Razib Khan's Unsupervised Learning

Razib Khan engages a diverse array of thinkers on all topics under the sun. Genetics, history, and politics. See: http://razib.substack.com/

Peachy Keenan: cosmopolitan radical traditionalist

  On this episode of Unsupervised Learning Razib talks to the pseudonymous commentator “Peachy Keenan.” A native of Los Angeles with an Ivy League education, Keenan worked in entertainment before detouring into punditry, writing for the Claremont Institute’s The American Mind, appearing on Fox News and penning Domestic Extremist: A Practical Guide to Winning the Culture War. Razib and Keenan discuss her peripatetic and unique journey from a relatively apolitical member of America’s liberal professional managerial class to a conservative Catholic housewife with a large family. Keenan talks about her ability to connect with audiences of all stripes despite her partisan leanings as the product of her cosmopolitan upbringing among coastal elites. Though in her values and practices she lives the life of the “domestic extremist,” she still retains an aesthetic appreciation of the broader culture in which she grew up. Domestic Extremist is to a great extent a roadmap from where she was, to where she is. Keenan offers a sort of  primer on how to change the “factory settings” for the American professional class, proposing traditional family life as an exit out of the endless rat race. They also discuss the reality that the modern conservative culture falls short of produce any art for its own sake, at most putting out fare that ranges from  overly didactic films produced by the Daily Wire to the cringe-inducing Christian film industry. Keenan emphasizes that good art must be good art, first and foremost, and whatever ideological valence should be layered in with subtlety and taste. She also discusses the problems with raising consciousness among conservative philanthropists about the problem of right-wing philistinism, and why aesthetic excellence would be a boon in any attempt to recapture the cultural high ground.

12-19
01:13:05

Jesse Singal: after the replication crisis and into the youth gender medicine debate

  On this episode Razib talks to Jesse Singal, a journalist who has covered the social science beat for the last decade. Singal has an undergraduate degree in philosophy from University of Michigan and a master’s in public affairs from Princeton. Currently a freelance journalist who writes his own Substack, Singal-Minded, and contributes to Blocked and Reported with Katie Herzog, Singal is formerly an editor at New York Magazine. His first book The Quick Fix: Why Fad Psychology Can't Cure Our Social Ills, covered the replication crisis. Razib and Singal first talk about what he learned, and unlearned, during his time as a reporter at New York Magazine, especially social psychology results that were long on glamor but short on robustness. They discuss how long we’ve known that social psychology had a problem, and whether it still hasn’t reformed itself. Singal also reflects on his role in publicizing sexy findings, and how journalism has taken steps to be more careful lately. They also address some of the specific findings that came out of early 2010’s social science, from implicit bias to power posing. Next, Razib asks Singal about youth gender medicine, and the major controversies over the last few years. Singal discusses the differences between female to male transitions as opposed to male to female, and relates the whole domain back to the replication crisis and the lack of good research. They also discuss political and social aspects, and where Singal sees youth gender medicine going in the next few years.

12-15
01:03:14

Sam Hammond: I for one welcome our A.I. overlords

On this episode of Unsupervised Learning Razib talks to economist Sam Hammond.  Canadian-born Hammond serves as the Senior Economist at the Foundation for American Innovation. His work primarily focuses on innovation and science policy, with particular attention to the societal and institutional impacts of disruptive technologies such as artificial intelligence. Before his role at FAI, Hammond was Director of Poverty and Welfare Policy at the Niskanen Center. Hammond also held a research fellowship at the Mercatus Center at George Mason University, focusing on policy issues related to technology and regulation. He holds a BA in Economics from Saint Mary’s University and MA's in Economics from George Mason University and Carleton University. After a quick discussion about Canadian housing, Razib and Hammond consider his piece 95 theses about AI. Hammond’s contention is that AI might prove as impactful as the printing press, or, at the outer edge equivalent to photosynthesis. Nearly two years into the current “AI hype cycle” we still haven’t found the “killer app” of AI, but thinkers like Hammond are getting ahead of the likely inevitable societal changes. He believes that change is inevitable, and the details that need to be worked out are how we as a species adapt and evolve in response to our technology. Hammond contends that the AI-revolution is likely to produce changes in the next generation analogous to industrial transformations of the late 19th centuries and early 20th centuries, when cars, electrification and airplanes transformed civilization.    For early access, feel free to explore it there. https://www.razibkhan.com/p/sam-hammond-i-for-one-welcome-our   

12-11
01:10:39

14,000 years of natural selection

    The full episode is available on: https://www.razibkhan.com/p/14000-years-of-natural-selection On this episode of Unsupervised Learning Razib talks about what we have learned from a blockbuster new preprint, Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation. Synchronously released was the Ancient Genome Selection browser, which allows you to trace the allele frequency of variants of interest over the last 10,000 years. Razib covers: The relationship of selection to adaptation and the Darwinian understanding of evolution Non-genetic selection Types of biological selection like positive, negative, background and balancing selection Hard vs. soft sweeps and their relevance to detecting selection in the genome Older forms of natural selection detection between species (dN/dS, Tajima’s D) Newer forms of selection detection within species with haplotype structure, outlier SNP analysis and site frequency spectra The Generalized Linear Mixed Model used to model allele frequency change over time, and estimates of selection in cases where population structure and drift are not sufficient Specific examples of SNPs whose variation can be examined in the browser and are clearly cases of selection Survey of traits that were revealed under selection, including blood groups, pigmentation and intelligence Critiques of the methods due to not accounting for drift or population structure, and its limitations in relation to the ability to port across populations due to LD structure

12-02
40:46

Europe: 40000 BC to 1200 BC

On this week’s episode of Unsupervised Learning Razib discusses the genetic and archaeological history of Europe from the arrival of modern humans (permanently) 45,000 years ago, to the end of the Bronze Age in the decades after 1200 BC. He covers these time periods: Pre-Aurignacian (before 43 kya)  Aurignacian (43-26 kya)  Gravettian (33-21 kya)  Solutrean (22-17 kya)  Magdalenian (17-12 kya)  Epigravettian (21-10 kya)  Mesolithic (12-7 kya)  Neolithic (9-5 kya)  Bronze Age (5-3 kya) The full episode is available for paid subscribers on: https://www.razibkhan.com/p/europe-40000-bc-to-1200-bc Relevant papers: Reconstructing contact and a potential interbreeding geographical zone between Neanderthals and anatomically modern humans The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal A genome sequence from a modern human skull over 45,000 years old from Zlatý kůň in Czechia An early modern human from Romania with a recent Neanderthal ancestor Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers Survival of Late Pleistocene Hunter-Gatherer Ancestry in the Iberian Peninsula A 23,000-year-old southern Iberian individual links human groups that lived in Western Europe before and after the Last Glacial Maximum Population genomics of Mesolithic Scandinavia: Investigating early postglacial migration routes and high-latitude adaptation Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia Genomic Evidence Establishes Anatolia as the Source of the European Neolithic Gene Pool ​​Massive migration from the steppe was a source for Indo-European languages in Europe The genomic ancestry of the Scandinavian Battle Axe Culture people and their relation to the broader Corded Ware horizon The genomic history of the Iberian Peninsula over the past 8000 years Steppe Ancestry in western Eurasia and the spread of the Germanic Languages

11-27
38:07

Misha Saul: the Antipodean Anglosphere

On this episode of Unsupervised Learning Razib talks to Misha Saul, the host of the Kvetch Substack. Saul is a first-generation Jewish Australian, born in Georgia (former Soviet republic), who grew up in Adelaide and now lives in Sydney. He graduated from the University of Adelaide with degrees in commerce and law. His day job is in finance, but the Kvetch highlights his interests in history and Jewish culture. Razib and Saul discuss extensively the differences and similarities between the US and Australia, and how each relates to other Anglophone nations like Canada, New Zealand and of course the UK. Saul asserts though Australia leans into its frontier reputation, in reality it is much more of a bureaucratic-ruled nation than the US, albeit with more of a Scots-Irish flavor than comparatively middle-class New Zealand. He also contrasts the relatively generous welfare-state of Australia and America’s inequality, which he describes by analogy to the film 2013 Elysium, with its contrast between an earth dominated by favelas and a well-manicured low-earth orbit utopia for the super rich. They also discuss the geographical and cultural coherency of a vast nation like Australia, which has a desert at its center. Saul mentions it is often actually cheaper to fly to and vacation in Bali or another Asian locale than going to Perth from Sydney. Despite the reality that Australia has exotic fauna, it is notably an overwhelmingly urban society, where few have any interaction with the “bush.” Though Australians appreciate archetypes like “Crocodile Dundee,” Saul paints a picture of a much more urbane reality. Razib asks about the phenomenon of “white-presenting” Aboriginals, and Saul argues all societies look somewhat crazy from the outside because of their shibboleths, and the debates around Aboriginality are Australia’s. As an immigrant and first-generation Australian, Saul also discusses Australia’s immigration system, which strictly controls and regulates migration. Saul argues that because of the high educational and skill qualifications most Australian immigrants assimilate well, and he contends that there is a broad consensus to maintain strict limits on inflows. He argues that the Anglo-Australian identity is strong enough that the assimilative process continues to work even with the large number of Asians from China and India, who have triggered nativist worries and political activism.

11-24
01:16:54

Crémieux Recueil: US election 2024 analysis

On this episode of Unsupervised Learning Razib talks to Cremieux, a Twitter anon who is regularly retweeted by the likes of Paul Graham, Noah Smith and Elon Musk. A data scientist and statistician, Cremieux specializes in visualizations and analyses that cut to the heart of social and cultural dynamics, from economics to behavior genetics. Cremieux and Razib first discuss the polls and demographic results of the 2024 election, in which Donald Trump seems to have made broad-based gains across all demographics. They also discuss the mirage of the “emerging Democratic majority,” and the possibility that Latinos and Asians shifted so much in the last four years that the racial depolarization predicted by analysts like David Shor since 2012 has finally come to pass. Cremieux also talks about the likely policy outcomes implied by Vivek Ramaswamy and Elon Musk’s slated heavy involvement in the next Trump administration, from the exit of Lina Khan to the reversal of numerous Biden executive orders in areas like employment and civil rights. Cremieux argues that there will be a massive house-cleaning in the civil service. Cremieux has talked to Ramaswamy’s people; if Ramaswamy gets a role like chief of staff, they plan to operationalize insights from Richard Hanania’s book, The Origins of Woke: Civil Rights Law, Corporate America, and the Triumph of Identity Politics.

11-07
59:08

Rachel Haywire: the edge of the avant-garde

On this episode of "Unsupervised Learning," Razib talks to Rachel Haywire, who writes at Cultural Futurist. Haywire is the author of Acidexia and began her career in futurism as an event planner for the Singularity Institute. She got her start as part of the "right-brain" faction around the Bay Area transhumanist and futurist scene circa 2010. Currently, she is working on starting an art gallery in New York City that serves as an event space for avant-garde creators who are not encumbered by mainstream or "woke" cultural sensibilities. Haywire recounts her experience as a creator in the early 2010s in the Bay Area and the transition from a socially libertarian milieu where diverse groups mixed freely to one more defined by a progressive cultural script, with the threat of cancel culture beginning to be noticeable. She points to the 2013 cancellation of Pax Dickinson for edgy tweets as a turning point. Razib and Haywire also allude to the role that the reclusive accelerationist philosopher  Nick Land played in seeding certain ideas and influencing movements like the  Dark Enlightenment. Jumping to the present, Haywire now lives in New York City, and she addresses the Dimes Square scene centered around the neighborhood in Manhattan's Lower East Side. Haywire points out that the actual artistic production from Dimes Square luminaries is quite low, with an almost total lack of music and a focus on online personas. Her goal with her salons and soon-to-open gallery is to put the emphasis on art above politics or e-celebrity culture. Finally, Razib discusses the impact of AI on creativity and whether it will abolish the artist. Haywire believes that AI is just another tool and has had mixed success leveraging it for her own artistic works in areas like industrial music. She believes that the real use of AI will be to create drafts and prototypes that artists will have to polish and reshape so that they reflect human creativity rather than just some averaged algorithm.

11-05
59:58

Halie May: the democratization of genomics

On this episode of Unsupervised Learning Razib talks to Halie May, the host of the Substack The Sequence, and a genetic counselor at Natera. May has a B.S. in chemical biology from Stevens Institute of Technology and a M.S. in human genetics from Sarah Lawrence. Before working at Natera she was a researcher and instructor at Columbia University and designed testing panels at genetics start-up, Tomorrow’s Health. Razib and May discuss how much the field has changed even in her short career, in large part because genetic counseling is a 50-year-old profession that has been transformed in the last decade by the introduction of genome-wide datasets. May highlights the changes in the last ten years, and how they have impacted counselors and end users, in particular the ubiquity of noninvasive prenatal screening tests. Here, she mentions that whole-genome analysis isn’t quite where she had expected when she began studying these issues six years ago, and Razib brings up the fact that it’s already a decade ago he had his son whole-genome sequenced. They discuss the hold-ups in the progress of genetic testing and analysis, and May points out that a major issue is likely the utter lack of federal guidelines, with oversight of genetic healthcare mostly being left to the states. This lack of coordination means that there is no top-down signal, and localities and institutions are left to cobble together frameworks in an ad hoc manner. Razib also asks May about how private companies, like Natera, might fill the gap in what hospitals can provide, and the potential pathways and promise of the democratization of genetic results.

10-30
50:00

Inez Stepman: Silicon Valley's post-human world

On this episode of Unsuperivsed Learning Razib talks to native Californian, Inez Stepman. Stepman has an undergraduate degree in philosophy from UC San Diego, and obtained her J.D. from University of Virginia. She is a Senior Policy Analyst at the Independent Women’s Forum, a Lincoln Fellow at the Claremont Institute and a contributor to The Federalist. Stepman is also a co-host of the High Noon podcast. Razib and Stepman first talk about her reaction to Marxist author Malcom Harris’ Palo Alto: A History of California, Capitalism and the World, exemplified by her piece in First Things, Ambitious Nihilism. A native of Palto Alto who went to high school with Harris in the early 21st century, Stepman believes that the left-wing narrative in Palo Alto is misleading. Though Silicon Valley avows fashionable social liberalism and radicalism, Harris argues that it is actually a seedbed for right-wing neo-Neo-Reaganism and capitalism. Stepman disagrees; though it is true that from a Marxist and explicitly socialist perspective Silicon Valley falls short, the overall political tenor was firmly on the left. She recalls even after 9/11 that her Palo Alto milieu took a dim view of American patriotism. For Stepman, Silicon Valley was more a laboratory of fashionable woke shibboleths, about a decade ahead of its time, as well as being the training ground for conformist grinds who were geared toward jumping over the next academic or professional hurdle. Stepman sees this narrow and short-sighted ethos throughout Silicon Valley, and the broader sense in American culture that technology will allow us to transcend our limits to humanity. She argues that wealthy tech entrepreneurs who aim to defeat death, like Bryan Johnson, are fundamentally inhuman in their goals and orientation. Razib and Stepman discuss extensively advances in biotechnology and fertility in particular that American society seems to take for granted, like noninvasive prenatal testing and gene editing, which are rolling out without much discussion.  

10-19
01:32:44

Christina Buttons: navigating the gender wars

On this episode of Unsupervised Learning Razib talks to Christina Buttons, who writes at Buttons Lives. A native Californian and erstwhile artist, Buttons switched to journalism two years ago, writing about gender medicine. A contributor to Quillette, The Post-Millennial and The Daily Wire, Buttons is now a freelance journalist living in Nashville, Tennessee. The first part of the conversation breaks down what “gender medicine” entails in its gory details. In April Razib had a conversation with Colin Wright about the relationship between sex and gender, and the broader philosophical issues entailed by the ideas of gender ideology. But in the discussion with Buttons, Razib asks what it means for a child to transition medically. What are the surgeries that transition a boy to a girl and a girl to a boy? They also discuss different hormone regimes, from those that block normal puberty to those that enhance the secondary sexual characteristics of the target gender to which the individual aims to transition. Buttons discusses why she got interested in the topic, the fraught area of medically transitioning children. She distinguishes her circumspect and focused critiques of gender transition from the catchall broadsides of so-called trans-exclusionary radical feminists and religious conservatives. Razib asks Buttons about her departure from The Daily Wire due to ideological differences, and what it feels like to be a moderate between militant factions to both her left and right. Though originally on the Left, and even woke, today Buttons identifies as a centrist classical liberal, which naturally means she tends to offend a great variety of factions with her individualistic viewpoints. Finally, they discuss youth treatment centers, group homes where self-destructive young people are sent to recover and be rehabilitated. Recently these have been in the news, with Paris Hilton claiming that she and others had been subject to abuse at these centers. Buttons herself spent much of her teens in youth treatment centers, and she believes that Hilton’s case is weak, and shutting down these facilities will result in higher rates of self-harm. Buttons plans on moving to this issue as her next project, because she believes people need to know the truth beyond the sensational headlines.

10-15
01:14:00

Sarah Haider: activist to podcaster and public intellectual

On this episode of Unsupervised Learning, Razib talks to returning guest, Sarah Haider. Haider is the co-host of the podcast A Special Place in Hell and the Substack Hold That Thought. A native of Houston, graduate of the University of Texas in Austin, Haider is the founder and former executive director of Ex Muslims of North America. Today Razib asks her about her move out of the nonprofit world, and into being a full-time public intellectual, speaking and writing on topics of interest to her beyond that of Muslim-born who become secular. And then, more specifically, Razib probes Haider about her thoughts on gender and politics. He asks her how becoming a mother in the last few years and idiosyncratic aspects of her personality may lend themselves to a comfortable home in the heterodox intellectual space. They extensively consider the different dynamics of male and female podcasters, and the comparative surfeit of men versus women willing to offer their opinions on all and sundry topics. Haider also contends that women, by their very nature, are going to be perceived differently than men, resulting in a different way of arguing and engaging with audiences, guests and co-hosts. They also discuss the reality that both their podcast audiences have a male tilt, and whether that is a direct outcome of their communication styles. Outside of the realm of podcasting Razib and Haider explore the implications of there being two ways of speaking and thinking when it comes to men and women, and how that shapes how you talk, think and value issues. Haider also discusses how her pregnancy, and becoming a mother, have changed her politics and social views. When Razib brings up Erik Hoel’s idea of “cultural billionaires,” Haider asks how many women are on the list of such individuals? She argues that becoming a mother is such an all-consuming task that it is no surprise that most of the prominent public women who contribute to opinion and academia are childless; Haider points that Betty Friedan was exceptional among second-wave feminists in having children.   If you have a sibling with autism, your future child’s risk for an autism diagnosis is increased by a factor of 2 to 3.5×. Orchid’s whole genome embryo reports can help mitigate your child’s risk by screening for over 200 genetic variants definitively linked to autism and other neurodevelopmental disorders. Discuss your situation with a genetics expert.

10-11
01:05:39

Aria Babu: pro-natalism in the shadow of empire

Today Razib talks to Aria Babu, a British think-thank professional who is part of the growing number of young men and women who are taking an interest in population decline and promoting pro-natalism. Babu has a degree in chemistry from University College London, and has long worked in areas related to the study of economic growth and entrepreneurship. Prior to her interest in pro-natalism Babu held conventional views about population growth and its ties to environmental alarmism. But she quickly saw that actually fertility is crashing worldwide, and with that there might be dire economic and social consequences. If that trend is left unchecked, she foresees a worst case scenario of massive economic decline and the replacement of our riotously varied modern civilization by a select few narrow subcultures, like the Amish or Somalis, who continue to favor reproduction as a social value. On the state level, declining populations will likely lead to the rise of culturally stagnant and politically authoritarian societies reminiscent of The Children of Men. Babu and Razib also discuss what it is like living as an urban professional in Britain in 2024. While the fact that the UK has one megacity can lead to disproportionate focus on London, Babu points out that it allows the entire nation’s intellectual and cultural class to be in close proximity, resulting in powerful synergies. She also argues that the problem in the UK is not immigration, but insufficient housing for larger populations and the lack of a system to allow in very skilled and value-add migrants. Rather than integration into the EU or an American-system, Babu favors an approach closer to Singapore, where the UK goes its own way and crafts its policies to take advantage of specific opportunities offered by blindspots in EU or American politics.   If you have a sibling with autism, your future child’s risk for an autism diagnosis is increased by a factor of 2 to 3.5×. Orchid’s whole genome embryo reports can help mitigate your child’s risk by screening for over 200 genetic variants definitively linked to autism and other neurodevelopmental disorders. Discuss your situation with a genetics expert.

08-28
01:00:27

Louise Perry: overcrowded Britain and the ennui of a post-imperial nation

On this episode of Unsupervised Learning Razib talks to Louise Perry. A British journalist known for her commentary on feminism and gender issues, Perry is the author of the book The Case Against the Sexual Revolution. She also contributes to The New Statesman, UnHerd, and The Daily Mail, and has a Substack at Maiden Mother Matriarch. Perry is a graduate of University of London’s School of Oriental and African Studies, with a degree in anthropology. Perry and Razib first discuss Britain’s current housing crisis, the reasons and possible solutions. Though the Office for National Statistics estimates the UK’s population at 67.1 million, Perry believes that the true number is likely higher because individuals who are present illegally or have a “gray” status are unlikely to respond. But even this population would make the UK over eight times more densely populated than the US, with England being 13 times denser. In fact, England’s population density is similar to India’s. Perry also brings up the reality of massive immigration flows over the last few years; where before 2020 net migration was around ~200,000 per year, since 2021 the figure has been closer to ~500,000. Additionally, many of these immigrants are placed in “social housing,” subsidized or owned by the government. Perry also points out that the legal regulations in Britain stipulate that about 30% of new developments be allocated for social housing, which incentivizes incumbent homeowners to block construction. Additionally, the rate of population growth is much higher than the British construction industry’s capacity to keep up with the theoretical demand. The UK does not produce enough bricks, nor does it have the labor pool of homebuilders. The conversation continues to a broader discussion of the ennui in modern British society. Perry asserts that a major problem driving the housing crisis is that the UK has only one major city, London, and any professional who wants to settle in a more affordable region must also take a major salary cut. Setting aside London, and its economic engines of finance and commerce, Perry characterizes the rest of the UK as more akin to a developing Eastern Europe nation. She also believes that the next decade will see a mass flight of the upper-middle-class, the primary tax base of the state. Perry herself has Australian citizenship through her parents (who immigrated from Australia to the UK), while her husband has an American mother. Her situation is common to many upper-middle-class Britons, who have connections to Canada, the US, New Zealand and Australia. Perry believes this is one reason the British political culture is not reforming itself: so many have in the back of their head that they can jump ship if it starts sinking. Ultimately, her thesis is that British openness and intellectual curiosity make the national character a poor seedbed for nationalism, and it may be inevitable that the UK is caught up and tossed about in a vortex of globalization.   If you have a sibling with autism, your future child’s risk for an autism diagnosis is increased by a factor of 2 to 3.5×. Orchid’s whole genome embryo reports can help mitigate your child’s risk by screening for over 200 genetic variants definitively linked to autism and other neurodevelopmental disorders. Discuss your situation with a genetics expert.

08-06
01:34:31

Bryan Ward-Perkins: The material consequences of the fall of Rome

On this episode of Unsupervised Learning Razib talks to archeologist and historian Bryan Ward-Perkins about his 2005 book The Fall of Rome: And the End of Civilization. Ward-Perkins was born and grew up in Rome, a son of architectural historian and archaeologist, John Bryan Ward-Perkins. Educated at Oxford University, Ward-Perkins eventually became a fellow of Trinity College at the same university, from which he has since retired. An archaeologist with a deep interest in economic history, Ward-Perkins’ standout book The Fall of Rome was to a great extent a restatement of traditional understandings of the Roman fall in the wake of academic revisions stimulated by Peter Brown’s 1989 World of Late Antiquity: AD 150-750. Ward-Perkins scholarship focuses on the outputs of economic production: fine pottery, grand public buildings and copious coinage. In contrast, Brown and his fellow travelers tended to focus on religious innovation and creativity in the centuries coincident with Rome's fall. The Fall of Rome documents in crisp, dense prose the material collapse attendant with the dissolution of the Western Empire in the late 5th and 6th centuries, from the vanishing of pottery in Britain to the cessation of the construction of massive buildings across  the Italian peninsula. Razib also asks Ward-Perkins his opinions on his colleague Pete Heather’s book The Fall of the Roman Empire: A New History of Rome and the Barbarians.  Ward-Perkins sees Heather’s work as complementary; while Ward-Perkins is interested in the material aspects of everyday Roman life, Heather documents and narrates the diplomatic and military affairs of the Roman elite. Ward-Perkins also comments on Chris Wickham’s work in books like The Inheritance of Rome: Illuminating the Dark Ages 400-1000, which outlines how the Roman and post-Roman states differed, in particular, the disappearance in Europe of professional soldiers paid in currency, rather than feudal levies. They also discuss  Walter Scheidel’s Escape from Rome: The Failure of Empire and the Road to Prosperity, and whether Roman citizens were actually materially better  off than their medieval successors. Ward-Perkins also gives his estimation of the time measured in centuries until Western Europe reattained Roman levels of social, technological and political complexity. If you have a sibling with autism, your future child’s risk for an autism diagnosis is increased by a factor of 2 to 3.5×. Orchid’s whole genome embryo reports can help mitigate your child’s risk by screening for over 200 genetic variants definitively linked to autism and other neurodevelopmental disorders. Discuss your situation with a genetics expert.

08-02
01:07:41

J. P. Mallory: Indo-Europeans found?

On this episode of Unsupervised Learning Razib welcomes back a returning guest, J. P. Mallory, to discuss his reaction to the recent preprint The Genetic Origin of the Indo-Europeans. Mallory is the author of In Search of the Indo-Europeans: Language, Archaeology, and Myth, The Oxford Introduction to Proto-Indo-European and the Proto-Indo-European World and The Tarim Mummies: Ancient China and the Mystery of the Earliest Peoples from the West. He is also a retired professor from Queen’s University Belfast in Northern Ireland. An archaeologist who trained under Marija Gimbutas, Mallory has long used linguistics to complement his disciplinary training in archaeology to understand the origin and location of Indo-European languages. Though Mallory admires The Genetic Origin of the Indo-Europeans, he still thinks more work needs to be done to pinpoint the original homeland of the Yamnaya or their ancestors. The fact is that the preprint remains somewhat vague in its final conclusion, and more work is needed to make sure the populace acquires the same level of community. Mallory also discusses the challenges inherent in interdisciplinary work, synthesizing archaeology, linguistics and now genetics. He believes that a key to grasping the emergence of pre/proto-Indo-European is tracing lineage groups through their Y chromosomes, as the genetics, mythology and anthropology indicate that pre/proto-Indo-Europeans were quite patriarchal and patrilineal. Though Mallory is hopeful that we are making progress on the topic of Indo-Europeans he worries that the fraught situation of disciplinary rivalries will retard synergy, where archaeogenetics engages in excessive imperialism vis-a-vis archaeology and linguistics.

07-10
01:03:25

Sean Anthony: the Muhammad of history

On this episode of Unsupervised Learning Razib talks to professor Sean Anthony about his book Muhammad and the Empires of Faith: The Making of the Prophet of Islam. Anthony is a historian in the Department of Near Eastern Languages and Cultures at The Ohio State University. He earned his Ph.D. with honors in 2009 at the University of Chicago in Near Eastern Languages and Civilizations, and has a mastery of Arabic, Persian, Syriac, French, and German. Anthony’s interests are broadly religion and society in late antiquity and medieval Islam, early canonical literatures of Islam (Koran and Hadith) and statecraft and political thought from the foundational period of Islam down to the Abbasid Caliphate over a century later. Razib and Anthony discuss the state of the controversial scholarship about the origins of Islam, which often comes to conclusions that challenge the orthodox Muslim narrative. This earlier generation of scholars, like Patricia Crone, challenged the historicity of Muhammad, the centrality of Mecca in early Islam and even the distinctive religious identity of the early 7th century’s Near East's Arab conquerors. This revisionist school serves as the basis for Tom Holland’s 2012 book, In the Shadow of the Sword: The Birth of Islam and the Rise of the Global Arab Empire. While Holland’s work was an accurate summary of research before the 2010’s, Anthony argues that since then new findings have updated and revised the revisionism itself. A Koran dating from the mid-7th century seems to confirm the antiquity of this text and traditions around it, while contemporaneous non-Muslim sources refer to Muhammad as an Arabian prophet. While it is true that coinage did not bear the prophet’s name until the end of the 7th century, it may be that earlier generations of scholars were misled by the lack of access to contemporary oral sources themselves necessarily evanescent. Razib and Anthony also discuss whether the first Muslims actually self-identified as Muslims in a way we would understand, as opposed to being a heterodox monotheistic sect that emerged out of Christianity and Judaism. Though classical Islam qua Islam crystallized under the Abbasids after 750 AD, it now seems quite clear that the earlier Umayyads had a distinct identity from the Christians and Jews whom they ruled.    

07-02
01:14:12

Nikolai Yakovenko: the stillborn promise of the LLM age

On this episode of Unsupervised Learning Razib talks to Nikolai Yakovenko, a returning guest to the podcast, about his new AI startup, DeepNewz, and the state of the LLM-driven AI landscape circa the summer of 2024, where we are in relation to earlier expectations and where we might be in the next decade. Yakovenko is an AI researcher who has worked at Google, Twitter and Nvidia, and is now a serial entrepreneur. He is also a competitive poker player. He currently lives in Miami, Florida, though he travels frequently to America’s numerous “ideaopolises,” from San Francisco, Austin, Boston to New York City. Razib and Yakovenko discuss the reality that in the middle of 2024 here they are again, chatting about the world on a podcast, a scenario not everyone anticipated in the heady days of December 2022/January 2023 when the more overheated visiony tech  imaginations swirled with expectations that the advent of artificial general intelligence, the “machine god,” was imminent. Though OpenAI’s GPT 3/3.5 was a leap ahead of GPT 2, GPT 4/4o has been a less spectacular advance. One of the major unforeseen aspects of the LLM-based framework in AI has been the returns to scale in terms of training data, but the last year and a half have not seen any great quantum jumps. The paradigm-shifting revolution that was promised has not arrived. Though AI has increased productivity on the margins, and certain artistic professions and translators have been decimated, overall, it is still a technology with more promise than realized outcomes. Yakovenko points out that AI-driven music creation produces serviceable outputs, but not great masterpieces. To test this, Razib used Suno to create a song “Nikolai’s Dream” within 5 minutesmid-conversation. Though mildly catchy, Suno’s lyrical styling elicited more amusement than awe. Yakovenko notes the importance of the LMSYS Chatbot Arena Leaderboard to get a sense of the performance of the various LLM projects. Using the feedback of participants, it produced an updated ranking of chatbot performance. The top ten models are from OpenAI, Anthropic, Google and a Chinese vendor. Yakovenko notes the compression, with a very tight distribution of scores at the top. It turns out that OpenAI is not running away from their competition contra  its brand visibility likely being two orders of magnitude greater than Anthropic’s. This brings to the fore the reality that these AI technologies have been viewed as both scientific research projects and potential business and consumer products. Finally, Yakovenko and Razib talk about DeepNewz. While most LLM-based chatbots tend to exclude very recent data and events, Yakovenko had the idea of creating DeepNewz to aggregate and assemble the breaking news in various categories like science and sports. Instead of a top-down query of news in various categories, the idea behind DeepNewz is to both cater to your preferences in terms of what you might find interesting, but also to surface stories that you might not know you might be interested in, adding more value. Related: David McKay: AI and the end of the world as we know it and Nick Cassimatis: fear not AI, this too shall pass.  

06-26
01:16:49

Chad Niederhuth: genetics in plants, from Mendel to GMOs

On this episode of Unsupervised Learning Razib talks to Chad Niederhuth, an erstwhile academic plant geneticist now working in industry. Niederhuth and Razib discuss the reality that in 2024 it is often human genetics that gets the glory, even though experiments on plants go back to the field’s very origins with Gregor Mendel and his peas. Niederhuth’s original training is in molecular genetics, and they discuss the relevance of differences in basic biological machinery between plants and animals, for example the reality that the former have chloroplasts while the latter have mitochondria. They also extensively discuss the flexibility and variation across plants in terms of size and organization of the genome; plants much more often deviate from a diploid two-gene-copy setup than animals, and their range of genome size is enormous. While the smallest plant genome is 61,000,000 bases, the largest is 148,800,000,000 bases (2,400 times larger than the human genome).  Razib and Niederhuth discuss the flexibility and utility of plants in basic genetic research, but also in the applied agricultural context. Though classic techniques of selection are still relevant, more and more researchers are using genomic methods that look at variation at the DNA level to predict traits in the next generation, and so allow for more robust and productive cultivars. Razib also notes that public queasiness over genetic engineering in animals, let alone humans, does not seem to apply equally to plants, meaning that GMO techniques can be perfected in crops first before transferring to animal or medical contexts. Finally, Niederhuth talks about his transition from being faculty at a research university to a scientist in the private sector. Overall Niederhuth is happy because his pay is greater, and his responsibilities are narrower and more focused. While as a professor he had to also split his time between teaching and serving extensively on committees, his current position is focused entirely on the research he finds so gratifying. Razib and Niederhuth also discuss the politicization of academic science that has occurred over the last 15 years, and the institution’s future prospects.

06-23
01:01:40

Jonathan Keeperman: becoming Lomez

On this episode of Unsupervised Learning Razib talks to Jonathan Keeperman, an former lecturer in writing at UC Irvine and proprietor of Passage Press. Keeperman also posts on the internet under what was until recently an anonymous pseudonym, Lomez. Unlike many anonymous accounts on X, “Lomez” developed a decade-long identity, to the point where Keeperman wrote articles under that name for publications like First Things, The Federalist and The American Mind. Razib and Keeperman talk about what it is like to go from someone with distinct and separate identities, a well-developed online life as well as a fairly conventional offline world, and how to reconcile them when they collide. Keeperman talks about the peculiar and often offensive scripts and modalities of the world of anonymous commentators, whose goals seem to be to have hidden discussions in plain sight, hiding their discourse through shock and obfuscation, and how difficult it can be to communicate this reality to people with more conventional outlooks.  Keeperman admits that he understood that at some point his anonymity would be stripped away from him, but admits that it is still a difficult path to negotiate. The Lomez identity was unabashedly on the political Right, but as an academic and writing lecturer he was much more discreet about his views, and many of his friends and acquaintances were shocked as to his true politics. Keeperman’s father was a liberal and a Jewish American, so many of his relatives would no doubt have been surprised by his political commitments.  Razib also asks Keeperman what exactly an MFA means as a credential, and what it teaches you. Though he does not think much of the credential itself, Keeperman explains that the MFA is a terminal degree for many interested in writing and literature, two loves that pulled him away from a life in the corporate world. He explains that one of his goals in entering the writing profession was to bring a masculine sensibility that he feels has been marginalized in the world of creative writing, which is today dominated by women. Razib and Keeperman talk about the marginalization of certain masculine values of vigorous competition and biting debate in many parts of the culture-producing industries, and how Passage Press is an attempt to cultivate voices that otherwise might not find  a platform. In this vein, Keeperman ends by asserting the importance of free speech for all views, from the most offensive to the most anodyne, as an essential part of American culture and the life of the mind. If you have a sibling with autism, your future child’s risk for an autism diagnosis is increased by a factor of 2 to 3.5×. Orchid’s whole genome embryo reports can help mitigate your child’s risk by screening for over 200 genetic variants definitively linked to autism and other neurodevelopmental disorders. Discuss your situation with a genetics expert.

06-16
01:24:12

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