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Sigma Nutrition Radio

Author: Danny Lennon

Subscribed: 5,948Played: 105,217


Discussions about the science of nutrition, dietetics and health. The podcast that educates through nuanced conversations, exploring evidence and cultivating critical thinking. Hosted by Danny Lennon.
396 Episodes
Dr. Mario Kratz is a clinical researcher in the areas of nutrition, obesity, and cardiometabolic disease, with more than 20 years of experience running clinical studies in a variety of populations. He is a former research associate professor at the University of Washington in the departments of Medicine and Epidemiology. And is also formerly an Associate Professor at the Fred Hutchinson Cancer Research Center in Washington state. You can find the show notes at or you can support the show on
In this episode we discuss the potential impact of dietary polyphenols on cardiovascular disease risk; including impacts on blood pressure, flow-mediated dilation, and other related outcomes. We talk about some potential mechanisms and then several specific randomized, controlled trials. You can find the show notes at and you can support the podcast on
In this episode we discuss the potential impact of dietary polyphenols on cognitive health; including cogitnitve funciton, memory, and risk of dementia and Alzeimher's. We talk about some potential mechanisms, cohort studies, and then direct controlled trials. You can find the show notes at and/or support the podcast at
Dr Adrian Brown is a NIHR Lecturer and Research Fellow in the Centre of Obesity Research at University College London. He is also a senior Specialist Weight Management and Bariatric dietitian with over 15 years of clinical experience and a PhD in Medicine from Imperial College London. His research interests centre around obesity, type 2 diabetes, bariatric surgery, weight stigma and the use of formula-based diets in different patient populations. He is an Honorary Academic for Public Health England Obesity and Healthy Weight Team, on the strategic council for APPG on Obesity and is on the scientific council of the British Nutrition Foundation.   You can find the show notes to this episode at and you can support the podcast at
Prof. Marion Hetherington is Professor of Biopsychology at University of Leeds, where her research is focused on the psychology of appetite across the lifespan. She has previously been at Johns Hopkins, the NIH, the University of Dundee, University of Liverpool and Glasgow Caledonian University, before taking up her role in Leeds in 2008, where she works within the Human Appetite Research Unit. You can find the show notes to this episode at and you can support the podcast at
Prof. David Jacobs, PhD is Professor of Public Health, in the Division of Epidemiology and Community Health, at the University of Minnesota. He has published highly inflential work in nutritional epidemiology and health epidemiolgy for decades. A number of his papers have brought up crucially important ideas about how to do good nutrition science. Specifically, he has talked about think of whole diet or foods as the exposure of interest, rather than individual nutrients. Essentially warning against the pitfalls of applying a biomedical lens to nutrition research. You can find the show notes to this episode at
Prof. Leanne Redman is a Professor of Reproductive Endocrinology & Women’s Health, based at the Pennington Biomedical Research Center. As the director of the Reproductive Endocrinology and Women’s Health Laboratory, she is focused on understanding the intergenerational transmission of obesity. She has published on maternal diet, preeclampsia, and gestational diabetes, amoung other issues. She and her colleagues are currently conducting a rigorous trial to determine the effects of a 6-month gestational intervention with calorie restriction and food provision to promote maternal weight maintenance and fat loss in 100 pregnant women with grades 2 and 3 obesity. Show notes are available at You can support the podcast at
We take a look at three more "quacks" who spread misinformation; Dr. Michael Greger (01:21), Eric Berg (36:26), and Dr. Paul Saladino (55:18). We give reference to some specific examples. Show notes available at If you wish to support the podcast you can do so via
To celebrate our 400th episode, we take a look at two "quacks" who spread misinformation; Dr. Aseem Malhotra and Dr. James DiNicolantonio. We give reference to some specific examples. Show notes available at Subscribe to Danny's free weekly email, the Sigma Synopsis at: Support the podcast on Patreon at:
James Betts is Professor of Metabolic Physiology at the University of Bath, where he is Co-Director of the Centre for Nutrition, Exercise & Metabolism. His research employs randomised controlled trials to study the effects of nutrition on metabolic regulation. His group recently published a trial aiming to separate out the effects of fasting from those of calorie restriction. Show notes at
Carole Hooven, PhD, is lecturer and codirector of undergraduate studies in the Department of Human Evolutionary Biology at Harvard University. She earned her PhD at Harvard, studying behavioral endocrinology and evolution of sex differences in humans (physiology, behavior and cognition). She has recently written a book on how testosterone influences behaviour and explains many sex differences. The book is titled 'T: The Story of Testosterone, the Hormone that Dominates and Divides Us'. Show notes available at
In this episode Danny & Alan discuss the impacts of nitrates and nitrites on health. They look at the beneficial impacts of dietary nitrate, as well as issues around nitrites in processed meat. Show notes available at
Dr. Leigh Frame, PhD is Director of Integrative Medicine at George Washington School of Medicine and Health Sciences in Washington DC. Dr. Frame received her PhD in Human Nutrition, as well as a Master of Health Science degree in Molecular Microbiology and Immunology, from the Johns Hopkins Bloomberg School of Public Health. In this episode we discuss a range of topics including: the role of placebo groups and the different types we see in nutrient supplementation trials, potential ethical issues, and the development of research ethics. Show notes available at
Professor le Roux is an expert in metabolic medicine and is currently a Professor of Experimental Pathology, University College Dublin. He is recognised as a world leader in metabolism and obesity. Professor le Roux’s clinical focus is in the management of Type 2 diabetes, pre-diabetes, obesity, cardiovascular risk and other metabolic disorders. Professor Carel le Roux has been published extensively and currently holds a number of editorial roles for journals in his field including, Clinical Obesity and Surgery for Obesity and Related Diseases. Show notes are available at:
Gar Benn is the Head of Coaching at Sigma Nutrition, where he works with nutrition coaching clients and oversees the coaching services. He is the owner of CityGym Limerick, a powerlifting-centric gym in Ireland. And he is also the co-founder of the European Powerlifting Confernce and Titan Ireland. Gar is a qualifed nutrition coach and has completed courses in Motivational Interviewing and Acceptance and Commitment Therapy (ACT). Show notes at
Vitamin D status is linked to a variety of health outcomes, and avoiding or correcting deficiency is important. However, does supplementing with vitamin D actually benefit most people? Is there evidence for supplementation improving health outcomes like mortality, cancer risk, depression or other outcomes? In this episode Danny and Alan look at intervention trials of vitamin D supplementation. Show notes available at:
Dr. Clare Pettinger is a Registered Dietitian, Public Health Nutritionist and experienced educator. Dr. Pettinger publishes research in the public health nutrition field, and lectures at the Universtity of Plymouth, UK.  Dr. Pettinger is actively engaged in community-focussed research around food systems, poverty and social justice. She is an enthusiastic 'sustainability advocate' involved in promoting environmentally sustainable diets for nutrition professionals and Allied Health Professioinals.  Show notes available at
In this episode Danny and Alan discuss the three primary models used to explain body mass regulation: 1) Set Point Model, 2) Settling Point Model, 3) Dual Intervention Model. They discuss the role of feedback systems, environment, behaviour, as well as discussing both the "thrifty gene hypothesis" and John Speakman's "drifty gene hypothesis".
Gil Carvalho, MD PhD is a medical doctor, research scientist, science communicator. Dr. Carvalho trained as a medical doctor in the University of Lisbon, in his native Portugal, and later obtained a PhD in Biology from Caltech (California Institute of Technology). He has published peer-reviewed medical research spanning the fields of genetics, molecular biology, nutrition, behaviour, aging and neuroscience.   In this episode we discuss: Dairy: is it over-emphasized in the Dietary Guidelines for Americans? Dairy tolerance Critical importance of substitution effects Differences between difference types of dairy on health Claims by some WFPB advocates that olive oil can negatively impact endothethial function Distinguishing between acute and chronic effects Gil's work with Antonio Damasio on feelings Show notes:
Renee McGregor is a leading sports dietitian, specialising in Eating Disorders, REDs, The Female Athlete, athlete health and performance. She is regularly asked to work directly with high performing and professional athletes that have developed a dysfunctional relationship with food that is impacting their performance, health and career. Her practice and knowledge is supported by extensive experience of working in both clinical and performance nutrition, including, Olympic, Paralympic and Commonwealth teams. She is the co-founder and director of #TRAINBRAVE a campaign raising the awareness of eating disorders in sport; providing resources and practical strategies to reduce the prevalence. She is on the REDS advisory board for BASES (The British Association of Sport and Exercise Science) and sits on the International Task Force for Orthorexia. Find the show notes at
Comments (19)

Matt M

A rehash of old episodes

May 13th

Matt M


Jan 26th


"nutrition lore" 🤣🤣 omg such a descriptive little phrase!

Sep 7th


what about choline supplementation for vegan diets, esp during pregnancy??

Jul 25th

Joern Utermann

really really enjoyed this episode! very interesting topic and cool new format!

Apr 26th


very good episode!

Nov 28th

Mason Verkruisen

assume foods are bad for you until proven innocent is a terrible idea.

Oct 11th

Shasa Bolton

Great non biased informative discussions with experts in their fields. Thanks for the show

Sep 19th


Worst podcast EVER. The audio quality is total crap. What a shame

Aug 19th

Bex G

Brilliant episode, thanks.

Jul 31st

Aaron Trowbridge

Very interesting debate, thanks for the quality content.

Jan 13th

Benyamin Asgari

excelent podcast . love it .

Jan 2nd

Maria Kirby

Another brilliant episode !! I wondered if you would consider doing an episode/discussing how to know what probiotics are recommended for different conditions. I have had my gallbladder removed and suffer with poor digestion and would love to hear more about what I can do to help digestion and possibly what probiotics are recommended for this. Thanks, Maria

Nov 29th

Matt M


Sep 18th

Matt M

Great episode 👍🏼

Sep 11th


Love the show!

Jun 8th

Artin Entezarjou

Great show! We use it to get insight into the evidence for our Instagram page @ebtofficial

May 18th


Just found your podcast loving it so far, ATP science is my other favourite but they are also selling products so it is a little bit tainted in that way. your podcast is refreshing because you aren't trying to sell me anything. excepting maybe your guests or sponsors but there's no getting around that. thanks for the hard work love it. p.s. is it possible to have your patreon link in the description on castbox?

May 15th

Andrew Moore

Very informative and enjoyable!

Mar 5th
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