Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This December, we'll highlight the antibody startup ecosystem, microfluidic strategies driving next-generation antibody discovery, and the landscape of psoriasis treatment.References:https://www.mdpi.com/2079-6374/15/7/409https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2597610?src=https://www.nature.com/articles/s41587-024-02346-5https://pubs.rsc.org/en/content/articlehtml/2025/lc/d5lc00340ghttps://www.sciencedirect.com/science/article/pii/S2667237524003242https://www.nature.com/articles/s41551-025-01411-xhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11417777/https://www.prnewswire.com/news-releases/chinas-first-domestic-il-23p19-monoclonal-antibody-innovents-pecondle-picankibart-injection-received-nmpa-approval-302627980.htmlhttps://www.nature.com/articles/d41586-025-02649-whttps://www.mdpi.com/1422-0067/26/19/9616
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This November, we'll highlight how non-canonical antibodies are reshaping immunotherapy, combination antibody therapies, and T cell exhaustion.References:https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1723343/fullhttps://www.tandfonline.com/doi/10.1080/19420862.2025.2583210#abstracthttps://www.cancertreatmentreviews.com/article/S0305-7372(15)00193-0/abstracthttps://link.springer.com/article/10.1186/s13045-023-01509-2https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1556245/fullhttps://link.springer.com/article/10.1186/s12879-025-11012-3https://www.sciencedirect.com/science/article/pii/S2274580724005934https://onlinelibrary.wiley.com/doi/10.1002/ctm2.70345https://www.pnas.org/doi/10.1073/pnas.2409564122https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1507501/fullhttps://www.nature.com/articles/s41577-019-0221-9https://www.sciencedirect.com/science/article/pii/S1074761325003711
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This October, we'll highlight advances in antibody design with AI, crossing the BBB, and universal antibodies. References:https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-025-00764-4https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1637602/fullhttps://pubs.acs.org/doi/10.1021/acs.bioconjchem.5c00379https://www.nature.com/articles/s41467-025-59447-1https://www.sciencedirect.com/science/article/pii/S0165614725001828https://pmc.ncbi.nlm.nih.gov/articles/PMC12306175/https://pubs.acs.org/doi/10.1021/acsami.4c18679https://www.nature.com/articles/s41590-025-02286-5https://www.science.org/doi/10.1126/sciadv.adx3505https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00481-5/abstracthttps://pubs.acs.org/doi/10.1021/acsnano.5c08128https://www.cell.com/cell/fulltext/S0092-8674(25)01032-3
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This September we'll highlight recent approvals in biosimilar drugs, conjugate linker designs, and discovery platform advances.Referenceshttps://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-025-00693-9https://pmc.ncbi.nlm.nih.gov/articles/PMC12185665/https://www.prnewswire.com/news-releases/professor-sarfaraz-k-niazi-secures-first-ever-fda-acceptance-to-waive-clinical-efficacy-studies-for-monoclonal-antibody-biosimilars-302542781.htmlhttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202500262https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c01500https://www.sciencedirect.com/org/science/article/pii/S1520480424010044https://www.nature.com/articles/s41598-025-13810-whttps://www.mdpi.com/1424-8247/18/8/1198https://jbioleng.biomedcentral.com/articles/10.1186/s13036-025-00513-zhttps://news.illinois.edu/high-volume-antibody-testing-platform-could-accelerate-disease-research-and-treatment-development/https://pmc.ncbi.nlm.nih.gov/articles/PMC11623700/https://pubs.rsc.org/en/content/articlehtml/2025/lc/d5lc00340g
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This August, we highlight drug advances in autoimmune and infectious diseases, as well as next-generation immune cell engagers.References:Pelkas, C., Franke, K. B., Vincent, F. B., & Rischmueller, M. (2025). Novel therapies in Sjögren’s disease: A systematic review of the literature. Best Practice & Research Clinical Rheumatology, 102084. https://doi.org/10.1016/j.berh.2025.102084Subramaniam, S., Saville, J. W., Feng, F., & Freiburger, L. (2025). Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future. Biochemistry. https://doi.org/10.1021/acs.biochem.5c00192Atanasov, P. Y., Moneva-Sakelarieva, M. G., Kobakova, Y. A., Ivanova, S. A., Becheva, M. V., Kirkova-Bogdanova, A. G., Chaneva, M. S., Atanasova, V. P., Todorov, R. F., Bashev, N. Z., Bashov, I. E., & Ibrahim, A. H. (2025). Monoclonal antibodies: their place in applied medicine and their role in the newest infectious disease – history, present, and future. Literature review. Pharmacia, 72, 1–18. https://doi.org/10.3897/pharmacia.72.e159772Fucà, G., Spagnoletti, A., Ambrosini, M., De Braud, F., & Di Nicola, M. (2021). Immune cell engagers in solid tumors: Promises and challenges of the next generation immunotherapy. ESMO Open, 6(1), 100046. https://doi.org/10.1016/j.esmoop.2020.100046In, H., Park, M., Lee, H., & Han, K. H. (2025). Immune Cell Engagers: Advancing Precision Immunotherapy for Cancer Treatment. Antibodies, 14(1), 16. https://doi.org/10.3390/antib14010016Albayrak, G., Wan, P. K., Fisher, K., & Seymour, L. W. (2025). T cell engagers: Expanding horizons in oncology and beyond. British Journal of Cancer, 1-9. https://doi.org/10.1038/s41416-025-03125-y
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This July, recent research includes computational tools for nanodiscs, antibody-drug conjugate (ADC) development, and antibody-antigen research.References:Yao, X., & Thomson, C. A. (2025). Review: Membrane protein nanodiscs for antibody discovery. Current Opinion in Structural Biology, 94, 103104. https://doi.org/10.1016/j.sbi.2025.103104Baskakova, K. O., Kuzmichev, P. K., & Karbyshev, M. S. (2024). Advanced applications of Nanodiscs-based platforms for antibodies discovery. Biophysical Chemistry, 313, 107290. https://doi.org/10.1016/j.bpc.2024.107290Dong, Y., Tang, H., Dai, H., Zhao, H., & Wang, J. (2024). The application of nanodiscs in membrane protein drug discovery & development and drug delivery. Frontiers in Chemistry, 12, 1444801. https://doi.org/10.3389/fchem.2024.1444801Kuai, R., Yuan, W., Son, S., Nam, J., Xu, Y., Fan, Y., Schwendeman, A., & Moon, J. J. (2018). Elimination of established tumors with nanodisc-based combination chemoimmunotherapy. Science Advances. https://doi.org/aao1736Noriega, H. A., & Wang, X. S. (2025). AI-driven innovation in antibody-drug conjugate design. Frontiers in Drug Discovery, 5, 1628789. https://doi.org/10.3389/fddsv.2025.1628789Croitoru, A., Orr, A. A., & MacKerell, A. D. (2025). Harnessing computational technologies to facilitate antibody–drug conjugate development. Nature Chemical Biology, 21(8), 1138-1147. https://doi.org/10.1038/s41589-025-01950-zChen, L., Li, B., Chen, Y., Lin, M., Zhang, S., Li, C., Pang, Y., & Wang, L. (2025). ADCNet: A unified framework for predicting the activity of antibody-drug conjugates. Briefings in Bioinformatics, 26(3). https://doi.org/10.1093/bib/bbaf228Su, A., Luo, Y., Zhang, C., & Duan, H. (2025). Linker-GPT: Design of Antibody-drug conjugates linkers with molecular generators and reinforcement learning. Scientific Reports, 15(1), 1-15. https://doi.org/10.1038/s41598-025-05555-3Sato, K., Uehara, S., Tsugita, A., Ishii, M., Ishiyama, S., Maejima, A., Nakahara, I., Nazuka, M., Matsui, T., Christos, G., Yokoyama, T., Kumagai, I., Makabe, K., Asano, R., & Tanaka, Y. (2025). Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement. Cell reports, 44(7), 115965. https://doi.org/10.1016/j.celrep.2025.115965Myung, Y., Pires, D. E., & Ascher, D. B. (2023). Understanding the complementarity and plasticity of antibody–antigen interfaces. Bioinformatics, 39(7). https://doi.org/10.1093/bioinformatics/btad392Heirene, L., Byrne, H., Sepp, A., Gaffney, E., & Yates, J. (2025). Understanding antibody-target antigen interactions and the avidity effect using mathematical modelling. Journal of the Royal Society, Interface, 22(228), 20240710. https://doi.org/10.1098/rsif.2024.0710Torrents de la Peña, A., Sewall, L. M., de Paiva Froes Rocha, R., Jackson, A. M., Pratap, P. P., Bangaru, S., Cottrell, C. A., Mohanty, S., Shaw, A. C., & Ward, A. B. (2023). Increasing sensitivity of antibody-antigen interactions using photo-cross-linking. Cell reports methods, 3(6), 100509. https://doi.org/10.1016/j.crmeth.2023.100509Manion, A., Brooks, T. M., & Brooks, C. L. (2025). Antibody-Antigen Epitope Mapping by X-Ray Crystallography. Methods in molecular biology (Clifton, N.J.), 2937, 15–31. https://doi.org/10.1007/978-1-0716-4591-8_2
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This June, recent research includes VHH antibodies, antibody-drug conjugates in oncology, and antibody engineering as a countermeasure to drug resistance.
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This May, top news includes BCMA-Targeted Therapies, Multifunctional (Natural Killer Cell Engagers), and Engineering IgE Antibodies.
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This April, top news includes Fc engineering, FcRn inhibitors, and Tregitopes.
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This March, top news includes ion channel and GPCR-driven diseases, affinity maturation, and a look back at SARS-CoV-2, 5 years on.
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This February, top news includes novel antibodies to treat obesity, hereditary angioedema, and B cells.
Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This January, top news includes glycoengineering, anti-malarial antibodies, and PROTACs.