Dr. Katherine Fitzgerald discusses a 2002 paper by Jürg Tschopp and colleagues that first defined the formation of the inflammasome complex.
Dr. Claudia Kemper discusses a 1985 PNAS paper that first identified CD46, a key regulatory molecule in the complement system.
Dr. Todd Fehniger discusses two seminal papers that demonstrated a role for IL-15 in the development and survival of natural killer cells.
Dr. Alberto Martin discusses A 1985 paper demonstrating that cancer could be caused by a non-mutated version of Myc
Dr. Craig Bassing discusses a 1993 Science paper by Frederick Alt that demonstrating a role for RAG2 in T cell development.
Dr. Shabaana Khader discusses a 2003 Nature paper by Daniel Cua that defined a specific role for IL-23 in autoimmune inflammation.
Drs. Bethany Moore and Steven Kunkel discuss a 1987 PNAS paper that first identified a chemotactic cytokine that would eventually be known as IL-8.
Dr. Uttiya Basu discusses a 1999 paper by the group of Tasuku Honjo that demonstrates a critical role for activation-induced cytidine deaminase in class switch recombination and somatic hypermutation of B cells.
Dr. Luc van Kaer discusses a 1994 paper by the group of Dr. Don Wiley that demonstrated the binding of superantigens with the MHC class II molecule.
Dr. Martin Flajnik discusses a 2004 Nature paper by Drs. Max Cooper and Zeev Pancer that identified the existence of variable lymphocyte receptors that which were generated by non-RAG-based rearrangement events.
Dr. Wolf H. Fridman discusses a 2001 paper by the group of Robert Schreiber that established the foundations of modern immune-oncology.
Dr. Philippa Marrack discusses a 1994 Nature paper by Charles Surh and Jonathan Sprent that identified apoptotic cells in the thymus during positive and negative selection.
Dr. Dr. Jordan Orange discusses a 1994 Cell paper by Ute Francke that reported the discovery of the Wiskott Aldrich Syndrome Protein gene.
Dr. Wendy Havran discusses a 2001 paper by Adrian Hayday that demonstrates anti-tumor functions for skin-resident gamma delta T cells.
Dr. Eric Vivier discusses a 1999 paper by Thomas Spies that revealed a new mode of immune recognition via NKG2D on NK cells.
Dr. Marc Peters-Golden discusses a 1978 paper by Robert Murphy and Bengt Samuelsson that provided the first structural characterization of leukotriene C4.
Dr. Sebastian Amigorena discusses a 1994 paper by Sallusto and Lanzavecchia that made significant contributions to the field of dendritic cell biology.
Dr. Patricia Gearhart discusses a 1965 paper from Michael Potter and the Michael Potter Homogenous Immunoglobulin workshops held at the NIH.
Dr. James Hagman discusses a 1997 paper from the laboratory of Tak Mak, which first described the phenotype of T and B cells in mice lacking IRF4.
Dr. Jane Buckner discusses 1974 papers from Bottazzo and MacCuish that were instrumental in determining that autoantibodies are directed at pancreatic islet cells in type I diabetes.