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Symptomatic: A Medical Mystery Podcast
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Symptomatic: A Medical Mystery Podcast

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How terrifying would it be to fight an unknown enemy? One you don’t recognize and didn’t see coming? What if that enemy was coming from within; a disease that even doctors couldn’t identify? Nearly half of all Americans suffer from some chronic illness and many struggle for an accurate diagnosis.


Every other week on Symptomatic, host Lauren Bright Pacheco unravels the medical mystery of a patient’s baffling symptoms and explores how their lives were turned upside down in search of answers. 


From the first signs of trouble, through a swirl of misdirection and failed treatment attempts, to the final relief at a confirmed diagnosis - these are their stories. This is Symptomatic.


We want to hear from you! Tell us what you think of the show or share your own medical mystery by emailing us at Symptomatic@iHeartMedia.com.

30 Episodes
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In this next installment of Symptomatic: House Calls, we catch up with Alisha from Case #13. Spoiler Alert: If you haven’t listened to this episode yet, you might want to do so first. Alisha was diagnosed with psoriasis at just 7 years old. Feeling deeply self-conscious and isolated by others’ reactions to seeing her body covered by plaques, she adapted by hiding under long sleeves in the summer and convincing herself she’d never feel the rain on her skin again. Then she discovered the power of biologics, which changed her life. Join host Lauren Bright Pacheco as she checks in with Alisha on her progress and the response she’s received since bravely sharing her story.See omnystudio.com/listener for privacy information.
Case #22: Mila

Case #22: Mila

2024-11-1241:282

In her mid-20s and thriving in a fast-paced communications job, Mila Clarke began experiencing symptoms reminiscent of those her mom had managed with diabetes for years. However, as time went on, it became clear that this was different. Little did she know, her life was about to take a significant turn, leading her on an unexpected journey with a chronic illness she never saw coming.See omnystudio.com/listener for privacy information.
Case #21: Scott

Case #21: Scott

2024-11-0540:162

In peak health, Scott Collin’s life took a drastic turn when a rare disease nearly claimed it all. Initially misdiagnosed and dismissed, his symptoms escalated into a near-fatal episode, revealing the true extent of his condition. Forced to confront challenges affecting his heart, lungs, and more, Scott’s journey became one of resilience and survival against all odds.See omnystudio.com/listener for privacy information.
In this bonus episode, we introduce Symptomatic: House Calls. Throughout Season 3, we will reconnect with past guests to get updates on how they’ve been managing their conditions and how their lives have changed since appearing on the show. For our first House Call, we revisit Athena from Case #2. As a young teenager, Athena began experiencing painful, pimple-like abscesses that were misdiagnosed for years.   Spoiler alert in case you haven’t listened to this episode…   Athena was eventually diagnosed with Hidradenitis Suppurativa, a chronic inflammatory condition. Join host Lauren Bright Pacheco as she catches up with Athena to hear exciting life updates and her latest experiences living with HS. Discover the challenges she’s faced, the progress she’s made, and the significant moments that have shaped her life.See omnystudio.com/listener for privacy information.
Case #20: Kelly

Case #20: Kelly

2024-10-2238:161

In her early 30s, Kelly DuBois was suddenly plagued by a series of inexplicable health issues, from severe heartburn to rapid weight gain, leaving doctors utterly baffled. Misdiagnosed and even subjected to brain surgery, Kelly’s journey took a shocking turn with an unexpected genetic revelation.See omnystudio.com/listener for privacy information.
Case #19: Jose

Case #19: Jose

2024-10-1538:15

At 18, Jose Torres faced a whirlwind of hospital visits, severe abdominal pain, and debilitating fatigue. Having already given up his dream of becoming a professional boxer and now risking his education, Jose was desperate for answers. At his lowest point, the fighter in him emerged, pushing him and his mom to seek solutions before the unknown illness could take even more from his life.See omnystudio.com/listener for privacy information.
Uncertainty. Isolation. Breakthrough. Symptomatic returns with new episodes starting October 15th!See omnystudio.com/listener for privacy information.
Case #16: Lauren

Case #16: Lauren

2023-12-1239:399

Lauren is a professionally trained dancer whose biggest strength has always been finding expression and connection through movement. However, as she pursued her college career, she felt her body slowing down. Simple exercises became challenging, and her flexibility turned into stiffness. Lauren’s condition worsened after having children, and she periodically had to rely on crutches to accommodate her growing immobility. She was desperate for a doctor who could help her. Without a proper diagnosis, she was being torn between maintaining her two passions: dancing and family. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** To find out more on psoriatic arthritis you can check out the Arthritis Foundation’s website at Arthritis.org. You can also find Lauren Scholl on Instagram @CoachScholl.See omnystudio.com/listener for privacy information.
Case #15: Eliza

Case #15: Eliza

2023-12-0534:333

For decades, Eliza dismissed her GI flare-ups and irritated skin. But after the birth of her first child, her concerns escalated, fearing she might faint while caring for her baby. She turned to her sister, who had paralleling symptoms, to explore any potential connection between their experiences. Ignoring the burning pains for so long, Eliza and her doctors dive into her symptomatic past and family history. They uncover a diagnosis that would restore normalcy in her life. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** You can find out more about celiac disease and Dr. Green’s work on Columbia’s Celiac Center website: CeliacDiseaseCenter.Columbia.edu. You can also find his book Celiac Disease: A Hidden Epidemic and Eliza Minot’s incredible catalog wherever books are sold. See omnystudio.com/listener for privacy information.
Case #14: Maria

Case #14: Maria

2023-11-2832:34

Maria is a neurological specialist who became a patient herself when she noticed problems with her mobility. She started to experience cramps in her hands that soon prevented her from driving or tying her shoes. As she saw her ability to care for her patients gradually decline, she faced the skepticism of her colleagues and the fear of not finding a diagnosis. Maria raced to get answers before she lost not only her profession but her whole way of life, as well. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** To learn more about Maria’s journey, check out her books, including Parkinson’s Diva. And for more information on the condition visit the Parkinson’s Foundation website at Parkinson.org. See omnystudio.com/listener for privacy information.
Case #13: Alisha

Case #13: Alisha

2023-11-2136:273

At just 7 years old, Alisha was diagnosed with plaque psoriasis - a condition that manifested in overwhelming flare-ups, covering nearly 90% of her body. Enduring both the physical toll and the harsh judgment of ignorant peers and their parents, she became so self-conscious about showing her skin. She would wear long sleeves in the middle of summer, would never go to the beach, and even feared she would never again be able to feel rain on her skin again. Alisha goes on a long, desperate journey to find a treatment for this disease, seeking not only physical relief but also respite from the mental and emotional trauma of living with psoriasis. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** If you’re looking for more information on plaque psoriasis, go to the National Psoriasis Foundation’s website at Psoriasis.org. You can also learn more through the Global Healthy Living Foundation at GHLF.org and follow Alisha Bridges on Instagram @AlishaMBridges.See omnystudio.com/listener for privacy information.
In this bonus segment, host Lauren Bright Pacheco checks in with Michele from Case #09 to share feedback from the Symptomatic community.See omnystudio.com/listener for privacy information.
Case #12: Chris

Case #12: Chris

2023-11-1432:053

After going through a challenging divorce and relocating cross country, Chris was struggling with depression and anxiety. For a while, he simply ignored his GI symptoms as they progressively got worse. His bowel issues were soon preventing him from living the life he loved: hiking, attending concerts, and participating in activities with his kids. The situation deteriorated to the point where he had to be rushed to the ER multiple times, sure he was having a heart attack. However, the reality was far more complex. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** To find out more about Alpha-gal syndrome, you can check out the CDC’s website at CDC.gov or check out AlphaGalInformation.org. See omnystudio.com/listener for privacy information.
Case #11: Jerad

Case #11: Jerad

2023-10-3138:134

Jerad had been battling an overwhelming amount of stress while juggling PhD studies, early parenthood, and work with the Minnesota Judicial System. Slowly losing his energy and ability to make it through day-to-day activities, he knew his developing condition meant something even bigger than just stress at work. With his wife’s fierce advocacy, Jerad hurried to find the source of his symptoms before permanent damage was done. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** If you’d like to follow Jerad Green's story you can find him on Instagram @HeartFailureHotTakes.See omnystudio.com/listener for privacy information.
Suffering from incessant fevers, muscle pain, and mysterious nodules across his body for nine years, Chuck's hope was fading. No doctor could explain his sporadic flu-like symptoms. Then, he crossed paths with Dr. Daniel Kastner, an unconventional and brilliant physician with a unique approach to disease research. Together with his colleagues at the National Institutes of Health, their groundbreaking discovery might just hold the key to Chuck's medical mystery. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** If you’re looking for more information on VEXAS and to learn about Dr. Kastner's work, go to the National Institutes of Health's website at NIH.gov. See omnystudio.com/listener for privacy information.
Case #09: Michele

Case #09: Michele

2023-10-0336:083

After the birth of her first child, Michele was hit with the onset of sporadic tingling and numbness on alternating sides of her face. Despite enduring years of the mysterious symptoms, she had given up hope of finding the root cause. Michele eventually built up walls of shame because of the uncontrollable flare-ups. It was the concern of her family and the unwavering support of her new partner that would reignite her hunt for a proper diagnosis.See omnystudio.com/listener for privacy information.
Symptomatic is Back!

Symptomatic is Back!

2023-09-1202:17

Join Lauren Bright Pacheco for an all-new season of “Symptomatic” starting Tuesday, October 3rd.See omnystudio.com/listener for privacy information.
Case #08: August

Case #08: August

2022-12-0530:201

Suffering from inexplicable sores & excruciating pain since he was 5 years old, August searched to uncover what plagued so many years of his life and threatened his mobility.  His dreams of a musical theater career quickly faded away as his condition worsened, so August decided to challenge the constant silencing of his symptoms and fight the cause of the irreversible physical damage. *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** If you’re looking for more information on Behcet’s, you can check out the American Behcet’s Disease Association by heading to www.behcets.com. You can also find August Rocha on Instagram & TikTok @WithLoveAugust.See omnystudio.com/listener for privacy information.
Case #07: Kam

Case #07: Kam

2022-11-2829:041

Kam is rapidly losing her motor skills as she’s attacked by an unknown & unseen disease. In a matter of months, she goes from starring on her high school soccer team to struggling to make it up the stairs. Bouncing between doctors and facing countless misdiagnoses, Kam never wavers in her chase to uncover what is threatening to take away her mobility.  *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** For more information on GNE Myopathy go to CureGNEM.org and check out the first ever GNE myopathy clinic at UC Irvine’s neuromuscular center led by one of Dr. Korb’s colleagues. You can also find Kam Redlawsk on Instagram & Twitter @KamRedlawsk. See omnystudio.com/listener for privacy information.
Case #06: Antoinette

Case #06: Antoinette

2022-11-2128:333

Diagnosed at a young age, Antoinette has dealt with Sickle Cell all her life. It’s not until she’s older that she realizes her Sickle Cell is unlike any case her doctor has seen before. With deliberating symptoms and multiple crises, Antoinette turns to her doctor for a life changing diagnosis.   *  *  *  *  *  * ****** SPOILER ALERT BELOW ****** To find out more information on Sickle Cell disease visit the Sickle Cell Disease Association of America at sicklecelldisease.org.See omnystudio.com/listener for privacy information.
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Comments (11)

samira jahangard

Thank you for this great podcast.is there transcript?

Nov 3rd
Reply

Brandy E

Amazing!!!

Jul 31st
Reply (1)

R Renee Gable

I have been missing diagnosed. I have rare disease sarcoidosis and inflammatory diseases. I have been told that since I received my diagnosis , sarcoidosis doesn't hurt, and my symptoms are all I n my head.. I have since gineb up on the American health system.

Jul 2nd
Reply

اسماعیل گل محمد زاده

how comes that kyle had so much fractures? because fracture is not one of the main characteristics of eds.

Apr 23rd
Reply

Melissa Thomas

FYI... poverty is NOT a race. The doctors that missed the diagnosis were white, obviously but the Dr that spoke on this podcast said Lupus is hard to diagnose and there isn't a specific test. That also has nothing to do with race but you made it out to be. Why can't these stories be inspiring to EVERYONE?

Nov 14th
Reply (2)

Carlos Barron

I absolutely love "Symptomatic: A Medical Mystery Podcast"! As a medical professional, I appreciate the way the show delves deep into the complexities of real-life medical cases. The storytelling is top-notch, and the host's ability to unravel these mysteries, while keeping the audience engaged, is truly commendable. https://trueen.com/business/listing/houston-packaging-solution/352655 The cases presented on this podcast not only educate but also leave you with a sense of awe at the intricacies of the human body and the challenges that doctors and patients face in diagnosing and treating rare and puzzling conditions. It's both informative and riveting, making it a must-listen for anyone interested in medicine, healthcare, or just captivating storytelling. Keep up the fantastic work! https://tx-houston.cataloxy.us/firms/custompackaginghouston.com.htm

Nov 4th
Reply

hwithoutsound

it took me 25 years from the onset of symptoms to be diagnosed with POTS. glad she finally got the right docs to finally listen to her!!

Oct 10th
Reply

hwithoutsound

I wish I knew what meds she was on b/c after 12 years (starting at 20 years old) I've been diagnosed with an autoimmune disease but not sure which one & lupus is a big one still on the table

Dec 30th
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