Send us a text In this first Health Edge podcast of 2025, Mark Pettus MD and John Bagnulo PhD, MPH review a 2024 study published in The Journal of Nutrition. https://www.sciencedirect.com/science/article/abs/pii/S002231662400289X?via%3Dihub https://www.thehealthedgepodcast.com
Send us a text In this Health Edge recording, Mark describes a model of integrative health-lifestyle medicine that is distinctly different from current allopathic disease-based models. He examines the metabolic perfect storm of insulin resistance and inflammation as passports to accelerated aging, chronic complex disease risk and poor quality of life or healthspan. His slides can be downloaded at www.thehealthedgepodcast.com
Send us a text Do you ever feel like everything you've been told about healthy eating seems to be teetering on the edge of being overturned? Welcome to a mind-bending exploration where we question the status quo, particularly the demonization of full fat dairy and saturated fats. I'm diving deep into a groundbreaking study suggesting that pentadecanoic acid, a saturated fat found in full-fat dairy could actually promote health and contribute to our longevity. We challenge the shortcomin...
Send us a text Are you ready to unlock the mysteries of protein and its pivotal role in our dietary intake? Strap in as we guide you through the complex world of essential amino acids, and the significant part they play in our bodies. We discuss the importance of achieving a balance in your protein consumption, focusing on the dietary reference intakes, and the potential risks of under-consuming protein. Discover why 25 grams of protein per meal can be beneficial for you, and the distinctions...
Send us a text In this podcast Mark reviews the current paradigm linking environmental inputs-lifestyle with epigenetics and the human microbiome. He translates these connections ibto effective lifestyle medicine interventions. The PowerPoint below goes with the audio recording. You Tube recording can be found below. PowerPoint slides can be downloaded at www.thehealthedgepodcast.com Enjoy!
Send us a text In this episode of the Health Edge Mark and John discuss areas of research they are closely following. John shares some interesting fatty acid research and introduces heptadecanoic acid as an emerging 17-carbon fat, important to healthy brain aging. Mark reviews some aging and longevity research he is following. Topics include epigenetic aging, biologic age regression using Yamanaka factors, gene and cell therapies, and senolytics.
Send us a text In this episode of The Health Edge Mark and John review some papers that challenge the well accepted clinical meme that lowering LDL should be the focal point of reducing CV risk and all-cause mortality risk. Papers referenced: https://www.nature.com/articles/s4159... https://bmjopen.bmj.com/content/6/6/e... https://www.ncbi.nlm.nih.gov/pmc/arti...
Send us a text In this episode of The Health Edge Mark and John review a recent paper drawing connections between excessive sodium restriction and insulin resistance. This adds to a growing body of research suggesting the restriction of sodium below 3-4 gms/day may in fact add to cardiometabolic risk. Current guidelines of 2300 mg/day or less fall well below these levels.
Send us a text This is a replay of a prior podcast examining the relationship between sodium and hypertension. A growing body of research suggests there is a point below which e.g. 3,000 mg/day where risk is increased. This recording is a prelude to our upcoming podcast on sodium restriction and insulin resistance.
Send us a text In this Health Edge podcast recording, Mark and John review a recent paper that drew a strong relationship between erythritol levels in the blood with major adverse cardiovascular (MACE) events. Mark and John anayize the study and offer perspective. https://www.nature.com/articles/s41591-023-02223-9 Another recent review of risks and benefits of erythritol. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824470/
Send us a text In this Health Edge recording Mark and John review recent data on the prevalence of CKD in the US. They review common drivers of CKD and offer many lifestyle medicine recommendations for prevention and management.
Send us a text In this episode of the Health Edge, mark and John review two important studies. The first is a systematic review/meta analysis that clearly links loss of lean body mass (sarcopenia) with all-cause mortality and cardiovascular disease risk. The second paper reviews the underlying mechanisms that link lower muscle mass with greater risk of cognitive decline with aging. https://bjsm.bmj.com/content/56/13/755.info https://pubmed.ncbi.nlm.nih.gov/35661882/
Send us a text Few age-related diseases are more devastating than Alzheimer's. A recent study from Columbia University suggests in individuals 65+ years of age, 10% have a dementia diagnosis and almost 25% have a diagnosis of MCI or mild cognitive decline. For the 90+ age demographic, over 30% have a dementia diagnosis. The costs to the individuals and those who care for them is staggering. In this recording, mark and John review the data from this paper (Annals of Neurology October 2022) and...
Send us a text Cardiovascular disease continues to be the #1 cause of mortality in the US and around the world. In this episode of The Health Edge, Mark and John review a paper that begins to address why it is that as we age, our risk for cardiovascular disease (CVD) and all other "age-related diseases" goes up dramatically. In this 2021 paper from the Journal of The American College of Cardiology, inhabitants of the Ikaria Island in Greece, a Blue Zone culture demonstrate lower levels of age...
Send us a text In this recording of The Health Edge, Mark and John discuss the importance of dietary intake and sources of omega 6 and omega 3 fats. An abundance of epidemiological and clinical trials suggest high ratios of O-6/O-3 drive increased inflammation, oxidative stress and are associated with increased cardiovascular and all-cause mortality. Mark and John look at the biochemistry and some clinical trials that support avoidance of processed omega-6 vegetable oils and encourage more wh...
Send us a text In this episode of The Health Edge Mark and John review some recent studies that continue to challenge the long held belief that saturated fatty acid intake (SFAs) is directly linked to diabetes and cardiometabolic risk. https://www.thelancet.com/article/S0140-6736(17)32252-3/fulltext https://pubmed.ncbi.nlm.nih.gov/36056919/
Send us a text In this recording of The Health Edge, Mark and John interview Mark Campbell PhD. We discuss the science linking time in Nature with global health outcomes. About Mark Campbell: Dr. Mark A. Campbell uses his background in wellness, sports medicine, exercise science, and performance psychology to impact change across all areas of life. His diverse background affords him the ability to help audiences see the world through many lenses. Mark shares his unique blend of holistic educa...
Send us a text In this latest Health Edge video John and Mark discuss their perspectives on protein intake. How much? Animal versus plant?
Send us a text In this episode of The Health Edge Mark and John review a recent study published by the Journal of the American College of Cardiology, Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Mark and John reflect on how we got here and why this is so important to recognize and respond to. Lifestyle drivers and interventions are discussed that have the potential to powerfully reverse these concerning trends. Article referenced: https://pubmed.ncbi.nlm.nih...
Send us a text Is it possible that consuming too much fruit could be detrimental to your health? Are all fruits the same? In this recording of The Health Edge Mark and John will explore the relationship between dietary fructose intake (from sugar and high fructose corn syrup and fruits), endogenous metabolic conversion of glucose to fructose (high glycemic foods), and high salt intake (> 5,000 mg sodium/day) with high uric acid cardiometabolic syndrome risk. The evolutionary biologic impor...