Performance Around The Clock

Welcome to episode 35 of the Performance Around the Clock podcast. We’re joined by Dr. Hemal Patel, a distinguished Professor and Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego (UCSD) and a VA Research Career Scientist. Holding a Ph.D. in Pharmacology and Toxicology, Dr. Patel's extensive research career has focused on caveolin and mitochondrial biology. In this episode, he discusses the critical role of cell membranes and mitochondria in cellular energy and disease, highlighting how his lab developed a non-invasive blood-based assay for mitochondrial function. This innovative assay, developed through the NASA Twin Study, can assess overall energetic health and disease states without invasive biopsies. Dr. Patel also shares his work on the therapeutic potential of the protein caveolin in conditions like heart disease and neurodegeneration (ALS, Alzheimer's, Parkinson's), and how his recent research has expanded to explore the mind-body connection through the transformative work of Dr. Joe Dispenza. We also talk about how his longtime interest in philosophy and religion has influenced his life and career. Please join us for an wonderful conversion between Dr. Panda and Dr. Patel. If you like this episode, please like, comment or follow. Thanks for listening. Guest:Dr. Hemal PatelProfessor and Vice-Chair Department of Anesthesiology, UC San Diego School of MedicineVA Research Career ScientistProfile:https://clre.ucsd.edu/faculty/hemal-patel/Instagram:@hemalpatelphdhttps://www.instagram.com/@hemalpatelphdHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Welcome to episode 34 of the Performance Around the Clock.  In this episode, host Dr. Satchin Panda, welcomes his esteemed colleague, Dr. Pamela Maher from the Salk Institute for Biological Studies.  Dr. Maher is a rare scientist who has taken drug discovery from basic science findings in cells all the way to compounds being tested in human clinical trials. In this episode, they discuss her journey through research on cell membranes and signaling, leading to her pivotal work on cell death pathways like oxytosis and ferroptosis. The conversation also covers the development of potential therapeutics for aging and Alzheimer's disease, including compounds like J147 and CMS-121, and the exploration of cannabinoids for neuroprotection.  If you like this episode, please like, comment or follow.  Thank you for listening.Guest:Dr. Pamela MaherResearch Professor at the Salk InstituteCellular Neurobiology LaboratoryProfile:https://www.salk.edu/scientist/pamela-maher/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast.  In this episode, Dr. Satchin Panda welcomes one of his scientific heroes, Dr. Susan Golden.  Dr. Golden is a pillar in the circadian and cyanobacteria science community and the former director for the Center for Circadian Biology at UC San Diego. She shares her journey from studying gene regulation in cyanobacteria to understanding the circadian clock through this unique organism.  Learn how these ancient blue-green algae were instrumental in the oxygenation of Earth's atmosphere and how tools developed to study cyanobacteria led to groundbreaking discoveries.  Beyond her research, Dr. Golden also made significant contributions to circadian rhythm education, teaching countless undergraduate students over the years.  If you like this episode, please like, comment or subscribe.  Thank you for listening.Guest:Dr. Susan GoldenDirector, Center for Circadian BiologyChancellor's Associates Chair (III) in Molecular BiologyDistinguished ProfessorX (Twitter): @susanksgoldenhttps://x.com/susanksgoldenProfile:UCSD:https://biology.ucsd.edu/research/faculty/sgoldenWikipedia:https://en.wikipedia.org/wiki/Susan_GoldenPaper:Circadian orchestration of gene expression in cyanobacteriahttps://pubmed.ncbi.nlm.nih.gov/7601351/Thanks to 理philosophia onlineについて for the photo of Dr. Takao Kondohttps://www.philosophia.sci.nagoya-u.ac.jp/snapshots/44.htmlHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

In our last episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are honored to host Dr. John Newman and Dr. Brianna Stubbs, both experts in ketone metabolism and aging.  Dr. Newman is a geriatrician and researcher at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF.  His research focuses on how ketone bodies, small molecules that our bodies make for energy during fasting or exercise, also work as molecular signals to control inflammation and gene expression.  Dr. Brianna Stubbs is an expert in exogenous ketone metabolism and the Director of Translational Science at the Buck Institute for Research on Aging. She's a former competitive rower and two-time world champion, and she completed her PhD in metabolic physiology at the University of Oxford, where she studied the metabolic effects of ketone esters.  Learn all about their work translating ketone research into the field. If you like this episode or podcast, please like, comment or follow. Thank you for listening.  Guests:Dr. John NewmanDivision of Geriatrics at UCSFAssistant Professor Buck Institute for Research on AgingX (Twitter): @geriscidochttps://x.com/geriscidocProfile:Division of Geriatrics at UCSFhttps://profiles.ucsf.edu/john.newmanhttps://medicine.ucsf.edu/people/john-newmanBuck Institute for Research on Aginghttps://www.buckinstitute.org/lab/newman-lab/Dr. Brianna StubbsDirector of Translational Science at Buck Institute for Research on AgingX (Twitter): @briannastubbshttps://x.com/briannastubbsHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Coming from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are excited to welcome Dr. Nathan LaBrasseur for the 31st episode of the Performance Around the Clock podcast. Dr. LaBrasseur is the director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic and an expert on senescence and aging. He's an author of the book "Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled" an updated guide on healthy aging. In this episode, learn about the latest in aging and senescence particularly therapeutics for senescent cells - senotherapeutics. Senotherapeutics can be broken down into senolytics which selectively kill senescent cells and senomorphics which suppress senescence-associated secretory phenotype (SASP) to reduce the negative effects of senescence. Thank you for watching. If you like this episode, please like, comment or subscribe. Guest:Dr. Nathan LaBrasseurDirector of the Robert and Arlene Kogod Center on Aging @MayoClinicX (Twitter): @NKLeBRASSEURhttps://x.com/nklebrasseurProfile:https://www.mayo.edu/research/faculty/lebrasseur-nathan-k-ph-d-m-s/bio-00055041Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilledhttps://www.amazon.com/Mayo-Clinic-Healthy-Aging-Comprehensive/dp/B0BQYKS8NDHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

We continue our series from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle.  Episode 30 of the Performance Around the Clock Podcast, features Dr. Courtney Peterson, a leading researcher in the field of intermittent fasting and time-restricted eating (TRE).  Dr. Peterson is an Associate Professor at the University of Alabama at Birmingham where she was notably the first to test early time-restricted eating (eTRE) in humans. Dr. Peterson is the principal investigator of numerous clinical trials on TRE, including the largest randomized controlled trial of intermittent fasting in individuals with type 2 diabetes. Her research combines chronobiology, nutrition, and metabolism and aims to develop dietary interventions to combat cardiometabolic diseases.  Learn all about her research in this episode. If you like this episode, please like, comment or subscribe.  Thank you for listening.  Guest:Dr. Courtney PetersonAssociate Professor University of Alabama BirminghamX (Twitter): @CourtneyP_PhDProfile:https://scholars.uab.edu/3393-courtney-peterson Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabeteshttps://pubmed.ncbi.nlm.nih.gov/29754952/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 29 of the Performance Around the Clock Podcast is our second episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle.  We are privileged to host Dr. Steven Austad who is a leading expert in aging biology. Dr. Austad is a Distinguished Professor and Chair of Biology at the University of Alabama at Birmingham, Director of UAB's Nathan Shock Center of Excellence in the Basic Biology of Aging and Senior Scientific Director of the American Federation for Aging Research (AFAR).  His varied career from large cat training, longevity field work with opposums, calculating the age of greenland sharks, to work with numerous other species gives Dr. Austad a unique view on longevity and aging.  He developed the Longevity Quotient (LQ) which is simplified measure that enables normalized comparisons of various species' longevity.  Learn all about his work on longevity and aging in this episode.  If you like this episode, please like or follow/subscribe.  Thank you for listening.In addition to authoring over 200 scientific articles and more than 150 newspaper columns on science. Dr. Austad has been a recipient of numerous awards such as:Fifth Nathan A. Shock AwardRobert W. Kleemeier awardPurdue University Outstanding Alumnus AwardIrving S. Wright Award of DistinctionFondation IPSEN Longevity PrizeCaroline P. and Charles W. Ireland Prize for Scholarly Distinction.He is also a fellow of the Gerontological Society of America (GSA) and the American Association for the Advancement of Science (AAAS). In 2021, he was appointed Protective Life Endowed Chair of Health Aging Research at the University of Alabama at Birmingham.Guest:Dr. Steven Austad'sX (formerly Twitter): @StevenAustadhttps://x.com/StevenAustadUAB Faculty Pagehttps://www.uab.edu/cas/biology/people/faculty/steven-n-austadBooks:“Why We Age”https://www.amazon.com/Why-We-Age-Science-Discovering/dp/0471148032/"Methuselah's Zoo."   https://www.amazon.com/Methuselahs-Zoo-Nature-Living-Healthier/dp/B0CL5D1SY7/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations:https://panda.salk.edu/giving/Research:https://www.salk.edu/scientist/satchidananda-panda/More science:https://mycircadianclock.org/

The Performance Around the Clock podcast episode 28 features  special guest Mukesh Bansal.  Bansal is a visionary entrepreneur in the fields of digital commerce, wellness and technology.  An IIT Kanpur graduate, Bansal's journey began with Myntra, an online fashion retailer that revolutionized apparel shopping in India.  His vision extended beyond e-commerce, leading him to co-found Cure.fit, a health and wellness platform.  Bansal's impact is further amplified through his venture studio, MerakiLabs, where he supports innovative startups including notable companies like Skyroot Aerospace and Groww. As an avid learner and reader, he put his insights to paper with books like "No Limits,"  and “Hacking Health”. Join us for an enlightening conversion with Bansal on his career and insights into wellness. If you like this episode, please like, follow or subscribe. Thank you for listening.Guest:Mukesh BansalX (Twitter):https://x.com/mukeshbansal06Sparx podcast:https://www.youtube.com/@sparxbymukeshbansalNo Limits:https://www.amazon.com/No-Limits-Science-High-Performance-ebook/dp/B0B5LCRC8DHacking Health:https://www.amazon.com/Hacking-Health-Only-Youll-Healthiest/dp/0670097136Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations:https://panda.salk.edu/giving/Research:https://www.salk.edu/scientist/satchidananda-panda/More science:https://mycircadianclock.org/

Happy 2025! Episode 27 of the Performance Around The Clock podcast is our last from the Society for Research on Biological Rhythms (SRBR) meeting in San Juan, Puerto Rico.  We are excited to have Dr. Till Roenneberg on the podcast.  Dr. Roenneberg is emeritus professor of chronobiology at the Institute of Medical Psychology at Ludwig-Maximilian University (LMU) in Munich, Germany.  He has dedicated most of his career to investigating the effects of light on circadian clocks, sleep, and health and is known for his seminal work with chronotypes and social jetlag.  Hear all about his work on chronotypes and social jetlag in this episode. Thank you for listening. If you enjoy this episode or podcast, please like, subscribe or comment. Thank you.Guest:Dr. Till RoennebergPrizes and Awards:1987 Harvard-Hoops Prize for Excellence in Teaching1993 Honma Prize "Outstanding contributions to the field of chronobiology”1998 "Aschoff's Ruler" Research Prize2004 Silver Medal (University of Munich)2011 Professional Lighting Design Recognition Award for Research and Education2012-2015 President European Biological Rhythms Society2013 Science Book Award of the British Medical Association Board2016 Galileo Award Italian Science Book Prize2018 Innovation in Academia Award (University of Kent)2019 Ambassador of Sleep (German Sleep Foundation)2024 Daylight Award for Daylight ResearchProfile:https://www.mcn.uni-muenchen.de/members/regular/roenneberg/index.htmlHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science:https://mycircadianclock.org/

Episode 26 of the Performance Around The Clock podcast comes from the GSA (Gerontological Society of America) meeting in Seattle. We are delighted to host, Dr. Jamie Justice, who is the Executive Vice President of the Health Domain at XPRIZE Foundation and adjunct professor in Gerontology and Geriatric Medicine at the Wake Forest University School of Medicine. We talk about her career in gerontology, expertise with biomarkers and XPRIZE Healthspan. Join us for an enlightening conversation about aging and learn about the big XPRIZE Healthspan initiative. Thank you for listening. Guest: Dr. Jamie Justice Executive Vice President of the Health Domain at XPRIZE Foundation Adjunct Professor in Internal Medicine Section on Gerontology and Geriatric Medicine, and Sticht Center on Healthy Aging and Alzheimer’s Prevention at Wake Forest University School of Medicine (WFUSM) - Jarrahi Research Scholars Fund in Geroscience Innovation - 2022 Vincent Cristofalo Rising Star in Aging Research - 2022 NIA Nathan W Shock Awardee XPRIXE profile: https://www.xprize.org/about/people/jamie-justice-ph-d XPRIZE Healthspan: https://www.xprize.org/prizes/healthspan TAME study: https://pubmed.ncbi.nlm.nih.gov/30151729/ Host: Dr. Satchin Panda X (Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/

We continue our series from the Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  In episode 25 of the Performance Around The Clock podcast, we have the pleasure of speaking with Dr. Phyllis Zee, one of the world’s experts on sleep.  Dr. Zee is a Director of the Center of Circadian and Sleep Medicine at Feinberg School of Medicine at Northwestern University.  She is also the Chief of Sleep Medicine in the Department of Neurology and Benjamin and Virginia T. Boshes Professor of Neurology.  In this episode, she talks about sleep disorders, using melanopsin as a chronobiotic, the interesting connection between melatonin and glucose metabolism and the establishment of circadian health clinics. Thanks for listening. Guest:Dr. Phyllis ZeeDirector, Center for Circadian and Sleep MedicineFeinberg School of Medicine at Northwestern UniversityChief of Sleep Medicine in the Department of NeurologyBenjamin and Virginia T. Boshes Professor of NeurologyX (Twitter): @PhyllisZeehttps://x.com/phylliszeeProfile:https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=13785International Association of Circadian Health Clinicshttps://circadianhealthclinics.com/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Welcome to episode 24 of the Performance Around The Clock podcast.  We resume our series from the Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  In this episode, we are joined by Dr. Annie Curtis, a professor at the Royal College of Surgeons in Ireland (RCSI), who studies the intersection between circadian rhythms and the immune system.  We talk about how the timing of infection affects the immune response and the implications for vaccinations.  In addition, we hear about the intriguing role of mitochondria in this immune response. Thanks for listening.Guest:Dr. Annie CurtisAssociate ProfessorRoyal College of Surgeons in Ireland (RCSI)School of Pharmacy and Biomolecular SciencesPrincipal Investigator of the Tissue Engineering Research Group (TERG)Executive Committee for the Irish Society for Immunology between 2016-2020L’Oreal Women in Science Fellowship in 2017SFI Career Development Award in 2017Irish Research Council Laureate Award in 2018President of the Irish Society for Immunology 2020-2022SFI Frontiers Award in 2021Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast. In episode 23, we are joined by Dr. Emily Manoogian, one of the foremost experts on Time-Restricted Eating (TRE), to discuss her latest research on TRE in adults with metabolic syndrome. We will explore how to implement TRE and its various benefits. Dr. Manoogian will also share insights on using the myCircadianClock app in her clinical trials to track TRE and other circadian metrics. For more information, you can visit the myCircadianClock website at www.mycircadianclock.org. If you are interested in participating in a Type 2 Diabetes and TRE study, please get in touch with Dr. Manoogian at preventivecvresearch@health.ucsd.edu. Her latest study was published in the Annals of Internal Medicine: (https://pubmed.ncbi.nlm.nih.gov/39348690/). Thank you for tuning in.Time-Restricted Eating in Adults with Metabolic Syndrome: A Randomized Control Trialhttps://www.acpjournals.org/doi/10.7326/M24-0859Guest:Dr. Emily ManoogianHillblom Fellow, Staff Scientist at the Salk Institute for Biological StudiesX (Twitter): @EmilyManoogianClinical Trials with Dr. Pam Taub: https://cardiology.ucsd.edu/research/labs/taub/research/clinical-trials.html#TRE-x-T2D-Study myCircadianClock website:www.mycircadianclock.orgParticipate in a Type 2 Diabetes Study by emailing:preventivecvresearch@health.ucsd.edu Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 22 of the Performance Around the Clock podcast is another episode from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We are honored to host this week’s guest, Dr. Charlotte Förster, who epitomizes perseverance in her long scientific career studying circadian rhythms  We’ll talk about her work to understand  the circadian clock at the molecular and neuronal level, how the clock synchronizes with the day/night cycles and how the clock controls behavior.  You’ll also hear about her fascinating research on the synchronization of menstrual cycles with lunar cycles and its implications.  Dr. Förster is a professor in Neurobiology and Genetics at the University of Würzburg.  Thank you for listening.Guest:Dr. Charlotte ForsterChronobiology Professor, Neurobiology and Genetics, University of WürzburgLab website:https://www.biozentrum.uni-wuerzburg.de/en/neurogenetics/research/wg-foerster/charlotte-foerster/Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 21 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  This week’s guest is Dr. Achim Kramer who developed an assay (BodyTime) to determine internal circadian time.  He talks about the development of the assay and how it can be used in circadian medicine.  Dr. Kramer is Head of Chronobiology at Charité – Universitätsmedizin Berlin, the largest research hospital in Europe. Thank you for listening.Guest:Dr. Achim KramerHead of Chronobiology at Charité – Universitätsmedizin BerlinLab website:https://www.achim-kramer-lab.de/Body clock test:https://www.bodyclock.health/BodyTimeHigh-accuracy determination of internal circadian time from a single blood samplehttps://pubmed.ncbi.nlm.nih.gov/29953415/Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Performance Around the Clock episode 20 comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the pleasure to talk with Dr. Christoph Scheiermann who studies the role of circadian rhythms in immune response and how this impacts health and disease.  In particular, he’s known for his research on the recruitment and localization of leukocytes which is under circadian control.  This process plays a crucial role in immune response which can be leveraged to improve cancer immunotherapy and vaccination efficacy.  Learn more about his impactful research in this episode. Thanks for listening.Guest:Dr. Christoph ScheiermannFull ProfessorDepartment of Pathology and ImmunologyCentre Medical Universitaire (CMU)X (formerly Twitter): @ScheiermannLabhttps://twitter.com/ScheiermannLabLab webpage:http://scheiermannlab.de/Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/

Episode 19 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biological Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the honor to talk with one of the pillars of the circadian field - Dr. Joseph Takahashi.  Dr. Takahashi pioneered the use of forward genetics and positional cloning in mouse as a tool to discover genes that underlie neurobiology and behavior.  His discovery of clock genes led to a description of a conserved circadian clock mechanism in animals. In this podcast, we hear about how his lab discovered and cloned the mouse circadianClock gene.  In addition, we find out how circadian alignment of feeding, daily fasting and caloric restriction can combine to increase longevity.Dr. Takahashi has authored more than 300+ scientific publications and the recipient of many awards and distinctions including:The Honma Prize in Biological Rhythms ResearchNSF Presidential Young Investigator AwardSearle Scholars AwardBristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. W. Alden Spencer Award in Neuroscience from Columbia UniversityFellow of the American Academy of Arts and SciencesMember of the National Academy of SciencesMember of the National Academy of MedicineGruber Neuroscience Prize at the Society for NeuroscienceGuest:Dr. Joseph TakahashiChair of the Department of Neuroscience at UT Southwestern Medical CenterLoyd B. Sands Distinguished Chair in NeuroscienceX (formerly Twitter): @CircadianClockshttps://twitter.com/circadianclocksUT Southwestern profile:https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.htmlLab webpage:https://labs.utsouthwestern.edu/takahashi-labHost:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 18, the final episode from the Cell Symposia meeting on Exercise Metabolism in Lisbon, features Dr. Bret Goodpaster. As the Scientific Director at AdventHealth's Translational Research Institute, Dr. Goodpaster is a leading expert in exercise physiology and metabolism. In this episode, he shares his insights on exercise, muscle, aging, and the athlete’s paradox. We also delve into two major scientific projects - HealthABC (Health, Aging Body and Composition) and MoTrPAC (Molecular Transducers of Physical Activity Consortium). HealthABC explores risk factors for functional decline in older adults, including muscle aging. MoTrPAC is a large consortium created to understand the molecular mechanisms of physical activity on health benefits. We hope you will find this episode intellectually stimulating. Thank you for listening.Guest:Dr. Bret GoodpasterScientific Director at Advent Health’s Translational Research Institutehttps://www.adventhealthresearchinstitute.com/team/bret-goodpasterHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 17 of the Performance Around The Clock podcast comes from the Cell Symposia meeting on Exercise Metabolism in Lisbon. We were honored to host Dr. Bente Klarlund Pedersen and to talk about her brilliant career from her seminal research on myokines to "exercise as medicine". Dr. Pedersen also tells us about how she uses her knowledge of exercise to educate the public and effect policy changes.Guest:Dr. Bente Klarlund PedersenDirector of Centre for Physical Activity Research (CFAS)https://www.inflammation-metabolism.dk/X (formerly Twitter): @benteklarlundphttps://x.com/benteklarlundpHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 16 of the Performance Around the Clock podcast comes from the Cell Symposium on Exercise Metabolism in Lisbon, Portugal and features Dr. Mark Febbraio who is the head of Cellular and Molecular Metabolism Laboratory at Monash Institute of Pharmaceutical Sciences. His research focuses on understanding mechanisms associated with exercise, obesity, type 2 diabetes and cancer with an aim towards developing novel drugs to treat lifestyle related diseases. In this episode, we hear about how he transitioned from a triathlete into a researcher in exercise science. We also learn about the link between exercise and inflammation and leveraging this knowledge to treat disease. Enjoy!Guest:Dr. Mark FebbraioProfessor, Drug Discovery BiologyCellular and Molecular Metabolism LaboratoryMonash Institute of Pharmaceutical SciencesX (formerly Twitter): @FebbraioMarkhttps://twitter.com/FebbraioMarkHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/