PaperBee

当受精卵开始第一次分裂，两个子代细胞平均地贡献了胚胎的细胞组成吗？ 你知道吗，黑猩猩的近亲倭黑猩猩中的雄性在雌性统领的社群结构中面临着父权制下的女性相同的处境？显微观察中遇到的自发荧光也许可以摆脱噪音的命运，成为主角。更多精彩内容，尽在本期的PaperBee。人类胚胎组成的“不平均主义”The first two blastomeres contribute unequally to the human embryo小磁珠，标记细胞分裂次数Phenotypic targeting using magnetic nanoparticles for rapid characterization of cellular proliferation regulators新的细胞器：固氮体Nitrogen-fixing organelle in a marine alga女性是一种处境：母系统治下，雄性倭黑猩猩的雄竞行为Animal behavior: A tale of two apes变废为宝：用自发荧光来表征神经干细胞的不同状态Autofluorescence is a biomarker of neural stem cell activation state

力，是物理学中一个抽象的概念，然而，它却实在地存在于我们所处的宇宙空间。大到星体的运行轨迹，小到细胞的分裂方向，它像一个隐形的雕刻师，无时无刻不在塑造着客观世界的形态。片头：《SAGA》 ---Hurray for the Riff Raff片尾：《Cancel the party》 ---Julie Doiron文献：Green, P. B. & Stanton, F. W. Turgor Pressure: Direct Manometric Measurement in Single Cells ofNitella.Science155, 1675–1676 (1967).Maeda, S.et al.The Conflict Between Cell Proliferation and Expansion Primarily Affects Stem Organogenesis in Arabidopsis.Plant and Cell Physiology55, 1994–2007 (2014).LeGoff, L. & Lecuit, T. Mechanical Forces and Growth in Animal Tissues.Cold Spring Harb Perspect Biol8, a019232 (2016).Elliott, L.et al.A self-regulatory cell-wall-sensing module at cell edges controls plant growth.Nat. Plants10, 483–493 (2024).Hamant, O. & Haswell, E. S. Life behind the wall: sensing mechanical cues in plants.BMC Biol15, 59 (2017).Landrein, B. & Ingram, G. Connected through the force: mechanical signals in plant development.Journal of Experimental Botany70, 3507–3519 (2019).Trinh, D.-C.et al.How Mechanical Forces Shape Plant Organs.Current Biology31, R143–R159 (2021).Mechanical forces in plant tissue matrix orient cell divisions via microtubule stabilization.Developmental CellA self-regulatory cell-wall-sensing module at cell edges controls plant growth.Nature Plants

降低胆固醇有各种各样的办法,如果不改变DNA序列只改变DNA的表观修饰会不会更加安全可控呢 ？一个细胞也要像一支队伍,生物电的传递让他们拥有了多样的行走模式。更多精彩内容尽在本期的paperbee。更安全可控的降胆固醇方案：PCSK9的抑制性表观标签加载Durable and efficient gene silencing in vivo by hit-and-run epigenome editing游仆虫：一个细胞也要像一支队伍Cell motility: Bioelectrical control of behavior without neurons腺毛也系了一条领带Novel lignin-based extracellular barrier in glandular trichome非哺乳动物的哺乳行为Milk provisioning in oviparous caecilian amphibians小贴士：加入KU复合物，提高同源重组的基因打靶效率Redirecting DNA repair for efficient CRISPR-Cas-based gene targeting in tomato

说到痤疮杆菌，你可能想到了可怕的痘痘，然而，说不定，它经过改造也可以称为我们的朋友。你大概玩过植物大战僵尸，但你可能不知道，一些凶狠的寄生者会把寄主变成僵尸。更多精彩内容，尽在本期的paper bee，欢迎您的收听。化敌为友：改造痤疮杆菌减少皮脂产生Delivery of a sebum modulator by an engineered skin microbe in mice煤气灯操纵者：绿僵菌 和 斯德哥尔摩综合症患者: 阿根廷蚁Fungal infection alters collective nutritional intake of ant colonies分布了几百个着丝粒的染色体在联会后怎么进行交换？Meiotic recombination dynamics in plants with repeat-based holocentromeres shed light on the primary drivers of crossover patterning空气污染阻隔了夜行昆虫的觅食路Pollution disrupts nighttime pollination by degrading scents小贴士pA-regulator的更安全的基因调控方法pA regulator: a system for controlling mammalian gene expression via the modulation of polyA signal cleavage

当给类脑器官插上电极，连上AI，人类是否开启了创造智慧生物的大门？植物的神奇总是超乎我们的想象。时间能让很多东西湮灭，却也能让很多东西重获新生。片头曲：《很多鹅》 —旺福乐队插曲：《休息》 —以莉.高露《It start out so nice》 —Rodriguez 《相思河畔》 —顾媚片尾曲：《Annika》 —Björn Olsson人脑连接AI：Biocomputer’ combines lab-grown brain tissue with electronic hardwareverve101:first in vivo base editing lowers cholesterol蛛丝纤维：Bioengineered spider silk without critters老碳新用的红杉：After fire, coast redwoods use decades-old carbon reserves to recover生物结皮：Biocrusts protect the Great Wall of China from erosion