The Bob Harrington Show

A review paper prompted a discussion among cardiologists Bob Harrington, Manesh Patel, and Michael Gibson on whether the ST-segment elevation myocardial infarction paradigm needs an update. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314 Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012 Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440 Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039 Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014 TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466 Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986 Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772 A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015 A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743 Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Cardiologists Bob Harrington and Dhruv Kazi discuss the projected burden of cardiovascular disease in 2050, why it's not sustainable, and what can be done to prevent it. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington INCLUDE URLS and full titles for some of the pertinent studies cited. Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050 https://doi.org/10.1161/CIR.0000000000001256 Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050 https://doi.org/10.1161/CIR.0000000000001258 Calculating the 30-day Survival Rate in Acute Myocardial Infarction: Should we Use the Treatment Chain or the Hospital Catchment Model? https://doi.org/10.5301/heartint.5000238 Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health https://doi.org/10.1161/CIR.0000000000001078 Current Trends in Hypertension Identification and Management: Insights from the National Health and Nutrition Examination Survey https://doi.org/10.1161/JAHA.123.034322 Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic https://doi.org/10.2337/dci22-0046 US Trends in Cholesterol Screening, Lipid Levels, and Lipid‐Lowering Medication Use in US Adults, 1999 to 2018 https://doi.org/10.1161/JAHA.122.028205 GLP-1 Receptor Agonist Discontinuation Among Patients With Obesity and/or Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/38787563 Health Care by Food https://healthcarexfood.org/ You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Dr Bob Harrington interviews journalist Shelley Wood about her new book, "The Leap Year Gene of Kit McKinley," her creative process, and the difference between medical journalism and writing fiction. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington The Leap Year Gene of Kit McKinley https://shelleywood.ca/the-leap-year-gene/ Tragedy and Hope Wrapped in a Medical Mystery: Abraham Verghese and The Covenant of Water https://www.medscape.com/viewarticle/991751 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Medical practices are increasingly being acquired by private equity. Bob Harrington discusses why and what the ramifications are with the authors and editorialist of a research paper on the private equity landscape in cardiology vs other specialties. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Private Equity Acquisitions of Outpatient Cardiology Practices in the United States, 2013-2023 https://doi.org/10.1016/j.jacc.2024.06.011 Private Equity in Cardiovascular Practice: Solution or Symptom? https://doi.org/10.1016/j.jacc.2024.06.012 Evaluating Trends in Private Equity Ownership and Impacts on Health Outcomes, Costs, and Quality: Systematic Review https://doi.org/10.1136/bmj-2023-075244 2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report https://doi.org/10.1161/CIR.0000000000000963 You may also like: Hear John Mandrola's, MD, summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington and Mitch Elkind discuss "food is medicine" initiatives and the challenges associated with conducting clinical trials. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Health Care by Food Initiative https://healthcarexfood.org/ 2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association https://doi.org/10.1161/CIR.0000000000001031 Rockefeller Foundation Food is Medicine https://www.rockefellerfoundation.org/initiative/food-is-medicine/ Targeted Scientific Research Projects to Demonstrate Effectiveness of 'Food Is Medicine' in Health Care https://newsroom.heart.org/news/targeted-scientific-research-projects-to-demonstrate-effectiveness-of-food-is-medicine-in-health-care Food Is Medicine: A Presidential Advisory From the American Heart Association https://doi.org/10.1161/CIR.0000000000001182 Medically Tailored Meal Delivery for Diabetes Patients With Food Insecurity: a Randomized Cross-over Trial https://doi.org/10.1007/s11606-018-4716-z 'Food Is Medicine' Strategies for Nutrition Security and Cardiometabolic Health Equity: JACC State-of-the-Art Review https://doi.org/10.1016/j.jacc.2023.12.023 Current Landscape of Produce Prescription Programs in the US https://doi.org/10.1016/j.jneb.2022.02.011 Behavioral Nudges Are Used Widely to Steer Clinicians and Patients Alike https://doi.org/10.1056/CAT.23.0125 A Primary Care Agenda for Brain Health: A Scientific Statement From the American Heart Association https://www.ahajournals.org/doi/10.1161/STR.0000000000000367# You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington interviews fellow cardiologist Mike McConnell about his new book Fight Heart Disease Like Cancer and the need to model heart disease prevention and treatment after cancer. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Fight Heart Disease Like Cancer https://www.press.jhu.edu/books/title/12793/fight-heart-disease-cancer PREVENT: AHA's New Risk Calculator Incorporates CKM Health https://www.medscape.com/viewarticle/998679 Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke https://doi.org/10.1136/bjo-2022-321842 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Cardiology researchers Bob Harrington and Bobby Yeh discuss how to do better observational research and the controversial notion of making causal inferences from such data. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Academic Cardiology and Social Media https://doi.org/10.1161/CIRCOUTCOMES.118.004736 Bringing the Credibility Revolution to Observational Research and Cardiology https://doi.org/10.1161/CIRCULATIONAHA.123.064645 Cardio Twitter: An Essential Tool for Staying Current https://www.medscape.com/viewarticle/897512 Identification of Causal Effects Using Instrumental Variables https://doi.org/10.2307/2291629 Explaining Charter School Effectiveness https://www.aeaweb.org/articles?id=10.1257/app.5.4.1 Methods of Public Health Research - Strengthening Causal Inference from Observational Data https://doi.org/10.1056/NEJMp2113319 Publish or Perish and the Incentive for Quantity over Quality Research Papers https://www.medscape.com/viewarticle/998417 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington, Erin Michos, and Brahmajee Nallamothu discuss how the publish or perish culture can lead to sloppy research and the need for alternative models to measure success in academic medicine. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington With Great Power Comes Great Responsibility Big Data Research From the National Inpatient Sample https://doi.org/10.1161/CIRCOUTCOMES.117.003846 Adherence to Methodological Standards in Research Using the National Inpatient Sample https://doi.org/10.1001/jama.2017.17653 Publish or Perish: Where are we heading? https://pubmed.ncbi.nlm.nih.gov/24778659 The Kardashian Index of Cardiologists: Celebrities or Experts? https://doi.org/10.1016/j.jaccas.2019.11.068 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington and Mike Gibson discuss two of the hottest topics in cardiology and medicine for 2023: a proposed alternative to the maintenance of certification process, and artificial intelligence. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Cardiovascular Organizations Pursue New, Independent Medical Board https://www.acc.org/About-ACC/Press-Releases/2023/09/21/15/02/Cardiovascular-Organizations-Pursue-New-Independent-Medical-Board The National Board of Physicians and Surgeons https://nbpas.org/ Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines https://doi.org/10.1161/CIRCOUTCOMES.118.005293 Validation of a Speech Analysis Application to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients https://www.abstractsonline.com/pp8/?_ga=2.17782015.7532578.1693882428-1949139275.1663003561#!/10871/presentation/16568 A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models https://doi.org/10.1016/j.jclinepi.2019.02.004 Recognizing a ruler instead of a cancer https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/ The Geographic Bias in Medical AI Tools https://hai.stanford.edu/news/geographic-bias-medical-ai-tools You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

For this year's review, Bob Harrington and Mike Gibson revisit the major cardiology conferences -- from ACC in New Orleans to AHA in Philly. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington ACC 2023 Top Trials - Bempedoic Acid Cuts CV Events in Statin-Intolerant Patients: CLEAR Outcomes https://www.medscape.com/viewarticle/989100 - Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients - Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616 https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018 ACC/WCC 2023 Collection Page https://www.medscape.com/viewcollection/36966 ESC 2023 Top Trials - Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844 - Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2306963 - Acoramidis Shows Encouraging Results in ATTR Cardiomyopathy https://www.medscape.com/viewarticle/995883 ESC 2023 Collection Page https://www.medscape.com/viewcollection/36988 AHA 2023 Top Trials - Semaglutide 'A New Pathway' to CVD Risk Reduction: SELECT https://www.medscape.com/viewarticle/998373 - Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 - Bariatric Surgery is Associated With Improved Coronary Microvascular Function and Cardiorespiratory Fitness in Patients With Ischemia and Non-Obstructive Coronary Arteries https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.18949 - Angioplasty Finally Proven Beneficial in Stable Angina: ORBITA-2 https://www.medscape.com/s/viewarticle/998375 - A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina https://www.nejm.org/doi/full/10.1056/NEJMoa2310610 - Impressive Bleeding Profile With Factor XI Inhibitor in AF: AZALEA https://www.medscape.com/viewarticle/998418 - Promising First Results With DNA Editing to Lower LDL https://www.medscape.com/s/viewarticle/998719 - Single Injection Reduces Blood Pressure for 6 Months: KARDIA-1 https://www.medscape.com/viewarticle/998666 AHA 2023 Collection Page https://www.medscape.com/viewcollection/37277 Other Mentions - N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173 - Rimonabant: From RIO to Ban https://doi.org/10.1155%2F2011%2F432607 - Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial https://doi.org/10.1016/S0140-6736(17)32714-9 - Asundexian Phase 3 AF Study Halted for Lack of Efficacy https://www.medscape.com/viewarticle/998665 - Challenges in the Design and Interpretation of Noninferiority Trials https://www.nejm.org/doi/full/10.1056/nejmra1510063 - Milvexian for the Prevention of Venous Thromboembolism https://www.nejm.org/doi/full/10.1056/NEJMoa2113194 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington and Manesh Patel discuss sudden cardiac death in athletes and the importance of the chain of survival. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington COVID and the Athlete's Heart https://www.medscape.com/viewarticle/945282 Outcomes Registry for Cardiac Conditions in Athletes https://doi.org/10.1161/JAHA.122.029052 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy https://doi.org/10.1161/CIR.0000000000000937 Point-of-care screening for HFrEF using artificial intelligence during ECG-enabled stethoscope examination https://doi.org/10.1016/s2589-7500(21)00256-9 International recommendations for electrocardiographic interpretation in athletes https://doi.org/10.1093/eurheartj/ehw631 Elevation of Cardiac Troponins After Endurance Running Competitions https://doi.org/10.1161/CIRCULATIONAHA.118.034655 Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy https://doi.org/10.1001/jamacardio.2023.1042 Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, Principles, and General Considerations https://doi.org/10.1161/CIR.0000000000000236 RACE-CARS Trial https://racecarstrial.org/ AHA CPR Resources https://cpr.heart.org/en/cpr-courses-and-kits/hands-only-cpr You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine   https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology   https://www.medscape.com/twic Questions or feedback, please contact   news@medscape.net

Bob Harrington interviews Jag Singh about the COVID journey that led to his book, Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine. https://www.jagsinghmd.com/book COVID-19 Hits Physician Couple: Dramatically Different Responses https://www.medscape.com/viewarticle/928530 Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study https://doi.org/10.1016/j.ijcard.2021.01.002 The Care of the Patient https://doi.org/10.1001/jama.1927.02680380001001 Advancements and future directions in the teamwork, targets, technology, and tight control-the 4T study: improving clinical outcomes in newly diagnosed pediatric type 1 diabetes https://doi.org/10.1097/mop.0000000000001140 Social determinants of telemedicine utilization in ambulatory cardiovascular patients during the COVID-19 pandemic https://doi.org/10.1093/ehjdh/ztab039 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact: news@medscape.net

Robert Harrington, MD and Jenine John, a cardiologist and machine learning research fellow discuss what you need to know about AI and ML in healthcare and where to find some helpful resources. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington 'One Brave Idea' Recipient on Predicting Who Will Develop CAD https://www.medscape.com/viewarticle/874536 Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection https://doi.org/10.1161/circulationaha.121.058696 Application of Artificial Intelligence to the Electrocardiogram https://doi.org/10.1093/eurheartj/ehab649 Using Machine Learning to Detect Problems in ECG Data Collection https://www.cinc.org/archives/2011/pdf/0437.pdf Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs https://doi.org/10.1161/CIRCEP.119.007284 External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients http://jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2021.2626 Sepsis Predictor Tool Falls Short in Emergency Setting https://www.medscape.com/viewarticle/982534 Dissecting Racial Bias in an Algorithm Used to Manage the Health of Populations https://doi.org/10.1126/science.aax2342 Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms https://jamanetwork.com/journals/jama/fullarticle/2770833 Can Medical Algorithms Be Fair? Three Ethical Quandaries and One Dilemma https://doi.org/10.1136/bmjhci-2021-100445 Healthcare Machine Learning: Getting Started https://medium.com/@jeninej/healthcare-machine-learning-getting-started-761a7dbb63a2 What Clinicians Should Know About Healthcare AI, Part 1: Why Care About AI? https://medium.com/@jeninej/what-clinicians-should-know-about-healthcare-ai-part-1-why-care-about-ai-aba6a06f696d AI in Healthcare Specialization https://www.coursera.org/specializations/ai-healthcare You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine: https://www.medscape.com/features/public/machine Hear John Mandrola, MD's, summary and perspective on the top cardiology news each week, on This Week in Cardiology: https://www.medscape.com/twic Questions or feedback, please contact: news@medscape.net

Bob Harrington talks to two former colleagues who made a mid- and senior-career switch to pharma and digital tech, respectively. How did they make this decision and what advice do they have for others? This podcast is intended for healthcare professionals only. To read a transcript or to comment https://www.medscape.com/author/bob-harrington Jeff Bezos - Regret Minimization https://www.youtube.com/watch?v=-qPii5ACVYw You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Trials on heart failure, hypertension and lipid-lowering drugs, and the evolution of antithrombin and antiplatelet therapy are discussed in part 2 of cardiologists Bob Harrington and Mike Gibson's annual review. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Lipid Lowering Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure (STRONG-HF): A Multinational, Open-Label, Randomised, Trial https://doi.org/10.1016/S0140-6736(22)02076-1 Why Combination Lipid-Lowering Therapy Should Be Considered Early in the Treatment of Elevated LDL-C for CV Risk Reduction https://www.acc.org/latest-in-cardiology/articles/2022/06/01/12/11/why-combination-lipid-lowering-therapy-should-be-considered Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs to Improve Statin Rates (NOTIFY-1 Project) https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062746 Equivalent Impact of Elevated Lipoprotein(a) and Familial Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease https://doi.org/10.1016/j.jacc.2022.09.021 Comparative Effects of Low-Dose Rosuvastatin, Placebo and Dietary Supplements on Lipids and Inflammatory Biomarkers https://doi.org/10.1016/j.jacc.2022.10.013 Antihypertensive Drugs No Survival Advantage for Either Torsemide or Furosemide in HF: TRANSFORM-HF https://www.medscape.com/viewarticle/983611 Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events www.nejm.org/doi/full/10.1056/NEJMoa2212270 Antiplatelets Duration of Antiplatelet Therapy After Complex Percutaneous Coronary Intervention in Patients at High Bleeding Risk: A MASTER DAPT Trial Sub-analysis https://doi.org/10.1093/eurheartj/ehac284 PANTHER: Should Clopidogrel Become the 'New Aspirin' in CAD? https://www.medscape.com/viewarticle/980117 P2Y12 Inhibitor Versus Aspirin Monotherapy for Secondary Prevention of Cardiovascular Events: Meta-analysis of Randomized Trials https://doi.org/10.1093/ehjopen/oeac019 Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes https://doi.org/10.1056/nejmoa0904327 TCT-320 Pharmacokinetic and Pharmacodynamic Profile of PL-ASA, a Novel Phospholipid-Aspirin Complex Liquid Formulation, Compared to Enteric-Coated Aspirin at an 81-mg Dose – Results From a Prospective, Randomized, Crossover Study https://www.jacc.org/doi/10.1016/j.jacc.2021.09.1173 Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation https://europepmc.org/article/pmc/pmc8773391 Antithrombins/Factor XI Rivaroxaban in Patients With a Recent Acute Coronary Syndrome https://www.nejm.org/doi/full/10.1056/nejmoa1112277 Genetically Determined FXI (Factor XI) Levels and Risk of Stroke https://doi.org/10.1161/strokeaha.118.022792 Factor XIa Inhibition With Asundexian After Acute Non-cardioembolic Ischaemic Stroke (PACIFIC-Stroke): an International, Randomised, Double-Blind, Placebo-Controlled, Phase 2b Trial https://doi.org/10.1016/s0140-6736(22)01588-4 Safety of the Oral Factor Xia Inhibitor Asundexian Compared With Apixaban in Patients With Atrial Fibrillation (PACIFIC-AF): a Multicentre, Randomised, Double-Blind, Double-Dummy, Dose-Finding Phase 2 Study https://doi.org/10.1016/S0140-6736(22)00456-1 A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction https://doi.org/10.1161/circulationaha.122.061612 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback? Please contact news@medscape.net

In part 1 of their annual review, cardiologists Bob Harrington and Mike Gibson discuss in-person meetings, wearables and AI, COVID lessons for medical research, and the growth of RCTs from China. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington COVID Therapies Therapeutic Anticoagulation With Heparin in Noncritically Ill Patients With Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2105911 Effect of Intermediate/High Versus Low Dose Heparin on the Thromboembolic and Hemorrhagic Risk of Unvaccinated COVID-19 Patients in the Emergency Department https://doi.org/10.1186/s12873-022-00668-8 Two Old Meds and a DOAC a Bust Across Range of COVID Severity: The ACT Trials https://www.medscape.com/viewarticle/980049 Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial http://jamanetwork.com/article.aspx?doi=10.1001/jama.2022.18590 FDA Halts Use of Some COVID Monoclonal Antibodies Due to Omicron https://www.medscape.com/viewarticle/967210 CT Surgeons Rise to Challenge, Lead Way in COVID Clinical Trials https://www.sts.org/publications/sts-news/ct-surgeons-rise-challenge-lead-way-covid-clinical-trials What Do We Know About Long COVID: A Cardiovascular Focus https://www.medscape.com/viewarticle/981435 COVID-19 and the Heart: Is Cardiology Ready? https://www.medscape.com/viewarticle/969206 The Stanford RECOVER Trial https://recovercovid.org/ The Heroes Study https://heroesresearch.org/ Artificial Intelligence Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs https://doi.org/10.1161/CIRCEP.119.007284 The Heartline Study https://www.heartline.com/about Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039 Recognizing a Ruler Instead of a Cancer https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/ Machine Learning Did Not Beat Logistic Regression in Time Series Prediction for Severe Asthma Exacerbations https://doi.org/10.1038/s41598-022-24909-9 A Systematic Review Shows No Performance Benefit of Machine Learning Over Logistic Regression for Clinical Prediction Models https://doi.org/10.1016/j.jclinepi.2019.02.004. Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection https://doi.org/10.1161/circulationaha.121.058696 Detection of Hypertrophic Cardiomyopathy Using a Convolutional Neural Network-Enabled Electrocardiogram https://doi.org/10.1016/j.jacc.2019.12.030 Here's Why We're Not Prepared for the Next Wave of Biotech Innovation (by Matthew Herper) https://www.statnews.com/2022/11/03/why-were-not-prepared-for-next-wave-of-biotech-innovation/ RCTs from China Bivalirudin Plus a High-Dose Infusion Versus Heparin Monotherapy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Randomised Trial https://doi.org/10.1016/S0140-6736(22)01999-7 Chinese Herbal Medicine May Offer Benefits in STEMI: CTS-AMI https://www.medscape.com/viewarticle/983619 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week on This Week in Cardiology https://www.medscape.com/twic Questions or feedback? Please contact news@medscape.net

Drs Bob Harrington and Betty Raman discuss the cardiovascular impact and long-term sequelae of COVID-19, the potential biology behind multisystem effects, and ongoing research. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Medium-term Effects of SARS-CoV-2 Infection on Multiple Vital Organs, Exercise Capacity, Cognition, Quality of Life and Mental Health, Post-Hospital Discharge https://doi.org/10.1016/j.eclinm.2020.100683 Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection https://doi.org/10.1016%2Fj.jacc.2020.06.007 Outcomes Among Confirmed Cases and a Matched Comparison Group in the Long-COVID in Scotland Study https://doi.org/10.1038/s41467-022-33415-5 Long COVID: Post-Acute Sequelae of COVID-19 With a Cardiovascular Focus https://doi.org/10.1093/eurheartj/ehac031 Cardiovascular Disease and COVID-19: A Consensus Paper From the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in Collaboration With the European Heart Rhythm Association (EHRA) https://doi.org/10.1093/cvr/cvab298 Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients https://doi.org/10.3390/ijms222111622 COVID-19 and Fat Embolism: A Hypothesis to Explain the Severe Clinical Outcome in people With Obesity https://pubmed.ncbi.nlm.nih.gov/32514077 Association Between Epstein-Barr-Virus Reactivation and Development of Long-COVID Fatigue https://doi.org/10.1111/all.15471 Activation or Exhaustion of CD8+ T Cells in Patients With COVID-19 https://doi.org/10.1038/s41423-021-00750-4 Skeletal Muscle Alterations in Patients With Acute COVID-19 and Post-Acute Sequelae of COVID-19 https://doi.org/10.1002/jcsm.12896 Gut Microbiota Dynamics in a Prospective Cohort of Patients With Post-Acute COVID-19 Syndrome http://dx.doi.org/10.1136/gutjnl-2021-325989 COVID-Vaccine Myocarditis: Rare, Mild, and Usually a Guy Thing https://www.medscape.com/viewarticle/966244 Myocardial Injury Pattern at MRI in COVID-19 Vaccine–Associated Myocarditis https://doi.org/10.1148/radiol.212559 Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm? https://doi.org/10.3389/fimmu.2020.607734 Myocarditis Associated With COVID-19 Vaccination https://doi.org/10.1161/CIRCIMAGING.121.013236 COVID and the Athlete's Heart https://www.medscape.com/viewarticle/945282 COVID-19 and the Heart: Is Cardiology Ready? https://www.medscape.com/viewarticle/969206 Lung Abnormalities Depicted With Hyperpolarized Xenon MRI in Patients With Long COVID https://doi.org/10.1148/radiol.220069 Long COVID Resource Center https://www.medscape.com/resource/long-covid You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine. Hear John Mandrola, MD's, summary and perspective on the top cardiology news each week on This Week in Cardiology. Questions or feedback, please contact news@medscape.net

Do cardiologists from the AFFIRM generation treat AF less aggressively than the EAST-AFNET generation? Bob Harrington and Jonathan Piccini discuss this and upcoming trials on atrial fibrillation. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation (AFFIRM) https://www.nejm.org/doi/full/10.1056/NEJMoa021328 Early Rhythm-Control Therapy in Patients with Atrial Fibrillation (EAST-AFNET 4) https://www.nejm.org/doi/10.1056/NEJMoa2019422 Early AF Rhythm-Control Advantage Climbs With Comorbidity Burden: EAST-AFNET4 https://www.medscape.com/viewarticle/979627 Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB) https://clinicaltrials.gov/ct2/show/NCT05130268 Generalizability of the EAST‐AFNET 4 Trial: Assessing Outcomes of Early Rhythm‐Control Therapy in Patients With Atrial Fibrillation https://doi.org/10.1161/JAHA.121.024214 Early Rhythm Control Therapy for Atrial Fibrillation in Low-Risk Patients A Nationwide Propensity Score–Weighted Study https://doi.org/10.7326/M21-4798 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Dr Bob Harrington talks with Drs Michelle Albert and Eldrin Lewis about the Association of Black Cardiologists' diversity scorecard for cardiovascular training programs. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington The ABC Updates its CV DIBS Rankings | Association of Black Cardiologists https://abcardio.org/recent-news/the-abc-updates-its-cv-dibs-rankings/ FDA Takes Important Steps to Increase Racial and Ethnic Diversity in Clinical Trials https://www.fda.gov/news-events/press-announcements/fda-takes-important-steps-increase-racial-and-ethnic-diversity-clinical-trials Gender Diversity in Cardiovascular Clinical Trial Research Begins at the Top https://www.jacc.org/doi/abs/10.1016/j.jacc.2022.01.001 A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops https://www.nejm.org/doi/full/10.1056/NEJMoa1717250 At Black Barbershops, BP Reductions Still in Style at 1 Year https://www.medscape.com/viewarticle/906724 Physician-Patient Racial Concordance and Disparities in Birthing Mortality for Newborns https://doi.org/10.1073/pnas.1913405117 Racial and Ethnic Diversity at Medical Schools -- Why Aren't We There Yet? https://www.nejm.org/doi/full/10.1056/NEJMp2105578 Medical School Enrollment More Diverse in 2021 https://www.aamc.org/news-insights/press-releases/medical-school-enrollment-more-diverse-2021#r You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact: news@medscape.net

Robert A. Harrington interviews LaShyra Nolen, a medical student and the 2021 recipient of the American Medical Student Association's Racial Justice in Medicine Award. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington How Medical Education Is Missing the Bull's-eye https://doi.org/10.1056/NEJMp1915891 This Is What I Want To Tell My White Professors When They Ask, 'How Are You Today?' https://www.huffpost.com/entry/black-medical-student-wants-white-professors-to-know_n_5ed91238c5b6e0feefc26315 Statue of Controversial Surgeon to Be Moved From Central Park https://www.medscape.com/viewarticle/891413 A Rift Over Carl Linnaeus Shows We Shouldn't Idolise Scientists https://science.thewire.in/the-sciences/carl-linnaeus-entomological-society-of-america-great-man-theory-progress/ Running Away from Drapetomania: Samuel A. Cartwright, Medicine, and Race in the Antebellum South https://muse.jhu.edu/article/699875 What Led Chicago to Shutter Dozens of Majority-Black Schools? Racism https://www.theguardian.com/us-news/2018/dec/06/chicago-public-schools-closures-racism-ghosts-in-the-schoolyard-extract Call to Action: Structural Racism as a Fundamental Driver of Health Disparities: A Presidential Advisory From the American Heart Association https://doi.org/10.1161/CIR.0000000000000936 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact: news@medscape.net