An interview with Dr Chloe Anthias, medical director of the new Cell Collection Centre has just opened by Anthony Nolan charity as part of our NIHR Nottingham Clinical Research Facility. Links a little while ago I talked to Prof Mark Bishton, who’s an oncologist at the hospital about stem cell research. Listen here NIHR Nottingham Clinical Research Facility To find out more about the Anthony Nolan Cell Collection Centre, to donate to Anthony Nolan or to find out how to join the stem cell register, visit: www.anthonynolan.org This Podcast is brought to you by the NIHR Nottingham Clinical Research Facility. Follow us on @NottmCRF, or email Nottingham research. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
Asthma is one of the most common conditions - there are 8 million of us in the UK who suffer from it. t can range from the needing a quick puff on your inhaler if you exercise and there’s a lot of pollen about it, to serious, fatal attacks, there’s still a lot we don’t know. That’s what this interview with our respiratory physician Matthew Martin is all about. One of the things we’re not sure about is to do with how people with inhalers use them - short version, we might doing it all wrong, then again we might not, this is research after all - and that’s what the second bit of the interview you’re about to hear covers. More on the APEX trial: https://nottinghambrc.nihr.ac.uk/research/respiratory/airway-disease-theme
The intro this week was from Harriet Anderson, who works in the Research and Innovation team at Nottingham University Hospitals NHS Trust. Keep listening for more team members introducing other episodes. If you're a clinical researcher at NUH or the University of Nottingham and want to be voice of the podcast contact us at R&Icomms@nuh.nhs.uk. Links Mental health citizen science - www.gladstudy.co.uk Participant in Research Experience Survey - The results for NUH: https://www.nuh.nhs.uk/ri-feedback, and for people in the East Midlands: https://sites.google.com/nihr.ac.uk/crneastmidspres/survey NHS East Genomics - https://www.eastgenomics.nhs.uk/for-healthcare-professionals/genomic-tests/ Liver walks: email Abhishek Sheth at nuhtnt.nottinghamhepatology@nhs.net LifeArc Centre for Rare Respiratory Diseases Willow Tranter appeal - https://www.justgiving.com/page/willowsjourneywithall and Cure Leukaemia https://www.cureleukaemia.co.uk/ Babi study - https://www.babinetwork.co.uk/ This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts or Spotify especially. It's For Science.
You’d think that clinical researchers would welcome surprises - but they don’t. Even if the results are new and groundbreaking, they want their trials and studies to run in a predictable, controlled way,. And that ability to deliver a total lack of surprise is one of the reasons that cancer research at Nottingham University Hospitals NHS Trust has made it into the top flight in the UK working with major pharmaceutical companies. As well as clinical and scientific excellence, it’s about building up relationships with our partners so that we know we can deliver on recruiting patients, managing the pharmacy needs, and study set up. The focus is particularly on chemo-free approach to lymphoma treatment, immunotherapy such as CAR T therapy, bispecific antibodies and using data analysis to target treatments. I talked to Professor Mark Bishton, who’s a consultant haemotologist and the divisional co-lead for research and innovation into cancer and associated. As well as his own research, he’s responsible for delivering the trust’s studies in the specialty. More information at https://www.nuh.nhs.uk/research-in-cancer This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
Staff at the NIHR Nottingham Clinical Research Facility talk about the UCAB trial. The facility worked with Swedish pharmaceutical Umecrime Cognition to study using a new molecule as a treatment for Primary Biliary Cholangitis (PBC) for patients with severe symptoms of fatigue and cognitive impairment. Quick takeaways - • one of only two UK locations for first stage drug trial • kept to tight, complex timelines • exceeded recruitment targets by building on existing relationships • patients praised care and treatment The NIHR Nottingham Clinical Research Facility (CRF) was one of just two centres worldwide – and the only UK facility – to conduct the first part of a clinical study. We were picked because of our expertise in liver disease. We hosted five patients on a purpose-built inpatient ward within the CRF, to confirm the correct dose of the molecule. During their seven-day stay, our team of research nurses and physicians assessed and cared for the patients around the clock. Nottingham CRF has 18 adult and five paediatric inpatient beds dedicated for research, alongside our dedicated outpatient and specialist clinics. In total, there is over 3,400m² of clinical space at our CRF. The PBC study was a randomised, double-blinded and placebo controlled two-part study to evaluate the pharmacokinetics, safety and tolerability, and preliminary efficacy of two dose levels of the new drug. There’s more about it at https://nottinghamcrf.nihr.ac.uk/facilities/case-studies Follow us on Twitter: @NottmBRC Follow us on Instagram: @NottmHealthScience Follow us on Facebook: https://www.facebook.com/ResearchNottingham Watch a video explainer about clinical trials: https://youtu.be/SWS4FCSMWAQ Read more at https://www.nottinghamresearch.org/get-involved and https://www.nuh.nhs.uk/take-part-in-a-trial and https://www.nuh.nhs.uk/researchvolunteers Email us at getinvolved@nuh.nhs.uk
Contacts for his episode: COACH trial for hearing aids vs cochlear implants - More information from coachtrial.ac.uk or email coach@nottingham.ac.uk Ultrasound probe for people with trauma injuries - contact Georgia Melia at georgia.melia@nuh.nhs.uk The studies in Norfolk and Leicester into communities and genomics - www.eastgenomics.nhs.uk or email the East Genomic Medicine Service Alliance (GMSA) at egmsa@nnuh.nhs.uk The Healthcare Scientists Research Showcase tickets are at https://www.eventbrite.co.uk/e/healthcare-scientists-research-showcase-tickets-835899837917
Bulletin 9 - developing treatments for cystic fibrosis, depression, alcoholic liver disease and eczema In this episode: We pick up on presentations from the NIHR Nottingham BRC conference, from: Dr Helen Barr, on matching medicines to gene for CF patients Prof Richard Morriss on treating depression and anxiety with transcranial magnetic stimulation - https://www.mindtech.org.uk/news-events/latest-news/brightmind-trial-improves-the-lasting-effects-of-treatment-for-severe-depression A Q and A on alcoholic liver disease - https://youtu.be/orJBGWAo8fM Finding out how often should you shower if you eczema - rapideczematrials.org/eczema-bathing-study Our YouTube channel: @NottinghamClinicalResearch This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
In this bulletin: Testing the Respirasense breathing monitor from PMD Solutions - https://www.pmd-solutions.com - https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3944-respirasense-trial Bone graft augmentation and gene therapy research with Theragenix - https://theragenix.health/ https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3942-nearly-1m-for-pioneering-gene-therapy-formulation-for-bone-graft-augmentation Rib fracture pain relief - https://orif.octru.ox.ac.uk/ https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3949-can-innovative-surgery-cut-mortality-after-major-trauma-injuries Medicine showcases Clinical Academie Research Partnership awards - https://www.nihr.ac.uk/documents/clinical-academic-research-partnership-carp/30439 Robot urology surgery to lessen erectile dysfunction - https://www.theurologyfoundation.org/get-involved/urology-awareness-month
In this bulletin: Secure Data Environments - https://transform.england.nhs.uk/key-tools-and-info/data-saves-lives/secure-data-environments/ Prof Guru Aithal appointed new medical lead for the Eastern Genomic Medicine Service Alliance - https://www.eastgenomics.nhs.uk Showcase of gastro intestinal research at Nottingham Meet the respiratory research team - with pizzas Networking for early career imaging researchers If you want to stay up to day with the clinical research podcast, you can find us on iTunes, Spotify, Google and where-ever you normally get your podcasts. The more shows are rated and reviewed, the easier it is for search engines to find us, so if you can subscribe and rate and review us, you'll be doing it for science. This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk, or visit nuh.nhs.uk/research for more information. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially.
Spend an evening with blood, urine, saliva and Nottingham researchers, looking to the future of research at NUH, helping children and young people with mental crises, and how to show a researcher you love them. Links: BioResource event booking - https://www.eventbrite.com/e/574447577167 NUH medical director Keith Girling on why the Nottingham BioResource is good for patients – https://youtu.be/AC49MnM_CtY Previous podcast with Natasha Hill, Nottingham bioresource manager - https://youtu.be/bQJ0S4l7uF8 SaPHE study explained - https://youtu.be/ldtPG21slEo Book tickets to the SaPHE study even - https://www.eventbrite.co.uk/e/the-saphe-study-disseminationcelebration-event-tickets-549208496397 SaPHE study website - sites.google.com/nihr.ac.uk/saphepathway/home NIHR Nottingham Clinical Research Facility – www.nottinghamcrf.nihr.ac.uk NUH medical director Keith Girling on talks about the CRF video - https://youtu.be/DWre8K7z4NQ UK CRF conference Registration - https://meetinnottingham.bzon.uk/ukcrf23-registration/ Staff awards - https://www.nuh.nhs.uk/research-excellence-awards-2023 Download a transcript of this episode. This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
In this clinical research bulletin from Nottingham: Notts County legend Les Bradd has been helping our researchers investigating football-related injuries. https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3927-notts-county-fc-legend-les-is-helping-researchers-investigating-playing-injuries We hit national and international headlines this week for study which identified 500 genes linked to lung health https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3932-nottingham-researchers-lead-gene-study-to-enable-personalised-lung-health-care a review of Covid treatments for vulnerable people in Nottingham showed that being white, female and better-off, meant you were more likely to accept covid-19 treatment https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3930-white-female-better-off-vulnerable-patients-more-likely-to-accept-covid-19-treatment-nottingham-study-shows If you fancy spending an evening discussing the possible uses of blood, urine, saliva and body tissue, together with their related health data, then we have an online event you’ll love - https://www.eventbrite.com/e/574447577167 If you want to stay up to day with the clinical research podcast, you can find us on iTunes, Spotify, Google and where-ever you normally get your podcasts. The more shows are rated and reviewed, the easier it is for search engines to find us, so if you can subscribe and rate and review us, you'll be doing it for science. This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC or email R&Icomms@nuh.nhs.uk, or visit nuh.nhs.uk/research for more information. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially.
In this episode - clinical research news of ASSIST MS study, World Hearing Day, NIHR researcher appointments, Liver Partnership launch, and the Tummy Tracker app for cystic fibrosis patients. Links ASSIST-MS - https://www.nihr.ac.uk/news/ground-breaking-ai-research-aims-to-improve-tests-and-treatments-for-thousands-of-patients/32852 World Hearing Day - https://worldhearingday.org/ Nottingham partnership - 3925-people-living-with-dementia-and-hearing-conditions-invited-to-shape-future-research Prof Morriss reconfirmed - https://arc-em.nihr.ac.uk/news-events/news/arc-east-midlands-theme-lead-reappointed-nihr-senior-investigator NIHR Nottingham BRC Mental Health and Technology researchers -https://nottinghambrc.nihr.ac.uk/research/mental-health-technology/mental-health-technology-team NIHR Nottingham BRC leadership team - https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/leadership-team KLIFAD open access registration - https://bmjopen.bmj.com/content/bmjopen/11/11/e054954.full.pdf Dr Subhani talks about the Liver Partnership - https://youtu.be/7BZEB6VbeHQ NIHR Nottingham BRC Gastrointestinal & Liver team https://nottinghambrc.nihr.ac.uk/research/gastrointestinal-liver/gastrointestinal-liver-team CF Tummytracker app - https://cftummytracker.org This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUHand @NottmBRC, or email R&Icomms@nuh.nhs.uk, or visit nuh.nhs.uk/researchfor more information.
Weekly updates from research and innovation team at Nottingham University Hospitals NHS Trust and NIHR Nottingham Biomedical Research Centre Links Methotrexate study - https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3925-methotrexate-study Tinnitus research - https://www.mdpi.com/2076-3425/12/4/484 PrAISED study - Video - https://youtu.be/VB6GET95Sgg - https://www.nottingham.ac.uk/research/groups/healthofolderpeople/projects/praised/ University of Nottingham respiratory research professorship application - https://jobs.nottingham.ac.uk/vacancy.aspx?ref=MED630022 CARP research grants - https://www.nihr.ac.uk/documents/clinical-academic-research-partnerships-carp/30439 BRAID breast cancer study - https://www.nottingham.ac.uk/research/groups/nottinghambreastcancerresearchcentre/index.aspx More information about research and innovation in general at Nottingham on the Nottingham University Hospital NHS Trust website which is www.nuh.nhs.uk/research, and about the NIHR Nottingham Biomedical Research Centre on our website, which is at nottinghambrc.ac.uk - and ourr email and social media links are there too. If you want to stay up to day with the clinical research podcast, you can find us on iTunes, Spotify, Google and where-ever you normally get your podcasts. The more shows are rated and reviewed, the easier it is for search engines to find us, so if you can subscribe and rate and review us, you'll be doing it for science.
Our guest this episode is Helen Navarra from the Children's Research Team at Nottingham University Hospitals NHS Trust. Helen is in conversation with Andrew Bennett and explains how COVID-19 changed everything for families taking part in clinical research at our hospitals. Helen herself is one of several members of the Children's Research Team, as well as the whole team and the work they did in partnership with the Cripps Health Centre in Nottingham, who received multiple nominations in our COVID-19 Research Heroes Awards last year. Helen explains the support they were able to give to children, young people and families which enabled them to take part in COVID-19 research. You can listen to interviews with some of our other COVID-19 Research Heroes, and many more people speaking about their research, by subscribing to The Clinical Research Podcast on your favourite Podcast app. This will help the work of heroes like the Children's Research Team get to a wider audience and to spread the word about research more generally. Thank you.
We’ve launched a new podcast, it’s a short update on research in Nottingham, and it’s for both researchers and anyone interested in clinical research and it’s out every fortnight. The first episode covers the Nottingham methotrexate study which has piqued worldwide interest and sparked tens of thousands of tweets, as well as research into dementia, tinnitus and breast cancer. We’ve also got details of grants, job vacancies and other support for researchers. If you’re already subscribed to the Nottingham Clinical Research podcast, it’ll show up in your feed without you doing anything at all. If you’re not, search for Nottingham Clinical Research where-ever you normally get your podcast.
As the NIHR Nottingham Biomedical Research Centre embarks on its second tranche of funding, we're developing our existing partnerships with other clinical research organisations in the East Midlands, especially Nottingham Trent University. One of our closest links there is Professor John Hunt, who's Head of NTU's medical technologies and advanced materials research theme. He's also just taken on a role as deputy director of the NIHR Nottingham Clinical Research Facility, based at Nottingham University Hospitals NHS Trust. I talked to him about his own research in clinical sciences, and particularly biomaterials, as well as his new role at the clinical research facility Links NIHR Nottingham Biomedical Research Centre NIHR Nottingham Clinical Research Facility NTU's Medical Technologies Innovation Facility This Podcast is brought to you by the NIHR Nottingham Biomedical Research Centre. Follow us on @NottmBRC, or email Nottingham research. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
October is a vital and important month for many ethnic minorities especially the Black community. In the UK Black History Month is celebrated every year with a different theme. This year’s theme is ‘Action not words’. In recent years we have seen the rise of Black communities and individuals sharing their experiences about the inequalities and injustices they go through. In this episode we speak to Tony Ndung’u, an emergency department nurse with a passion for research. We discussed the meaning of this year’s BHM theme, also his journey into research and Pre-doctoral Clinical and Practitioner Academic Fellowship Scheme also known as the PCAF, looking at where ethnic minorities get their health information particularly during the pandemic. The Health Education England (HEE)/NIHR scheme offers salaried time to develop a doctoral fellowship application and to undertake funded academic training. It’s open to early career researchers from the health and care professions (excluding doctors and dentists) who are committed to a clinical academic or practitioner academic career.
Leaps forward in the understanding of the Human Genome in recent years stand to offer huge benefits to patients - including the possibility of personalised care. As a large acute hospital, Nottingham University Hospitals NHS Trust is one of the organisations at the forefront of this exciting health revolution, which also brings some challenges. But what does Genomics mean in reality to healthcare professionals working at NUH? And how can they access genetic medicine services - including testing for patients, in their day-to-day practice? Dr Matt Hall, a consultant nephrologist based at Nottingham University Hospitals NHS Trust, is medical lead for the Genomics Medicines Service Alliance (GMSA), which is trying to embed genetic medicine into everyday practice. Episode links: The National Genomic Test Directories - www.england.nhs.uk/publication/national-genomic-test-directories/ East Genomics – eastgenomics.nhs.uk. This includes information on how to request a test for your patients If you are a clinician: https://www.eastgenomics.nhs.uk/for-healthcare-professionals/genomic-tests/referral-forms-index/ Genomics Education resources – genomicseducation.hee.nhs.uk This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
Genomics is the future of healthcare which we’re told will revolutionise how patients are treated – but what is it, exactly? And how can healthcare professionals use it day to day? Dr Matt Hall, a Consultant Nephrologist at Nottingham University Hospitals NHS Trust, is the medical lead for the Genomics Medicines Service Alliance (GMSA), which means he’s leading how genetic medicine is becoming embedded in everyday practice, and he’s our next interviewee. So now’s your chance to find out in the next episode the Clinical Research podcast.
Nottingham's long been a leader in researching and treating blood cancer - we pioneered blood stem cell transplantation and we're still one of the biggest centres in the UK. We bring together oncology, clinical haemotology, neuro imaging and surgery and over the last five years we've increased our experimental cancer research trials by 30 percent. So it's naturally one of the priorities of our new Clinical Research Facility, which recently had its £2.6 million pound funding confirmed by the National Institute for Health and Social Care Research. The Nottingham facility's team delivers early phase experimental trials not just in cancer, but across the board, including areas such as gastro intestinal disorders, inflammatory conditions, musculoskeletal conditions and respiratory diseases. It's closely integrated with the hospital and is expanding its inpatient, day beds and out patient facilities, including for children as well as adults. Its new deputy director is Professor Chris Fox, a consultant haematologist at Nottingham University Hospitals NHS Trust, who has a track record of research into lymphoma and stem cell transplantation, among other things. I spoke to him as he was taking up his new post. Links NIHR Nottingham Clinical Research Facility Follow Prof Fox on Twitter Cancer research at Nottingham University Hospitals NHS Trust This Podcast is brought to you by the NIHR Nottingham Biomedical Research Centre. Follow us on @NottmBRC, or email Nottingham research. If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.