The Existential Hope Podcast

<p>The <strong>Existential Hope Podcast</strong> features in-depth conversations with people working on positive, high-tech futures. We explore how the future could be much better than today—if we steer it wisely.</p><br /><p>Hosts <strong>Allison Duettmann</strong> and <strong>Beatrice Erkers</strong> from the <a href="https://foresight.org/" rel="noopener noreferrer" target="_blank"><strong>Foresight Institute</strong></a> invite the scientists, founders, and philosophers shaping tomorrow’s breakthroughs— AI, nanotech, longevity biotech, neurotech, space, smarter governance, and more.</p><p><br /></p><blockquote><strong>About Foresight Institute:</strong> For 40 years the independent nonprofit <strong>Foresight Institute</strong> has mapped how emerging technologies can serve humanity. Its <strong>Existential Hope program</strong> is the North Star: mapping the futures worth aiming for and the breakthroughs needed to reach them. This podcast is that exploration in public. Follow along and help tip the century toward success.</blockquote><p><br /></p><p><strong>Explore more: </strong></p><ul><li>Transcript, listed resources, and more:<strong> </strong><a href="https://www.existentialhope.com/podcasts" rel="noopener noreferrer" target="_blank">https://www.existentialhope.com/podcasts</a></li><li>Follow on <a href="https://x.com/HopeExistential" rel="noopener noreferrer" target="_blank"><strong>X</strong></a></li></ul><hr /><p style="color: grey; font-size: 0.75em;"> Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer" style="color: grey;" target="_blank">acast.com/privacy</a> for more information.</p>

Nathan Labenz on What the Best-Case Scenarios for AI are

What does a genuinely positive future with AI look like? While dystopian visions are common, the most valuable—and scarcest—resource we have is a concrete, hopeful vision for where we're headed.In this episode, we're joined by Nathan Labenz, host of the popular Cognitive Revolution podcast, to explore the tangible possibilities of a beneficial AI-driven world. Nathan shares his insights on everything from the near-term transformations in education and healthcare—like AI-driven antibiotic discovery and personalized learning—to the grand, long-term visions of curing all diseases and becoming a multi-planetary species.We dive deep into crucial concepts like Eric Drexler's "comprehensive AI services" as a model for safety through narrowness, the transformative power of self-driving cars, and how we can collectively raise our ambitions to build the future we actually want. On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

09-30
01:05:32

Fin Moorhouse on Why We Need to Aim Higher Than Survival

For years, the conversation about the long-term future has been dominated by a crucial question: how do we avoid extinction? But what if ensuring our survival is only half the battle? In this episode, Beatrice is joined by Fin Moorhouse, a researcher at Forethought and co-author with Will MacAskill of the Better Futures series, to make the case for focusing on the other half: flourishing. Or as we'd like to say in this podcast: Existential Hope!Fin challenges the idea that a great future will emerge automatically if we just avoid the worst-case scenarios. Using the analogy of a grand sailing expedition, he explores the complexities of navigating towards a truly optimal world, questioning whether our current moral compass is enough to guide us.The conversation dives into the concept of "moral catastrophes"—profound ethical failings, like industrial animal farming, that could persist even in technologically advanced futures. Fin also tackles the complex challenges posed by digital minds, from the risk of accidental suffering to the creation of "willing servants." He argues for the power of "moral trade" as a tool to build a more pluralistic and prosperous world, and explains why we should aim for a "Viatopia"—a stable and self-sustaining state that makes a great future highly likely.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

09-17
55:34

Sam Arbesman on Vibe Coding, AI, and the Magic of Code

Is code just a technical skill for engineers, or is it a deeply humanistic art form capable of expanding our minds? In this episode, host Beatrice Erkers is joined by scientist, author, and Coder-in-Residence at Lux Capital, Sam Arbsman, to explore the profound ideas in his new book, The Magic of Code.Sam reframes our relationship with computing, arguing that code is one of history's most powerful "tools for thought," standing alongside the alphabet and paper in its ability to augment human intellect. He delves into the fascinating history of this idea, from Don Swanson's concept of "undiscovered public knowledge" in scientific literature to the modern potential of AI to connect disparate ideas and accelerate discovery.The conversation also explores the democratization of creation through "vibe coding," the power of thinking of an app as a "home-cooked meal," and the critical importance of humility as our technological systems become too complex for any single person to fully understand—a theme from his previous book, Overcomplicated. Sam connects these ideas to the ever-changing nature of knowledge itself, drawing from his first book, The Half-Life of Facts.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

09-15
55:06

Pablos Holman on Creating Technology That Actually Matters

The tech industry we read about every day accounts for only 2% of the global economy. So what about the other 98%? In this episode, host Beatrice Erkers talks to hacker, inventor, and author Pablos Holman about his new book, Deep Future, and why it’s time to look beyond software to solve the world’s biggest problems.Pablos argues that for decades, our brightest minds have been focused on apps and ads while ignoring the fundamental industries that civilization depends on: energy, manufacturing, shipping, and food. He makes the case for "deep tech"—everything but software—and explains why now is the perfect moment to deploy our "software toolkit" to reinvent these stagnant, trillion-dollar sectors.From computer-controlled sailing ships and factory-built nuclear reactors buried a mile underground, to the simple genius of a better milk jug that can double a farmer's income, Pablos shares mind-bending examples of technology that truly matters. He also offers a grounded take on AI, explaining why computational modeling for disease control is more impactful than AGI hype, and delivers a powerful vision for a future where energy abundance ends global conflict and automation frees humanity to focus on what makes us thrive: care, community, and connection.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

09-12
01:04:37

Andrew White on Building an AI Scientist to Automate Discovery

What if we could build an AI that doesn't just answer questions, but makes fundamental scientific discoveries on its own? That's the mission of Future House, and in this episode, host Allison Duettmann sits down with its co-founder, Andrew White.Andrew shares the incredible journey that led him from chemical engineering to the forefront of the AI for Science revolution. He gives us a look under the hood at Future House's flock of specialized AI agents, like Crow, Finch, and Owl, and reveals how they recently accomplished in just three weeks what could have taken years: identifying an existing drug as a potential new treatment for a common cause of blindness.But the conversation doesn't stop at the successes. Andrew offers a sharp critique of the current methods for evaluating AI, explaining what’s wrong with benchmarks like "Humanity's Last Exam" and why the ultimate test is real-world discovery. He also makes a compelling case for completely reinventing the slow and inefficient scientific publishing system for an era where machines are both the producers and consumers of research.Andrew is also fundraising for the Frontiers Society at IPAM to advance this work. If you’d like to support, you can donate here: IPAM Donation Page.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

09-10
01:03:14

Tools or Agents? Choosing Our AI Future | Anthony Aguirre

What if the most desirable AI future is made of powerful tools, not autonomous agents? Physicist and futurist Anthony Aguirre joins us to unpack the Tool AI pathway, how incentives, liability, and design choices could steer us toward AI that empowers people rather than replaces them. We also situate this episode in AI Pathways, our two-scenario project exploring Tool AI and d/acc futures. Explore the project: https://ai-pathways.existentialhope.com/On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

08-22
46:33

Autonomous Vehicles Special: Andrew Miller on Self-Driving Futures

Self-driving cars aren’t science fiction, they’re already here. But what kind of future are they steering us toward?In this episode, Beatrice speaks with Andrew Miller, mobility expert and author of The End of Driving, about the transformational promise, and very real risks, of autonomous vehicles. They explore why driverless tech isn’t just about hardware or software, but about regulation, land use, curb management, jobs, and values.From robo-taxis in San Francisco and driverless trucks in Texas, to curb chaos, job displacement, and how we reclaim space from parked cars, this episode goes far beyond the hype. On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

08-12
35:22

Jim O'Shaughnessy on Investing in Infinite Human Potential

How do we shape a future worth rooting for? In this episode, Beatrice Erkers talks with Jim O'Shaughnessy, founder of O'Shaughnessy Ventures and author of What Works on Wall Street, about his third act: backing creators, thinkers, and innovators across publishing, film, AI, and investment. They dive into the cultural power of storytelling, what it means to be “AI-first,” and why cognitive diversity and personal agency are key to navigating a rapidly changing world.Jim shares his existential hope for the next 30 years, explores how to make AI work for everyone, and offers a call to action for people with ideas: get in the arena. Along the way, we cover self-driving cars, tutoring AIs, philosophical simulations, and why beautiful books still matter.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

08-09
01:01:55

Michael Nielsen on Hyper-entities, Tools for Thought, and Wise Optimism

How do we imagine, validate, and steer toward better futures?In this conversation, scientist and writer Michael Nielsen joins Beatrice Erkers to explore the idea of “hyper-entities”, future artifacts that reshape our capabilities and the verbs we use to describe them. They discuss how science fiction, public goods mechanisms, and open science feed into real-world innovation, and how imagination and design shape the trajectory of civilization.Michael reflects on dual-use technologies, from quantum physics to cryptography, and explains why deep truths about the universe often come bundled with both promise and peril. They also dive into "tools for thought," kindness as a moral technology, and why exploration, however illegible, is crucial for progress.‍On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

08-07
01:09:27

A Handheld Device to Defeat Cancer | Mary Lou Jepsen

What if the bulky, expensive machines that fill hospital radiology departments could be replaced by a wearable? In this episode, we speak with Mary Lou Jepsen — founder of Openwater and pioneering inventor — about how breakthroughs in light-based imaging could democratize access to brain and body scans.From her work at Google X and Facebook’s moonshot labs to her current mission at Openwater, Jepsen has spent decades at the frontier of tech and health. Now, she’s building a future where scanning the body for disease is as simple as putting on a hat — no radiation, no giant machines, no $1M price tag.We explore:Why light could be the key to affordable, real-time medical diagnosticsHow her device works — and what it might replaceWhat it takes to challenge the medical-industrial complexHer vision for global healthcare access and early detection‍On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

07-09
45:21

How Science Fiction Can Inspire Real-World Innovation with Ed Finn

In this episode of the Existential Hope Podcast, Ed Finn, founding director of ASU’s Center for Science and the Imagination, explores the impact of storytelling on our ability to envision and create better futures—and why we urgently need more hopeful narratives.Ed shares his journey from a generalist interested in how technology shapes culture to co-creating initiatives like "Project Hieroglyph" with celebrated sci-fi author Neal Stephenson. He argues that our collective imagination is often stuck in dystopian loops or unable to escape the status quo, hindering our capacity for large-scale, positive change. By bringing together storytellers, scientists, and artists, we can craft "technically grounded, hopeful stories about futures we might actually want to live in."In this conversation, we explore:The fundamental role of imagination and narrative in how we understand the world, make decisions, and even perceive reality.Why science fiction can be a powerful tool for foresight, societal deliberation, and inspiring innovation (the "hieroglyph" concept).The importance of moving beyond easy apocalypses to explore "protopian" futures where things are actively getting better, and the challenge of crafting compelling narratives of social change.How reflecting on classic tales like Frankenstein can inform our approach to scientific creativity, responsibility, and the societal implications of new technologies like AI.The potential resurgence of the humanities in an AI-driven world and why critical thinking and a rich self-imagination are crucial for collaborating with new technologies.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

06-25
57:34

How AI Can Accelerate Science & Its Own Adoption with Niklas Lundblad

In this episode of the Existential Hope Podcast, Niklas Berild Lundblad, a philosopher, researcher, and former policy lead at Google DeepMind, Google, and Stripe, explores the interplay between progress, complexity, and the transformative potential of artificial intelligence.Niklas discusses why asking the right questions is crucial for navigating our future, especially as AI challenges our self-perception and introduces new forms of complexity. He discusses the "soft narcissism" in AI development, the distinction between AI and AGI, and why we should view current AI not as a mirror, but as a strange, exotic artifact whose full capabilities we are still underestimating. In this conversation, we explore:The critical relationship between progress and complexity, and why managing this dynamic is essential for societal growth (including the "Red Queen effect").Why current AI developments feel different from past tech hypes.The potential for AI to revolutionize scientific discovery.How AI could accelerate its own diffusion.The need for curious regulators, mechanisms for change, the challenges of agentic AI, and how cultural biases might affect our approaches to regulation.The Solow Paradox and the Gartner Hype Cycle as frameworks for understanding technology adoption.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

06-17
01:00:58

Nobel Laureate David Baker on Using AI for Science to Solve Humanity's Biggest Problems

In this episode of the Existential Hope Podcast, Nobel Laureate David Baker reveals how scientists are now inventing entirely new proteins—life's fundamental building blocks—to tackle some of the world's most pressing challenges.David shares his journey and his vision for a future where custom-built "molecular machines," an idea once explored by thinkers like Eric Drexler, could repair our bodies, clean up pollution, and create sustainable materials. He explains how breakthroughs in AI are supercharging this field, but also why human ingenuity and collaborative science are still essential to unlocking these revolutionary possibilities.In this conversation, we explore:The incredible power of designing brand-new proteins for groundbreaking medicines, environmental cleanup, and creating novel materials.The exciting prospect of "molecular machines": tiny engines built from proteins to perform complex tasks, inspired by early visions of nanotechnology.How AI is accelerating scientific discovery, and what it takes to translate these digital designs into real-world solutions.David’s "communal brain" philosophy for fostering innovation and his advice for anyone wanting to solve big, meaningful problems.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

06-11
43:44

David Deutsch on Knowledge, Progress, and the Future of Everything

In this episode of the Existential Hope Podcast, physicist and author David Deutsch joins us to explore the deeper principles behind knowledge, progress, and the future of humanity.David is known for founding the field of quantum computation and, alongside Richard Jozsa, creating the first quantum algorithm that solves problems exponentially faster than classical methods. He’s also the originator of constructor theory—a bold framework aiming to redefine the foundations of physics.In this conversation, we explore:Why beauty and explanatory power are central to scientific progress—and how they guide us toward better theories.The challenges and promise of aligning AI with human values, and how critical thinking plays a key role.How education systems could be redesigned to foster creativity, curiosity, and deeper understanding.The case for optimism—not as wishful thinking, but as a rational stance grounded in our capacity for error correction and improvement.This episode was originally published in April 2023. On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

06-06
01:04:41

David Pearce on Ending Suffering and Reimagining Humanity

In this episode of the Existential Hope Podcast, philosopher and transhumanist David Pearce joins us to explore a bold vision of the future—one where suffering is abolished, aging is optional, and human potential is radically expanded.David is best known for The Hedonistic Imperative, a manifesto arguing that biotechnology can—and should—be used to eliminate all forms of suffering in sentient life. As a leading voice in transhumanism and bioethics, he challenges us to think beyond what we’ve accepted as “natural.”In this conversation, we explore:The scientific and ethical case for ending suffering—across humans and non-human animals.How cognitive enhancement could reshape consciousness, creativity, and compassion.Whether radical life extension is a moral imperative—and what it means for future generations.The role of technology in creating a future that’s not just free from harm, but full of flourishing.If you’ve ever questioned the limits of the human condition—or wondered what a truly compassionate future could look like—this episode will stretch your thinking in surprising ways.Full transcript, list of resources, and art piece: https://www.existentialhope.com/podcastsOn the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

06-06
01:02:51

Steven Pinker on Why the Future Looks Better Than You Think

In this episode of the Existential Hope Podcast, cognitive psychologist and bestselling author Steven Pinker explores why, despite massive gains in human progress, many people remain pessimistic about the future—and why that matters for shaping what comes next.Steven argues that while progress isn’t automatic, it is real. By tracking long-term trends in violence, poverty, democracy, and innovation, we can see how human effort—driven by reason, science, and cooperation—has repeatedly pushed civilization forward. Yet, media narratives and cognitive biases often make us blind to these achievements, reinforcing a sense of stagnation or decline.In this conversation, we explore:The hidden progress shaping our world today—from rising literacy rates to declining poverty, and why these trends rarely make the news.Why pessimism can be self-defeating—and how a more accurate understanding of history can help us build a better future.The role of AI, biotech, and clean energy—and why they might unlock transformative improvements, if used wisely.How to communicate ideas that inspire hope—including Steven’s advice on cutting through jargon and tribalism to make ideas stick.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

06-06
39:39

Introducing the New Existential Hope Podcast

We’re excited to share that the Existential Hope Podcast now has its own dedicated feed—and we’re kicking things off with a wave of new episodes.This podcast is for anyone curious about how powerful technologies—AI, biotech, neurotech, nanotech, and more—can help create futures that are not just survivable, but radically better than today.You’ll hear in-depth, idea-rich conversations with the people shaping those futures. Follow now—new episodes dropping soon.On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures. Full transcript, listed resources, and more: https://www.existentialhope.com/podcastsFollow on X. Hosted on Acast. See acast.com/privacy for more information.

06-05
00:46

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