for agriculture and industry. The techniques she pioneered have already led to the development of a new treatment for diabetes and are now reducing industry's reliance on toxic chemicals in manufacturing. Proteins she has created for use in brain imaging may soon lead to improved testing and treatment for depression, Parkinson's and Alzheimer's. Her work has been honored with an array of awards, including the Charles Stark Draper Prize and the National Medal of Technology. This year she was inducted into the Inventors Hall of Fame. In this podcast, recorded at the 2014 International Achievement Summit in San Francisco, Dr. Arnold recounts the unusual career path that led to her revolutionary breakthrough.

Although he is renowned in medical circles as "the father of Viagra," the discoveries of Louis Ignarro have profound implications for all circulatory conditions, not least heart disease, the leading cause of death around the world. Nitroglycerin has been used in treating heart disease since the 1870s, but for over a century no one knew what property of the chemical causes constricted blood vessels to dilate. Ignarro determined that nitroglycerin, and other nitrates and nitrites, are metabolized as nitric oxide, relaxing the smooth muscle surface of the blood vessels, and inhibiting the growth of blood platelets. He was the first to observe that nitric oxide is a neurotransmitter mediating erectile function, a discovery that led to the creation of Viagra and other drugs for impotence, as well as nutritional supplements that improve cardiovascular health and athletic performance. Louis Ignarro embarked on his journey of discovery from humble beginnings. Born in Brooklyn, New York to working-class immigrant parents, he received the Nobel Prize in Medicine in 1998. As he told a Congressional committee, "Only in America could the son of an uneducated carpenter win the Nobel Prize in Medicine." In this podcast, recorded at the 2014 International Achievement Summit in San Francisco, he recounts the career path that led to his groundbreaking discoveries.

Vocalist, composer and instrumentalist Esperanza Spalding fell in love with music as a little girl in Portland, Oregon. She first drew acclaim as a child violinist before discovering the upright bass as a teenager. Within months she was playing in local clubs, exploring pop, rock, hip-hop and especially jazz. By age 20 she was an instructor at Boston's prestigious Berklee College of Music, and was performing with singer Patti Austin and a stellar roster of jazz greats. Her 2008 album Esperanza topped Billboard's Contemporary Jazz chart. The following year, she was invited to perform at the White House and the Nobel Peace Prize ceremony in Stockholm. At the 53rd annual Grammy Awards, she was honored as Best New Artist of the Year. With her 2011 album Chamber Music Society, she became the bestselling contemporary jazz artist in the world. On the follow-up, Radio Music Society, she played her own compositions alongside an eclectic selection of tunes by everyone from the Beach Boys to one of her heroes, jazz great Wayne Shorter. In this podcast, recorded at the 2014 International Achievement Summit in San Francisco, Esperanza Spalding performs solo, and in duet with Wayne Shorter. Excerpts from her interview with the Academy of Achievement are interspersed with highlights of that performance.