Program notes:0:40 IVF clinics and private equity1:40 Provide over 54% of all IVF cycles in U.S.2:41 Perhaps a more positive result3:30 EKGs and liver cirrhosis4:30 New diagnosis of advanced liver disease5:30 Most physicians didn't follow up6:18 Management of acute back pain7:18 Did it improve pain or disability?8:18 Four- to eight-hour-long sessions to teach8:46 Lay health worker led intervention for older adults with cancer9:46 Reviewed with advanced practice practitioners10:46 Huge benefit from modest intervention11:46 Pick up the phone and ask12:20 Modest outlay13:09 End
Program notes:0:40 Saturated fat and CVD1:40 When it was reduced in diet only helped in those with high risk2:40 Obesity, diabetes and metabolic syndrome also important3:30 Diagnostic follow up after lung CT4:30 Less intensive than recommended in non-Hispanic blacks5:31 Herpes antiviral and Alzheimer's6:30 Followed for five years7:30 80-90% of population exposed8:30 Change screening criteria for lung ca9:33 Population based study10:30 Calculating pack years11:20 Rolling out through national organizations12:17 End
Program notes:0:37 Breast density knowledge outcomes1:37 Breast density notification and education2:37 Can't assess the import individually3:30 CV outcomes with tirzepatide4:30 HbA1c 8.45:30 GLP-1s have many benefits6:30 No difference in adverse events7:10 Covid vaccination in pregnancy8:10 20K women included9:10 Initial benefit is it durable?9:30 Complex regional pain syndrome treatment10:30 Using bisphosphonates for treatment11:33 Even light contact causes severe pain12:28 End
Program notes:0:35 Should surgery efficacy1:30 10-year follow of ASD surgery2:30 Exercise does relieve pain3:00 Association of pain with intrinsic capacity and inflammation4:00 Domains including locomotion and others5:01 Pain impacts a number of capacities6:01 Aspirational to figure out pain6:30 Scheduling birth at term to avoid preeclampsia7:30 High-risk pregnancy delivered at term8:35 Is there impact on the infants?9:18 AI decision support for large-vessel stroke10:20 71,000+ patients with ischemic stroke11:25 U.S. data also not impressive12:54 End
Program notes:0:35 Update on RSV, flu and COVID-19 vaccines1:35 500 studies included2:35 Rare myocarditis3:35 Flu vaccine in older adults4:30 Tai chi or CBT-I for chronic insomnia5:30 Trained in one or the other6:30 Inexpensive and accessible7:30 $150 billion cost of chronic insomnia7:45 GLP-1s and WHO guidance8:50 Multimodal approach required9:45 Prevention is important9:55 Corticosteroids in pregnancy10:50 1.3 million pregnancies11:50 Used for multiple indications12:46 End
Program notes:0:40 CVD risk factors and texting1:40 How many undergo screening?2:41 Impact of personalized messaging3:25 Decentralized trials versus centralized 4:25 Decentralized much larger5:25 Does the trial move in one way or another?6:15 Two studies related to use of peripregnancy GLP-1 use7:15 Stopping at pregnancy8:15 Is overweight worse than stopping?9:00 Machine learning model, tissues, genetics and age10:00 Practical for assessing genetic basis11:00 Sequential tissue samples11:57 End
Program notes:1:25 mRNA flu vaccine2:25 Phase three trial3:25 Preventing infection with a respiratory virus4:25 Prophylaxis with NSAID?4:45 Umbrella review of acetaminophen in pregnancy, ASD and ADHD5:42 Confidence was low to critically low6:45 Other factors such as environmental exposures7:22 Increasing potassium to prevent heart arrythmias8:33 Increase with supplements or dietary advice9:18 Canceling funding for clinical trials10:18 In the process of receiving interventions11:18 Can't not analyze 12:15 End
Program notes:0:50 Fish oil supplements and hemodialysis1:50 1200 individuals to fish oil or not2:50 Needs another study3:11 PCSK9 inhibitor in people without MI or stroke4:13 3- or 4-point MACE5:11 Getting LDL down helps6:11 Addition of more than one oral agent6:50 Right therapy for afib and a stent7:50 Noninferiority trial8:50 After 12 months single agent works9:27 Anticoagulation after afib tx10:30 Low primary safety outcomes11:25 96% won't have a stroke12:16 End
Program notes:0:37 An oral med for obesity1:37 Five to 10% stopped medication2:35 Need head-to-head trials with injectable3:00 Stem cell infusion after MI and heart failure4:01 Reduced heart failure in recipients5:01 Twice as many in the control arm6:01 Moving past BMI in predicting atherosclerosis7:01 Especially in overweight but not obese8:01 Almost 3000 participants in Brazil8:25 Blood samples precede MS9:04 Seen seven years beforehand10:02 Twin studies and relatives11:03 Way to intervene earlier11:15 Applaud OpenAI13:00 End
Program notes:0:45 Steps, more and longer?1:45 8,000 steps or less2:45 Nothing on intensity3:30 Mediterranean diet for IBS4:30 Reduction in IBS symptom severity scale5:30 Easy to accommodate with high compliance6:30 Exercise for knee osteoarthritis7:30 All types of exercise examined8:30 Initiated exercise to try to address9:00 AI intervention in prediabetes10:00 Based on diabetes prevention program11:00 AI and human led essentially the same12:00 99% of eligible group don't have access13:09 End
Program notes:0:40 Nicotine reduction for various subgroups1:40 Native American and Alaskan populations benefit most2:42 Black, rural populations 10 million lives saved3:40 19-39 million life years saved4:00 Food insecurity and blood pressure5:00 Food vouchers most successful6:00 May be more involved and motivated6:35 PFAS and infant brain architecture7:35 Children assessed with MRI8:30 Didn't correct for various factors9:31 Other types of plasticized chemicals9:50 Afib after cardiac surgery10:50 Only found with implantable monitor11:50 Very short duration of afib12:51 End
Program notes:0:40 New drug for SLE1:41 Monitored for a year2:43 Only one pathway limited3:00 AI and health care4:00 How to assure compliance?5:00 Policy changes needed6:01 Pessimistic about oversight6:50 Genetic treatment for ADA deficiency7:50 Using a viral vector8:50 A curative treatment9:30 Social media and cognitive performance in adolescents10:30 Low and high increasing social media use11:30 Good enough evidence12:31 End
Program notes:0:40 Aldosterone as a risk factor for heart disease1:40 Spectrum of renin-aldosterone levels2:40 As many as 25-30% may have3:11 All pharmacologic interventions for obesity tx4:14 All effective compared with placebo5:12 Meta-analysis 6:13 Very little data in overweight or massively obese6:35 Where do U.S. antibiotics come from?7:35 India leading country for finished product8:20 Environmental impact of inhalers9:20 Annual emissions increased by 24%10:23 Decreased by 43%11:23 Three forms of inhaler12:40 End
Program notes:1:21 Bronchiectasis treatment2:22 Twenty sites in UK3:20 Medical imaging and cancer risk in kids4:20 3000 hematologic cancers5:20 Consider other types of imaging6:23 Head CT increases risk by 35%7:24 Treating pulmonary arterial hypertension8:24 Improved mortality in another trial9:25 Antibody prevention of RSV in healthy infants10:25 Healthy preterm and full term infants11:25 Argues for use of this antibody globally12:25 Antibodies against antibody didn't compromise13:08 End
Program notes:0:40 Private equity takeover of hospitals1:40 Reduced salaries or staffing2:40 Patients likely to cost system3:30 Use of anti thymocyte globulin to slow down T1D in youth4:30 Diagnosed within 9 weeks prior5:30 Serum sickness in 82% of highest dose group6:30 Incidence increasing by 2% per year over 20 years7:00 Aspirin in CRC8:00 1100 patients with mutation9:00 Can this mutation be acquired?9:15 Alcohol and dementia10:15 Confounding factors relative to alcohol use11:15 Is there a safe level of consumption?12:40 End
Program notes:0:45 Intimate partner violence and CVD1:45 12% reported stalking2:46 Screening in primary care3:47 Fifty to 200% increased risk4:00 Number of psychiatric disorders and dementia risk5:00 Important to be aware when mental health disorders exist6:03 Anxiety and depression associated6:33 Lipoprotein(a) and widespread vascular disease7:31 High risk of extracoronary vascular disease8:32 Also associated with complications9:32 Unknown why some areas affected10:00 Second cancers after early invasive breast cancer11:00 Contralateral breast cancer greater in younger women12:00 Not excessive risk13:31 End
Program notes:0:45 LSD and treatment of generalized anxiety disorders1:45 Change in anxiety score to 12 weeks post administration2:45 100 micrograms appear most efficacious3:45 Require inpatient 12 hours4:44 Cardiac rehab in older patients after MI5:44 Frail individuals can improve outcome6:45 Oftentimes think it won't make a difference7:10 CT and pregnancy outcomes8:10 Linear relationship with increasing CT scans9:10 Closer to conception more likely 10:10 Sometimes not really necessary10:21 New tx for resistant hypertension11:20 Baxdrostat inhibits aldosterone12:20 What happens when aldosterone drops13:07 End
Program notes:0:53 Who needs a beta blocker after MI1:53 Those with mild reduction of ejection fraction2:53 Confined to those with 40-50% ejection fraction3:15 Revascularization in NSTEMI4:20 Composite outcome5:20 Closes gap, do FFR6:20 May not be physiologically significant6:40 Is lifelong anticoagulation needed after ablation7:41 Occurred less in those who stopped8:30 RSV, cardiac events and hospitalizations9:30 Lower hospitalization in those who got the vaccine10:30 Acute respiratory illness hospitalization11:30 Less benefit with existing CVD or immunocompromise12:15 Several RSV vaccines13:16 End
Program notes:0:44 Drug prices around the world1:41 German prices as standard2:40 Wide variation in price and affordability3:40 Generic pricing 4:20 ADHD meds and behavior choices5:20 Largely treated with methylphenidate6:20 Significantly impacted suicidality and other behaviors6:49 AI assistance and colonoscopy skills7:49 When you stop AI assistance8:50 Does this apply to other procedures that use AI9:20 Trauma predictive brain networks10:20 Use of hydrocortisone to damp down11:20 Previous trauma impact12:25 Developmental timing13:30 End
Program Notes:0:44 Spuds are what we call potatoes1:47 Followed for over 5million person years2:45 No mechanism for why french fries are problematic3:25 DASH4D diet for glycemic control4:25 4 diets compared 5:25 Extends benefits outside hypertension6:20 A new antibiotic for staph infections7:20 IV therapy until cultures are negative8:20 Cost of new therapy, cost effectiveness8:40 Geographic variation in subspeciality cancer care9:40 Highest income managed by specialists10:40 Guidelines expanded11:36 Telemedicine may help12:10 End