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The Peter Attia Drive

Author: Peter Attia, MD

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Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.
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Today's episode of The Qualys is from podcast #28 – Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life.   The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 
In this “Ask Me Anything” (AMA) episode, Peter answers a wide range of fasting-specific questions from subscribers. Peter starts by defining the various fasting protocols, details his own personal fasting regimen, explains his revised plan for 2020, and provides a ton of value to anyone interested in fasting. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #11 show notes page. We discuss: Defining the various fasting protocols [1:00]; Why Peter plans to switch to a 3-day fast once per month in 2020 [11:00]; How Peter uses his CGM to gain insights into the depth of fast [13:15]; Peter’s supplement protocol during fasting, and why he eats a ketogenic diet leading up to a prolonged fast [17:00]; Peter’s exercise regimen during a fast [23:30]; Peter’s hunger levels during a typical 7-day fast [26:45]; Fasting observations—Core body temperature and thyroid hormone [30:30]; Fasting observations—Glucose, BHB, and hunger levels [33:15]; Peter’s sleep protocol during a fast [40:15]; Does Peter observe any differences between men and women in their ability to fast? [47:00]; How Peter prefers to break a long fast [50:15]; Importance of community support while fasting, and is there a perfect fasting protocol? [52:00]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/ama11/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #34 – Sam Harris, Ph.D.: The transformative power of mindfulness.   The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 
In this episode, Paul Grewal, internal medicine physician and co-author of Genius Foods, discusses what has got him so focused on lifestyle changes for metabolic health which was partly brought on by his own experience of losing almost 100 pounds at two points in his life. Paul and Peter discuss how the results from a NuSI-funded study has impacted their feelings about the supposed “metabolic advantage” of a low-carb diet. Paul then makes the case for what he calls the “active poisoning” of the American food supply, defines his five phenotypes of obesity manifestation, as well as lays out his nutritional and training approach with his patients (as well as himself personally). Overall, this discussion is a treasure trove of topics from endocrinology, insulin resistance, caloric restriction, fasting, exercise, causes of obesity, LDL and heart disease, and much more. We discuss: Paul’s health story—two instances of major weight loss [3:15]; The multiplication of adipocytes after weight loss, and why an obese adult that was overweight in childhood is harder to treat than adult-onset obesity [7:30]; Low-carb diets—Is there a metabolic advantage in energy expenditure? (And Peter’s take on the NUSI study) [12:45]; The relationship between hyperinsulinemia and hyperglycemia—which is causing which? [27:00]; Weight gain—Which macronutrients are driving it, processed foods, and overfeeding studies [31:15]; The active poisoning of our food supply with processed foods [36:15]; The role of fructose in metabolic disease and NAFLD [39:00]; Where traditional medicine falls short in the real world and why “functional medicine” is gaining steam [45:45]; Relationship between heart disease and LDL, residual risk, LDL clearance problem, and a patient case study [54:00]; Relationship between heart disease and fatty acids (SFA, PUFA, seed oils, etc.) [1:04:30]; Paul’s nutritional approach with patients [1:12:30]; High-carb/low-fat diet for muscle gain, and the “reverse diet” to combat the slowdown of metabolism after caloric restriction/weight loss [1:15:00]; Fasting—ideal duration, how to preserve muscle mass, and the ultimate tool of medicine [1:23:30]; The 5 phenotypes of obesity, and the impact of carbs, cortisol, and sleep on adiposity [1:28:30]; Uric acid [1:38:15]; Paul’s 2nd big physical transformation—How he did it and kept the weight off [1:39:15]; Paul and Peter’s personal struggles with food, internal dialogue, and self-image [1:45:00]; Paul’s personal nutritional strategy (and how his exercise influences it) [1:52:00]; A low-fat diet Peter is willing to try [2:00:40]; The keto diet for competitive athletes [2:05:00]; How Peter prescribes exercise to his patients [2:08:30]; Calculating glycogen depletion and RQ, creatinine-kinase system, Tabata workouts, and more [2:10:30]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/paulgrewal Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease.   The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
In this episode, Rick Johnson, Professor of Nephrology at the University of Colorado, explains how his research into the causes of blood pressure resulted in a change of research direction to focus more on how fructose has such profound metabolic effects. Rick discusses the relationship between salt and high blood pressure, provides a masterclass into uric acid, and expertly reveals the mechanisms and pathways by which sugar (specifically fructose) can profoundly impact metabolic health. From there, he explains how he applies this information to real life patients, as well as touches on some of the most promising ideas around pharmacotherapy that are being developed in response to the epidemics of fatty liver, insulin resistance, diabetes, and obesity. Furthermore, Rick gives his take on artificial sweeteners compared to real sugar, discusses cancer’s affinity for fructose, and much more. We discuss:  The connection between blood pressure and fructose that shifted Rick’s professional focus [4:00]; The relationship between salt and blood pressure (and the role of sugar) [5:45]; Defining fructose, glucose, and sugar [19:30]; An ancient mutation in apes that explains why humans turn fructose into fat so easily [23:00]; The problems with elevated uric acid levels, and what it tells us about how sugar causes disease [31:30]; How sugar causes obesity—explaining the difference in glucose vs. fructose metabolism and the critical pathway induced by fructose [40:00]; Why drinking sugar is worse than eating it [50:00]; Unique ability of sugar to drive oxidative stress to the mitochondria, insulin resistance, and diabetes [54:00]; Why cancer loves fructose [1:00:15]; The many areas of the body that can use fructose [1:05:00]; Fructokinase inhibitors—a potential blockbuster? [1:07:15]; Treating high uric acid levels—Rick’s approach with patients [1:10:00]; Salt intake—what advice does Rick give his patients? [1:16:30]; How excess glucose (i.e., high carb diets) can cause problems even in the absence of fructose [1:21:00]; Artificial sweeteners vs. real sugar—which is better? [1:29:15]; Umami, MSG, alcohol, beer—do these have a role in metabolic illness? [1:33:45]; Fructose consumption—Is any amount acceptable? Is fruit okay? Where does Rick draw a hard line? [1:38:45] How does Rick manage the sugar intake of his young kids? [1:43:00]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/rickjohnson Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #06 – D.A. Wallach: music, medicine, longevity, and disruptive technologies. The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 
In this episode, Damon Hill, 1996 Formula 1 World Champion, opens up about his personal struggles with depression, feelings of inadequacy, loss of identity, and his ultimate path to healing following his remarkable racing career. Damon’s life was given a tragic jolt at 15 years of age when his father and legendary F1 driver Graham Hill died suddenly—the common string that ties together so much of his life and has forged so much of who he is to this day. We discuss Damon’s unique and remarkable racing career including his legendary battles with Michael Schumacher as well as Damon's firsthand account of what happened that tragic day on May 1st, 1994, when his teammate, Ayrton Senna, died at Imola. But this is not just about racing; rather it’s a human story that's cloaked in a racing one. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/damonhill/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #03 – Ron Krauss, M.D.: a deep dive into heart disease. The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 
In this episode, Dr. Iñigo San Millán, Assistant Professor at the University of Colorado School of Medicine, explains the crucial role of mitochondrial function in everything from metabolic health to elite exercise performance. Iñigo provides a masterclass into the many different energy system pathways, the various fuel sources (including the misunderstood lactate), the six zones of exercise training, and the parameters he uses to measure metabolic health. Additionally, he highlights the power of zone 2 training in its ability to act as a powerful diagnostic tool, and perhaps more importantly as a treatment for mitochondrial and metabolic dysfunction. We discuss: Iñigo’s background in sports and decision to focus on education [7:15]; Explaining the various energy systems and fuels used during exercise [14:45]; Iñigo qualifies energy systems into six training zones [26:00];  Lactate is an important fuel source [33:00]; Zone 2 training—physiologic characteristics, fuel sources, lactate, and the transition into zone 3 [40:30]; Using blood lactate levels (and zone-2 threshold) to assess mitochondrial function [47:00]; Accessing mitochondrial function by looking at one’s ability to utilize fat as fuel (with an RQ test) [55:00]; Athletes vs. metabolically ill patients—mitochondria, fat oxidation, muscle glycogen capacity, “fat droplets”, and more [1:00:00]; Physiologic characteristics of zone 3, zone 4, and the lactate threshold [1:20:00]; Fueling exercise—dietary implications on glycolytic function [1:30:30]; Relationship between exercise and insulin sensitivity (and what we can learn from studying patients with type 1 diabetes) [1:46:30]; Metformin’s impact on mitochondrial function, lactate production, and how this affects the benefits of exercise [2:04:15]; Raising awareness for risk of “double diabetes” [2:15:00]; How to dose zone 2 training, and balancing exercise with nutrition [2:18:00]; Proposed explanation of the Warburg Effect: Role of lactate in carcinogenesis [2:27:00]; Doping in cycling, and the trend towards altitude training [2:39:15] and; More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/inigosanmillan Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #25 – Scott Harrison: transformation, finding meaning, and taking on the global water crisis. The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
In this “Ask Me Anything” (AMA) episode, Peter answers a wide range of questions from subscribers. Bob Kaplan, Peter’s head of research, asks the questions. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed. You can also listen to this full episode on our website at the AMA #10 show notes page. We discuss: Does testosterone supplementation impact longevity? [2:40]; Under what conditions does Peter decide to treat patients who have low testosterone? [8:50]; Are there risks involved with testosterone replacement therapy? [17:10]; How does Peter diagnose and treat hypothyroidism? [21:30]; How might someone do time-restricted feeding while also adding muscle mass? [26:30]; If building muscle requires higher levels of IGF-1, should we be concerned about longevity? [34:45]; How to preserve muscle mass while fasting [41:45]; Is it possible to simultaneously lose fat and add muscle mass? [46:30]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/ama10 Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system. The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 
In this episode, Bill Harris, Ph.D. in human nutrition and expert on omega-3 fatty acids, sets the table by clearly defining the families of fatty acids (saturated, monounsaturated, polyunsaturated) before diving into the current landscape of polyunsaturated fat (omega-6 and omega-3) with a particular focus on EPA and DHA (the two main elements of fish oil supplements). Bill gives a historical overview, updates us on the latest science related to the health benefits, and provides plenty of insights as to how we should think about increasing our EPA and DHA intake. We discuss: Bill’s long history of studying fatty acids [6:30]; Defining the fatty acids—SFA, MUFA, PUFA, omega-3, omega-6, and more [9:45]; What is the significance of fatty acids? Why should we care? [19:45]; History of fat phobia, saturated fat, and does PUFA reduce cholesterol? [23:45]; Breaking down the conversion process of omega-6 and omega-3 fatty acids including how we get to EPA and DHA [28:00]; Takeaway from Bill’s 1980 study looking at how salmon oil affected cholesterol and triglyceride levels [36:15]; History of our understanding of omega-3 and its effect on LDL cholesterol [45:00]; Prescribed fish oil drugs vs. OTC supplements—Differences and recommended brands [52:00]; Health benefits of EPA [57:45]; Potential benefits of ALA and how it compares to taking EPA and DHA directly [1:12:45]; Health benefits of DHA [1:17:15]; Cell membrane omega-3 index—What is it, the role of genetics, how to increase it, and a recommended target [1:19:00]; Is EPA or DHA neuroprotective? Can it help with depression? [1:23:30]; Recommended fish to eat for EPA and DHA - Any mercury concerns? [1:25:45]; Can omega-3 mitigate risks associated with smoking? [1:29:15]; The problem with the omega-6 to omega-3 ratio [1:30:00]; The problem with labeling any kind of fatty acid as “bad” [1:36:00]; Why increasing EPA and DHA intake matters more than reducing omega-6 intake [1:38:00]; Important takeaway from the VITAL study [1:46:30]; Importance of testing your omega-3 index [1:53:00]; Exciting study coming out soon, and why you need to take your fish oil with food [1:57:15]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/billharris Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system. The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 
In this episode, Mark Messier, six-time Stanley Cup champion, shares the most valuable lessons he picked up over 25+ years of professional hockey resulting in one of the longest and most decorated careers in hockey history. Mark shares what lead to his unique brand of humble leadership, how he was able to get talented individuals to effectively work as a team, the importance of maturing and evolving as a person, and how he was able to stay calm and perform at his best under enormous amounts of pressure. Additionally, we go through his favorite moments as a player, what it was like playing with and learning from The Great One, Wayne Gretzky, and much more. We discuss: Overview of Mark’s extraordinary 25+ year professional hockey career [7:15]; The trend towards kids focusing on one sport earlier and earlier—A good or bad thing? [12:00]; Mark’s early passion for hockey, and when he realized it could be his “job” [14:15]; Going pro at age 17 [19:30]; Mark’s favorite experience playing professional hockey [25:45]; Playing with (and learning from) the great Wayne Gretzky [26:40]; A hard lesson learned in his first year as a pro [32:00]; Lessons learned from losing his first Stanley Cup Finals [35:45]; Redemption—Winning his first Stanley Cup and the beginning of a dynasty in Edmonton [41:15]; Importance of team character [54:00]; The shocking trade of Wayne Gretzky, and Mark stepping up as the new leader and team captain [59:30]; Playing for the New York Rangers—the lure of the city and the pressure to perform [1:07:00]; Ending the 54-year championship drought for the New York Rangers [1:13:30]; Becoming a great leader [1:16:30]; How to win the mental war against your opponent [1:20:30]; Opposing players for which Mark had great respect [1:22:00]; Retiring after an unbelievably long and lustrous career [1:27:00]; How to leverage stress and nervousness into a positive force [1:32:45]; The most important quality—A willingness to learn, improve, and evolve [1:36:00]; What does Mark do today for exercise to stay in great shape? [1:44:30]; Why playing sports is such a great thing for kids [1:49:30]; The Mark Messier Foundation [1:53:00]; How has Mark avoided the “loss of identity” feeling which plagues many retired athletes? [1:56:15]; Does Mark think it’s possible to reproduce a team as good as his Oilers teams of the 80s? [1:59:30]; Would Mark ever want to coach in the NHL? [2:03:00]; Will the Toronto Maple Leafs ever win the Stanley cup? [2:04:00]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/markmessier Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #32 – Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process.    The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 
In this episode, Dr. Debra Kimless and Steve Goldner share their knowledge on the science, policy, and market evolution of medicinal cannabis. We start with the differences between THC and CBD, how they work in the body, and how they act on the brain. We discuss the many potential benefits of using CBD, THC, hemp in the various forms of administration (smoking, vaping, edibles, oils, etc.) as well as some of the safety issues including the recent uptick in incidents of hospitalization and death linked to vaping. Debra and Steve are both involved with the company, Pure Green—Debra the Chief Medical Officer and Steve the founder and CEO—whose aim is to create the safest, most efficacious form of delivery of cannabis. Their bigger mission is to shift the perception of the cannabis plant, garner acceptance of its medicinal benefits, and ultimately get it descheduled on a federal level so more people can access cannabis for a range of chronic ailments. We discuss: Debra and Steve’s background reason for their interest in medical cannabis [7:00]; The history of medical use of cannabis [11:15]; How THC, CBD, and other cannabinoids work [16:00]; Hemp—What it is, special uses, and the 2018 farm bill [22:45]; The legal status of CBD, Deb and Steve’s clinical trial, and how CBD differs from THC [30:15]; The safety profile of THC [35:00]; Is marijuana as a gateway drug? [45:30]; Smoking vs. vaping vs. edibles—Benefits, risks, and mechanistic differences [53:30]; Can you build up a tolerance to the effects of THC? [1:15:00]; What do people generally want to get from using marijuana? [1:17:15]; Cannabinoid synthetics [1:22:30]; Efficacy of CBD oils as a sleep aid [1:25:00]; Pure Green Cannabis [1:30:30]; Anecdotal evidence and managing the hype surrounding cannabis in medical treatment [1:38:45]; Aspirations for the future of medicinal cannabis, and the legal challenges that await them [1:45:15]; Descheduling cannabis: A human rights issue [2:04:00] and; More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/debrakimless-stevegoldner/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Today's episode of The Qualys is from podcast #10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — man’s best friends? — living longer, healthier lives and turning back the clock on aging and age-related diseases.   The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
In this special, bonus celebrity AMA episode, Peter answers questions from former Olympians and past guests, Apolo Ohno and Sasha Cohen, on a wide range of subjects including fasting, learning, training for performance versus longevity, and much more. This bonus AMA is available in full to everyone. Apolo's questions begin [1:45]; Why women may have a harder time fasting, and tips for those who are struggling [2:10]; Is there any place for fasting as part of a nutritional strategy in adolescents? [6:15]; Tips for learning and retaining large amounts of new information (and the best nutritional approach) [9:15]; Must read books of 2019 [14:45; If you could only keep a few watches for the rest of your life which would they be? [16:45]; What workout would Peter do inside a hotel room? [22:15]; What is Peter’s ultimate gorge meal? [23:45]; How do you foresee fasting as a mechanism for performance in athletes? [25:30]; What is driving Peter to strive for excellence? [33:30]; Sasha's questions begin [38:40]; What are you most excited about in the longevity space? [38:45]; At what point do you see enough data or proof that a new drug, or type of fasting is worth trying it out for yourself? [41:30]; Is it possible to obsess so much about your health that it becomes a negative stressor? [46:45]; Which tests are worth doing if you want to be proactive about your health? [48:15]; Are there any supplements Peter things are beneficial to be taking? [55:15]; How does Peter’s training differ when optimizing for performance versus longevity? [56:30]; How does taking testosterone and growth hormone affect performance versus longevity? [59:15]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode:https://peterattiamd.com/celebrityama01 Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
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Comments (69)

Chris Wilson

what an awesome podcast!

Dec 6th
Reply (1)

Jason Thomas

$15 a month subscription. That's more than Netflix.. no thanks

Oct 28th
Reply

Jason Thomas

6:50

Oct 28th
Reply

Pedro Corpuz

Great episode!

Oct 27th
Reply (1)

Jason Thomas

the volume fluctuations through this pod are so look annoying 🤨

Sep 25th
Reply (1)

Jason Thomas

3:57

Sep 25th
Reply

Chris Greive

thanks! My dad died of Alzheimer's so all info from experts is massively appreciated.

Sep 20th
Reply

Richard Ledyard

oh. my. God.

Sep 17th
Reply

fragelicious

That's the recipe for obscurity. Your brand will be limited.

Aug 24th
Reply

fragelicious

You said that the listeners that cant afford the subsciption would still be able to hear the podcast. Three restricted 'Qualies' in a row?

Aug 24th
Reply (1)

Tamás Payer

OMG! One of the bests I have ever heard! Must listen multiple times...

Aug 15th
Reply

Grant Robbins

One of the best podcast episodes I've heard

Aug 13th
Reply (1)

Xtian Dassa

avoid the last 30 min of this one. just car talk

Jul 27th
Reply

Jun Huh

this one is only 13 mins long :/

Jul 22nd
Reply (1)

konkistador90

Very useful podcast, thank you for that

Jul 19th
Reply

JACK SPARROW

great topic, my dad had diffused type b cell lymphoma stage 3 and is in remission now. then last year was confronted with a throat cancer, had it cut out thank god we got it early. the best cure is early detection.

Jul 15th
Reply

Aaron

How many times did he say 'Actually' in this podcast

Jul 10th
Reply

Mary Whitaker

This is boring

Jun 25th
Reply

Christian Velez

Sleep is so important

Jun 3rd
Reply

Steve Quinn

As a T1 diabetic from Australia, I found this insider insight into Dexcom's strategy incredibly insightful. We're yet to get complete coverage for CGMs (currently under 21s and aged care), but there are systems in place that will hopefully get us there eventually. Podcasts like this can only help matters. Thanks!

May 24th
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