Note to File: A Clinical Research Podcast

Welcome to another "Sticky Notes" live session of Note to File – the only clinical research podcast that's part insightful conversation, part general nonsense. Today, we're braving the December chill, celebrating a totally wild (and possibly confusing) 50k YouTube subscribers, and pondering whether people forget how to drive in snow every single year (spoiler: they do). We dig into the latest so-called "landmark" UK/US pharma trade deal (cue eye rolling at historic headlines), the gritty truths about public sector R&D cuts, and why axing funding and getting stingy on immigration probably isn't how you keep America "exceptional." Don't worry, we squeeze in healthy skepticism, plenty of hot takes, and our usual professional-grade side eyes for political "bravery." Plus, we get philosophical on whether critical thinking can actually be taught—or if some folks are just destined to be, let's say, less-than-critical. If you somehow still believe in innovation, or if you want to listen to clinical research pros vent about the stuff no one else says out loud, you're in exactly the right place. Smash that subscribe button, drop us a comment, and let us know what you want us to rant about next. Thanks for being one of the "hardcore of the hardcore."

This week, we dive headfirst into the holiday madness: the fine art of pretending things can wait till January, how stuffing a week's worth of chaos into three days is our new normal, and why Thanksgiving is synonymous with "eating a regrettable amount of food" (parades optional). But don't worry, we're not just here for turkey talk. We rip into site centricity (is it more than branding?), the never-ending sponsor/CRO shuffle, and why clinical research still can't figure out standardization to save its life. Private equity's creeping fingers? NIH funding's real impact? Fragmented systems that would drive anyone to drink? Yep, it's all in here. We even tackle the million-dollar question: is there a user-friendly, centralized home for finding trials? (Spoiler: "No.") Plus, anecdotes, Reddit gems, and a little healthy skepticism about the "synergies" of consolidation. Got thoughts, rants, or industry beef? Drop us a line at notetofilepodcast.com. Subscribe, listen, and join the conversation as we pull no punches and keep clinical research as weird - and real - as it deserves to be.

In this episode, we discuss the Abbott-Exact Sciences mega-acquisition, the nuanced world of CROs, challenges and opportunities in decentralized clinical trials (DCT), the explosive growth of clinical trial technology, and the real-world impact of NIH grant funding cuts. We also debate the ethics of drug availability in international trials and dig into site-centricity, innovation, and the ever-changing clinical research landscape. Also, Denali says "niche" wrong. Enjoy candid commentary, industry news, and some laughs along the way! Got feedback or want to be a guest? Reach out via LinkedIn or our anonymous form at notetofilepodcast.com.

In this episode: does AI really want your job, or is it just here for the snacks? Why does "communication" mean "good luck finding my phone number," and can the job market get any weirder (spoiler: yes)? Brad and Denali banter about the latest "new normal," classic tech headaches, and why public awareness still needs new batteries. You'll get poetry, wild tangents, a little outrage, and a lot of the good stuff they never put in the company newsletter

In this episode, Denali and Brad are joined by the ever-chill Steve Wimmer of 1nHealth for a wide-ranging, caffeine-fueled chat about everything from AI-powered patient recruitment to why running clinical trials sometimes feels like herding digital cats. We take you behind the scenes of recruitment campaigns, hash out whether AI is the solution or just a new sticker for your PowerPoint, and dig into why some sites treat digital ads like cryptic hieroglyphs. Along the way, you'll hear hot takes on industry best practices, cold weather in Orlando (spoiler: "frigid" means below 70°F), and the eternal struggle of getting patients to pick up the damn phone.

In this episode, Denali and Brad sit down with Del Smith, founder of Acclinate, to explore the challenges and opportunities in increasing representation in clinical research. They discuss the intersection of technology and trust, the importance of community-first approaches, the role of sites and sponsors, and offer actionable tips for sites of all sizes. Del shares his personal journey from business school dean to healthcare entrepreneur, highlighting real-world solutions for building trust and engagement in underrepresented communities.

Join us for an insightful conversation with Walt Bogdanich, three-time Pulitzer Prize-winning investigative reporter from The New York Times, as we dive deep into the world of clinical research oversight. Walt discusses his investigations into institutional review boards (IRBs), the growing influence of private equity in healthcare, transparency issues within drug trials, and the broader implications for patient safety and trust in medical innovation. Whether you're a clinical researcher, healthcare professional, or simply interested in the intersection of medicine, business, and ethics, this episode offers eye-opening stories and critical perspectives you won't want to miss.

Denali and Brad talk about horror movies, take a deep dive into the real experiences of clinical research coordinators, and discuss whether degrees or work experience matter more. We also explore the environmental impact of clinical trials, issues of trust in research roles, and take a look at Nike's latest innovation—motorized sneakers. Join us for thoughtful discussion and some lighthearted moments.

Denali and Brad tackle a wide range of critical topics in clinical research. We dive deep into the realities of CRA burnout, the shifting landscape of global clinical trials, and the implications of the U.S. focusing more on manufacturing than R&D. We also explore the challenges faced by patients navigating site errors and expanded access, discuss how technology and AI are changing the field, and reflect on the human element that underpins the industry. Along the way, you'll hear honest perspectives, industry insights, and some lighthearted banter—including a surprise appearance from a feline friend. Whether you're a clinical research professional, a patient advocate, or simply curious about what happens behind the scenes, this episode offers an engaging look at the current and future state of clinical trials. Subscribe for weekly insights, guest interviews, and real talk about the topics that matter most in research.

In this episode, Denali and Brad welcome Doug Bain (ClinFlo) for a no-holds-barred chat about why site tech still stinks, EDC headaches, AI hype (and hope), platform silos, and why so many research sites are still using sticky notes for passwords. From the joys of Italian coffee breaks to Black Mirror references, Doug shares war stories, practical fixes, and predictions for where real change might finally happen. If you've ever wondered why clinical research tech feels 20 years behind (and how AI could actually help), don't miss this episode!

In this episode, we dive deep into the growing influence of private equity on Institutional Review Boards (IRBs), the challenges of maintaining transparency and avoiding conflicts of interest, and the explosion of data collection in modern clinical trials. We also discuss the promises and pitfalls of AI in research, share personal stories from the field, and reflect on the latest industry news and conferences.

Join us for a special episode recorded live at the ING conference in Westchester! Denali and Brad dive into the unique format of this innovative clinical research event, from TEDx-style main stage talks to collaborative dive teams and the exciting whale tank for startups. We discuss the latest New York Times article on private equity's impact on research ethics, memorable sessions (including Catherine Gregor's insights on site burden), and the importance of breaking down silos in the industry. Plus, get a behind-the-scenes look at the social events, the conference's growth, and what makes ING a must-attend for clinical research professionals.

Join us for "Sticky Notes" edition of the Note to File podcast! In this episode, we celebrate National Research Administrator Day, dive into the growing complexity of data collection in clinical research, and discuss the surprising ways the Family and Medical Leave Act supports clinical trial participants. We also explore the results of the first-ever ACRP national workforce survey and reflect on the challenges and opportunities for collaboration and innovation in the clinical research industry

Join Denali and Brad on the Note to File podcast as they welcome Liz Beatty (Co-Founder & Chief Strategy Officer, Inato) and Jovani Rivera (Site Director & Founder, Novum Research) for an in-depth discussion on the evolving landscape of clinical research technology. In this episode, they explore how AI and innovative tech are streamlining patient pre-screening, reducing administrative burdens, and improving site efficiency—while keeping the human element at the forefront. Discover the challenges and solutions around integrating new tools with existing systems like EHR and CTMS, the complexities of patient record retrieval, and the importance of real site feedback in product development. The conversation also delves into protocol design, vendor selection, and the future of tech adoption in both independent and academic research centers. Whether you're a clinical research professional, tech enthusiast, or just curious about the intersection of healthcare and innovation, this episode offers valuable insights and practical advice for navigating the rapidly changing world of clinical trials.

In this lively discussion, Brad and Denali and guests, Dan Schell and Katlyn Delaney, dive into the latest happenings in clinical research, including highlights from the DPharm conference, the evolving role of sites and vendors, and the challenges of EHR/EDC integration. We explore the real-world impact of AI and automation on patient outreach and pre-screening, and share candid thoughts on industry buzzwords, vendor relationships, and the future of clinical trials. Plus, hear personal stories, conference takeaways, and what's next for the clinical research community.

In this episode, Brad and Denali dive into the biggest news shaking up the clinical research world, including Novo Nordisk's historic layoffs and what it means for the industry. We break down the FDA's new crackdown on pharmaceutical advertising and discuss how upcoming reforms could change the way drugs are marketed to consumers. We also spotlight the ACRP's initiative to formally recognize clinical research professionals and what that could mean for the future of the field. Plus, we take a critical look at the rise of course-selling culture in clinical research, with a special mention of the mysterious "Pharma TNT" group. Stick around for updates on our upcoming round robin episode—if you want to join the conversation, find out how to get involved! Don't forget to like, comment, and subscribe for more unfiltered coverage of the clinical trial industry.

Join Denali and Brad for a special recap of the SOS Regional Meetup! We're joined by Ashley Margo and Monica Cultiva as we dive into what makes SOS events unique—focusing on community, open conversation, and real connections in the clinical research world. Hear how regional meetups differ from big conferences, why a relaxed environment sparks better ideas, and what's coming up next for SOS, including the Houston event and the 2025 conference. Learn how you can get involved, submit your ideas, or even become a speaker.

Live from the Veeva Summit, this episode dives into the latest trends and key takeaways from one of the industry's biggest events. Denali and Brad discuss the importance of bringing together sponsors, sites, and stakeholders to foster real conversations and collaboration. Highlights include insights from the Veeva keynote, the launch of Veeva AI and CTMS, and reflections on the evolving landscape of clinical research technology.

Dr. Daniel Fox join Denali and Brad as he shares expert insights on clinical research site management, financial best practices, and common pitfalls. Learn about the three pillars of site operations, strategies for financial health, and Dr. Fox's new textbook designed for site administrators. Perfect for research professionals looking to optimize their site's success!

In this episode, Denali and Brad discuss the upcoming Veeva R&D Summit, analyze the new partnership between Veeva and IQVIA, and explore Pluto Health's launch of the "Care on Deck" platform. They also review WCG's Total Training solution and share candid insights on clinical trial awareness, site engagement, and the evolving landscape of clinical research.