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For more than half a century, lithium has been one of the most reliable treatments for bipolar disorder. It has given countless people the ability to stabilize their moods and reclaim lives otherwise disrupted by cycles of mania and depression. But lithium comes with inherent risk: its therapeutic range is narrow, which means that the difference between a helpful dose and a harmful one is surprisingly small. Too much lithium in the body can lead to a cascade of health problems, including neurological confusion, tremors, kidney dysfunction, and, though much less well known, potentially dangerous effects on the heart. In a recent publication, Dr. Jeffrey Curran Henson of the University of Arkansas for Medical Sciences, and colleagues, shed light on one of lithium’s most alarming but underappreciated risks: its ability to disrupt the heart’s natural pacemaker, the sinus node. Their case study and systematic review tell the story of a patient whose life was threatened not by the mental illness she had long managed, but by the very medication that had allowed her to manage it. And in that story, the researchers also describe a novel way out: a treatment that avoided the need for invasive procedures and could reshape how we think about emergency care for lithium-related heart complications.
Penelope J. Corfield’s groundbreaking book, entitled Time-Space: We Are All in It Together, presents a multidimensional framework for understanding how humans exist within the cosmic continuum of time and space. Corfield agrees with the modern scientific consensus post-Einstein, where time is understood not as a separate dimension but as being integrally yoked with space. Together, time and space form one dynamic system, which shapes all of existence. But Corfield argues that the continuum should properly be named time-space rather than spacetime, because time is the dynamo and space is its physical manifestation. The book then explores how this great time-space continuum frames the entire cosmos, including all human existence and our collective journey through history.
Research from Professor Dr Susanne Maria Maurer, former chair of social pedagogy at the Philipps-Universität Marburg, reveals how social work institutions and practices serve as repositories of knowledge about historical struggles over class, gender, and race. She conceptualizes social work as both a "memory of conflicts" and an "open archive" that holds different answers to social problems from across history. Her work shows that to truly understand social work today we need to look at the ideas that were pushed aside and the ongoing debates that still shape how social workers do their jobs.
Soil is one of the most important resources on the planet. It grows our food, regulates water, supports ecosystems, and stores vast amounts of carbon. But it’s also incredibly complex, and surprisingly poorly understood. In Australia, Prof. Alex McBratney of the University of Sydney and his colleagues are changing that. By working with the Soil Security Assessment Framework, they’ve developed new tools and approaches that are helping to reshape how we measure and manage soil. From identifying similar soils and grouping them into categories, to estimating the monetary value of their ability to support food production, to surveying how people relate to the land beneath their feet, their work is creating a new language for talking about soil. Here, we explore the studies that put the framework into action and show why securing our soils is essential not just for farming and food security, but for ecosystems, economies, and climate resilience too.
Soil sits at the heart of nearly every major challenge humanity faces, from food, water and energy security to climate change, biodiversity loss, human health, and the delivery of vital ecosystem services. But, soil itself is increasingly under threat. As these pressures intensify, soil security has become a global priority in its own right. Yet despite its critical role, there are still gaps in how we understand, study and manage soil. Too often, soil research fails to reach the land managers, policymakers and communities who need it most. At the University of Sydney, Professor Alex McBratney and his colleagues are working to change that. They’re leading the development of the Soil Security Assessment Framework, a new approach that considers not just what soil is, but what it does, how it’s valued, and how it’s governed. By defining five interconnected dimensions of soil security, the team is helping to shape a more strategic, outcome-focused research agenda, designed to translate scientific insight into practical actions.
When we think about science, we often imagine a universal language of knowledge in the form of a shared code of numbers, graphs, and precise words that transcend borders. But what happens when the language of science is not the language of the scientist? This is the challenge explored in a recent study by a group of publication professionals from the pharmaceutical and medical communications industries across the Asia Pacific region. The study looked at how researchers in this region navigate the world of English-language scientific publishing. Their findings remind us that words matter, and the language we use can either invite voices into global conversations and knowledge exchange, or keep them out.
In the 20th century, antibiotics transformed medicine. Infections that once killed millions could be cured with a pill or injection. Surgeries became safer, cancer treatments more effective, and advanced medical interventions, such as organ transplants, became possible, all because doctors could rely on these drugs to control infections. Unfortunately, today, that foundation is crumbling. Bacteria are evolving faster than medicine can keep up. Common antibiotics are failing, and infections that were once easily treatable are becoming deadly again. In 2019 alone, antimicrobial resistance was linked to nearly five million deaths worldwide, making it deadlier than HIV or malaria. The economic cost is equally staggering: the World Bank warns of trillions lost in global productivity and millions pushed into poverty if nothing changes. This crisis, caused by antimicrobial resistance, has been described as a “silent pandemic.” Unlike a sudden outbreak, it spreads quietly, making routine medical care slightly more dangerous each year. Yet amid this grim outlook, new research is opening a window of hope. At the forefront of new innovations in this area are Dr. Kai Hilpert of City St George's, University of London, and his colleagues, who are pioneering an approach that combines biology, chemistry, and artificial intelligence to reinvent how we discover infection-fighting medicines. Their work has been recognised with a prestigious award from the UK’s Biotechnology and Biological Sciences Research Council, BBSRC.
Across North America, the phrase “fuel management” is used almost as often as “climate change” when people talk about wildfires. The idea is simple: forests burn because they are full of fuel, including trees, shrubs, branches, and dried leaves. If you remove some of that material, you make it harder for a wildfire to spread. Provincial governments, towns, and even ski resorts such as Whistler in British Columbia, Canada have invested millions of dollars in “fuel thinning,” which involves sending crews into the woods to cut down trees and haul away brush. While fuel thinning feels like common sense, Dr. Rhonda Millikin, a scientist based in Whistler, and her colleagues have found that what seems like common sense in one type of forest can be dangerously misleading in another. Their research, recently published in the journal Fire, revealed that in Whistler’s coastal rainforests, dense, wet, and shaded ecosystems, fuel thinning often has the opposite effect of what is intended. Instead of making these forests safer, thinning makes them drier, windier, and hotter: exactly the conditions that help wildfires spread.
The way molecules arrange themselves into crystals can affect the stability, safety, and effectiveness of medicines and advanced materials. Dr Ivo Rietveld at the University of Rouen Normandy and his collaborators are developing new benchmark data that help scientists to accurately predict the stability of crystal structures of molecules, helping to reduce risks in drug development and enabling the design of better materials.
When we think of spies and their activities, we imagine trench coats, hidden cameras, and tense exchanges in safehouses. Hollywood has given us the daring adventures of James Bond and Jason Bourne, along with the clever trickery of films such as Argo. But behind the cinematic flair lies a quieter, more subtle reality: espionage often depends less on gadgets, weapons and car chases than on the delicate art of deception, an art rooted in psychology, perception, and human behaviour. This is the world explored by Dr. Rafael Lenzi, in a work developed at the Centre de Recherches Sémiotiques in Limoges, France. His study of Cold War espionage, drawing on declassified CIA manuals and philosophical theories of perception, reveals how deception is not just about tricking the eye, but about shaping the mind. In other words, spying succeeds not when someone fails to see, but when they see exactly what they expect to see, and therefore overlook the trickery in front of them.
Most of us never give much thought to the small artery that runs along the inside of our wrist, the radial artery. You can feel it easily if you press your fingers just below your thumb. Yet in modern medicine, this little vessel has become one of the most important gateways to the heart. Imagine a doctor threading a tiny tube, called a catheter, through the radial artery to reach your heart. This technique, called transradial access, has transformed modern cardiology. By entering through the radial artery, doctors can perform life-saving cardiac procedures with fewer complications, faster recovery, and even lower costs than older methods that went through the leg. Many people can even walk out of the hospital on the same day. Over the past two decades, doctors have increasingly chosen the radial artery as their entry point for procedures like angiography (imaging of the heart’s blood vessels) and angioplasty (opening blocked arteries). But there’s a catch: sometimes the artery rebels. It tightens suddenly, almost like a muscle cramp, gripping the medical instruments and making the doctor’s job harder. This is known as radial artery spasm (or RAS for short). In rare cases, the spasm is so severe that it traps the catheter or damages the artery wall.
Research from Professor John Willoughby and Christian Fignole at American University in Washington DC examines how diverse ownership structures persist in market economies, challenging the assumption that capitalist ownership automatically emerges as the most efficient form. Using economist Henry Hansmann's institutional framework, they argue that while capitalist owners contribute little to enterprise operations, this does not guarantee that worker ownership would become dominant in post-capitalist societies. Their analysis reveals that heterogeneous ownership forms will likely continue to exist due to the varying conditions that exist in different sectors of a market economy.
In the Autumn of 2022, hopeful college students across the United States clicked through the questions on the Common Application, the digital gateway to more than one thousand colleges and universities. For the first time, alongside their grades, essays, and extracurricular lists, applicants had the chance to provide their gender and pronouns. These questions might seem a small detail, tucked between test scores and teacher recommendations, but their impact is enormous. They mark a turning point in higher education, one where students are able to represent themselves more authentically. Thanks to the work of Dr. Genny Beemyn of the University of Massachusetts Amherst and Dr. Abbie Goldberg of Clark University, we now have the first large-scale glimpse into how a new generation of young people is reshaping society’s understanding of gender.
Research from Dr. Andrey Kostyuk at the Grenoble Ecole de Management supervised by Prof. Martina Battisti, a Senior Fellow of Higher Education Academy, and Director of European Council for Small Business and Entrepreneurship, reveals that successful startup mentoring operates as a complex social exchange where both mentors and entrepreneurs must benefit for ventures to thrive. The findings advance the understanding of entrepreneurial mentoring and provide a blueprint for designing more effective mentoring programs that could accelerate sustainable startup growth worldwide.
Despite decades of awareness about gender equality, a persistent pleasure gap remains between women and men in sexual encounters, with women experiencing significantly fewer orgasms and less sexual pleasure. It is important to note that this gender difference exists primarily in contexts where women have sex with men, while women who have sex with women tend to experience more orgasms and sexual pleasure. Since the gendered pleasure gap cannot be explained by biological factors, researchers continue investigating hidden sociocultural forces that perpetuate this inequality. Two complementary studies from Tanja Oschatz at Johannes Gutenberg University and her colleagues reveal previously overlooked contributors to this gap: women's performance of sexual emotional labor in intimate relationships and biased media representations of sexual pleasure.
Imagine a future where treating cancer doesn't just depend on high-tech machines or potent drugs, but also on something as simple, and as complex, as the bacteria living in your gut. This future might be closer than we think, thanks to groundbreaking research led by Professor Andrea Facciabene at the University of Pennsylvania. In a randomized pilot study recently published in the Journal for ImmunoTherapy of Cancer, Prof. Facciabene and an international team of researchers explored a curious and compelling idea: could altering the gut microbiome enhance the effectiveness of radiation therapy in patients with inoperable early-stage lung cancer? The answer, at least in this early stage, appears to be yes.
Research from communication scholars at The Ohio State University reveals fascinating new insights about the dynamics of conversations about race-related issues in the USA. Two complementary studies show that White participants expected more negative outcomes and were more likely to avoid conversations with fellow White people from different political parties than with Black people from different parties. The findings challenge assumptions about racial identity and suggest that partisan divisions have become more influential than racial divisions in shaping willingness to engage in difficult conversations.
When they design mechanical systems, engineers first need to understand how they will behave using mathematical modelling tools that can simulate their movements. In recent years, they have increasingly explored the possibilities of ‘compliant’ mechanisms: highly flexible systems which are now being applied across numerous leading fields of technology. However, because their motions are often incredibly complex, engineers have so far found it difficult to recreate their behaviours in the mathematical tools needed to design them. Because they involve complex, nonlinear behaviour, designing compliant mechanisms has posed a long-standing challenge for engineers. While several advanced synthesis methods are now available, they’re often computationally intensive and can’t readily cope with the inevitable uncertainties in a system’s operating variables. In their latest research, Ahmed Alhindi and Dr. Meng-Sang Chew at Lehigh University, Pennsylvania, propose a novel approach that directly accounts for uncertainty in the design process. By reformulating widely used equations, their ‘dimensional synthesis’ method offers a streamlined yet powerful way to design compliant mechanisms under real-world, uncertain conditions.
Loneliness is often described as the invisible epidemic of our time. It creeps quietly into lives, eroding confidence, weakening social bonds, and, at its most dangerous, pushing individuals toward the edge of despair. Stigma can prevent the lonely from seeking help and as loneliness is largely experienced through the prism of isolation, those in need of support may feel they have no-one to turn to. In his chapter “Loneliness, Social Isolation, and Suicidal Behavior: ‘Only Girl, Middle Child’” from the Edited Volume “Loneliness - The Ultimate Suffering in Modern Society”, Dr. Raymond Atwebembere of the Washington University in St. Louis examines this crisis not through abstract statistics alone but through vivid personal stories. His work underscores the truth that loneliness is not just a feeling; if left unaddressed it can be lethal.
Operating and maintaining highway rest areas across the United States has long posed a costly challenge for state transportation departments, especially amid tightening budgets and rising demand. In a new study, Dr. Kishor Shrestha, associate professor at Washington State University finds that one outsourcing method known as method-based contracting is significantly more cost-effective than its two main alternatives. The results offer transport officials a clearer path forward for running rest areas more efficiently, and could help to preventing costly, potentially dangerous closures in the future.
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