The Drug Science Podcast

Join us in this episode as we speak with Emma Robinson, a professor of psychopharmacology at the University of Bristol with extensive experience in animal research. She unpacks the regulations surrounding animal research, offering a scientist’s view on animal rights activism, ethical tension, and why this work remains essential. Robinson also delves into the emerging intersection of psychedelics and animal research, describing how these substances are studied and how they might help reshape mental illness. Professor Emma RobinsonUK Government’s Roadmap to Ending Animal TestingPETA ConfrontationCognitive and affective models of psychedelics in rodentsPsilocybinKetamineBritish Neuroscience lecture with Prof Robinson and Prof NuttThe 3Hs Initiative ★ Support this podcast ★

In this episode of the Drug Science Podcast, we talk to Simon Doherty, a journalist and content creator with a focus on harm reduction. He explores how reporting on electronic music and rave culture naturally led to his work on harm reduction. He goes on to dissect Talk to Frank and its flaws in providing accurate, evidence-based information. Finally, by comparing the unique landscape of free parties to the regulated club scene, Doherty discusses why and how clubs avoid common sense harm reduction techniques, endangering clubgoers. LinksSimon’s TikTokInvestigating Talk to FrankCalling FrankThe LoopRave Aid CrewGHB/GHLKetamineNitazenes ★ Support this podcast ★

Join us in this episode as we talk to Prof Sara Tai, a professor of clinical psychology at the University of Manchester and an NHS consultant clinical psychologist. Sara’s research is grounded in biopsychosocial frameworks, with a focus on understanding the mechanisms of change that underpin effective psychological therapies. She has extensive experience delivering therapy, and training other clinicians to deliver interventions with individuals, families, and young people across diverse settings, including acute in-patient units, community mental health services, and schools.For many years, Sara has been at the forefront of research into psychedelic-assisted therapies, working collaboratively with academic and industry partners to explore how psychedelics bring about therapeutic change. She has been instrumental in manualising psychological support models that integrate the core effective components shared across evidence-based psychotherapies, helping to define best practice in this rapidly advancing area. An experienced researcher, clinician, and trainer, Sara has led and collaborated on large-scale randomised controlled trials and has played a central role in training psychedelic therapists worldwide. Her work continues to bridge scientific research and clinical practice, advancing safe, effective, and compassionate approaches to mental health care.Sara explores her research into the oft-overlooked role of therapy within psychedelic treatments. She discuses how her work has helped to challenge the notion of psychedelic compounds as medicine in themselves, shifting the focus onto the therapeutic approaches alongside them. Ultimately, Sara underscores the need for more transformative psychedelic experiences grounded in peer support, indigenous knowledge, or therapeutic experience in order to facilitate positive outcomes. Links Prof Sara Tai Cognitive Behavioural Therapy Acceptance and Commitment Therapy Method of Levels ★ Support this podcast ★

In this episode, we speak with Adam Zmith, podcast producer, writer, and author of Deep Sniff: A History of Poppers and Queer Futures. He describes his motivation behind writing the book, all before diving into the complex history of poppers. By speaking to the policing and regulation of poppers, Zmith explores broader struggles between the queer community and the government, in addition to the necessity for greater harm reduction for poppers. Despite these struggles, he underscores the ways in which queer culture has been shaped by poppers and how, in return, poppers have been shaped by queer culture. Links●      Adam Zmith●      Deep Sniff●      Poppers●      The Log Books●      Switchboard●      Sir Thomas Lauder Brunton●      UK Man Consumes Poppers Accidentally ★ Support this podcast ★

Join us in this episode as Prof Nutt speaks to John, Joanne, and Ryan of the Scottish Ambulance Service in Glasgow. They explore their backgrounds in the Service and how their work exposed them to challenging situations that caused severe detriment to their mental health. After describing the failings of traditional mental health support for emergency workers, they tell their story of travelling to Peru for an ayahuasca retreat, an eye-opening and profoundly heartening experience. LinksScottish Ambulance ServicesAyahuascaHeroic Hearts Project UKThe ShipiboScottish Psychedelic Research Group ★ Support this podcast ★

In this episode of the Drug Science podcast, we speak to Dr Andy Letcher, a religious scholar and author of the book Shroom: the Cultural History of the Magic Mushroom. He explores his complimentary background in science and the humanities, depicting how this combination structured his thinking. Noting the religious potential of psychedelic experiences, Letcher links the spiritual with the psychedelic, explaining what he sought to capture in his book and where it has gone since. Finally, he discusses how his interest in transdisciplinary perspectives on psychedelics has coalesced in the University of Exeter’s psychedelic postgraduate courses. PSYCH SYMPOSIUM 2025  LinksShroom: A Cultural History of the Magic MushroomPsychedelics: Mind, Medicine, and CulturePsilocybinSeeking the Magic Mushroom by R. Gordon WassonPsychedelia Britannia: Druids on Drugs ★ Support this podcast ★

Tune into the latest episode of the Drug Science Podcast, where we talk to Jenny Chapman and Dr. Stephen Naulls, researchers at the Parliamentary Office of Science and Technology (POST) and authors of ‘Psychedelic-assisted therapy for mental health: Policy considerations, a briefing for Parliament’ on the state of psychedelic research. They explore the remit of POST in highlighting objective, emerging scientific research, and how psychedelics have come into their focus. With backgrounds in biology and medicine, both Jenny and Stephen stress the interwoven nature of science and policy. Through this intersection, they highlight the policy levers holding psychedelic researchers back and what Parliament and the greater public can take from the POST brief.   Links Parliamentary Office of Science and Technology POST report on Psychedelic-assisted therapy for mental health: Policy considerations, a briefing for Parliament Psychedelic drugs to treat eating disorders Psychedelic drugs to treat post-traumatic stress disorder (PTSD) Psychedelic-assisted therapy to treat anxiety disorders Psychedelic drugs to treat depression Psychedelic-assisted therapy in the treatment of addiction POST Board Fellowship opportunities  POST All Reports Knowledge Exchange Unit – KEU Horizon Scanning Ketamine ★ Support this podcast ★

In this episode of the Drug Science Podcast, we speak with Darren Le Baron, an accomplished mycologist and educator. He discusses how his hardships from his upbringing in East London have informed his current work, where he uses horticulture to connect with children at risk of being drawn into crime. He transitions to explore his series Psychedelics in Africa, explaining some of the many links between psychedelics and African culture, both in ancient times and modernity. Throughout, he emphasises the importance of African perspectives and similar indigenous ones, challenging their absence in mainstream psychedelic discourse. LinksDarren Le BaronWho is Darren Le BaronDarren's Instagram   We Are Grow Mushrooms Psilocybin About Kilindi Iyi Psychedelics in Africa: The Untold Story Ibogaine  ★ Support this podcast ★

Join us in this episode as we speak to Bruce Parry, the creator and star of the BBC series Tribe With Bruce Parry. He explains his sharp career change from a Royal Marine to an advocate for indigenous rights, where he’s developed a humble approach to learning from indigenous tribes, defined by listening and witnessing. He talks about his experiences of psychedelics in these contexts, namely ayahuasca, which have vastly shaped his outlook on life. Through this lens, he lends his opinions on topics like ayahuasca tourism and capitalist culture in the psychedelic space.Tribe with Bruce Parry Psilocybin Ayahuasca ★ Support this podcast ★

In this episode of the Drug Science Podcast, we speak with Sam Bloomfield, founder of PsyEdu, and Dr. Eddie Jacobs, the first person to complete a doctorate in psychedelic ethics. Drawing on their backgrounds in education and ethics, they explore why these perspectives are essential to the evolving field of psychedelics. They also discuss the role of trials, clinics, and retreats within the broader psychedelic ecosystem, highlighting a major blind spot: the vast majority of psychedelic experiences occur outside of these settings. The conversation additionally examines how understandings of medicine often must adapt to the unique nature of psychedelics. Throughout, they underscore the importance of education in driving long-term policy change that ensures safer, more equitable, and more ethical psychedelic access.Psychedelic Training in the UKPsyEdu Beckley FoundationPsychedelic Ethics  Psilocybin MDMA MAPS Public Attitudes to Psilocybin-Assisted Therapy HOPE Statement ★ Support this podcast ★

In this episode of the Drug Science Podcast, we meet with Dr. Joe Tafur, MD, an integrative Family Physician, curandero, author and speaker. He discusses his book, The Fellowship of the River, exploring the role of spiritual healing in modern healthcare. Within this episode. Tafur further delves into topics such as biological and psychological links to Generational trauma as well as the relationship between spiritual practice and healing.  Dr Joe TafurModern SpiritMedicine SongFellowship of the riverIntro into Therapeutic psychedelicsDepressionPeyoteAyahuascaEmotional dysregulationMamosInner childPsoriasis MigraineAllostatic loadAllostasis EpigeneticsMeditationSupport the Podcast Link ★ Support this podcast ★

In this episode of the drug science Podcast, we meet with Mike Jay, author and 2024 Cheiron Book Prize winner who has written extensively on scientific and medical history with a special interest in Psychedelics. In this Podcast, he discusses with us his newest book, Free Radicals: How a Group of Romantic Experimenters Gave Birth to Psychedelic Science, which tells the story of early invention and experimentation with Nitrous Oxide (Laughing gas). He discusses various key figures at this time and the work they conducted, including Humphry Davy and Thomas Beddoes as well as discussing early theories into the potential use of gas in medicine which lead to the development of the Pneumatic Institute. Further, they discuss how this 18th-century research links to the psychedelic renaissance  Free Radicals: How a Group of Romantic Experimenters Gave Birth to Psychedelic ScienceMike Jay AuthorHumphrey Davy Humphry Davy BookThomas Beddoes Joseph Priestley Davis Giddy Miners lung Tuberculosis Michael Pollan Default mode network Mescaline Drug Science Podcast with Mike JayLink in show notes  ★ Support this podcast ★

Join us in the latest episode of the Drug Science Podcast, where we talk with Dr. Grace Blest-Hopley, Director of Research for Heroic Hearts Project UK, Chief Scientific Officer of NW PharmaTech, and founder and CEO of Hystelica. In the episode, she explore where psychedelic studies have largely ignored women’s physiology, particularly in failing to acknowledge and control for hormonal fluctuations. Grace particularly emphasises the necessity for greater investigations and understandings around the intersection of psychedelics and the menstrual cycle, explaining how Hystelica attempts to bridge this gap with naturalistic and observational studies. Throughout, the discussion examines how, by researching these unknowns, we can discover new treatment opportunities that better serve women’s health.Heroic Hearts Project UK HystelicaNWPharmaTech MDMAPsilocybin Retreats Study Mothers of the mushroom Microdosing Study ★ Support this podcast ★

In this latest episode of the Drug Science Podcast, we talk with Natalia Rebollo and Jesús Alonso Olamendi of the International Center for Ethnobotanical Education, Research, and Service (ICEERS). They discuss the lasting legacy of colonialism in the psychedelic culture of indigenous communities, stressing the need for the sacredness of these substances to be uplifted and not commodified. Throughout, they explore their work with ICEER’s Ayahuasca Defense Fund and how it has begun to change the narrative surrounding psychedelics in prohibitionist countries. Operating between indigenous communities and the Western world, they provide a unique perspective that shows how both communities can learn from each other. ICEERSAyahuasca Defense FundAyahuascaDMTAyahuasca Legal Battle in FranceTechnical Report on AyahuascaColombia's CND68 ResolutionIbogaineSpanish Ibogaine TrialContact Email ★ Support this podcast ★

Tune in to the latest episode of the drug science podcast where David Nutt meets with Tim Kerr, a doctoral research student in Psychiatry at King’s College London. Tim discusses his journey from slowly falling into drug addiction and dealing whilst studying for his medical degree eventually leading to arrest and imprisonment. Tim shares how he used this time in an open prison to apply for and study a Neuroscience masters with Kings College London with the support of the Longford trust, a charity that supports people with lived experience of prison to access higher education.  The Longford TrustHoward League for Penal ReformNHS Practitioner HealthAlcoholic liver diseaseJaundiceEcstasyKetamineCocaineFreud and cocaineNitrous oxideGHB SpiceWeedVenlafaxineModafinil Open and closed PrisonAlcoholics Anonymous ★ Support this podcast ★

Join us in the latest episode of the Drug Science Podcast where David Nutt meets with Psychedelic psychotherapy experts Laurie Higbed and Owain Winfield to dive into how to use psychedelics in psychotherapy. In this episode, they discuss the different techniques used with different psychedelics for different conditions to optimise this type of therapy and why these differences are necessary. They discuss MDMA, Ketamine and Psilocybin in a range of applications including trauma and addictions.MDMAKetaminePsilocybinSubstance MisusePTSDMAPSMDMA study into Substance Use DisorderCompass PathwaysCompass Pathways Psilocybin for Treatment Resistant DepressionAwakn life sciencesAmygdalaLink in show notes ★ Support this podcast ★

In this episode, we meet with Bessel van Der kolk, a trauma based psychiatrist, author, researcher and educator. Since the 1970s his research has been in the area of post-traumatic stress and he is the author of four books including best seller “the body keeps score”. Within this episode, he dives into what trauma is and different research into the impact trauma can have on the body and brain. He further discusses various traditional and alternative treatments for trauma and where these may be appropriate for different people with specific emphasis on EMDR and MDMA.   The body keeps score Nutt's paper lancet psychiatry 50 years of failure MDMA SSRIEMDR GabaBenzodiazepinesRorschach testNorepinephrine Bowlby MAPSWhen the spirit catches you, you fall downNeuroplasticity  ★ Support this podcast ★

In this episode of the Drug Science Podcast, David Nutt meets with psychopharmacologist Phil Cowen and Psychiatrist Sameer Jauhar  to discuss the neuroscience behind and treatments for depression. Within the episode they touch on various neurotransmitters involved in depression as well as research studies into each of their impact, stigma around antidepressants and the role of psychedelics in treatment.  DepressionSerotoninTryptophanHamilton depression scaleAntidepressantsGeddes paper on preventing relapseSupport the Podcast ★ Support this podcast ★

In this episode of the Drug Science podcast, we speak with Josh Dugdale of the Wasing Estate, described as a "mindful aristocrat." He shares his experiences with Ayahuasca in the Amazon and how they influenced his journey upon returning to the UK. Josh discusses the creation of a mindful and spiritual festival during the pandemic, its evolution over time, and its wider impact. He also explores the challenges surrounding psilocybin access rights, the changes needed in this area, and what the future of psychedelic reform might look like.Medicine Festival Psilocybin Access RightsAyahuascaPsilocybinMDMADrug Science Reschedule PsilocybinMedical CannabisPTSD Veterans PTSDIndustrial Hemp LicensingDEFRASubscribe to podcast  ★ Support this podcast ★

Prof Ravi Das is a leading expert in psychopharmacology and cognitive neuroscience, with a career dedicated to understanding and developing innovative treatments for addiction and anxiety disorders. He completed his BSc in Psychology and MSc in Cognitive Neuroscience at University College London (UCL), followed by a PhD in Psychopharmacology at the UCL Clinical Psychopharmacology Unit. Prof Das’s research takes a translational and experimental medicine approach, focusing on the mechanisms of memory plasticity and their role in the development of addictive and anxiety disorders. A key area of his work is memory reconsolidation—the process by which established memories become temporarily unstable when retrieved, creating an opportunity to modify maladaptive memories. By targeting these unstable memories, Prof Das explores how drug or behavioral interventions could potentially disrupt the cravings and relapse associated with addiction, the fear underlying anxiety disorders, or the flashbacks experienced in PTSD. In addition to his work on memory reconsolidation, Prof Das is deeply interested in the phenomenology and effects of illicit drug use, as well as the role of cognitive and mindfulness-based strategies in treating substance use disorders. His research bridges the gap between scientific discovery and clinical application, with the ultimate goal of developing more effective, evidence-based treatments for mental health challenges. Prof Celia MorganProf Val CurranProf Sunjeev KambojMemory Research and consolidation Biggest DMT studyPlacebos in psychedelic clinical trials Prof Mitul MehtaPsychedelic gold rush RFK Jr pro-psychedelics FDA reject Lykos decision UNITy screening form Wellcome LeapLSD study Preparation for Psilocybin studyUNITy ★ Support this podcast ★