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© Siim Land
Description
Siim Land is an author, speaker, and consultant. He talks about optimizing health, performance, and longevity with different techniques and biohacking.
443 Episodes
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Timestamps:
00:00 What's the unhealthiest thing in my life
08:00 Bon Charge sponsorship
08:55 How to have good kidney markers
16:18 Does niacinamide inhibit SIRT1
18:55 How to optimize shift work
23:54 What routines to keep when you have a deadline
28:07 Is a hot tub the same as sauna
30:00 Alternatives to olive oil
33:35 Does astaxanthin inhibit exercise benefits
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Timestamps:
00:00 Intro
00:35 Raghav’s new study on epigenetic age
04:25 Biological age explained
10:45 How epigenetics affects aging
12:40 Biological age clocks and biomarkers
21:50 Top performers in lowering epigenetic age
32:20 How chronological age affects biological age
35:20 Gene therapies
40:10 Effect of diet and exercise
45:40 What biomarkers affect biological age
49:45 Organ aging
58:00 Final thoughts
Raghav Sehgal Twitter: https://twitter.com/rv_sehgal
Raghav Sehgal website: https://www.raghav-sehgal.com/
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Timestamps:
00:00 Intro
01:30 What are peptides and how are they made
07:20 Safety of peptides
12:52 FDA and peptides
18:45 BPC157
31:10 TB500
37:20 Growth hormone peptides
44:20 Longevity peptides, Epitalon, Melanotan
52:35 Fundamentals of lifestyle
56:45 Preparing for peptide protocols
Dr Silvana Laith Instagram: https://www.instagram.com/drsilvanalaith/
Noah Laith Instagram: https://www.instagram.com/thestoicbiohacker/
I Took BPC 157 Peptide for 2 Months and Here's What Happened: https://youtu.be/9qc9dhDDDhc
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Hello, this is a casual livestream. The list is based on my opinion
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Timestamps:
00:00 Intro
00:32 Bon Charge Sponsorship
01:20 Declining Heart Disease Rates
05:10 Biggest Risk Factors of Heart Disease
10:15 What Is Heart Disease and Atherosclerosis
13:55 When Does Atherosclerosis Begin
20:55 Biggest Risk Factors of Heart Disease
27:55 Role of Genetics in Heart Disease
31:50 High vs Low Lipids
39:40 Managing Your Risk Trajectory Over Time
45:30 Lp(a)
52:30 ApoB vs Cholesterol
57:20 Does HDL Reduce the Risk of Heart Disease
59:35 Homocysteine
01:02:55 Does Too Much Exercise Cause Atherosclerosis
01:09:55 Practical Steps to Heart Disease Prevention
01:15:30 Detecting Calcium in the Arteries
01:20:35 Calcified Hard Plaques vs Non-Calcified Plaques
01:22:45 At What Calcium Score Can You Get a Heart Attack
Dr Paddy Barrett Twitter: https://x.com/paddy_barrett
Dr Paddy Barrett Substack: https://paddybarrett.substack.com/
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Timestamps:
00:00 Introduction
00:37 Twenty since Aubrey coined the Longevity Escape Velocity
11:13 When will we reach Longevity Escape Velocity
16:45 Slowing down aging vs regeneration
19:44 What breakthroughs we need for longevity escape velocity
24:00 Seven types of aging damage that needs to be repaired
24:37 Loss of cells and stem cells
33:57 Regenerating limbs and organs
36:10 Mitochondrial free radical theory of aging
41:15 Intracellular and Extracellular waste products
47:15 How far is gene therapy now?
49:15 Death resistant cells
53:52 Do you need long telomeres
57:15 Extracellular matrix stiffening and glycation
01:00:48 Biggest breakthroughs in the next 5 years
01:04:30 What to do to live until the longevity escape velocity
The Longevity Escape Velocity Foundation: https://www.levf.org/
Aubrey de Grey Twitter: https://x.com/aubreydegrey
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Timestamps:
00:30 Introduction
00:50 What is cancer
04:30 Does everyone have cancer all the time?
06:30 When does cancer become lethal
11:30 Hallmarks of cancer
21:20 Senescent cells vs cancer cells
25:00 Evolutionary purpose of cancer
27:30 Cancer prevention
30:10 Ultra processed food and cancer risk
35:35 Organic vs non-organic food
38:40 What are carcinogens
45:10 Immune function and cancer
48:15 Meat and cancer
51:20 mTOR and cancer
01:02:20 Glucose, Warburg Effect and cancer
01:07:00 Ketones and cancer
01:11:00 Artificial sweeteners
01:16:40 Environmental toxins
Dr Joe Zundell YouTube channel: https://www.youtube.com/@dr.joezundell
Dr Joe Zundell Instagram: https://www.instagram.com/dr.joezundell/
Use code SIIM for a 15% discount off Bon Charge: https://boncharge.com/pages/siimland
Timestamps:
00:01 Supplements that are bad for the heart
08:45 Will we see someone live to 125
11:56 Bon Charge sponsorship
12:46 Maltodextrin in protein powder
13:59 Hyaluronic acid supplementation and cancer
15:32 Creatine reduces VO2 max
17:55 Limiting factor in losing visceral fat
20:45 Which disease am I most afraid of
25:13 Weighted stretching for muscle growth
28:00 Protein restriction and lifespan
32:22 How to train with joint pain
35:39 How much NAC for 60+
37:23 How to stimulate appetite
40:47 What's a good VO2 max for women
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Get The Longevity Leap Worksheet: https://www.siimland.co/offers/gX7pV7RF
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Timestamps:
00:37 Omega 3 Health Benefits as of 2024
03:50 Why Are Omega 3 Fats Beneficial
08:57 My New Book The Longevity Leap
09:15 Why Aren't Omega 3s Essential
09:57 What Is the Omega 3 Index
14:45 Is There Risk of Healthy User Bias
17:50 How High Omega 3 Index Is Optimal
26:28 How to Increase Omega 3 Index
29:38 Different Types of Omega 3 Supplements
32:40 Are Omega 3 Supplements Oxidized and Rancid
35:15 How to Choose an Omega 3 Supplement
40:15 Heart Disease and Omega 3s
46:25 Neurodegeneration and Omega 3s
48:00 Omega 6 Fats and Mortality
55:00 How Much Omega 6 Is Too Much
59:48 Omega 9 Fats
01:02:15 How to Store Omega 3 Supplements
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Timestamps:
00:29 Introduction
02:43 Question 1: Death and longevity
11:23 Julie’s advice to Siim
12:58 Meeting likeminded people interested in longevity
17:33 Dave getting stem cells
19:33 Rejuvenation Olympics
22:18 How I share evidence
28:53 Longevity as a sport
40:58 How the Rejuvenation Olympics works
48:28 What’s the best biological age clock
53:58 Telomere length
58:31 How long can we make humans live
01:12:52 Panel about exercise routines
01:19:38 Panel about sleep
01:25:52 Panel about nutrition
01:36:44 Panel about supplements
01:46:44 Best low-hanging fruits
Adam the host's channel: https://youtube.com/@nopara73?si=7z6gKAq6s5vZTT_T
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Timestamps:
00:30 Misconceptions about stem cell therapy
04:20 Different types of stem cells
07:10 Bon Charge sponsorship
07:55 Stem cells and aging
09:00 Studies about stem cell anti-aging effects
13:32 FDA regulations regarding stem cells
25:19 How Joy got into stem cells
36:39 Cost of stem cell therapy
43:40 Process of getting umbilical cord stem cells
49:45 Stem cell procedures
57:55 Finding reliable stem cell clinics
01:02:48 Joy Kong's clinic and content
Dr Joy Kong YouTube channel: https://www.youtube.com/@JoyKongMD/featured
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Code LEAP for 15% off the Longevity Leap Bundle: https://donotage.org/longevity-leap-bundle
Timestamps:
00:29 Leigh’s background
06:44 Health benefits of cold exposure and breathwork
09:44 Mammalian dive reflex
11:45 DoNotAge Longevity Leap supplement bundle
13:20 Benefits of breath holds
16:55 How long can you hold your breath for
20:30 Are there benefits to being able to hold your breath for long
25:56 Hyperventilation vs breath holds
34:46 Breathwork exercises for beginners
40:27 How to breathe correctly
45:00 Nasal breathing vs mouth breathing
52:00 How to breathe during exercise
54:45 Leigh’s new book
Leigh Ewin's new book: https://www.leighewin.com/leigh-events/p/re-spiritual-awakening-audiobook-pre-order
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Timestamps:
00:01 Are Too Many Supplements Bad for Organs
03:46 How to Clear Caffeine From the Body
07:00 When Do I Think Longevity Escape Velocity Will Begin
11:05 Bon Charge Sponsorship
11:49 How to Improve Sleep
14:45 What Biomarker I Want to Improve
19:04 mTOR and Longevity
24:05 How to Increase HRV Besides Exercise
26:25 Do I Have Cheat Meals
27:46 Astaxanthin and Testosterone
29:02 Taking 35 Grams of Glycine Per Day
31:09 Thoughts on Pterostilbene for Longevity
32:25 Essential Supplements for Vegans
34:20 Cancer Prevention
35:42 How to Improve Skin Elasticity
36:43 Does Calorie Restriction Decrease Performance
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Get The Longevity Leap Worksheet: https://www.siimland.co/offers/gX7pV7RF
Join my next retreat at a longevity clinic: https://www.siimland.co/retreat
Get The Longevity Leap Worksheet: https://www.siimland.co/offers/gX7pV7RF
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
Timestamps
00:12 Alexis' background
03:00 What's available for regeneration currently
04:37 Alexis’ 3 step process for longevity medicine – Phase 1
09:30 The Longevity Leap Worksheet
10:09 Phase 2 - cleanup
12:35 Evidence for chelation therapies
13:58 Effects of senolytics
18:20 Phase 3 - regeneration
19:39 Exosomes and stem cells
28:09 Can exosomes extend lifespan
33:25 Peptides
39:08 Restoring melatonin levels
42:13 How many stem cells do you have
45:05 Why don't we live to 120
51:30 Can you remove plaque from arteries
56:10 What supplements Alexis takes
01:12:00 Diet and exercise
01:17:28 After the 3 phase plan
Alexis Ortega MD Instagram: https://www.instagram.com/alexis_ortega_md/
Get my new book The Longevity Leap: https://www.siimland.co/offers/Mo7aiaAh/
Join our next retreat: https://www.siimland.co/retreat
Timestamps:
00:40 Joe's 7th time at the clinic
01:25 Utilization of amino acids
09:00 What tests is Joe doing frequently
10:29 My new book The Longevity Leap
11:08 Joe on taking 150 supplements per day
22:02 Why Joe takes so many supplements
28:42 How genetics affects homocysteine
33:12 How Joe started coaching Liver King
36:47 Does everyone in the modern world need supplements
46:15 Genetics
Joe Cohen YouTube channel: https://www.youtube.com/@thejoecohenshow
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Timestamps:
01:00 Senescent Cells and Aging
09:18 Bon Charge Sponsorship
10:00 Immune System Aging
15:08 What Triggers Cell Senescence
18:50 How to Measure Cell Senescence
22:58 Senolytic Supplements and Drugs
35:50 mTOR, Rapamycin and Senescence
38:25 Aging and Autoimmunity
46:00 Recent Study on IL-11 and Life Extension
55:00 Mice Living Pathogen Free in Labs
Matt Kaeberlein Optispan YouTube Channel: https://www.youtube.com/@optispan
Get my new book The Longevity Leap: https://www.siimland.co/thelongevityleap
Use code SIIM for a 15% discount off Bon Charge: https://boncharge.com/pages/siimland
Timestamps:
00:01 Recommended supplements for people in their 40s?
08:44 Three simplest ways to increase VO2 max
13:45 What will you do in your 30s that makes the biggest bang for your buck that is not exercise?
16:42 How to decrease stress levels? Any breath method? Supplements to deal with it?
19:57 I supplement with omega 3 high dose but I eat many nuts as well. Is my omega 3 wasted?
22:34 If you don’t have a sauna does a very hot shower bring the same or near benefits?
25:11 Does sex help increase longevity?
27:52 How did you do a fat loss phase? Lower carbs or fat?
30:42 I’d like to gain the weight healthy. Do you have any recommendations for the food, training?
34:16 Are you planning to start taking rapamycin?
36:24 When is your next retreat to India cause we’re coming
37:28 How did you lower your LDL?
38:54 Top 5 things that improved your sleep
42:42 What oil do you use to fry your sweet potato fries?
43:41 Thoughts on astaxanthin? Daily dose?
44:44 Do you take novos core supplement?
Pre-order my new book: https://www.siimland.co/offers/Mo7aiaAh
Join my next retreat at a longevity clinic: https://www.siimland.co/retreat
Pre-order my new book The Longevity Leap: https://www.siimland.co/offers/Mo7aiaAh/checkout
Timestamps:
00:31 Life Expectancy Trends
03:08 Delay Chronic Diseases
06:26 Longest Living Man In History
10:21 Timeline of Chronic Diseases
12:23 Heart Disease and Neurodegeneration
14:45 Metabolic Syndrome
18:27 Slow Down Decline
22:17 Heart Rate and HRV
24:04 Muscle and Strength
25:35 Cognitive Decline
Join the Biohacker Summit: https://biohackersummit.com/
Pre-order my new book The Longevity Leap: https://www.siimland.co/offers/Mo7aiaAh/checkout
Pre-order my new book The Longevity Leap: https://www.siimland.co/offers/Mo7aiaAh/checkout
Timestamps:
00:56 The Longevity Mix
01:28 Calcium Alpha-Ketoglutarate
03:58 Vitamin C
06:30 Creatine Monohydrate
07:32 Magnesium Citrate
09:18 Glucosamine Sulfate
10:15 Taurine
11:08 Glycine
13:17 Glutathione
14:14 Lysine
15:26 Ashwagandha
16:40 Theanine
17:26 Sodium Hyaluronate
18:42 Essential Softgels
19:05 Vitamin K1
21:00 Vitamin K2
22:20 Astaxanthin
23:35 Lutein and Zeaxanthin
24:25 Lycopene
25:06 Essential Capsules
25:41 Nicotinamide Riboside (NR)
26:40 Spermidine
27:37 Lithium
28:15 Rhodiola Rosea
28:30 CoQ10
29:17 NAC+Ginger+Curcumin
29:20 NAC
30:01 Curcumin
30:41 Ginger
31:34 Red Yeast Rice
32:10 Garlic
33:20 My Final Rating for Blueprint Supplements
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There was a great deal of discussion of how mitochondria dysfunction is a major problem with chronic fatigue, but pretty much denial that anything works to fix it. Also, if the guest has any ideas of anything that helps, he avoids mentioning any of those things. This was not a good use of my time.
There is a great deal of discussion of how mitochondria dysfunction is a major problem with chronic fatigue, but pretty much denial that anything works to fix it. Also, if the guest has any ideas of anything that helps, he carefully avoids mentioning any of those things. This was frustrating, and not a good use of my time.
Great input about the activated charcoal to detoxify when changing to healthy fats!
Living in close quarters stresses the me put completely.....the cost we pay for paying to live in the city.....we need to go back to caveman era
Another extremely helpful podcast. Thanks Siim!
Outstanding information!
05:30 #mitochondria
Great episode 💪🙌
This is a fantastic podcast really enjoyed it 😊
One of my favorite podcasts.
Nice podcast
amazing
Thanks Luis
thought provoking
One of the best podcasts I have ever given a Chance 😃
loving this