Why do we age? Is it simply the passage of time — or something far more precise, and far more modifiable?In this episode of The Science of Age-less Living, Dr. Ethan Hausman-Marquis takes you deep into the real biology of aging, revealing why growing older is not an inevitable countdown, but a consequence of accumulated cellular damage and declining repair capacity.You’ll learn why aging is best understood as a systems-level failure — a breakdown in information, energy, and repair — rather than a single disease. We explore how DNA damage accumulates over time, why epigenetic regulation drifts and causes identical twins to age differently, and how loss of proteostasis leads to protein misfolding and neurodegenerative disease.The episode then zooms into the cell’s power plants: mitochondria. You’ll discover why mitochondrial dysfunction may be the true biological clock of aging, how redox imbalance and failed mitophagy turn cells into energy-starved “zombie” states, and why restoring mitochondrial health has such wide-ranging effects on longevity.We break down the critical role of NAD⁺ — the cell’s universal energy currency — explaining how its age-related decline impairs DNA repair, silences longevity genes, and accelerates cellular dysfunction, and why NAD⁺ restoration has become a cornerstone of modern longevity medicine.Finally, we demystify peptides. Far from hype or bro-science, peptides are revealed as precision signaling molecules that restore lost cellular communication, gently reminding cells how to behave the way they did in youth — supporting tissue repair, neuroplasticity, immune balance, and healthy growth hormone signaling.This episode reframes aging as a treatable, measurable process — not an unavoidable fate. By the end, you’ll walk away with a clear framework for understanding how modern longevity medicine targets the root causes of aging at the cellular and molecular level, and why multi-layered, systems-based interventions are the future of healthy aging.If you’re ready to move from passive aging to proactive longevity, this episode lays the scientific foundation.
Dr Ethan Hausman-Marquis dismantles the hype around MTHFR in this evidence-based 16:30 talk. Learn what MTHFR actually does, what common variants like C677T and A1298C mean, how homocysteine, folate, B12 and lifestyle shape risk, and when testing or targeted supplementation is appropriate. Perfect for evidence-based health seekers confused by genetic marketing and “methylation” protocols—this calm guide shows how to integrate MTHFR responsibly into clinical care without fear or oversimplification. Watch for clear clinical vignettes, practical treatment principles, and communication tips for patients. If this helped, please like and share with someone told they “have MTHFR.”#MTHFR #Methylation #Homo
Dive into SS-31 Explained: Unlock Youthful Energy at the Mito Level — a 6:45 deep-dive on SS-31 (Elamipretide), mitochondrial health, and the latest 2025 clinical updates. Dr. Ethan breaks down mechanisms, preclinical wins, human trials, safety, and real-world anti-aging potential for longevity seekers (35–65). Learn how SS-31 targets cardiolipin, reduces ROS, boosts ATP, and why FDA approval for Barth syndrome matters for mitochondrial medicine. Perfect for anyone curious about mitochondrial dysfunction, sarcopenia, HFpEF, AMD, and translational longevity science. Like and share if you found this useful. #SS31 #Elamipretide #Mitochondria #Longevity #AntiAging #BarthSyndrome #MitochondrialHealthOUTLINE:00:00:00 Opening and Episode Intro00:01:32 Chapter 1 - Introducing SS-3100:07:06 Chapter 2 - Mechanism00:13:45 Chapter 3 - Preclinical Studies00:21:14 Chapter 4 - Human Trials00:26:31 Chapter 5 - Age-less Living Benefits00:28:46 Chapter 6 - Safety00:30:14 Chapter 7 - Future Outlook00:31:13 Chapter 8 - Wrap Up
Forget Peptides—Sleep Is the Real Longevity Hack — Dive into this episode of The Science of Age-less Living: a 27:30 deep-dive using stock visuals that unpacks why restorative sleep outperforms trendy fixes like peptides and stem cells for healthspan, cellular repair, cognitive resilience, and hormonal balance. Evidence-driven, practical, and tailored for longevity enthusiasts and biohackers, this episode covers sleep science, glymphatic clearance, telomeres, sleep hygiene tips, CBT‑I, wearables, and real-world strategies to optimize circadian rhythm. Follow the script word-for-word for a focused, actionable listen. If this helped you rethink your bedtime, please like and share with fellow biohackers. #Longevity #SleepHygiene #Biohacking #Healthspan #CircadianRhythmOUTLINE:00:00:00 Opening and Setup00:01:27 The Lure of Longevity Hype00:11:08 Stem Cells vs Reality00:16:00 The Science of Sleep00:22:40 Culture, Psychology, and Practical Tools00:28:50 Vision and Call to Action
Join Dr. Ethan at The Catalyst Clinic for "Precision Longevity: Real Cases, Real Results" — a deep dive into evidence-based longevity medicine. Follow patient case studies on tendon regeneration, chronic fatigue, hair/skin restoration, and cognitive recovery using precision diagnostics, NAD+, targeted peptides (BPC-157, TB-500, MOTS-c, SS-31, GHK-Cu, KPV, Semax, Selank), red-light therapy, exosomes, and AURION™ AI-guided protocols. Learn how systems-level medicine, mitochondrial support, circadian optimization, and nutrition combine to restore function, resilience, and quality of life for longevity seekers aged 35–55. Like and share if this brought clarity or hope. More at thecatalystclinic.com. and Instagram @thecatalytclinic #Longevity #PrecisionMedicine #PeptideTherapy #NAD #RegenerativeMedicine
Dr. Ethan breaks down the science behind reversing biological age in The Age-less Code: Reversing Time with Peptides, Stem Cells & Gene Therapy. This episode from The Catalyst Clinic explores peptides (BPC-157, TB-500, GHK‑Cu, Epithalon), stem cells & exosomes, and gene/epigenetic therapies—connecting practical clinical use with the future of longevity and regenerative medicine. Ideal for longevity seekers (35–65) curious about biological age, NAD, sirtuins, exosome therapy, and personalized protocols. All visuals use licensed stock media. Like and share if you found this valuable. Learn more at thecatalystclinic.com and follow @thecatalystclinic for updates. #Longevity #RegenerativeMedicine #Peptides #StemCells #GeneTherapy00:00:00 Opening00:00:38 The Nature of Aging00:01:38 The Peptide Revolution00:04:37 Stem Cells and Exosomes00:07:04 Gene Therapy and Epigenetic Reprogramming00:09:28 The Continuum of Repair00:10:53 Clinical Translation and Case Reflections00:12:20 The Philosophy of Ethical Rejuvenation00:12:58 The Future Horizon00:13:53 Closing Reflections00:15:12 End Slate and Credits
Dive into the remarkable world of peptides with Dr. Ethan in this enlightening episode of "The Science of Age-less Living." While BPC-157 and TB-500 often steal the spotlight, we'll uncover the hidden potential of KPV and VIP—two lesser-known peptides that hold incredible promise for healing and regeneration. Discover how KPV acts as an anti-inflammatory powerhouse, promoting gut health, while VIP serves as a multi-system modulator affecting everything from the brain to the immune system. Join us as we explore the science behind these game-changing compounds and their therapeutic applications. Like this video and share your thoughts in the comments below!OUTLINE:00:00:00 Welcome to The Science of Age-less Living00:00:37 Shifting the Spotlight to KPV and VIP00:01:02 What to Expect in This Episode00:01:16 The Limitations of Popular Peptides00:01:48 The "Poster Children" of Peptide Therapy00:02:03 The Deeper Benefits of Peptides00:02:22 The Unsung Heroes00:02:38 KPV – The Anti-Inflammatory Powerhouse00:02:56 Origin and Mechanism of KPV00:03:26 How KPV Works in the Body00:03:47 KPV in Simpler Terms00:04:01 Clinical Relevance of KPV00:04:24 KPV and Gut Health00:04:55 KPV and BPC-15700:05:04 KPV’s Expanding Role00:05:28 Current Research on KPV00:05:50 Anecdotal and Clinical Use of KPV00:06:28 KPV Tolerance and Safety00:06:34 What KPV Represents in Medicine00:06:50 VIP – Vasoactive Intestinal Peptide00:06:58 What VIP Is00:07:18 VIP is More Than a Vascular Regulator00:08:01 VIP Effects on Inflammation00:08:18 VIP and Circadian Rhythm00:08:36 VIP Neurons and Biological Clocks00:08:47 Clinical Applications of VIP00:09:25 VIP Influences Brain-Gut Communication00:09:57 Human Trials for VIP00:10:10 Anecdotal Use of VIP00:10:30 VIP is a Double-Edged Sword00:10:50 VIP is Promising for Homeostasis00:11:06 Why Aren’t KPV and VIP More Well-Known?00:11:12 Market Dynamics and Visibility00:11:35 KPV and VIP Act Quietly00:11:46 Complexity of Administration00:11:58 KPV and Marketing Limitations00:12:06 Access and Regulation Challenges00:12:21 Hidden Gems of Peptide Therapy00:12:30 The Future of KPV and VIP00:12:33 Rise in Studies and Research00:12:46 Cornerstones of Repair00:12:56 VIP Could Emerge as a Leading Therapy00:13:06 Imagine a Future with Peptide Therapy00:13:24 Consult a Healthcare Provider First00:13:36 Stay Curious – The Field is Evolving00:13:44 KPV – The Quiet Powerhouse00:13:56 VIP – The Multi-System Modulator00:14:06 The Next Evolution in Peptide Therapy00:14:13 Reach Out and Connect00:14:30 Subscribe for More Longevity Science00:14:54 Stay Curious, Stay Vital, Live Age-lessly
Dr. Ethan breaks down epigenetics and how your daily choices shape biological age in this 19:45 deep-dive. Learn DNA methylation, histone modification, non-coding RNAs, epigenetic drift, methylation clocks (Horvath, GrimAge), and practical lifestyle levers—nutrition, exercise, sleep, stress management, and environmental hygiene—to “rewrite” your cellular code. Explore cutting-edge therapies like peptides, NAD+ micro-dosing, senolytics, and partial reprogramming, plus consumer methylation tests and future epigenetic editing. Perfect for health-conscious adults 35+ seeking science-backed longevity strategies and actionable tips. If this episode helped, please like and share with someone you care about. Visit The Catalyst Clinic for more resources.
Dr. Ethan breaks down how peptide therapy is transforming perimenopause care—targeting hormone balance, mitochondrial function, inflammation, sleep, cognition, libido, and metabolic health. This 38:15 deep-dive covers Epitalon, DSIP, Semax, Selank, Kisspeptin-10, CJC-1295 + Ipamorelin, PT-141, BPC-157, Thymosin Alpha-1, NAD+ support, and practical protocols used at The Catalyst Clinic. If you’re a woman 35–55 navigating perimenopause, learn precision approaches to reduce brain fog, restore energy, protect bone and muscle, and optimize long-term health. Like and share if you found this helpful—help other women discover science-led options for thriving through midlife. #Perimenopause #PeptideTherapy #Longevity #WomensHealth #Mitochondria00:00:00 Opening 00:02:04 Differentiating Perimenopause00:03:46 Cellular Mechanisms00:06:54 Peptides 10100:09:15 Mechanisms and Examples00:13:30 Categories and Protocols00:18:18 Sexual Health and Energy; Inflammation and Longevity00:21:35 Synergistic Protocols00:23:43 Evidence00:28:14 Case Studies00:30:59 Risks, Ethics, and Regulation00:35:55 Sum Up
Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis breaks down genome sequencing, five major genetic pathways to aging (DNA repair, metabolism, inflammation, mitochondria, neurodegeneration), and real-world clinical applications from The Catalyst Clinic. Learn how PRS can shift prevention from one-size-fits-all to truly individualized interventions—while understanding limits like population bias and probabilistic risk. Perfect for longevity science fans curious about precision medicine, NAD+, peptides, and building cognitive and mitochondrial resilience. If this episode helped you, please like and share with someone interested in age-less living. #PolygenicRiskScore #Longevity #PrecisionMedicine #AntiAging #GenomicsOUTLINE:00:00:00 Title and Introduction00:02:35 Genes Aren't Destiny00:06:19 What Is a Polygenic Risk Score?00:10:28 Two Patients Example00:13:17 Five Major Pathways00:20:58 Limitations and Caveats00:25:30 Clinical Application00:27:56 Emotional Impact00:29:58 Closing Reflection
In this episode of The Science of Age-less Living, Dr. Ethan—doctor, molecular biologist, athlete, and regenerative medicine expert—explores the fascinating world of peptides and their essential role in cellular health, performance, and longevity. This episode demystifies peptides, describing them as short chains of amino acids that function as “project managers” within our cells. Using engaging construction site analogies, Dr. Ethan explains how peptides are created from DNA instructions, undergo precise modifications, and are tightly regulated to perform specific tasks. Unlike proteins, peptides are shorter and act mainly as messengers and coordinators, directing when and how cells grow, heal, and defend themselves.Listeners learn about:The biological processes of transcription and translation, which turn DNA blueprints into peptide messengers.How peptides signal, regulate, and coordinate vital cellular functions—like hormone release, tissue repair, and immune defense.The dynamic regulation, modification, and recycling of peptides, and their impact on age-related health and disease.The expanding potential of peptide-based medicine, from anti-aging therapies to immune boosters.Dr. Ethan concludes by emphasizing the adaptability and responsiveness of the body’s peptide system, inspiring listeners to make informed, proactive choices to support their own health and longevity. The episode encourages curiosity, self-education, and an active role in personal wellness, celebrating peptides as unsung heroes at the heart of age-less living.
This podcast episode of "The Science of Age-less Living," hosted by Dr. Ethan , delves into the burgeoning world of peptide therapies and their role in modern medicine, particularly in the context of longevity and wellness. The discussion highlights the science behind peptides—short chains of amino acids with targeted effects on bodily processes—and contrasts their rapid rise in the wellness community with the traditional, cautious approach of Big Pharma. Through real-world case studies, market data, and expert insights, the episode explores whether peptides are a disruptive force or a complementary innovation, examining regulatory challenges, safety concerns, and rampant misinformation in the marketplace. Ultimately, the narrative underscores that while peptides hold immense promise for age-less living and transformative healthcare, their integration requires rigorous science, informed consumer choices, and collaboration between innovators and established pharmaceutical companies to maximize benefits and minimize risks.
Are NAD+ supplements the key to age-less living, or could they pose a cancer risk? In this episode of "The Science of Age-less Living," Dr. Ethan Hausman-Marquis delves into the complexities surrounding nicotinamide adenine dinucleotide (NAD+).Discover its crucial role in energy production, DNA repair, and cellular health, as well as the rising popularity of NAD+ supplements.We’ll examine the scientific evidence linking NAD+ to cancer growth and discuss the implications for those with a history of cancer. With caution advised for certain individuals, learn how to navigate the fascinating landscape of NAD+ supplementation.Join us as we separate fact from fiction and empower your health journey!#NADplus #AgingScience #HealthAndWellness #CancerResearch #AgeLessLivingOUTLINE:00:00:00 The Foundation of Age-less Science or Cancer Curse?00:02:33 NAD+ Basics and Its Importance00:06:16 Hype vs. Science00:09:51 NAD+ and DNA Repair00:11:23 NAD+ and the Immune System00:13:01. Cancer Cells Hijacking NAD+00:15:54. Concerns About NAD+ Supplementation and Cancer00:17:16. NAD+'s Dual Role in Cancer Biology00:18:44. Expert and Regulatory Perspectives on NAD+00:22:22. Recommendations and Conclusion
Can a peptide hold the key to age-less vitality? Join Dr. Ethan on The Science of Age-Less Living as he delves into the science behind testosterone's crucial role in aging and explores the potential of Testagen, a peptide bioregulator, to support natural testosterone function. Discover the theoretical mechanisms, potential benefits for energy, muscle, and overall well-being, and the critical importance of approaching such interventions with caution and expert medical guidance.00:00:00. Introduction to Age-Less Living00:00:30. The Quest for Longevity00:00:49. The Role of Testosterone00:01:05. Understanding Testosterone00:01:29. The Challenge of Aging00:01:57. Symptoms of Testosterone Decline00:02:25. Long-Term Health Implications00:03:09. Maintaining Healthy Levels00:03:37. Exploring Testagen00:04:02. What is Testagen?00:04:32. How Testagen Might Work00:05:12. Connecting to Longevity00:05:41. Caution and Critical Thinking00:06:21. Longevity Medicine Philosophy00:06:50. Hormonal Optimization00:07:29. Personalized Medicine and Monitoring00:08:08. Caution and Controversy00:08:38. Potential Risks and Unknowns00:09:17. Theoretical Benefits vs. Unknown Risks00:09:38. The Non-Negotiable00:09:59. Individual Assessment00:10:11. Synergy and Integration00:10:39. Exercise and Hormonal Environment00:11:04. Diet and Hormonal Function00:11:29. Longevity Supplements and Hormonal Health00:11:56. Building a Comprehensive Plan00:12:23. Understanding Potential Interactions00:12:34 Conclusion and Final Thoughts00:13:09 Grounded in Perspective00:13:46. Empowering Knowledge00:14:00. Final Words00:14:14. Closing
Today, Dr Ethan dives into a topic that's close to his heart, and likely to many of yours: ADHD. For decades, stimulants have been the go-to treatment, but what if there's more to the story? What if we could support brain function in a way that complements, or even transcends, traditional approaches?In this episode, we're going beyond the familiar, and venturing into the realm of NAD+. Yes, that NAD+ – the cellular powerhouse we often associate with longevity. But could it also be a key player in managing ADHD? We'll explore the science, the potential benefits, and the practical considerations of using NAD+ as a complementary approach. From cellular energy to neurotransmitter balance, we'll uncover how this fascinating molecule might offer new hope for those seeking a more holistic path to clarity and focus. So, buckle up, because we're about to delve deep into the cellular level, and explore a potential game-changer in ADHD management. Let’s get started.00:00:00 Introduction00:01:25. The ADHD Challenge00:02:29. Introduction to NAD+00:03:36. NAD+ and Brain Health00:05:06. Potential Benefits of NAD+00:05:50. Current Research and Future Directions00:07:18. Holistic ADHD Management00:10:53. Practical Considerations for NAD+00:14:10. Conclusion00:16:11. Call to Action
In this episode, we delve into the cutting edge of aging research, exploring a truly groundbreaking molecule: FOXO4-DRI. This peptide has the scientific community buzzing with its potential to fundamentally reshape our understanding of aging and cellular health by targeting rejuvenation at the most basic level. Join us as we unpack the science behind FOXO4-DRI and its implications for our quest to not just live longer, but better.OUTLINE:00:00:00 Introduction00:00:57 The Quest for Longevity00:01:23 Understanding Cellular Senescence00:02:37 Introducing FOXO4-DRI00:03:06 The Science Behind FOXO4-DRI00:07:33 Mechanism of Action00:12:45 Research and Potential Applications00:17:12 Ethical Considerations00:19:43 Conclusion
In this episode, we delve into the cutting edge of aging research, exploring a truly groundbreaking molecule: FOXO4-DRI. This peptide has the scientific community buzzing with its potential to fundamentally reshape our understanding of aging and cellular health by targeting rejuvenation at the most basic level. Join us as we unpack the science behind FOXO4-DRI and its implications for our quest to not just live longer, but better. OUTLINE:00:00:00 Introduction00:00:57 The Quest for Longevity00:01:23 Understanding Cellular Senescence00:02:37 Introducing FOXO4-DRI00:03:06 The Science Behind FOXO4-DRI00:07:33 Mechanism of Action00:12:45 Research and Potential Applications00:17:12 Ethical Considerations00:19:43 Conclusion
In this episode of "The Science of Age-Less Living," Dr. Ethan explores the revolutionary world of bioregulatory peptides. These short chains of amino acids act as messengers within the body, regulating crucial biological processes. The podcast delves into the science behind these peptides, explaining how they function as a "communication network" for cells, promoting healing, enhancing recovery, and boosting immune function. Dr. Ethan discusses the applications of peptides in medicine, showcasing their ability to accelerate tissue repair (BPC-157), modulate immune responses (Thymosin Alpha-1), and slow degenerative diseases.The episode further examines the transformative impact of peptides in aesthetic medicine, highlighting their role in stimulating collagen production (GHK-Cu), improving skin elasticity, and promoting hair growth (PTD-DBM). In the realm of fitness, peptides like IGF-1 LR3 and TB-500 are shown to enhance muscle repair, growth, stamina, and performance. The podcast also addresses Testogen, a peptide used for hormone health, particularly testosterone optimization.OUTLINE:00:00:00 Introduction to The Science of Age-Less Living00:03:26 What Are Bioregulatory Peptides?00:05:04 How Do Bioregulatory Peptides Work?00:05:46 Examples of Bioregulatory Peptides00:07:44 Applications of Bioregulatory Peptides in Medicine00:11:05 Peptides in Aesthetic Medicine and Anti-Aging00:13:10 Peptides in Fitness and Performance00:16:52 The Future of Bioregulatory PeptidesTo learn more about bioregulatory peptides, contact The Catalyst Clinic! Click here.
Discover the science behind caloric restriction and its profound impact on longevity in this video. Join Dr. Ethan as he unpacks the intricate biochemical pathways—like insulin signaling and the mTOR pathway—that connect calorie intake to aging. Learn how reducing calories (without sacrificing nutrients) can lower oxidative stress, inflammation, and promote cellular repair. Whether you're curious about optimizing health or extending lifespan, this episode is your guide to living an "Age-Less" life. Don't miss practical tips on implementing caloric restriction safely for a healthier future!OUTLINE:00:00:00 Introduction00:02:29 Understanding Caloric Restriction00:06:41 Biochemical Pathways Involved in Longevity00:11:51 The Science of Aging and Caloric Restriction00:15:53 Practical Considerations and Takeaways00:19:23 Conclusion
Join Dr. Ethan, a leading medical innovator and aesthetic and longevity pioneer, in this enlightening episode of The Science of Age-Less Living, where we explore the fascinating biology of aging and the cutting-edge therapies that aim to slow it down.From understanding the roles of cellular senescence and telomere shortening to delving into groundbreaking treatments like Epithalon peptide therapy, senolytics, and stem cell research, this episode unpacks the science behind living longer and healthier lives. Dr. Ethan also discusses the ethical implications of anti-aging therapies and speculates on future breakthroughs in longevity science.Whether you're curious about the secrets of healthy aging or eager to learn about the latest advancements, this episode provides a comprehensive guide to the future of aging research. Stay tuned for insights that could transform how we approach aging!00:00:00 Introduction00:00:33 Exploring the Science of Aging and Emerging Therapies00:02:20 The Biology of Aging00:03:38 Cellular Senescence00:05:46 Telomere Shortening00:08:34 Peptide Therapy Using Epithalon00:12:34 Other Therapeutic Interventions00:18:57 Future Perspectives in Aging Research00:26:16 Conclusion and RecapVisit The Catalyst Clinic at: https://www.thecatalystclinic.com/wellness/peptide-therapy-london