DiscoverNEJM This Week — Audio Summaries
NEJM This Week — Audio Summaries
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NEJM This Week — Audio Summaries

Author: The New England Journal of Medicine

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The New England Journal of Medicine (NEJM) Weekly Audio Summary RSS feed. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.
11 Episodes
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Featuring articles on exome sequencing analysis in stillbirth, a two-year trial of belimumab in lupus nephritis, nocturnal oxygen in COPD, adjuvant targeted therapy in melanoma, and daratumumab in refractory lupus; a review article on immune tolerance; a case report of a man with fever and shortness of breath after liver transplantation; and Perspective articles on consent to trainee involvement in pediatric care, on examining examinations conducted under anesthesia, on June Medical Services v. Russo, and on sticks and stones. Supplement to the New England Journal of Medicine, Vol. 383, No. 12.
Featuring articles on strategies for tracheostomy decannulation, extending factor VIII activity in hemophilia A, eflornithine–sulindac in familial adenomatous polyposis, darolutamide in castration-resistant prostate cancer, the NIH RADx initiative, and on training innate immunity; a review article on pharmacologic treatment of ADHD; a case report of a man with intrusive thoughts and fear of poisoning; and Perspective articles on health equity, on the cancer risk associated with lorcaserin, on whether Covid can catalyze an educational transformation, and on the ideal intern. Supplement to the New England Journal of Medicine, Vol. 383, No. 11.
Featuring articles on weight loss in underserved patients, the effect of phenylbutyrate–taurursodiol on ALS progression, tepotinib in lung cancer, capmatinib in MET-altered lung cancer, and reopening primary schools during the pandemic; a review article on pulmonary fibrotic diseases; a Clinical Problem-Solving describing a curve ball; and Perspective articles on progress in cancer research, prevention, and care; on public health decision making during Covid-19; on long-term care policy after Covid-19; and on the tragedy of measles. Supplement to the New England Journal of Medicine, Vol. 383, No. 10.
Featuring articles on selpercatinib in RET fusion–positive lung cancer, selpercatinib for medullary thyroid cancer, a closed-loop system in children with type 1 diabetes, sticky findings in breast cancer, and reconsidering the use of race correction in clinical algorithms; a review article on atherosclerotic plaque healing; a case report of a woman with headache and gait imbalance; and Perspective articles on improving the quality of U.S. health care, on Covid-19 and immunity in aging populations, and on U.S. efforts to curb antibiotic resistance. Supplement to the New England Journal of Medicine, Vol. 383, No. 9.
Featuring articles on evinacumab for familial hypercholesterolemia, the effects of diet vs. gastric bypass in diabetes, drug-coated balloons for dysfunctional dialysis arteriovenous fistulas, fracture risk vs. fracture prevention with bisphosphonates, and the challenges of “return to work” in an ongoing pandemic; a review article on trigeminal neuralgia; a case report of a woman with altered mental status and weakness on the left side; and Perspective articles on low-threshold buprenorphine initiation, on when prescribing isn’t enough, on the death throes of Mercy, and on when the EMR stole a doctor’s pen. Supplement to the New England Journal of Medicine, Vol. 383, No. 8.
Featuring articles on azacitidine plus venetoclax in AML, compression for recurrent cellulitis of the leg, decreased population-based mortality from lung cancer, the United States and the WHO, the need for a tighter particulate-matter air-quality standard, and bilirubin in IBD and pancreatitis; a review article on epigenetic therapies for cancer; a case report of a woman with a lung mass; and Perspective articles on whether we spend too much on health care, on people with hepatitis C who inject drugs, on hepatitis C treatment in correctional facilities, and on a national medical response to crisis. Supplement to the New England Journal of Medicine, Vol. 383, No. 7.
Featuring articles on hydroxychloroquine for Covid-19 prophylaxis, subcutaneous or transvenous ICD therapy, Zika virus disease in Colombia, ofatumumab vs. teriflunomide in multiple sclerosis, and spending after state specialty-drug out-of-pocket caps; a review article on native-valve infective endocarditis; a Clinical Problem-Solving on being led astray; and Perspective articles on the National Academy of Medicine and the quality of health care, on care churn, on mental health and the Covid-19 pandemic, and on preventing a parallel pandemic. Supplement to the New England Journal of Medicine, Vol. 383, No. 6.
Featuring articles on nirsevimab for the prevention of RSV disease, RSV vaccination during pregnancy to protect infants, uterine-artery embolization or myomectomy for uterine fibroids, a trial of a therapeutic anti–yellow fever virus antibody, and a bad acid trip for sarcomas; a review article on chronic lymphocytic leukemia; a case report of a woman with chest pain, dyspnea, and shock; and Perspective articles on health care as an ongoing policy project, on Covid’s color line, and on the illusion of inclusion. Supplement to the New England Journal of Medicine, Vol. 383, No. 5.
Featuring articles on postexposure influenza prophylaxis, growth stunting and intestinal microbiota, multisystem inflammatory syndrome in children, and vitamin D supplements for the prevention of tuberculosis; a review article on coffee, caffeine, and health; a case report of a woman who died from Covid-19; and Perspective articles on border babies, on failing the test, on Covid-19 epidemiologic models, and on the pandemic as teacher. Supplement to the New England Journal of Medicine, Vol. 383, No. 4.
Severe Covid-19

Severe Covid-19

2020-05-2025:143

A 50-year-old, previously healthy man presents to the ED with 2 days of worsening dyspnea. He had fever, cough, and fatigue during the week before presentation. He appears acutely ill. The body temperature is 39.5°C, heart rate 110 beats per minute, respiratory rate 24 breaths per minute, and blood pressure 130/60 mm Hg. The oxygen saturation is 87% while the patient is breathing ambient air. The white-cell count is 7300 per microliter with lymphopenia. Chest X-ray shows patchy bilateral opacities in the lung parenchyma. An RT–PCR assay detects the presence of SARS-CoV-2 RNA in a nasopharyngeal swab. How would you evaluate and manage this case? Full-text recordings of Clinical Practice articles can be found at NEJM.org.
A 73-year-old man with hypertension and chronic obstructive pulmonary disease calls to report that he has had a fever and a dry cough for the past 2 days. He notes that his shortness of breath has worsened. His medications include losartan and inhaled glucocorticoids. He lives alone. How should he be evaluated? If he has Covid-19, the disease caused by SARS-CoV-2, then how should he be treated? Full-text recordings of Clinical Practice articles can be found at NEJM.org.
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