Rational Wellness Podcast

The HRT Questions Most Women Never Get Answered with Karen Martel | Rational Wellness Podcast 481 Perimenopause to Menopause: Testing, Progesterone First, and Evidence-Informed HRT with Karen Martell Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews hormone specialist Karen Martell about perimenopause and menopause, emphasizing that midlife hormonal shifts affect metabolism, sleep, mood, cognition, bone and cardiovascular health. Martell says perimenopause can begin in the mid-30s, often with declining progesterone from less frequent ovulation, leading to heavy periods, insomnia, anxiety, and perceived "estrogen dominance," while estrogen later becomes erratic and then declines toward menopause around age 51. She critiques common responses like birth control, hysterectomy, and symptom-only medications, and recommends combining bloodwork with saliva or urine metabolite testing (e.g., DUTCH) when cycling. For HRT, she prefers transdermal estradiol over oral estrogen, discusses progesterone delivery options and sensitivities to oral metabolites, addresses testosterone (often compounded; injectable preferred), and notes roles for DHEA and pregnenolone. She also covers vaginal therapies, dosing based on both symptoms and protective lab ranges, and cautious later-life initiation.   00:00 Show Intro and Mission 00:59 Why Midlife Hormones Matter 02:23 Perimenopause Starts Early 03:18 Progesterone Drop Signs 06:17 Testing Hormones and Thyroid 08:02 Bad Advice and Quick Fixes 09:33 When Supplements Aren't Enough 10:52 Starting Progesterone Therapy 12:49 Best Hormone Testing Methods 15:36 Endocrine Disruptors Cleanup 17:40 Choosing Estrogen Delivery 18:43 Pellets and Testosterone Risks 22:27 Progesterone Forms and Dosing 25:21 Why Avoid Oral Estrogen 27:00 Estradiol for Life 27:38 Estriol vs Estradiol 30:23 Patch vs Cream Dosing 31:56 E4 Estrogen Debate 33:39 Cycling Progesterone 35:38 DHEA and Pregnenolone 37:39 Vaginal Hormone Options 40:18 Optimizing HRT Levels 43:52 Starting HRT After 70 47:45 Perimenopause Timing Tips 50:19 Where to Find Karen Karen Martel is a Certified Hormone Specialist and Transformation Nutrition Coach and the host of The Hormone Solution podcast, which focuses on perimenopause, menopause, hormone replacement therapy, metabolic health, weight loss resistance, and thyroid health.  Her website is KarenMartel.com.   Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

What are the Functions of Microbial Gases, Hydrogen, Methane, & Hydrogen Sulfide with Dr. Tom Fabian | Rational Wellness Podcast 480 Gut Microbial Gases Beyond SIBO: Hydrogen, Methane, and Hydrogen Sulfide as Signaling Metabolites Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews Dr. Tom Fabian, PhD, to discuss gut microbial gases beyond the usual SIBO framing. They explain that hydrogen, methane, and hydrogen sulfide are normal microbial metabolites with potential signaling roles, alongside key microbiome products like short-chain fatty acids (especially butyrate), which fuels colon cells, supports tight junctions, regulatory T cells, and helps maintain an anaerobic colon environment. Fabian notes metabolomics (e.g., GI-MAP stool add-ons) can provide functional insight beyond which microbes are present, highlighting butyrate producers such as Faecalibacterium and Roseburia. They review controversies in breath testing interpretation, discuss methane biology and debated links to constipation, and emphasize emerging research that hydrogen sulfide is widely produced (often from cysteine metabolism), supports colon mitochondria and anaerobiosis, may relate to stress responses and longevity, and that excessive sulfur restriction may be misguided; fiber and polyphenols may mitigate protein-driven hydrogen sulfide. 00:00 Show Intro 00:59 Why Gut Gases Matter 04:04 Microbiome Metabolites 05:52 Butyrate Deep Dive 09:07 Measuring SCFAs 13:20 Hydrogen and Breath Tests 19:12 Hydrogen Benefits 28:19 Methane and Motility 31:06 Sponsor Break 32:13 Methanogens Explained 35:24 Hydrogen Sulfide Science 50:59 Clinical Takeaways   Dr. Tom Fabian has a PhD in molecular biology and who has spent many years researching the microbiome and translating the scientific literature into practical applications for functional medicine practitioners.  Currently, Dr. Fabian serves a consultant and science advisor with Diagnostic Solutions Laboratory. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.  

Galectin-3, Modified Citrus Pectin, and Therapeutic Apheresis: Emerging Applications in Sepsis, Cancer, and Chronic Inflammation   Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews returning guest Dr. Isaac Eliaz about galectin-3 as an upstream driver of inflammation and fibrosis implicated in chronic degenerative disease, autoimmunity, cancer progression, and acute sepsis. Eliaz explains modified citrus pectin (PectaSol) as a researched galectin-3 inhibitor, discusses dosing ranges, and describes its clinical relevance across inflammation, cardiovascular risk, microbiome effects, and cancer (including prostate cancer trials). The conversation focuses on therapeutic apheresis and plasma exchange, contrasting nonselective plasma exchange with selective approaches such as LDL apheresis and Eliaz's developing Xgal-3 filter designed to remove circulating galectin-3. He cites porcine sepsis data, an FDA breakthrough designation, upcoming sepsis trials, and potential to enhance cancer immunotherapy, while warning about hype, safety, training, and misuse in integrative settings. 00:00 Show Introduction 00:59 Meet Dr Isaac Eliaz 02:47 What Is Galectin 3 09:25 Galectin 3 And Sepsis 11:45 Modified Citrus Pectin Basics 17:11 MCP Dosing Guide 20:43 MCP Gut And Cancer Research 25:33 Why Galectin 3 Is Overlooked 26:49 Apheresis Filter Breakthrough 28:57 Will Galectin 3 Return 29:49 Sepsis Immune Overdrive 30:39 Galectin-3 Cancer Shield 31:13 MCP Prostate Trial Wins 33:33 Boosting Immunotherapy Response 35:32 Therapeutic Apheresis Explained 36:48 Plasma Exchange Hype Risks 39:12 Safer Protocols And Expertise 47:02 Personal Longevity And LDL 49:53 Selective Vs Plasma Outcomes 52:59 Future Trials And Wrap Up   Dr. Isaac Eliaz is an internationally recognized expert in the field of integrative medicine. A highly skilled physician and healer trained across diverse medical systems, Dr. Eliaz offers an unparalleled holistic approach to health and healing. He is a leading specialist in integrative cancer treatment and prevention, mind-body medicine, and the application of strategic protocols to address complex, degenerative conditions. At Amitabha Medical Clinic, Dr. Eliaz and his team have pioneered the use of the blood filtration treatment, therapeutic apheresis, as a groundbreaking clinical procedure for cancer, chronic kidney disease, Lyme disease and other inflammatory conditions—with outstanding clinical success. His websites are DrEliaz.org and Amitabhab.com and Eliazapheresis.com Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.  

IBS and SIBO Breath Testing with FoodMarble: Real-Time Hydrogen and Methane Monitoring Dr. Ben Weitz introduces the Rational Wellness Podcast episode on IBS and SIBO with guests Angus Short, PhD (CEO/co-founder) and Claire Short, PhD (chief clinical officer) of FoodMarble, creators of the handheld AIRE breath analyzer that measures hydrogen and methane in real time to track fermentation patterns at home. Inspired by Angus's wife's unresolved IBS symptoms and restrictive dieting, the device evolved from early prototypes into a validated product, including published research with Johns Hopkins showing equivalence to a leading mail-in breath test kit. They discuss following North American Consensus SIBO protocols (prep diet, fasting, lactulose or glucose, readings every 15 minutes for two hours with customizable options), additional at-home FODMAP intolerance tests, symptom/diet/stool tracking, and personalization. They note ongoing development of hydrogen sulfide measurement, factors affecting readings, and how monitoring can guide diet, supplements, and treatment choices. 00:00 Podcast Intro 00:59 IBS SIBO Episode Setup 02:29 Why FoodMarble Started 06:54 Early Prototypes to Product 07:46 Clinical Validation Studies 10:06 How to Run SIBO Tests 12:34 FODMAP Intolerance Testing 16:11 Stool Microbiome Links 20:17 Building a Healthier Microbiome 24:30 Daily Tracking and H2S Sensor 27:00 Diet Variability Matters 27:39 Tracking Meals and Symptoms 28:56 Personalization Factors in Data 29:39 Meal Timing and Liquids 30:48 GLP-1s and Gut Transit 31:56 Patient Engagement and App Modes 33:38 Avoidance and Food Reintroduction 34:32 Lactose Myths and Hidden FODMAPs 36:09 How FODMAPs Really Work 39:20 Food Database and Alternatives 40:16 Enzymes and Supplement Testing 41:54 Breath Sampling Technique 44:28 Calibration and Device Longevity 48:18 Breath Testing Misconceptions 49:59 SIBO Treatments and Research 54:51 Wrap Up and Where to Buy Claire Shortt, PhD and Aonghus Shortt, PhD are the creators of the Food Marble, the handheld SIBO breath analyzer that measures hydrogen and methane in real time to track fermentation patterns at home. To learn more, go to FoodMarble.com and use the code WEITZ15 to get 15% off. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.  

Environmental Toxins, Wildfire Smoke, and Practical Detox Strategies with Dr. Joe Pizzorno   Dr. Ben Weitz hosts the Rational Wellness Podcast and interviews Dr. Joe Pizzorno on latest research about environmental toxins, emphasizing wildfire smoke risks, PM2.5 penetration, rapid body and brain distribution, and links to neurological, respiratory, and cardiovascular disease. Pizzorno argues toxins are a primary, solvable driver of chronic illness and that oxidized cholesterol reflects toxic exposure more than cholesterol itself. Practical protections include running high-MERV (≥12, ideally 16) HVAC filtration 24/7, avoiding incense, and supporting detox with glutathione (liposomal or via NAC), increased and diverse fiber to reduce toxin reabsorption, and saunas to sweat profusely (except PFAS "forever chemicals," which don't excrete via sweat). They discuss mercury release from forest fires, microplastics and gut binding, arsenic reduction from rice cooking, water filtration (carbon block, RO for arsenic), endocrine disruptors like bisphenols, and toxin assessment using GGTP, ALT, eGFR, and urinary 8-OHdG rather than challenge tests.   01:02 Meet Dr Joe Pizzorno 02:24 Wildfires and Toxic Exposure 05:21 PM2.5 and Systemic Damage 07:24 Cholesterol Oxidation and Toxins 09:35 Home Air Filtration Tips 11:25 Mercury From Forest Fires 13:15 Glutathione and NAC Basics 14:41 Binders and Fiber Strategy 17:26 Persistent vs Nonpersistent Toxins 19:21 Saunas and Forever Chemicals 21:47 Microplastics and Gut Binding 24:13 Post Fire Cleanup Safety 25:21 Arsenic in Water Rice Chicken 27:54 Whole House Water Filters 29:08 Chlorine Fluoride Tradeoffs 31:08 Plastic Bottles and Bisphenols 31:54 Endocrine Disruptors Explained 33:58 Phytoestrogens vs Xenoestrogens 35:49 Safer Drinkware and Cookware 36:37 Testing Toxins Smarter 39:49 Biomarkers GGTP ALT eGFR 44:37 Detox Nutrition and Glutathione 46:54 Toxins and Autoimmune Disease 48:22 Cure Versus Suppression 53:44 Final Thoughts and Outro   Dr. Joe Pizzorno is one of the founders of the modern naturopathic medicine and also the Functional Medicine movement, founding president of Bastyr University, editor of the Textbook of Natural Medicine, and one of the world's leading authorities on environmental toxins and chronic disease. He's the author of at least 14 outstanding books, including The Toxin Solution and a textbook on toxins that he cowrote with Walter Crinion, Clinical Environmental Medicine and he continues to publish groundbreaking research on the role of environmental toxicants in human health. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.