Osterholm Update

<p>In "Brighter Days Ahead," Dr. Osterholm and Chris Dall discuss the latest national and international COVID trends, recent research on long COVID, and measles cases in the U.S. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews two members of the podcast team.</p> <p>Please fill out our <a href="https://redcap.ahc.umn.edu/redcap/surveys/?s=DKAXDYKTDXCN4HLT">Listener Feedback Survey</a>!</p> <p><a href="https://www.cidrap.umn.edu/covid-19/three-studies-spotlight-long-term-burden-covid-us-adults">Three studies spotlight long-term burden of COVID in US adults</a> (Van Beusekom, <em>CIDRAP News</em>)</p> <p><a href="https://www.science.org/content/article/long-covid-trials-aim-clear-lingering-virus-help-patients-need">Lessons in persistence: new long COVID trials aim to clear lingering virus—and help patients in dire need</a> (Couzin-Frankel, <em>Science</em>)</p> <p><a href="https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates">The pandemic’s true death toll</a> (<em>The Economist</em>)</p> <p><a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/superbugs-you">Superbugs &amp; You podcast</a></p> <p><a href="https://www.cidrap.umn.edu/osterholm-update">More episodes</a></p> <p><a href="cidrap.umn.edu/support">Support this podcast</a></p> <ul>&nbsp;</ul>

<p>In "H5N1 Uncertainty," Dr. Osterholm and Chris Dall discuss the latest national COVID trends, a recent study on Paxlovid, and H5N1 avian flu virus infection in cattle. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews two members of the podcast team.</p> <p>Please fill out our <a href="https://redcap.ahc.umn.edu/redcap/surveys/?s=DKAXDYKTDXCN4HLT">Listener Feedback Survey</a>!</p> <p><a href="https://www.cidrap.umn.edu/covid-19/swedish-study-suggests-link-between-long-covid-and-severity-illness">Swedish study suggests link between long COVID and severity of illness</a>&nbsp;(Stephanie Soucheray,&nbsp;<em>CIDRAP News</em>)</p> <p><a href="https://www.cidrap.umn.edu/covid-19/study-long-covid-affects-8-those-covid-19-more-common-women">Study: long COVID affects 8% of those with COVID-19, is more common in women</a> (Stephanie Soucheray,&nbsp;<em>CIDRAP News</em>)</p> <p><a href="https://www.cidrap.umn.edu/covid-19/new-neurologic-issues-less-likely-after-severe-covid-flu-research-suggests">New neurologic issues less likely after severe COVID than flu, research suggests</a> (Mary Van Beusekom,&nbsp;<em>CIDRAP News</em>)</p> <p><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2309003">Nirmatrelvir for vaccinated or unvaccinated adult outpatients with COVID-19</a> (Hammond et al.,&nbsp;<em>New England Journal of Medicine</em>)</p> <p><a href="https://www.nejm.org/doi/full/10.1056/NEJMe2402224">Treating acute COVID-19 — final chapters still unwritten</a> (Gandhi &amp; Hirsch,&nbsp;<em>New England Journal of Medicine</em>)</p> <p><a href="https://www.cidrap.umn.edu/osterholm-update">More episodes</a></p> <p><a href="cidrap.umn.edu/support">Support this podcast</a></p>

<p>In "Good News in a COVID-Indifferent World," Dr. Osterholm and Chris Dall discuss the national and international COVID trends, the latest research on long COVID, and antibiotic-resistant <em>Shigella</em>. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews members of the podcast team.&nbsp;</p> <ul> <a href="https://doi.org/10.1038/s41590-024-01754-8">Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19</a> (Hanson et al.,&nbsp;<em>Nature Immunology</em>)<br> <a href="https://www.pewresearch.org/science/2024/03/07/how-americans-view-the-coronavirus-covid-19-vaccines-amid-declining-levels-of-concern/">How Americans view the coronavirus, COVID-19 vaccines amid declining levels of concern</a> (Tyson &amp; Pasquini,&nbsp;<em>Pew Research Center</em>)<br> <a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/spike-extensively-drug-resistant-shigella-cases-reported-uk-europe">Spike in extensively drug-resistant Shigella cases reported in UK, Europe</a> (Dall,&nbsp;<em>CIDRAP News</em>)<br> <a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/cdc-warns-increase-extensively-drug-resistant-shigellosis">CDC warns of increase in extensively drug-resistant shigellosis</a> (Dall,&nbsp;<em>CIDRAP News</em>)<br> <a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/superbugs-you">Superbugs &amp; You podcast</a> — new episode&nbsp;coming 3/26!<br> <a href="https://www.theguardian.com/society/2020/may/26/last-iron-lung-paul-alexander-polio-coronavirus">The man in the iron lung</a> (McRobbie, <em>The Guardian</em>)<br> <a href="https://www.cidrap.umn.edu/osterholm-update">More episodes</a><br> <a href="cidrap.umn.edu/support">Support this podcast</a> </ul>

<p>In "A Tough Conversation," Dr. Osterholm and Chris Dall discuss the new CDC COVID isolation guidelines, a measles outbreak in Florida, and the latest news on avian influenza.&nbsp;Dr. Osterholm also provides an update on influenza and RSV cases in the U.S. and shares the latest "This Week in Public Health History" segment.</p> <ul> <a href="https://www.cdc.gov/respiratory-viruses/background/index.html">Background for CDC’s Updated Respiratory Virus Guidance</a> (CDC)<br> <a href="https://www.cidrap.umn.edu/support">Support this podcast</a> </ul>

<p>In this episode, Dr. Osterholm and Chris Dall discuss COVID isolation guidelines, the BA.2.87.1 variant, and the importance of measles and other rare public health threats.&nbsp;</p>

<p>In "A Family Discussion," Dr. Osterholm and Chris Dall discuss the latest SARS-CoV-2 variant, consider the current and future challenges accessing Paxlovid, and explore new long COVID research. Dr. Osterholm also revisits last episode's discussion on changing public health guidelines and celebrates some canine heroes in the "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="https://www.pnas.org/doi/10.1073/pnas.2300644120">Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes</a> (Yue Zhang,&nbsp;<em>PNAS</em>)<br> <a href="https://www.startribune.com/minnesota-hospitals-say-65000-days-of-care-were-avoidable-if-patients-had-somewhere-to-go/600340025/">Minnesota hospitals say 65,000 days of care were avoidable if patients had somewhere to go</a>&nbsp;(Jeremy Olson,&nbsp;<em>Star Tribune</em>)<br> <a href="https://www.health.state.mn.us/diseases/coronavirus/paxrx.pdf">Have a Paxlovid Prescription? Low Cost Options Available</a> (Minnesota Department of Health)<br> <a href="https://treatments.hhs.gov/">Find COVID-19 Medications</a> (Administration for Strategic Preparedness and Response, HHS)<br> <a href="https://www.washingtonpost.com/lifestyle/2024/01/31/shelter-dog-rescue-homeless-fayetteville/">Homeless man leaves puppies at N.C. shelter with heart-tugging note</a> (Cathy Free,&nbsp;<em>Washington Post</em>) </ul>

<p>In "A Period of Transition," Dr. Osterholm and Chris Dall discuss the latest COVID-19 trends in the U.S. and around the world, a recent study on long COVID, and the rise of measles cases in the United States. Dr. Osterholm also provides an update on influenza and RSV cases in the U.S. and shares the latest "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="https://www.science.org/doi/10.1126/science.adg7942">Persistent complement dysregulation with signs of thromboinflammation in active long COVID</a> (Cervia-Hasler et al.,&nbsp;<em>Science</em>)<br> <a href="https://erictopol.substack.com/p/lighting-up-long-covid">Lighting up long COVID</a> (Eric Topol,&nbsp;<em>Ground Truths</em>)<br> <a href="http://tinyurl.com/LCEditorial">Follow up, funding critical on long COVID</a> (Jill Burcum,&nbsp;<em>Star Tribune</em>)<br> <a href="https://www.cidrap.umn.edu/covid-19/does-paxlovid-prevent-long-covid-maybe-experts-suggest">Does Paxlovid prevent long COVID? Maybe, experts suggest</a> (Stephanie Soucheray,&nbsp;<em>CIDRAP News</em>) </ul>

<p>In "No Time to Quit," Dr. Osterholm and Chris Dall discuss the JN.1 variant, Paxlovid uptake, and COVID-19 vaccine disinformation. Dr. Osterholm also provides an update on influenza and RSV transmission and shares the latest "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="https://www.latimes.com/opinion/story/2024-01-04/covid-2024-flu-virus-vaccine">Opinion: The U.S. is facing the biggest COVID wave since Omicron. Why are we still playing make-believe?</a> (Eric Topol, <em>LA Times</em>)<br> <a href="https://www.nytimes.com/2024/01/04/health/paxlovid-covid-treatment.html">Paxlovid Cuts Covid Death Risk. But Those Who Need It Are Not Taking It</a> (Christina Jewett,&nbsp;<em>New York Times</em>)<br> <a href="https://www.cidrap.umn.edu/covid-19/commentary-what-can-masks-do-part-1-science-behind-covid-19-protection">COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection</a> (Brosseau et al.,&nbsp;<em>CIDRAP</em>) </ul>

<p>In this episode, Dr. Osterholm and Chris Dall discuss the JN.1 variant, the rising levels of SARS-CoV-2 in wastewater, and the low uptake of the COVID-19, RSV, and influenza vaccines. Dr. Osterholm also shares his thoughts on hospital capacity issues in the U.S. and shares the latest "This Week in Public Health History" segment.&nbsp;</p> <ul> <a href="cidrap.umn.edu/support">Support this podcast</a> </ul>

<p>In "A Seasonless Virus," Dr. Osterholm and Chris Dall discuss the latest COVID-19 trends in the U.S. and around the world, provide an update on influenza and RSV activity, and review two recent studies on long COVID. Dr. Osterholm also answers a listener question on fomite transmission of SARS-CoV-2 and celebrates a recent event in public health history.&nbsp;</p> <ul> <a href="https://www.cidrap.umn.edu/covid-19/report-underscores-financial-pressure-long-covid-families">Report underscores financial pressure of long COVID on families</a> (CIDRAP News)<br> <a href="https://www.cidrap.umn.edu/covid-19/5-covid-infected-us-veterans-still-had-symptoms-1-year-later">5% of COVID-infected US veterans still had symptoms up to 1 year later</a>&nbsp;(CIDRAP News) <p><a href="https://www.nature.com/articles/s41467-021-25156-8">SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters</a> (<em>Nature Communications</em>, Port et al)</p> <p><a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/high-prevalence-multidrug-resistant-infections-reported-ukraine-hospitals">High prevalence of multidrug-resistant infections reported in Ukraine hospitals</a> (CIDRAP News)</p> </ul> <p>As we near the end of the year, please consider CIDRAP in your charitable giving. To contribute to this podcast and everything we do here at CIDRAP,&nbsp;visit&nbsp;<a href="https://www.cidrap.umn.edu/support">CIDRAP.umn.edu/support</a>.</p>

<p>In "The Hospital Capacity Crisis," Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and around the world, the reclassification of the BA.2.86 variant as a variant of interest, and the surge in pediatric pneumonia hospitalizations in China. Dr. Osterholm also provides an update on influenza and RSV in the U.S. and shares a moment of joy from one of our listeners.&nbsp;</p> <ul> <a href="https://www.cdc.gov/respiratory-viruses/whats-new/covid-19-variant-update-2023-11-27.html#print">Update on SARS-CoV-2 Variant BA.2.86 Being Tracked by CDC</a><br> <a href="https://www.covid.gov/tests">Free at-home COVID tests</a><br> <a href="https://www.nytimes.com/2023/11/13/upshot/long-covid-disability.html">Can’t Think, Can’t Remember: More Americans Say They’re in a Cognitive Fog</a> (Francesca Paris,&nbsp;<em>New York Times</em>) </ul>

<p>In "A Slow Motion Tsunami," Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and around the world, the latest data on influenza and RSV, and potential funding cuts to a federal HIV program. Dr. Osterholm also answers two ID Queries and shares his thoughts on the importance of antimicrobial resistance awareness.</p> <ul> <a href="https://www.cidrap.umn.edu/antimicrobial-stewardship/superbugs-you">Superbugs &amp; You</a> Podcast<br> <a href="/sites/default/files/DebbieGoffarticle-CID.pdf">Isolated and Lonely in a Nursing Home During the Coronavirus Disease 2019 Pandemic: A Deadly Combination for My Mom</a>&nbsp;(Debra Goff, <em>Clinical Infectious Disease)</em><br> <a href="https://www.harvardsquarelibrary.org/biographies/sara-josephine-baker/">Sara Josephine Baker</a> (<em>Harvard Square Library</em>) </ul>

<p>In this episode, Dr. Osterholm and Chris Dall discuss national and international COVID trends, the low uptake in the latest COVID vaccine, and share thoughts about which infectious agents have pandemic potential. Dr. Osterholm also answers an ID query about influenza vaccination and shares a moment of joy from one of our listeners.</p>

<p>In this episode, Dr. Osterholm and Chris Dall discuss the latest national and international COVID trends, an intranasal COVID vaccine candidate, and some recent findings on long COVID. Dr. Osterholm also answers an ID Query about the timing of COVID booster doses and shares two historic public health moments in our new "This Week in Public Health History" segment.</p>

<p>In "One Huge Puzzle," Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and around the world, the rollout of the updated mRNA vaccines, and two recently published studies on long COVID. Dr. Osterholm also shares his thoughts on the updated Novavax vaccine and answers an ID Query about COVID vaccine side effects.&nbsp;</p> <ul> <a href="https://www.washingtonpost.com/health/2021/10/01/katalin-kariko-covid-vaccines/">A one-way ticket. A cash-stuffed teddy bear. A dream decades in the making.</a> (Carolyn Johnson,&nbsp;<em>Washington Post</em>)<br> <a href="https://www.washingtonpost.com/science/2021/10/01/drew-weissman-mrna-vaccine/">A scientific hunch. Then silence. Until the world needed a lifesaving vaccine.</a> (Carolyn Johnson,&nbsp;<em>Washington Post</em>)<br> <a href="https://www.cidrap.umn.edu/anti-science/deadly-societal-force-qa-author-dr-peter-hotez-anti-science-movement">‘A deadly societal force’: A Q&amp;A with author Dr. Peter Hotez on the anti-science movement.</a> (Mary Van Beusekom,&nbsp;<em>CIDRAP News</em>)<br> <a href="https://www.scientificamerican.com/article/do-you-matter-to-others-the-answer-could-predict-your-mental-health1/">Do you ‘matter’ to others? The answer could predict your mental health.</a>&nbsp;(Francine Russo,&nbsp;<em>Scientific American</em>) </ul>

<p>In this episode, Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and around the world as they reflect on infectious disease challenges of the past, present, and future. Dr. Osterholm also shares his thoughts on the CDC's new vaccine recommendations and answers an ID query about outdoor transmission of SARS-CoV-2.</p> <ul> <p><a href="https://www.cidrap.umn.edu/covid-19/cdc-advisers-make-universal-covid-vaccine-recommendation">CDC advisers make universal COVID vaccine recommendation</a> (CIDRAP News, Schnirring)</p> <p><a href="https://polioeradication.org/wp-content/uploads/2023/09/22nd-Report-of-The-Independent-Monitoring-Board-IMB.pdf">Closing in on Zero: Adapting to Complexity and Risk on the Path to End Polio</a> (GPEI Independent Monitoring Board)</p> <p><a href="https://www.cdc.gov/media/releases/2023/s0411-sti.html">U.S. STI Epidemic Showed No Signs of Slowing in 2021 - Cases Continued to Escalate</a> (CDC Newsroom)</p> <p><a href="https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022">Global Tuberculosis Report 2022</a> (WHO)</p> <p><a href="https://www.cdc.gov/mmwr/volumes/72/wr/mm7235a4.htm?s_cid=mm7235a4_w">Outbreak of Multidrug-Resistant Tuberculosis - Kansas, 2021-2022</a> (CDC MMWR)</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33249484/">Outdoor Transmission of SARS-CoV-2 and Other Respiratory Viruses: A Systematic Review</a> (J Infect Dis., Bulfone et al)</p> <p><a href="https://www.hiv.gov/hiv-basics/overview/history/hiv-and-aids-timeline/#year-1981">A Timeline of HIV and AIDS</a> (hiv.gov)</p> </ul>

<p>In "Time for a Mindset Change," Dr. Osterholm and Chris Dall discuss the rise in COVID activity in the U.S. and around the world, a recent study on COVID in white-tailed deer, and a survey on vaccine hesitancy in pet owners. Dr. Osterholm also provides an update on avian and human influenza and shares a moment of joy from one of our listeners.&nbsp;</p> <ul> Amy's <a href="/sites/default/files/amysbeautifulplace.pdf">moment of joy</a> </ul>

<p>In this episode, Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and around the world, the latest research on long COVID, and the recently approved RSV vaccine for infants.</p> <ul> <a href="https://erictopol.substack.com/p/long-term-long-covid?utm_source=post-email-title&amp;publication_id=587835&amp;post_id=136246566&amp;isFreemail=false&amp;utm_medium=email">Long-term long COVID</a> (Eric Topol,&nbsp;<em>Ground Truths</em>)<br> <a href="https://www.statnews.com/2023/08/23/covid-19-has-not-yet-fallen-into-a-seasonal-pattern/?utm_campaign=morning_rounds&amp;utm_medium=email&amp;_hsmi=271352051&amp;_hsenc=p2ANqtz-98anero9akRIPazLXV4xCUocQcT17YGhYzM4lMdv-ODw8IKZvREqP1iLFOjAM7VioQcwv8Zd2HIXzkThVo3-MXbkVSSQ&amp;utm_content=271352050&amp;utm_source=hs_email">COVID-19, a disease with tricks up its sleeve, hasn’t fallen into a seasonal pattern — yet</a> (Helen Branswell,&nbsp;<em>STAT</em>)<br> Leonard's <a href="/sites/default/files/Cranes%20(3974)_70a.JPG">beautiful place</a> </ul>

<p>In this episode, Dr. Osterholm and Chris Dall discuss national and international COVID trends, record dengue outbreaks around the world, and the updated timeline for the new COVID booster shots. Dr. Osterholm also answers an ID query on leprosy in Florida and shares a moment of joy from one of our listeners.</p> <p>Content Warning: This week's dedication and closing include discussion about suicide awareness and prevention. For listeners who would prefer to avoid this topic, we recommend skipping 3:35-6:28 and 1:00:34-1:03:32.&nbsp;</p> <ul> <a href="https://suicidology.org/wp-content/uploads/2019/07/Resources-for-Survivors-of-Suicide.pdf">Resources for suicide loss survivors</a><br> <a href="https://www.nami.org/Support-Education/Support-Groups/NAMI-Family-Support-Group">NAMI Family Support Group</a> </ul>

<p>In "Perspective and Humility," Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and internationally, a recent study on recombinant flu vaccines, and respiratory protection in healthcare settings.</p> <ul> <a href="https://www.who.int/news/item/06-07-2022-un-report--global-hunger-numbers-rose-to-as-many-as-828-million-in-2021">UN Report: Global hunger numbers rose to as many as 828 million in 2021</a> (WHO)<br> <a href="https://erictopol.substack.com/p/from-asymptomatic-covid-to-long-covid">From Asymptomatic COVID to Long COVID: Major Advances in Genetic Underpinnings</a> (Eric Topol, <em>Ground Truths</em>)<br> <a href="https://doi.org/10.1038/s41586-023-06331-x">A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection</a> (Augusto et al.,&nbsp;<em>Nature</em>)<br> <a href="https://www.medrxiv.org/content/10.1101/2023.06.29.23292056v1">Genome-wide Association Study of Long COVID</a> (Lammi et al.,&nbsp;<em>MedRxiv</em>)<br> <a href="https://www.medrxiv.org/content/10.1101/2023.07.13.23292611v1">Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis</a> (Taylor et al.,&nbsp;<em>MedRxiv</em>)<br> <a href="https://doi.org/10.1016/j.vaccine.2023.06.056">Vaccine effectiveness of recombinant and standard dose influenza vaccines against influenza related hospitalization using a retrospective test-negative design</a> (Zimmerman et al.,&nbsp;<em>Vaccine</em>) </ul>