The Readout Loud

<p>STAT’s weekly biotech podcast, breaking down the latest news, digging deep into industry goings-on, and giving you a preview of the week to come.</p>

332: Pfizer's new R&D head, a VC deep-dive, and a new FDA commissioner?

Atlas Venture Partner Bruce Booth joins the podcast to discuss his annual year in review report, the influence of China, and what the new Trump administration might mean for innovation. Adam and Allison also recap the latest news in the life sciences, including a new science chief at Pfizer, a new job for Ned Sharpless, and the ongoing presidential appointments.

11-21
35:08

331: AbbVie’s stumble, Amgen’s tumble and more election fallout

Why are AbbVie executives feeling the M&A blues? What does it take to slice $12 billion from Amgen’s market value? And why are STAT’s D.C. correspondents working so hard?  We talk about all that and more on this week’s episode of the “The Readout LOUD,” STAT’s biotech podcast. It’s a “Chatty Cathy” episode! Elaine, Allison and Adam lead off with a discussion about AbbVie’s M&A miscue following the failure of a closely followed schizophrenia drug. You’d hate us if obesity drugs weren’t mentioned, so we oblige with a tick-tock on what went down between Amgen and a Wall Street analyst who noted a possible safety issue with the obesity drug candidate MariTide.

11-14
30:16

330: How a Trump presidency could affect the FDA, the biotech industry, and its stocks

To dig into how the election results could affect all things biopharma, we brought on three guests for this episode: Lizzy Lawrence, STAT’s FDA reporter, Baird analyst Brian Skorney, and longtime biotech executive Daphne Zohar.

11-07
39:22

329: Lilly's earnings surprise, investors mull the election, & a spooky ghost story

Adam, Allison, and Elaine get into the Halloween spirit this week, discussing their favorite candies — and Eli Lilly and Pfizer's surprise earnings reports. Then, they discuss what a Trump or Harris presidency could mean for health care and the biopharma industry, and what investors and biopharma executives think about either outcome.

10-31
28:25

328: Pfizer's activist troubles, gene therapy questions, RFK Jr.'s MAHA ambitions

Will an activist investor campaign against Pfizer lead to big changes at the struggling Pharma giant? Why are some experts questioning the regulatory standards used to approve gene therapies for Duchenne muscular dystrophy? What’s the difference between Novo Holdings and Novo Nordisk, and will it impact a $16 billion acquisition of Catalent? And what lies ahead for Robert F. Kennedy Jr. and the Make America Healthy Again movement?

10-24
33:46

327: Biotech's next gold rush, GLP-1 shortages, and STAT Summit highlights

Elaine, Allison, and Adam chat about investors' interest in using CAR-T to treat autoimmune conditions, the latest developments with the supply of Eli Lilly’s blockbuster weight loss drug, and the invisible medical groups behind the dozens of telehealth platforms providing GLP-1 drugs. They also look back at STAT's two-day summit that brought together biopharma executives, scientists, policymakers and patient advocates for conversations about the future of health care.

10-17
34:19

326: Crypto for CRISPR, a new RNAi startup, & a Nobel for AI

First, biotech veteran John Maraganore calls in to discuss his new startup, City Therapeutics, this week's Nobel Prize awards, and the nerdy accolade he just received. Then STAT's Megan Molteni tells us about "CRISPR baby" scientist He Jiankui and his new cryptocurrency financier.

10-10
40:08

325: Biden's health care AI czar, a new obesity company, and its dealmaking CEO

Our colleague Mohana Ravindranath joins us to talk about Micky Tripathi, charged with coordinating how AI is used across different government agencies and more broadly across the health care industry. We also chat about some important biotech study readouts due before the end of the year, a new, well-funded obesity company, and the successful serial CEO running it. Finally, Adam and Allison lament the fact that Elaine hasn't yet watched the first episode of this season's "Great British Baking Show."

10-03
32:48

From Tradeoffs: Race to the Bottom

We’re excited to share the first episode in a new podcast series on generic drugs from Tradeoffs. It’s called ‘Race to the Bottom,’ and each week the show examines the problems undermining the generic drugs we all rely on — and how we could fix them. Take a listen, and we’ll see you next week.

09-28
28:08

324: Genentech's cancer pivot, Pfizer's sickle cell withdrawal, and a new schizophrenia drug

Our colleague Jonathan Wosen joins us to discuss the recent setbacks and wins in oncology R&D, including Genentech's decision to shut down its cancer immunology group, and the global ambitions of Akeso, the Chinese biotech behind Summit Therapeutics’ recent positive results. We also chat about the latest news in the life sciences, including Pfizer’s sudden announcement to pull its sickle cell drug and the imminent approval of Bristol Myers Squibb’s schizophrenia treatment.

09-26
32:02

323: Cannabinoids for weight loss, a cancelled ad comm, and the Fed lowers interest rates

Mizuho analyst Jared Holz joins us to discuss what the Federal Reserve's long-awaited decision to lower interest rates means for biotech stocks and startups. Elaine, Adam, and Allison also discuss the latest news in life sciences, including the use of cannabinoid receptor drugs in weight loss and the Lasker Awards, a.k.a. "America's Nobel."

09-19
35:21

322: A new threat to Merck's blockbuster cancer treatment, Moderna's cutbacks, and obesity drugs for kids

STAT reporter Matt Herper joins us to break down all the angles of this week's tumultuous week in cancer immunotherapy, including his up-close look at Summit co-CEO Bob Duggan. We also discuss the latest news in the life sciences, including Moderna pruning its pipeline and its spending, plus results from a study that tested a GLP-1 drug in children.

09-12
32:57

321: Summit's upcoming cancer results, Recursion's mixed data, and the next big obesity target

We discuss the next big trend in obesity drug development — treatments that target the amylin hormone. Companies argue that these types of drugs could lead to less nausea and muscle loss, and the first big readout is coming later this year. We also chat about an upcoming presentation from Summit Therapeutics on its cancer drug that beat Merck’s Keytruda, mixed data from Recursion’s lead AI-derived drug candidate, and more news in the life sciences.

09-05
35:18

320: Jim Wilson's next venture, a surprise startup shutdown, & Lilly's Zepbound strategy

STAT biotech reporter Jonathan Wosen joins us to discuss gene therapy pioneer Jim Wilson's exit from his decades-long tenure at the University of Pennsylvania. We also discuss the latest news in the life sciences, including the surprising collapse of a gene editing company, Eli Lilly's pitch to consumers, and more.

08-29
37:34

From "Say More": What Happens When AI Decides Your Medical Coverage

This week, STAT's Casey Ross and Bob Herman joined the Boston Globe's "Say More" podcast to talk about their reporting on AI and Healthcare. We're sharing that episode here with you now. Enjoy!

08-23
22:42

319: BioMarin's executive shakeup, a GLP-1 lowers diabetes risk, and a deep look at Recursion's AI bona fides

It's a guest-free episode this week, giving Allison, Adam and Elaine ample time to chat about the management shakeup at BioMarin, including the announcement that James Sabry, the former Roche dealmaker, was joining the company as its new chief business officer. We can't seem to go a week without talking about GLP-1 medicines, so in true form, Elaine walks us through new study findings that showed Lilly's Zepbound greatly reduced the risk of diabetes. We also discuss a separate study that potentially links GLP-1 drugs to a higher rate of suicidal thoughts. Lastly, Adam and Elaine interrogate Allison about her deeply reported corporate profile of AI drug developer Recursion. Is all the hype real?

08-22
34:07

318: Drug pricing drops & psychedelics under fire

STAT’s chief Washington correspondent Rachel Cohrs Zhang joins us to discuss the discounts and how this first round of negotiations between pharmaceutical companies and Medicare officials played out. After that, we chat with our colleague Meghana Keshavan about the latest news in the psychedelics world, including the retraction of three research papers.

08-15
21:16

317: VC struggles, drug pricing negotiations, & Novo's abrupt Wegovy decision

STAT's Washington Correspondent John Wilkerson joins us to discuss the first round of drug pricing negotiations under the Inflation Reduction Act, which will wrap up by September 1. We also cover the latest news in the life sciences including the merger of AI drug development companies Recursion Pharmaceuticals and Exscientia, Novo Nordisk's decision to pause its regulatory submission for Wegovy's use in patients with heart failure with preserved ejection fraction, and the state of biotech VC.

08-08
28:52

316: The long journey to make malaria vaccines, and Sarepta's ties with patient advocates

Andrew Joseph, STAT's Europe correspondent, joins us to talk about his special report on the 40-year quest to develop the world's first malaria vaccines. We also cover the latest news in the biotech industry, including Sarepta Therapeutics' move to censor a patient video, data from a new Duchenne gene therapy, and a campaign by Mount Sinai to stifle debate about its controversial brain research following revelations made by a STAT investigation.

08-01
34:15

315: UnitedHealth's doctor empire, an FDA departure, and Viking's obesity moves

What makes UnitedHealth similar to Standard Oil? Is Viking Therapeutics an attractive acquisition target? And is Adam good at math? We discuss all that and more in this week’s episode of “The Readout LOUD,” STAT’s biotech podcast. Tara Bannow, our hospitals and insurance reporter, joins us to talk about a new investigation that shows how UnitedHealth wields its unrivaled physician empire to boost its profits and expand its influence. We also cover the latest news in the life sciences, including Viking's sped-up plans in obesity, the departure of a long time official at the Food and Drug Administration, and Kamala Harris' views on health policies.

07-25
32:46

Martin Baba

This is a very high quality podcast news show on life sciences / biotech / pharma industry. I really like the pace and segmentation of stories - long enough to be informative, but does not bog down on every minutiae and angles. It's clear the team does quality prep work. Well done.

09-22 Reply

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