Optimal Protein Podcast with Vanessa Spina

This episode featured Dr. Dom D'Agostino- the world's pre-eminent ketone scientist! We discuss the concept of a PSMKD (Protein Sparing Modified Ketogenic Diet) to Optimize Protein Intake for Fat Loss & Protecting Muscle While Gaining the Benefits of Ketosis, Measuring Breath Acetone & More! His thoughts on breath acetone to monitor fat loss, having a glucose to breath acetone index, why having high BHB may not be optimal for health under certain scenarios, and much more!! Dr. Dominic D’Agostino is a Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida and Research Scientist at the Institute for Human and Machine Cognition (IHMC).  His laboratory develops and tests metabolic-based strategies for neurological disorders, cancer, and for enhancing safety and resilience of military personnel in extreme environments.  His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. For more from Dr. D'Agostino, visit https://ketonutrition.org/ Some of the studies mentioned in this episode:  Measuring breath acetone for monitoring fat loss Study with measuring Acetone & Latency to Seizure George Cahill fasting study & what initiates ketosis. Ketones as a super fuel  Virta study long term BHB levels FAQ on the Acetone, Ketones & The Tone  Introducing the brand new TONE Device! Struggling to lose weight or reach your fitness goals? The TONE is a new breath acetone meter which lets you know if your body is burning fat!  All TONE devices are NOW SHIPPING Worldwide!! Order the TONE here. Now shipping worldwide!!  Order the Black & Gold TONE HERE Order the Black & Rose Gold TONE HERE Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl - Prior to beginning a ketogenic diet you should undergo a health screening with your physician to confirm that a ketogenic diet is suitable for you and to rule out any conditions and contraindications that may pose risks or are incompatible with a ketogenic diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A ketogenic diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

This episode is featuring Dr. Dom D'Agostino- the world's pre-eminent ketone scientist! We discuss using breath acetone to monitor fat loss, understanding how to measure various ketones, fasting and ketosis, acetone's powerful effects on latency to seizure, acetone to BHB ratios and what determines the ratio of BHB to acetoacetate, why having high BHB may not be optimal for health under certain scenarios, and much more!! Dr. Dominic D’Agostino is a Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida and Research Scientist at the Institute for Human and Machine Cognition (IHMC).  His laboratory develops and tests metabolic-based strategies for neurological disorders, cancer, and for enhancing safety and resilience of military personnel in extreme environments.  His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. For more from Dr. D'Agostino, visit https://ketonutrition.org/ Some of the studies mentioned in this episode:  Measuring breath acetone for monitoring fat loss Study with measuring Acetone & Latency to Seizure George Cahill fasting study & what initiates ketosis. Ketones as a super fuel  Virta study long term BHB levels FAQ on the Acetone, Ketones & The Tone  Introducing the brand new TONE Device! Struggling to lose weight or reach your fitness goals? The TONE is a new breath acetone meter which lets you know if your body is burning fat!  All TONE devices are NOW SHIPPING Worldwide!! Order the TONE here. Now shipping worldwide!!  Order the Black & Gold TONE HERE Order the Black & Rose Gold TONE HERE Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl - Prior to beginning a ketogenic diet you should undergo a health screening with your physician to confirm that a ketogenic diet is suitable for you and to rule out any conditions and contraindications that may pose risks or are incompatible with a ketogenic diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A ketogenic diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

Unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa The Bloating Episode! If you’ve ever struggled with bloating after eating, digestive discomfort, or wondered if your body is really absorbing all the protein and nutrients you consume, this episode is for you. I’m joined by Wade Lightheart, co-founder and president of BiOptimizers, to dive into the science of digestive enzymes and how they can transform digestion, nutrient absorption, and protein utilization. A former natural bodybuilding champion, Wade developed MassZymes after struggling with his own digestion on a high-protein diet. We cover: What EXACTLY causes bloating and poor protein digestion Why low stomach acid and declining enzyme levels with age can cause bloating and poor nutrient absorption. Clinical research on protease blends and a 2024 protein study showing improved amino acid absorption with enzyme support. A university laboratory test on MassZymes suggesting over 1,200% more amino acids released compared to digestion alone. How lipase enzymes can reduce bloating and fullness after high-fat meals. Why older adults and high-protein eaters may especially benefit from enzyme supplementation for muscle and metabolic health. If bloating, slow digestion, or protein absorption has ever held you back from feeling your best, this conversation will help you fix your bloat and unlock the full benefits of your nutrition. 👉 Get 15% off MassZymes by BiOptimizers with the code VANESSA at bioptimizers.com/vanessa. Free high-protein keto guide: The Keto Reset eBook https://ketogenicgirl.com/pages/new-free-ebook Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and décolleté and get 20% OFF with the code VANESSA Free high-protein keto guide: The Keto Reset eBook 👤 Connect with Vanessa: • Instagram: @ketogenicgirl • 🔗 Learn more about the TONE Breath Ketone Analyzer — 20% OFF with code VANESSA • Tone Collagen 📱 Follow @ketogenicgirl for the latest studies and strategies on fat loss and protein optimization 📸 Follow @optimalproteinpodcast for episode visuals and updates 💬 Join the Facebook group: Optimal Protein Podcast Community 🎙 The content in this podcast is for informational purposes only and not medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.

Unlock sharper focus and support long-term brain health with Ketone-IQ — clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. Today’s episode features Dr. Carlene Starck, a nutrition scientist whose groundbreaking research is changing the way we think about protein and amino acid requirements. Her work suggests that current recommendations for essential amino acids may be far too low, with major implications for fat loss, muscle preservation, and how we define protein quality. NEW! I love Puori for their pure, science-backed supplements. Creatine+ is one of my top recommendations for women, as it’s a foundational supplement that supports fat loss, body recomposition, lean muscle, and even cognition. Get 20% off at puori.com/VANESSA We discuss her research on: Why true protein and amino acid needs are higher than guidelines suggest How this widens the gap between animal and plant-based proteins The impact of gut and oxidative amino acid losses on protein requirements Novel strategies to improve protein digestion, from kiwifruit enzymes to keratin hydrolysates Dairy vs. plant alternatives, and what her latest A2 milk study revealed about mood and cognition Affordable ways to close key nutrient gaps for better body composition and health Dr. Starck also shares a preview of her upcoming work on protein requirements and what it means for the future of nutrition science. This is a must-listen episode if you want to understand why protein is so central to fat loss, metabolic health, and long-term body recomposition. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In this solo recap episode, Vanessa breaks down her in-depth interview with Dr. Andy Galpin, one of the world’s leading muscle scientists and performance physiologists. This 60-minute masterclass distills the most important takeaways from their conversation into clear, actionable steps for fat loss, body recomposition, and metabolic health. 👉 Unlock better protein absorption and digestion with MassZymes by BiOptimizers. Get 10% off your order with the code VANESSA at bioptimizers.com/vanessa What You’ll Learn in This Episode: The real science of fat loss — why stored fat leaves your body as exhaled carbon, not sweat. Carbon in vs. carbon out — how to think about energy balance more clearly. Why nutrition drives fat loss — the 90/10 rule of diet vs. exercise. The two macros most women misjudge — why we consistently overestimate protein and underestimate fat. What to do if you’re stuck at 1,200 calories — Andy’s three-step framework: reevaluate, build muscle, or take a structured diet break. Protein timing truths — total daily protein matters more than timing, plus the role of pre-sleep protein. Metabolic flexibility demystified — why it’s about switching fuels efficiently, not always “burning fat.” The sleep–fat loss connection — how poor sleep alters hormones, cravings, and body composition. Anabolic resistance and menopause — why blood flow and activity may matter more than hormones alone. A one-week action blueprint — practical steps you can apply right away for better results. This episode is packed with clarity and practical insights to help you optimize protein, training, and recovery so you can burn fat, preserve lean mass, and unlock your healthiest, strongest self. Free high-protein keto guide: The Keto Reset eBook https://ketogenicgirl.com/pages/new-free-ebook Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and décolleté and get 20% OFF with the code VANESSA Free high-protein keto guide: The Keto Reset eBook 👤 Connect with Vanessa: • Instagram: @ketogenicgirl • 🔗 Learn more about the TONE Breath Ketone Analyzer — 20% OFF with code VANESSA • Tone Collagen 📱 Follow @ketogenicgirl for the latest studies and strategies on fat loss and protein optimization 📸 Follow @optimalproteinpodcast for episode visuals and updates 💬 Join the Facebook group: Optimal Protein Podcast Community 🎙 The content in this podcast is for informational purposes only and not medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.

Unlock sharper focus and support long-term brain health with Ketone-IQ — clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In this episode of the Optimal Protein Podcast, I’m joined by Dr. Andy Galpin — world-renowned muscle physiologist, strength coach, and leading expert in human performance optimization. We dive deep into the cutting-edge science of muscle, metabolism, fat loss, and how to train smarter at every stage of life. NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with magnesium and vitamin B12. Get 20% off at puori.com/VANESSA This conversation covers the latest research on muscle fiber types, how to maintain fast-twitch muscle into your 40s and beyond, and why many women are far more predisposed to strength and power than we’ve been led to believe. Dr. Galpin also shares actionable strategies to break out of fat loss plateaus, reverse chronic dieting, improve metabolic flexibility, and strategically use tools like intermittent fasting, pre-sleep protein, and creatine to maximize fat loss and muscle retention. You’ll learn: What actually happens to fat when you lose it (hint: it leaves your body when you exhale!) Why most people are eating way less protein than they think — and how that sabotages recomposition The truth about sarcoplasmic vs. myofibrillar hypertrophy How to train if you’re stuck at 1200 calories and not seeing progress The surprising impact of sleep on fat metabolism and why pre-sleep protein may boost your overnight fat burning How to use your circadian rhythm to schedule workouts for maximum performance What Dr. Galpin recommends if your peak energy window is in the late afternoon — including ideal wake-up and bedtimes Whether Pilates, intermittent fasting, or creatine actually work for fat loss and muscle building And how women can use strength training to build muscle, reverse aging, and become “metabolically bulletproof” If you’re looking to overcome metabolic resistance, finally see results from your fat loss efforts, and train in a way that respects your biology — this episode is a masterclass in practical, science-backed strategies from one of the top experts in the world. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In this Friday episode, I’m diving into my fascinating conversation with Will Nitze, the founder and CEO of IQBAR—a bar formulated to fuel both the brain and the body. This solocast-style recap explores the unique backstory of how Will built IQBAR from the ground up and how the brand became a leader in the functional protein space. We break down: How Will developed the idea and scaled IQBAR from concept to nationwide success The exact macronutrient profile behind IQBAR and why it’s ideal for fat loss The powerful synergy between high protein and high fiber for satiety, stable blood sugar, and body recomposition Why ingredients like MCT oil, lion’s mane, magnesium, and omega-3s were included for cognitive support How smart snacking can support fat loss goals—especially when macros are optimized If you’re someone who struggles with hitting protein targets on the go, curbing cravings, or simply wants a science-backed, low-carb snack that supports your fat loss journey—this is the episode for you. Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and décolleté  and get 20% OFF with the code VANESSA Free high-protein keto guide: The Keto Reset eBook 👤 Connect with Vanessa: • Instagram: @ketogenicgirl • 🔗 Learn more about the TONE Breath Ketone Analyzer — 20% OFF with code VANESSA • Tone Collagen 📱 Follow @ketogenicgirl for the latest studies and strategies on fat loss and protein optimization 📸 Follow @optimalproteinpodcast for episode visuals and updates 💬 Join the Facebook group: Optimal Protein Podcast Community 🎙 The content in this podcast is for informational purposes only and not medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.  

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In today’s episode, Vanessa sits down with Dr. Samuel Dicken, Research Fellow at University College London’s Centre for Obesity Research and lead author of the UPDATE Trial — the longest and most rigorous clinical study to date comparing ultra-processed (UPF) vs. minimally processed (MPF) diets. This landmark trial revealed a game-changing finding: 👉 Even when calories, protein, and nutrients were matched to healthy eating guidelines, participants eating minimally processed foods lost twice as much weight, significantly more body fat, and experienced fewer cravings than those on ultra-processed foods. We dive deep into: Why food processing level impacts fat loss and body recomposition beyond calories How minimally processed diets preserve muscle while reducing fat mass The role of appetite hormones (ghrelin, GLP-1, PYY) and the thermic effect of food in regulating intake Dr. Dicken’s Lancet cohort study linking ultra-processed foods to a 17% higher risk of diabetes per 10% increase in diet share Practical food swaps to maximize satiety per calorie and overcome cravings Where “better” processed foods (like whole-grain breads and fermented dairy) fit into the picture How minimally processed diets compare with — and complement — GLP-1 weight-loss medications If you’ve ever felt like you eat “healthy” but still struggle with fat loss, this episode uncovers why the quality and processing level of your food may matter as much as the nutrients themselves. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA Join the Community! Follow Vanessa on Instagram to see her meals, recipes, informative posts, and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Discover how Protein-Sparing Modified Fasting PSMF) Days can unlock rapid fat loss without sacrificing muscle. Vanessa shares her own recent results alongside the latest studies on intermittent high-protein fasting in women. Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and décolleté  and get 20% OFF with the code VANESSA Have you ever wondered if you could accelerate fat loss with just a few high-protein, very low-calorie days each week? In this episode, Vanessa dives deep into the modern science of Protein-Sparing Modified Fasts (PSMF) and how intermittent high-protein fasting can help women lose fat, preserve lean muscle, and improve metabolic health. Vanessa reviews the latest studies on: 1–3 PSMF days per week compared to daily dieting Alternate-day and 5:2 style intermittent fasting approaches with high protein How PSMF days stack up against water fasting and generic low-calorie diets Fat loss, lean mass retention, and insulin sensitivity outcomes in women She also shares her personal PSMF experiment — one month of cycling three PSMF days per week — and reveals her results: fat loss, waist measurement changes, muscle preservation, and how it felt in real life. If you’ve been curious about modern approaches to PSMF, how to implement them safely, and whether they truly outperform traditional dieting, this episode brings you the evidence and the personal perspective. IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. Free high-protein keto guide: The Keto Reset eBook 👤 Connect with Vanessa: • Instagram: @ketogenicgirl • 🔗 Learn more about the TONE Breath Ketone Analyzer — 20% OFF with code VANESSA • Tone Collagen 📱 Follow @ketogenicgirl for the latest studies and strategies on fat loss and protein optimization 📸 Follow @optimalproteinpodcast for episode visuals and updates 💬 Join the Facebook group: Optimal Protein Podcast Community 🎙 The content in this podcast is for informational purposes only and not medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.  

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. This episode of the Optimal Protein Podcast takes a deep dive into the Protein-Sparing Modified Fast (PSMF) — a scientifically designed approach for rapid fat loss that prioritizes lean muscle preservation. Listeners will learn: What defines a PSMF and how it works in practice The latest research on fat loss outcomes and muscle retention How PSMF compares with ketogenic diets, VLCDs, and intermittent fasting Differences in results between men and women Short-term benefits and potential challenges with long-term use How to implement cycling strategies, refeed phases, and sustainable maintenance plans Evidence-based guidelines for safe and effective use Packed with research findings and practical insights, this episode provides a clear, evidence-based look at how PSMF can be used as a tool for body recomposition, fat loss, and long-term health. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at Ketogenicgirl.com with the code VANESSA Join the Community! Follow Vanessa on Instagram to see her meals, recipes, informative posts, and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast: The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. Today’s episode is a deep-dive recap of my mind-blowing conversation with Dr. Paul Laursen — one of the world’s top experts in exercise physiology, high-intensity interval training (HIIT), and fat-adapted performance. If you’ve ever wondered: Why you feel better fat-fueled than carb-loaded How diet actually drives fat loss more than training Why ketones might be more than a fuel — and actually a proxy for VO₂ max How to optimize your metabolic flexibility using HIIT and protein-forward nutrition …this episode will change how you see your body composition journey — especially if you’ve been trying to out-exercise a poor diet. 🔗 Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and decollete  and get 20% OFF with the code VANESSA  We break down: Why diet beats exercise for fat loss — results from Dr. Laursen’s VLCHF vs. HIIT study Fat-adaptation as a proxy for VO₂ max and why that matters for metabolic fitness & longevity How metabolic flexibility fuels both performance and brain health Why animal protein quality is a game-changer for recovery, energy, and lean mass The neuroprotective power of ketones for focus, resilience, and endurance How to train the brain first, body second for performance Why your body rebuilds itself every 6 months — and how to upgrade the raw materials 💡 Dr. Laursen’s 6 Step Body Recomposition Blueprint: Start with a high-protein, low-carb diet built on quality animal protein Use HIIT strategically — not excessively Track your own responses with CGMs and breath ketones Get fat-adapted for longevity, mental clarity, and metabolic resilience Support your brain — the true driver of performance Whether you’re an athlete or simply chasing better metabolic health, this episode delivers the science and strategy to help you get leaner, stronger, and more metabolically fit. Free high-protein keto guide: The Keto Reset eBook 👤 Connect with Vanessa: • Instagram: @ketogenicgirl • 🔗 Learn more about the TONE Breath Ketone Analyzer — 20% OFF with code VANESSA • Tone Collagen 📱 Follow @ketogenicgirl for the latest studies and strategies on fat loss and protein optimization 📸 Follow @optimalproteinpodcast for episode visuals and updates 💬 Join the Facebook group: Optimal Protein Podcast Community 🎙 The content in this podcast is for informational purposes only and not medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. Today’s guest is Dr. Paul Laursen — exercise physiologist, endurance coach, co-author of HIIT Science: The Science and Application of High-Intensity Interval Training, and co-founder of Athletica.ai. Dr. Laursen has coached athletes to 17 world championships, and his research on HIIT, metabolic flexibility, and low-carb nutrition has shaped how athletes and everyday people train for health and performance. In this episode, we cover: Why diet—not exercise—is the key driver of fat loss (and the clinical study that proved it) How being fat-fueled is actually a proxy for VO₂ max, a key marker of cardiovascular fitness and longevity The difference between burning carbs vs. burning fat during exercise — and why metabolic flexibility matters for performance and health How to use HIIT protocols strategically for fat loss, insulin sensitivity, and body recomposition without overtraining Why low-carb and very low-carb high-fat diets can supercharge fat oxidation, recovery, and cognitive clarity The role of ketones in appetite control, recovery, and brain performance Dr. Laursen’s top recommendations for training, nutrition, and recovery to optimize body composition and metabolic health Whether you’re an athlete, a weekend warrior, or someone looking to improve body composition and metabolic resilience, this conversation is packed with actionable strategies to help you get leaner, stronger, and more metabolically fit. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at Ketogenicgirl.com with the code VANESSA Join the Community! Follow Vanessa on Instagram to see her meals, recipes, informative posts, and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast: The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In this Part 2 solo recap episode, Vanessa Spina continues breaking down her powerful conversation with protein pioneer Dr. Donald Layman—covering the second half of their in-depth interview on metabolism, insulin resistance, muscle maintenance during menopause, and the launch of a groundbreaking new Protein Quality Hub. If you’ve ever wondered how to structure your meals to maximize fat loss, support lean mass, and protect your metabolic health as you age—this is the episode you’ve been waiting for. 🔬 What You’ll Learn in This Episode: • Why fasted workouts and AMPK activation can block muscle growth • How protein distribution and meal spacing impact fat loss • The link between muscle capacity and blood sugar regulation • Why most women need at least 100g of protein per day • How to pair carbs and protein in a 1:1 ratio to support metabolism • Stretch-based movement vs. heavy lifting for menopause muscle maintenance • What drives insulin resistance (hint: it’s not just carbs) • Why public health guidelines focus on survival—not optimization • The launch of Dr. Layman’s new Protein Quality Hub and how it can help you choose better protein sources Whether you’re in a fat loss phase, navigating perimenopause, or simply want to support long-term metabolic health, Dr. Layman’s research offers clarity and actionable steps you can start applying today. Free high-protein keto guide: The Keto Reset eBook  👤 Connect with Vanessa: • Instagram: @ketogenicgirl  •🔗 Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and decollete  and get 20% OFF with the code VANESSA  • Tone Collagen  Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.  Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen. 📲 Stay Connected with Vanessa: Instagram: @ketogenicgirl ⭐️ If You Loved This Episode… Please consider leaving a 5-star rating and review on Apple Podcasts or Spotify. It helps more women discover the truth about protein, strength, and sustainable fat loss!

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In Part 2 of this powerful interview, legendary protein researcher Dr. Donald Layman returns to the Optimal Protein Podcast to unpack some of the most misunderstood concepts in nutrition today—and to reveal potential groundbreaking changes to the U.S. dietary guidelines around protein, red meat, saturated fat, and carbohydrates. Dr. Layman breaks down what the science actually says about protein dosing, timing, oxidation, and muscle uptake—and who truly needs to worry about protein distribution. Vanessa and Dr. Layman also discuss: 🔬 Why protein timing matters more after age 30 🍽️ Why your first meal of the day may be the most critical for muscle preservation 🧠 Protein synthesis as a major driver of metabolism—and how it’s as energy-demanding as an hour of cardio 🔥 How high-protein diets increase fat loss by up to 300 calories per day via thermogenesis 🧬 AMPK, insulin, and muscle protein synthesis: what happens during fasted workouts and calorie restriction 💪 Why “lifting heavy” isn’t required—yoga, stretching, and muscle tension can preserve muscle as we age 🥩 The truth about red meat, saturated fat, and decades of flawed epidemiology 🧮 Dr. Layman’s 100g protein minimum for women, and why 1.2–1.6 g/kg is the sweet spot for recomposition 🌾 Why current global nutrition guidelines are built around survival—not optimal health—and how that’s changing 🌍 His new open-access protein quality hub to empower consumers and scientists alike This conversation is essential listening for anyone serious about optimizing their fat loss, preserving muscle, and finally understanding how protein quality and quantity affect long-term metabolic health. 🔗 Mentioned in the Episode: Dr. Layman’s new protein quality database  Muscle Full Effect & importance of protein distribution in aging Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at Ketogenicgirl.com with the code VANESSA Join the Community! Follow Vanessa on Instagram to see her meals, recipes, informative posts, and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. Jump to start of the episode: 13:30 In this Friday solo episode, Vanessa Spina breaks down the first half of her latest interview with Dr. Donald Layman — legendary protein researcher and one of the most featured guests in the history of the Optimal Protein Podcast. They cover game-changing updates to U.S. dietary guidelines, red meat’s misunderstood role in metabolic health, and the science of protein timing for fat loss and body recomposition. Whether you’re over 30, in a fat loss phase, or simply looking to optimize your protein intake, this episode is packed with insight. 🔬 What You’ll Learn in This Episode: • Why the 10% saturated fat cap may be removed from dietary guidelines • How red meat got falsely blamed for chronic disease • Why plant-based proteins are not nutritionally equivalent to animal proteins • The leucine threshold and how it changes with age • Why breakfast should be your most anabolic meal • How high-protein meals increase energy expenditure • Stretch-based resistance (like yoga and Pilates) vs. heavy weights for muscle preservation • The truth about meal distribution and muscle protein synthesis (MPS) • Real-world protein targets and strategies for fat loss This is Part 1 of a two-part solo recap. Tune in next Friday for Part 2 where Vanessa explores Dr. Layman’s take on the new Protein Hub, essential amino acid requirements, the role of insulin and AMPK in fat loss, and optimal carb intake by training status and age. Links mentioned: ➡️ Ketone IQ – 30% off subscription + free gift with second shipment: https://ketone.com/VANESSA ➡️ TONE Breath Ketone Analyzer – 20% off with code VANESSA ➡️ Tone Luxe Red Light Therapy Collection – 20% off with code VANESSA Free high-protein keto guide: The Keto Reset eBook  👤 Connect with Vanessa: • Instagram: @ketogenicgirl  • Tone Collagen - Save 15% with a Subscription Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast:  Link to join the facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen. 📲 Stay Connected with Vanessa: Instagram: @ketogenicgirl ⭐️ If You Loved This Episode… Please consider leaving a 5-star rating and review on Apple Podcasts or Spotify. It helps more women discover the truth about protein, strength, and sustainable fat loss!

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. This week on the Optimal Protein Podcast, I’m thrilled to be joined once again by Dr. Don Layman, one of the world’s foremost experts in protein metabolism and amino acid science. In this first part of our two-part conversation, we take a deep dive into the true definition of protein quality, the flaws of current scoring systems, and the metabolic significance of leucine as a primary trigger for muscle protein synthesis. Dr. Layman also introduces the EAA-9 protein quality model, a new way of evaluating protein sources that takes into account the body’s exact essential amino acid requirements—moving beyond methods like PDCAAS. Get 20% off on the Tone LUX Crystal Red Light Therapy Mask Ketogenicgirl.com with the code VANESSA We also discuss: Why protein quality should be defined by amino acid content, not nitrogen How leucine “shows up in nature” in exact ratios that muscle recognizes The four key signals muscle responds to: energy, leucine, insulin, and IGF-1 What activates and suppresses mTOR, and why AMPK shuts down MPS in low energy states How protein turnover drives up to 20% of your resting metabolic rate The concept of metabolic prioritization and what happens when your diet lacks adequate EAAs Why the term “protein requirement” is misleading—and why we actually have amino acid requirements Dr. Layman’s response to the 100 g of protein study on protein distribution  A preview of what’s really happening during fat loss, and how muscle preservation strategies can make or break long-term success This episode is a masterclass in muscle metabolism, protein science, and the tools you need to optimize your nutrition—especially for fat loss and body recomposition. 🎧 Stay tuned for Part 2 next week, where we explore updated USDA guidance, insulin’s role in MPS, essential amino acid supplementation, and Dr. Layman’s go-to blueprint for maintaining muscle in a calorie deficit. 🔗 Mentioned in the Episode: Dr. Layman’s new protein quality database  Muscle Full Effect & importance of protein distribution in aging Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Join the Community! Follow Vanessa on Instagram to see her meals, recipes, informative posts, and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In this solocast episode, Vanessa shares a detailed recap of her interview with Dr. Eduardo de Souza, associate professor at the University of Tampa and one of the world’s leading researchers in body recomposition and exercise science. This episode is a masterclass on building muscle and losing fat at the same time—even for trained individuals. ➡️ Tone Luxe Red Light Therapy Collection – 20% off with code VANESSA Vanessa dives deep into: The myth that you can’t gain muscle while losing fat Why protein intake is critical during fat loss How much of a calorie deficit is too much What matters more: training volume, intensity, or frequency? Whether cardio helps or hurts your gains The science behind meal timing and nighttime protein How sleep deprivation impacts protein synthesis and fat burning The truth about bulking and cutting vs. lean gains Dr. de Souza’s “recomposition roadmap” for sustainable results The real “secret” to fat loss: consistency Emerging research on creatine for cognition and sleep Vanessa’s personal results with exogenous ketones for brain and fat loss This recap is packed with actionable advice to help you optimize your fat loss, preserve your muscle, and build a body that reflects your hard work. Whether you’re plateaued in your results or just want to take your progress to the next level, this episode is filled with evidence-based tools to guide your journey. Links mentioned: ➡️ Ketone IQ – 30% off subscription + free gift with second shipment: https://ketone.com/VANESSA ➡️ TONE Breath Ketone Analyzer – 20% off with code VANESSA ➡️ Tone Luxe Red Light Therapy Collection – 20% off with code VANESSA Free high-protein keto guide: The Keto Reset eBook  👤 Connect with Vanessa: • Instagram: @ketogenicgirl  • Tone Collagen - Save 15% with a Subscription Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast:  Link to join the facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen. 📲 Stay Connected with Vanessa: Instagram: @ketogenicgirl ⭐️ If You Loved This Episode… Please consider leaving a 5-star rating and review on Apple Podcasts or Spotify. It helps more women discover the truth about protein, strength, and sustainable fat loss!

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In this powerhouse episode, Dr. Eduardo de Souza breaks down the real science of body recomposition—how to lose fat and build muscle simultaneously, even for advanced lifters. He shares the key strategies proven to work: optimal training volume, smart calorie deficits, high protein intake, and the underrated role of sleep. If you’ve hit a plateau or want to skip the bulk-cut cycle, this episode delivers clear, research-backed guidance to help you achieve lasting results. Get 20% off on the Tone LUX Crystal Red Light Therapy Mask at https://ketogenicgirl.com with the code VANESSA 💡In This Episode You’ll Learn: The truth about recomposition: why fat loss and muscle gain can happen simultaneously—even for trained individuals How training volume and intensity interact with diet to shape your physique The importance of protein intake—and the “minimum effective dose” to preserve lean mass How to structure your diet (deficit size, protein targets, carb balance) for fat loss without muscle loss Whether you need to bulk and cut—or can pursue long-term lean gains The key role of sleep in fat-burning, protein synthesis, and recomposition success Meal timing and why a pre-sleep protein shake might matter more than your post-workout window What to do when you plateau: advanced strategies and mindset shifts How consistency—not advanced tactics—is the true “magic bullet” for lasting results 📲 Stay Connected with Vanessa: Instagram: @ketogenicgirl Free High-Protein Keto Guide Join the Community! • Instagram: @optimalproteinpodcast • Facebook Group for the Optimal Protein Podcast  The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen. ⭐️ If You Loved This Episode… Please consider leaving a 5-star rating and review on Apple Podcasts or Spotify. It helps more women discover the truth about protein, strength, and sustainable fat loss!

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000.  That’s VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In this solo recap episode, Vanessa breaks down the top takeaways from her interview with one of the world’s leading experts in body composition and metabolism — Dr. Mike Ormsbee, Professor at Florida State University and Director of the Institute of Sports Sciences and Medicine. Dr. Ormsbee has published over 200 peer-reviewed papers and is globally recognized for his pioneering research on protein intake, nutrient timing, and metabolic adaptation. This recap explores the practical strategies from his decades of research to help you not only lose fat — but actually change your body shape by preserving lean mass and boosting metabolic health. •🔗 Learn more about the Tone LUX Red Light Therapy line and get 20% OFF with the code VANESSA  🔍 What You’ll Learn in This Episode: Why fat loss alone doesn’t change your body shape How to avoid becoming just a “smaller pear or apple” The minimum daily protein intake needed for recomposition What the science says about pre-sleep protein (and why it won’t make you gain fat!) Resistance training as the non-negotiable driver of body transformation The PRISE protocol: protein pacing, resistance training, sprints, stretching, and endurance How women — especially through menopause — can benefit from higher protein and performance goals Whether you need 3 meals… or 6 (and how to choose what’s best for you) 📚 Studies Referenced: Ormsbee et al., Pre-Sleep Protein & Resting Metabolic Rate (J Int Soc Sports Nutr, 2022) Arciero & Ormsbee, PRISE Protocol Trials (multiple studies on protein pacing & multimodal training) Ormsbee et al., Body Composition Study in Bariatric Patients — Muscle preservation with high protein + resistance training Position Stand on Nutrient Timing (ISSN, 2017 – co-authored by Dr. Ormsbee) 💡 Key Quote: “I’ve never done a protein study in women that showed a negative outcome on body composition — ever.” – Dr. Mike Ormsbee 📱 Connect: Follow Vanessa on Instagram: @ketogenicgirl Learn more about fat burning tracking tools like the Tone Device: www.ketogenicgirl.com  🔗 Learn more about the Tone LUX Red Light Therapy line and get 20% OFF with the code VANESSA  Tone Collagen  Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.  Link to join the facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen. 📲 Stay Connected with Vanessa: Instagram: @ketogenicgirl ⭐️ If You Loved This Episode… Please consider leaving a 5-star rating and review on Apple Podcasts or Spotify. It helps more women discover the truth about protein, strength, and sustainable fat loss!

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In this episode of the Optimal Protein Podcast, Vanessa Spina sits down with one of the world’s leading experts in sports nutrition and metabolism — Dr. Mike Ormsbee. With over 200 peer-reviewed publications, Dr. Ormsbee brings unmatched insight into how to optimize fat loss, preserve muscle, and transform your body composition through nutrition, protein timing, and targeted exercise. Vanessa and Dr. Ormsbee explore: Why calorie restriction alone just makes you a smaller version of the same shape How to change your body shape, not just your weight The truth about pre-sleep protein intake — and why it doesn’t make you fat How much protein you actually need daily (spoiler: it’s more than the RDA) The science behind multi-modal training and the “PRISE” protocol How women, especially during menopause, can benefit from a high-protein lifestyle Real lab data from studies on metabolic rate, fat oxidation, and overnight muscle protein synthesis Whether you’re trying to burn fat, gain muscle, or reshape your body — this is a must-listen episode packed with practical, evidence-based advice from one of the world’s most respected researchers in exercise science. 🧬 Topics Covered: The science of body recomposition Resistance training vs. cardio for reshaping your body High-protein diets: optimal intake ranges Meal timing and protein distribution strategies Pre-sleep protein: benefits, myths, and studies Research on resting metabolic rate and fat oxidation Female-specific insights: menopause, recovery, and strength The PRISE protocol and sustainable fat loss 📚 Mentioned in This Episode: Changing Body Composition Through Diet and Exercise (course by Dr. Ormsbee – The Great Courses) Dr. Ormsbee’s research via the FSU Institute of Sports Sciences and Medicine The PRISE protocol (Protein, Resistance, Intervals, Stretching, Endurance) 📱 Connect with Dr. Mike Ormsbee: Instagram: @mikeormsbee FSU Profile: Florida State University Institute of Sports Sciences and Medicine Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at Ketogenicgirl.com with the code VANESSA Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide Join the Community! Follow Vanessa on Instagram to see her meals, recipes, informative posts, and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast: The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.