The Energy Balance Podcast

In this episode we discuss: What Layne Norton is missing regarding seed oils What we think of Liver King’s steroid use and how this relates to fitness culture and unhealthy body image Ben Bikman’s complete misapplication of a study regarding blood sugar and insulin resistance Jay’s response to Thomas DeLauer regarding omega-3s and cod liver oil     Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Danny's Telegram: https://t.me/dannyroddy     Timestamps: 0:00 – intro 0:28 – Andrew Huberman and Layne Norton on whether seed oils are inherently harmful 4:18 – why Layne Norton's "calories-only" view is flawed, as it ignores how the type of food actually affects our bodies 9:58 – whether animal studies are useful in nutritional research, or if only human randomized control trials (RTC) should be considered 15:57 – problematic assumptions and biases in nutritional research and how they can shape research outcomes 20:59 – why the reported health benefits of polyunsaturated fats in research are misleading and harmful 26:54 – the connection between chronic disease and polyunsaturated fats, and how focusing solely on calories relieves the food industry of responsibility for health outcomes 31:43 – Liver King's self-esteem, body image struggles, steroid use, health risks, and why his apology was commendable 41:36 – why cultural standards for physical appearances are unrealistic, unhealthy, and can lead to conflating steroid-enhanced bodies for genuine health 51:12 – health risks associated with steroid-use and having too much muscle mass 1:00:34 – Thomas Delauer and Derek from moreplatesmoredates discuss omega-3s 1:06:21 – whether the antioxidants in fish oil are worth the damage caused by lipid peroxidation 1:10:54 – whether cod liver oil is any better than fish oil 1:17:11 – how to effectively hydrate your cells and the importance of getting enough salt 1:24:44 – why consuming a lot of plain water without electrolytes actually impairs hydration, contributing to increased swelling, increased stress, and impaired energy production 1:32:38 – the importance of getting adequate potassium in addition to salt intake 1:38:03 – factors that may increase your need for water 1:40:02 – what Ben Bikman misses when it comes to blood glucose and insulin resistance 1:48:15 – the true relationship between insulin and blood sugar regulation 1:54:30 – Ben Bikman misapplies this study: it does not support that carbohydrates cause insulin resistance 2:00:38 – creating content in the health sphere, choosing high quality foods, and the benefits of tracking food (using Cronometer or another similar app)

In this episode we discuss: Whether estrogen is just a reproductive hormone Whether you need to be concerned about testosterone converting to estrogen How you can have excess estrogen production even after menopause The best way to use progesteron Whether Calcium D-glucarate is effective for lowering estrogen     Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/     Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-124-forget-about-cico-a-smarter-approach-to-fat-loss/     Timestamps: 0:00 – intro  1:07 – our thoughts on Wendy Sellens’ recent interviews with the Strong Sistas (Ashley and Sarah Armstrong)  6:30 – the importance of reviewing research with an open mind, avoiding any rigid or authoritative stance  9:38 – whether all research should be rejected due to Rockefeller funding and whether Dr Ray Peat was “Rockefeller trained”  15:47 – whether reproductive hormones affect only reproductive organs  20:35 – how hormonal imbalances affect all areas of health—reproduction, digestion, edema, bloating, cancer risk, weight gain, brain health, bone health, and muscle growth  23:38 – whether Dr Hobbins’ experiments proved that there are no receptors for reproductive hormones in non-reproductive organs  26:51 – why Wendy’s claim—that the rise in estrogen during pregnancy is caused by exogenous compounds (phytoestrogens and xenoestrogens)—is incorrect  29:29 – estrogen’s role as a growth-promoting hormone and how progesterone counterbalances it by promoting cellular differentiation  35:47 – whether testosterone can be converted into estrogen  36:52 – how you can have excess estrogen production even after menopause and problems with estrogen testing  40:19 – body fat as a major source of estrogen  44:33 – why Wendy’s claim that calcium D-glucarate increases estrogen is incorrect  46:56 – the mechanism through which calcium D-glucarate effectively lowers estrogen levels  50:28 – confounding variables that make it difficult to accurately interpret the results of breast thermography scans 

In this episode we discuss: The criticism of Georgi regarding estrogen and cancer The major point that Siim Land is missing when it comes to increasing NAD+ Why we think Dr. Berg is completely wrong on serotonin Nutrition With Judy’s suggestion that thyroid issues on a carnivore diet are not caused by the lack of carbohydrates, and why we think this isn’t the case Dave Asprey’s recommendation to drink orange juice and whether it’s for the right reasons Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Danny's Telegram: https://t.me/dannyroddy   Timestamps: 0:00 – intro 1:10 – whether estrogen is a carcinogen  6:13 – estrogen’s role in driving weight gain and chronic diseases such as cancer, Alzheimer’s disease, and Type 2 Diabetes  8:03 – the dangers of synthetic progesterone (progestin) use  10:14 – the difference between estrone and estradiol and the problems with estrogen testing  16:14 – whether estrogen therapy should be used in post-menopausal women  17:17 – the difference between oral and transdermal estrogen use  24:44 – the connection between inflammation and estrogen production  27:57 – why estrogen levels are not actually low in post-menopausal women  37:59 – our take on Siim Land's post on NAD+ and mitochondrial uncoupling  48:25 – why intentionally seeking hormetic responses, like the activation of heat-shock proteins, should be avoided  50:37 – which form of CoQ10 is better: ubiquinone or ubiquinol  53:34 – what Siim Land and many others get wrong when it comes to raising NAD+   55:44 – does fasting and AMPK upregulation cause cancer?  1:00:29 – fat fuels cancer and why not to restrict sugar for cancer  1:09:56 – Dr Berg’s take that serotonin is the “happy hormone” – why we disagree  1:19:06 – serotonin’s role in driving chronic diseases and conditions including depression, anxiety, IBS, and cancer  1:27:24 – Nutrition with Judy claims that the low thyroid levels generally seen on the carnivore diet have nothing to do with a lack of carbohydrates  1:39:01 – how the rate of living theory changed mainstream medicine’s view that thyroid health is important  1:45:37 – how excessive exercise raises stress hormones, setting you up for weight regain  1:51:30 – why the combination of fasting and exercise is detrimental to our health  1:53:44 – how estrogen is used to fatten animals   2:02:42 – why Dave Asprey is talking about endotoxin and orange juice  2:07:00 – whether the sugar in orange juice feeds bacteria and increases endotoxin  2:09:40 – why the low-carb trend keeps resurfacing, despite the growing evidence against it  2:14:41 – where to find Georgi and IdeaLabs 

In this episode we discuss: An alternative framework to CICO for conceptualizing fat loss Why eating less and exercising more is not the best solution for fat loss Why excess energy does not cause fat gain and instead leads to fat loss How you can get stuck in a cycle of weight gain, undereating, and constant hunger, and how to get out of that cycle   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/     Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-124-forget-about-cico-a-smarter-approach-to-fat-loss/   Timestamps: 0:00 – intro 1:06 – recapping the problems with CICO 5:02 – the Energy Balance approach as an alternative to CICO for fat loss 12:12 – why calories do not equal energy and considering the possible fates of the food we consume 17:39 – efficient mitochondrial function as a central piece that determines whether substrate will be stored as body fat 19:39 – the amount of food you eat does matter 21:46 – conceptualizing Energy Balance with numerical units 24:00 – fat gain as a consequence of impaired mitochondrial function 29:01 – how you can lose fat while eating more 33:12 – the effects of energy availability on hunger and stress hormones 36:41 – how stress hormones, along with energy deficits, cause the body to break down muscle, bone, and skin for energy 43:16 – the benefits of having an energy surplus: improved sleep, immune function, digestion, cognitive function, and more 46:20 – comparing the Energy Balance approach with CICO and the major cost of the advice to “eat less and exercise more

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Danny's Telegram: https://t.me/dannyroddy   Timestamps: 0:00 – intro 0:36 – catching up: fruit quality in the Philippines and Ecuador, and the effects of mold toxicity 5:28 – Kiran Krishnan and Nutrition with Judy discuss why they believe coconut oil should not be consumed 9:55 – whether coconut oil causes greater release and absorption of endotoxin (LPS) 12:11 – should you eat coconut oil even if your ancestors didn't? 21:08 – how MCT oil compares to coconut oil as it relates to the microbiome 32:28 – concerns with adopting dietary ideologies 36:21 – Morley Robbins on why the thyroid doesn’t run the body and we shouldn’t ignore the adrenals 47:05 – adrenal fatigue as a systemic issue and whether the thyroid or adrenals run the body 56:45 – our take on Real Food Gangsta’s (Josh & Jeanne Rubin) view that the adrenal glands regulate the body’s mineral and fuel availability 1:07:02 – the importance of optimal gut motility and how to alleviate gut motility issues such as constipation and loose stools 1:19:54 – which lab tests provide the most valuable information 1:25:14 – the benefits of spending time without stimulation (letting your mind wander) during the day 1:27:20 – simple mindset strategies to help you reach your goals 1:32:55 – Alan Aragon’s argument that not all seed oils are harmful 1:40:56 – why the claim that seed oils lower cholesterol does not mean they are healthy 1:42:25 – whether animal studies are valuable for understanding the effects of seed oils on human health

In this episode we discuss: Whether “calories in, calories out” is physiologically accurate The many misconceptions related to “calories in, calories out” Why a calorie deficit is NOT required for fat loss Why “calories in, calories out” does not mean that eating less and exercising more is good advice for fat loss What most people miss when it comes to “calories in, calories out”   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/     Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-123-debunking-the-cico-myth-calorie-deficits-are-not-required-for-fat-loss/   Timestamps: 0:00 – intro 1:07 – questions about the calories-in, calories-out (CICO) model of weight loss that I’ll be answering  7:18 – what is (and isn’t) a calorie?  11:49 – misapplications of CICO and why CICO is not physiologically accurate in the ways most people use it  19:46 – why the idea that “a calorie is a calorie” is misleading  29:11 – how energy in food is measured and the inaccuracy of food labels  36:16 – the impact of behavioral compensation and metabolic adaptation on energy expenditure  42:07 – how cutting calories lowers metabolism, reduces thyroid function, and increases stress hormones, appetite, and weight regain  48:26 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits  52:21 – whether CICO can accurately represent physiology  1:00:04 – a simplified version of CICO  1:05:41 –why calories do not equal usable energy or weight  1:13:27 – examples demonstrating the issues with common CICO misconceptions  1:21:09 – summarizing the central issues with CICO and how you can lose body fat without a caloric deficit  1:28:13 – whether there’s value to CICO

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Danny's Telegram: https://t.me/dannyroddy   Timestamps: 0:00 – intro 0:33 – why we started this podcast 6:25 – our take on Bryan Johnson’s Longevity Blueprint and problems with biohacking 12:13 – whether we should adopt any of the strategies from Bryan Johnson’s Blueprint to achieve optimal health 14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity 21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 28:00 – potential pros and cons of Bryan Johnson’s Blueprint and how to measure health 32:39 – Bryan Johnson’s supplement protocol 41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status 46:20 – whether body fat percentage and cholesterol levels can be too low 52:20 – what is stress? 1:03:20 – issues with hormesis and the idea that stress is beneficial 1:07:34 – whether avoiding stress is possible and how to develop resilience to stress 1:13:17 – addressing Marty Kendall’s response to our take on glucagon and insulin 1:24:17 – glucagon’s short-term and long-term effects on metabolic function 1:26:46 – glucagon’s role in insulin resistance and type 2 diabetes 1:37:16 – metabolic dysfunction as a driver of insulin resistance 1:41:06 – whether we need to be concerned about wasting energy on hormone production 1:44:50 – whether we should always try to avoid gluconeogenesis 1:51:45 – how to use carbohydrates to stabilize your blood sugar 1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health

In this episode we discuss: Whether Berberine and Urolithin A are good options for weight loss How Berberine lowers your blood sugar and whether this is really a good thing The effects of Berberine and Urolithin A on your gut Whether you always need to avoid blood sugar spikes Whether you always need to have protein with your carbohydrates   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-122-weight-loss-with-berberine-and-urolithin-a-blood-sugar-spikes-and-pairing-protein-with-carbs-qa/   Timestamps: 0:00 – intro 1:10 – what are berberine and urolithin A? 2:26 – the benefits of berberine on gut health 9:06 – berberine as a mitochondrial poison and the mechanisms of berberine’s toxicity and blood-sugar-lowering effects 13:13 – of the effects urolithin A on mitochondria and the gut 18:15 – whether urolithin A is beneficial for weight loss and increases brown adipose tissue activity 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 26:31 – powerful weight loss strategies that are simple and effective, without supplementation 31:02 – whether we always need to avoid blood sugar spikes and dips 35:30 – when having protein alongside carbs is necessary and why increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes 40:49 – how fat, fiber, and protein help slow the absorption of carbohydrates and improve blood sugar management 46:20 – issues with grain-based carbs and the importance of finding carb sources that work for you

In this episode we discuss: How to fix adrenal fatigue and adrenal insufficiency and whether these are really adrenal problems Whether it makes sense to use desiccated adrenal products or hydrocortisone for adrenal fatigue How the GAPS diet can resolve autoimmune issues and whether you should consider trying it How to improve fat digestion and bile flow How to improve digestion without a gallbladder   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-121-how-to-address-adrenal-fatigue-gaps-diet-concerns-and-gallbladder-health/   Timestamps: 0:00 – intro 1:13 – what is adrenal insufficiency and what causes it? 7:02 – what is adrenal fatigue and how can we reverse it? 11:54 – the drivers of adrenal fatigue and issues with typical treatments 18:51 – the importance of establishing solid diet and lifestyle foundations before adding supplements for adrenal support 24:42 – whether our bodies lose the ability to produce hormones as we age 27:20 – concerns with the use of natural supplements like desiccated adrenal glandulars, licorice, and hormone replacement therapy (HRT) 36:07 – whether the GAPS diet is ideal for healing autoimmune conditions 40:01 – problems with the GAPS diet and other elimination diets 47:37 – the importance of individualizing your gut protocol and the problems with a cookie-cutter approach 52:09 – the connection between gut health, stress hormones, mental health, and autoimmunity 55:40 – how to improve digestion without a gallbladder 59:13 – common issues seen in those without a gallbladder 1:02:08 – long-term consequences of gallbladder removal and how to heal gallbladder issues 1:05:30 – when to use ox bile, TUDCA, taurine, glycine, or vitamin C 1:09:16 – how much fat to include in your diet to stimulate bile flow, and what types of fats are optimal 1:12:55 – strategies for preventing and resolving bile dumping and reflux 1:15:44 – additional consequences of gallbladder removal 1:17:36 – gallbladder issues in relation to hypothyroidism and estrogen dominance

In this episode we discuss: The research behind vitamin A toxicity and whether vitamin A is really a poison Whether you need to be concerned about the use of Accutane Whether retinoic acid is toxic because it’s used as a chemotherapeutic agent Whether Grant Genereux’s claims about vitamin A toxicity are valid   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-120-vitamin-a-toxicity-retinoic-acid-toxicity-accutane-and-whether-hypervitaminosis-a-exists   Timestamps: 0:00 – intro 1:15 – why we're examining Grant Genereux's take on vitamin A toxicity and the evidence behind his claims 4:50 – conceptualizing the amount of vitamin A needed for toxicity 7:07 – is hypervitaminosis A (vitamin A toxicity) real? 9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis 12:36 – is there a conspiracy to poison the masses with vitamin A? 18:36 – how likely is it that you have vitamin A toxicity? 22:30 – problems with the first in vivo study that Grant uses to support vitamin A toxicity 35:14 – vitamin A toxicity in the studies Grant cited require massive doses of vitamin A that would be impossible to obtain from diet 42:44 – Grant’s cited research actually supports the safety of vitamin A 50:52 – more of Grant’s cited research supporting vitamin A safety 58:25 – further research supporting that extremely high doses are required to cause vitamin A toxicity 1:07:57 – whether vitamin A toxicity is driving autoimmunity 1:09:54 – whether retinoic acid is toxic based on concerns regarding the use of Accutane  1:15:40 – how conflating Accutane with retinoic acid is misleading  1:22:12 – whether retinoic acid is toxic because Accutane is used as a chemotherapeutic agent  1:29:37 – evaluating Grant’s claim that retinol automatically becomes “toxic” retinoic acid  1:35:05 – our concluding thoughts on Grant’s arguments regarding vitamin A toxicity

In this episode we discuss: Whether vitamin A toxicity exists and is something you need to be worried about Whether Grant Genereux’s claims about vitamin A deficiency are valid Whether vitamin A is actually a poison rather than a vitamin What we think about the current state of the Ray Peat forum The research on vitamin A deficiencies and whether vitamin A deficiencies exist   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-119-vitamin-a-toxicity-examining-the-evidence-for-vitamin-a-deficiency   Timestamps: 0:00 – intro 1:09 – why we’re discussing vitamin A toxicity and Grant Genereux’s perspective 4:53 – closedmindedness within the “low vitamin A” sphere and how it compares to Ray Peat’s work 7:33 – how a low vitamin A diet can have benefits 9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis 12:33 – the importance of evaluating information objectively while avoiding censorship, tribalism, fearmongering, and religiosity 21:17 – concerns with the current state of the Ray Peat Forum and how to recognize unsubstantiated claims 26:45 – Grant's initial critiques of the original studies on vitamin A deficiency are extremely weak and unsubstantiated 41:48 – introducing Wolbach’s 1925 study on vitamin A deficiency 45:47 – refuting Grant's argument that the retinoic acid in the vitamin-free casein would have caused toxicity 52:35 – refuting Grant's argument regarding confounding variables in lard and butter 1:02:53 – research on vitamin A deficiency and whether vitamin A deficiencies exist 1:20:32 – the necessity of vitamin A for pregnancy, fetal growth, and development

In this episode we discuss: Why serotonin is NOT the “happy hormone” and you may not want to increase it How serotonin and depression relate to stress and energy balance Whether SSRIs are effective for depression How SSRIs actually work, their impact on metabolism, and whether they’re the best treatment option for depression The real drivers of depression and anxiety   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-118-the-truth-about-serotonin-and-ssris-why-serotonin-is-not-the-happy-hormone   Timestamps: 0:00 – intro 0:58 – the research showing that serotonin is not the “happy hormone” 4:56 – serotonin’s role in driving the stress state that leads to depression 8:26 – the overlap between anxiety and depression and why they are both characterized by elevated serotonin levels 10:27 – the origins of the idea that serotonin is the “happy hormone” and how serotonin became a marketing tool for pharmaceutical companies 14:49 – serotonin is increased during fasting and starvation and why increasing serotonin should not be our goal 20:16 – serotonin is increased during stress, shock, and infection and leads to learned helplessness 29:04 –SSRIs use in neonates causes depression in adulthood 31:35 – the serotonergic system as an adaptive stress response to a lack of energy 39:09 – serotonin’s role in energy redistribution under stress 43:15 – how SSRIs inhibit mitochondrial respiration, glucose metabolism, and energy production in the brain and liver 47:13 – how SSRIs can reduce symptoms and how the brain responds to SSRIs 52:42 – the true drivers of depression and anxiety 1:01:30 – how serotonin relates to stress hormones, including cortisol, and energy balance

In this episode we discuss: Concerns surrounding fructose malabsorption and whether fructose is really a FODMAP Whether you need to be concerned about excess fructose in foods Whether you should avoid sugar and supplement with fish oil for brain inflammation Diet and supplement strategies for brain injuries The impacts of drinking alcohol from the Bioenergetic view   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-117-fructose-malabsorption-protecting-against-alcohol-and-brain-injuries-and-inflammation-q-and-a   Timestamps: 0:00 – intro 1:15 – how fructose gets absorbed in the small intestine 4:24 – the optimal fructose to glucose ratio and how to tell if you have fructose malabsorption 8:41 – the details of how glucose helps with fructose absorption 12:04 – which foods have a high fructose to glucose ratio 16:24 – issues with FODMAP categorization and whether fructose is really a FODMAP 21:23 – listening to your body and understanding individual context vs following rigid “food rules” 27:39 – anti-inflammatory diets and whether we should avoid sugar and supplement with fish oil to reduce brain inflammation 32:06 – dietary and supplement strategies to promote an anti-inflammatory state in the brain 39:15 – the effectiveness of red-light therapy, methylene blue, progesterone, exogenous ketones, and polyphenols in treating brain injuries 44:31 – why we don’t want to prioritize omega 3s in the diet and whether eating fish is any better than fish oil supplementation 47:21 – reducing inflammation with the use of aspirin 47:53 – the main concerns with drinking alcohol: intestinal permeability, endotoxin production, and liver health 52:32 – stress-relieving supplement alternatives to alcohol and the effects of alcohol on vitamins and minerals 54:37 – strategies to mitigate the effects of alcohol in the short-term 58:14 – whether it makes sense to drink alcohol, alcohol use as a coping mechanism, and the impact of culture 1:00:07 – more strategies for mitigating the effects of alcohol in the short and long term

In this episode we discuss: The validity of the counterarguments against the Lipid Energy Model Whether the Lipid Energy Model means that high LDL does not increase cardiovascular disease risk How thyroid and metabolism relate to high LDL on a low-carb diet What the Lean Mass Hyper-Responder phenotype means in terms of metabolic health Whether low-carb diets are ideal for cardiovascular disease health and health in general   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-116-the-truth-about-ldl-and-heart-disease-lmhr-and-the-lipid-energy-model/   Timestamps: 0:00 – intro 1:17 – the primary counterarguments against the Lipid Energy Model  4:15 – BMI, not saturated fat, correlates with the LMHR phenotype  8:15 – eating carbs dramatically lowers cholesterol in LMHR  11:14 – whether Oreos are more effective at lowering cholesterol than statins  17:30 – high cholesterol levels in the LMHR phenotype are not due to excess saturated fat intake or cholesterol production  19:25 – prominent cardiologists and researchers dismissing the lipid energy model due to dogmatism interferes with progress in science and medicine  24:40 – Dr. Shawn Baker’s carbohydrate experiment and contextual considerations when reintroducing carbs into the diet  28:46 – further support for the lipid energy model and the relationship with thyroid function  33:32 – the difference between saturated, monounsaturated, and polyunsaturated fats in relation to lipid profiles  34:40 – whether LDL cholesterol and ApoB cause heart disease and plaque formation  42:18 – how the Lipid Energy Model helps uncover the underlying cause of heart disease  45:15 – LDL levels as a marker of metabolic health rather than a cause of cardiovascular disease and why we may not always want to lower LDL  55:02 – evidence suggesting that LDL does not drive cardiovascular disease  1:05:43 – the difference between high LDL due to metabolic dysfunction and high LDL due to a low-carb diet  1:09:58 – lipid values don’t tell us the whole picture: the Kitavans  1:16:54 – why decreases in insulin, glucose, and HbA1C as well as increased lipolysis and fat oxidation on a low-carb diet is not necessarily a sign of improvement  1:22:57 – increased lipolysis on low-carb diets does not lead to body-fat loss  1:24:25 – whether the Lipid Energy Model proves that low-carb diets are optimal for health

In this episode we discuss: Whether you should be concerned about high LDL or high cholesterol on a low-carb diet The validity of the Lean Mass Hyper-Responder (LMHR) Phenotype and Lipid Energy Model proposed by Dave Feldman The metabolic state that drives the Lipid Energy Model How the "Lean Mass Hyper-Responder" and Lipid Energy Model support the Bioenergetic view of cardiovascular disease   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-115-lmhr-and-the-lipid-energy-model-implications-for-metabolism-and-hormones   Timestamps: 0:00 – intro 1:14 – what is the Lean Mass Hyper-Responder (LMHR) phenotype 3:33 – how the Lipid Energy Model challenges the mainstream dogmatic view linking high cholesterol levels to heart disease 6:33 – the protective effects of cholesterol and why it does not cause heart disease, despite being necessary for atherosclerosis 9:49 – the distinction between Lean Mass Hyper-Responders and those with high cholesterol levels in the context of metabolic dysfunction 15:10 – what is the Lipid Energy Model 22:10 – how the body adapts to a lack of carbohydrates, leading to elevated cholesterol levels 27:22 – the hormonal and metabolic state underlying the Lean Mass Hyper-Responder phenotype 32:21 – how adding carbohydrates lowers cholesterol levels in those who don't have metabolic dysfunction at a cellular level 37:11 – whether Lean Mass Hyper-Responders are at increased risk of cardiovascular disease 42:00 – why the Lean Mass Hyper-Responder phenotype isn't ideal: stress and low thyroid function 51:10 – the parallels between the lipid energy model and physiological insulin resistance