One Day with Jon Bier

He grew up in Yugoslavia. Twenty years of communism, crushing poverty, and hunger every single day. He left at 20 with nothing, landed in El Paso, Texas, got a PhD, spent twelve years at Los Alamos National Laboratory, and then co-founded a company that has tested over 500,000 people in 100 countries. He should have been in a wheelchair by now. He cured himself instead. Jon Bier sits down with Dr. Momo Vuyisich, co-founder and Chief Science Officer of Viome, for one of the most genuinely mind-expanding conversations this show has produced. Momo spent six years developing proprietary RNA-based technology that measures tens of thousands of biomarkers in a single test, giving people the kind of precision map of their own biology that has never existed before. No other company in the world has it. Not a university. Not a government lab. Not a competing startup. Just Viome. This isn’t a wellness conversation. It’s a conversation about how medicine actually works, why it is designed the way it is, and what it would look like to actually fix it. In this episode:- Why every chronic disease you have been told is genetic or incurable is almost certainly neither, and what the incentive structure of academic medicine and Big Pharma has to do with that - How Momo cured his own autoimmune condition by removing mammalian foods from his diet, and the molecular mechanism behind it that doctors still won’t acknowledge - Why analyzing RNA is a quantum leap beyond every other microbiome or blood test on the market, and what the airplane analogy reveals about how shallow the competition actually is Find Momo & Viome:- Viome: https://www.viome.com- Viome on Instagram: https://www.instagram.com/viome/

83 million Americans have sleep apnea. Most of them don't know it. And most of the ones who do know it refuse to treat it, because the only solution anyone offered them came with a mask, a hose, and a machine that sounds like a wind tunnel.Jon Bier sits down with Wesley Lones, founder and CEO of Daybreak, the company building the first real alternative to the CPAP for the 80% of sleep apnea sufferers who will never use one. The solution is a custom-fit oral device that looks like a night guard, ships to your door, and works about 90% of the time. The diagnosis happens at home too. No sleep lab. No referral chain. No reason to avoid finding out anymore.This is one of those businesses where the TAM is everyone, the problem is urgent, and the incumbent solution is so bad that people have Facebook support groups for getting diagnosed. Wesley is building into that gap with urgency, discipline, and the kind of founder energy that comes from someone who genuinely believes the problem is solvable.It is.In this episode:- Why 80% of sleep apnea sufferers go undiagnosed and untreated, and why the CPAP being the only known solution is the core reason for that- How Daybreak built a fully at-home pathway from testing to treatment, and why the oral appliance that replaces a CPAP fits in your pocket and ships to your door- What it looks like to build a healthcare company that actually scales, and why the leadership philosophy Wesley is building toward matters as much as the productFind Wesley & Daybreak:- Daybreak: https://www.thedaybreak.com- Daybreak on Instagram: https://www.instagram.com/getdaybreak/

He started medical school at 15. Graduated as a doctor at 21. Did over 10,000 surgeries. Then walked away from the operating room to build something he thinks can actually fix healthcare.Jon Bier sits down with Dr. Darshan Shah, board-certified surgeon, founder of Next Health, and one of the most grounded longevity voices in a space that desperately needs grounding. Next Health is now 20 locations and growing, built on a simple premise: don't wait until you're sick to think about your health. Come in when you're healthy and keep it that way.This conversation covers the full arc. The kid who was severely bullied in a New Jersey high school where he was one of two brown kids. The surgeon in his early 20s getting side-eyed in operating rooms. The moment he realized the sick-care system was unfixable and decided to build a parallel one instead. And the new book, Your New Health OS, that makes the case for using AI and personal data to completely rethink how you manage your own health.Dr. Shah is not jaded. That might be the most impressive thing about him.In this episode:- Why the American healthcare system is unfixable from the inside, and why building a parallel system focused on longevity and health optimization is the only real solution- What it looks like to enter medical school at 15, train at the Mayo Clinic, do over 10,000 surgeries, and then pivot entirely to preventive medicine because the operating room is treating the wrong problem- How AI is about to unburden doctors, empower patients, and fundamentally change what it means to take care of your health, including the first fully AI-enabled autonomous surgery that just happenedFind Dr. Shah & Next Health:- Dr. Shah on Instagram: https://www.instagram.com/darshanshahmd/- Dr. Shah's website: https://www.drshah.com- Next Health: https://www.next-health.com- Next Health on Instagram: https://www.instagram.com/nexthealth/

The water filter category hasn't meaningfully changed in forty years. Every pitcher looked the same. Every one was made of plastic. Nobody could tell you what was actually in your water, or what the filter was actually removing.Jon Bier sits down with Brian Keller and Charlie Carlisle, co-founders of Rorra, the brand reimagining water filtration from the ground up, for a conversation about what happens when personal experience turns into a company. Brian's daughter Aurora developed eczema with no known cause shortly after birth. Charlie faced lead contamination in Denver's water supply. They went looking for a solution, couldn't find one they trusted, and spent three years building it themselves in glass and stainless steel, with NSF-certified filtration and an Andrew Huberman partnership to show for it.Before Rorra, they built Love Your Melon into a brand that donated nearly $10 million to pediatric cancer before getting acquired. They know how to build something real. And they think clean water is the most overlooked pillar in the entire wellness conversation.They're probably right.In this episode:- Why the water filtration category is one of the last places in wellness where nobody has built a brand worth talking about, and what it actually takes to change that- The personal stories behind Rorra: two kids with unexplained eczema, one lead contamination problem in Denver, and a combined realization that the solution didn't exist yet- What three years of engineering, design iteration, and filtration research taught two founders who came from hats, and why starting from scratch as a consumer was actually the advantageFind Brian, Charlie & Rorra:- Brian on Instagram: https://www.instagram.com/briandkeller7/- Charlie on Instagram: https://www.instagram.com/charliecarlisle_/- Rorra: https://www.rorra.com- Rorra on Instagram: https://www.instagram.com/rorrawater/Timestamps:0:00 – What's actually in your tap water0:35 – Introducing Brian Keller and Charlie Carile of Aurora4:57 – The personal water problems that led them to start Aurora7:57 – Three years of R&D before ever launching10:17 – Raising their first round with no sales yet17:00 – Eight figures in revenue in year one20:56 – Designing appliances to last decades, not a year26:18 – How they actually use AI (and where they don't)30:42 – Why every city's water problem is different37:27 – How forever chemicals accumulate in the body48:07 – Aurora's vision for a fully integrated water platform

Most people in the wellness space are trying to get from 91 to 100. Nobody's talking about how to get from 0 to 90.Jon Bier sits down with Dr. Jeff Wiegers — double board-certified anesthesiologist, interventional pain specialist, and regenerative medicine expert at BioReset Medical, for a conversation about what it actually means to pursue longevity when most of the market is selling you the shortcut. Jon and Jeff met in Cabo over a $25,000 experimental gene therapy shot. This is the follow-up conversation they should have had before that trip and it's better for it.Peptides. Stem cells. Gene therapy. GLP-1s. Growth hormone. These are the things everyone is talking about and almost nobody is contextualizing correctly. Jeff is one of the rare doctors who will slow down, ask the foundational question, and tell you when the answer is actually just: go outside, eat real food, and sleep.The cutting edge is real. But most people haven't fixed the basics yet.In this episode:Why the peptide boom needs a reality check — what unregulated sourcing actually means, why lead has shown up in tested products, and how to think about trust as the most important factor in this space- The difference between chasing a number and fixing the underlying reason the number is off and why most longevity protocols skip the most important question- What reversible gene therapy, Muse cells, and the next generation of regenerative medicine actually look like and why the delivery method revolution might matter more than the therapies themselvesFind Dr. Wiegers & BioReset: - Dr. Wiegers on Instagram: https://www.instagram.com/jeffwiegers/- BioReset Medical: https://www.bioresetmedical.com- BioReset on Instagram: https://www.instagram.com/bioresetmedical/