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Thrive Alcohol Recovery
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The Thrive Alcohol Recovery Podcast is your go-to resource for all things related to The Sinclair Method (TSM)—a groundbreaking treatment for alcohol use disorder with a clinically proven 78% success rate.
TSM uses the medication naltrexone to help people naturally reduce or stop drinking over time. What makes this method so unique is that abstinence isn’t required. Instead, it works on a deeper level—within the brain—to rewire habits and reduce cravings. This allows many people to return to moderate, safe drinking or choose an alcohol-free life without the fear of relapse. 🧠✨
In each weekly episode, we dive into inspiring Sinclair Method success stories, share expert tips and insights, explore the latest science and research, and cover so much more.
We’re so glad you’re here and part of our growing community of Thrivers.
✨ Change your drinking, change your life. ✨
TSM uses the medication naltrexone to help people naturally reduce or stop drinking over time. What makes this method so unique is that abstinence isn’t required. Instead, it works on a deeper level—within the brain—to rewire habits and reduce cravings. This allows many people to return to moderate, safe drinking or choose an alcohol-free life without the fear of relapse. 🧠✨
In each weekly episode, we dive into inspiring Sinclair Method success stories, share expert tips and insights, explore the latest science and research, and cover so much more.
We’re so glad you’re here and part of our growing community of Thrivers.
✨ Change your drinking, change your life. ✨
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The Sinclair Method: Just an EXCUSE to keep drinking? Brian Noonan, Nurse Practitioner Responds
Thrive Alcohol Recovery | Katie Lain
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566 views 2 years ago Thrive Alcohol Recovery
We help you find freedom from problem drinking using the Sinclair Method so you can live your best life https://www.thrivealcoholrecovery.com/ About Thrive’s Program: …
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This episode provides an in-depth discussion about the Sinclair Method (TSM), a treatment approach for alcohol use disorder that involves taking the medication Naltrexone prior to drinking to reduce the rewarding effects of alcohol. Katie and Brian addresses common skepticism from loved ones, clinical observations on success rates, challenges faced in practice, and future possibilities for personalized medicine with Naltrexone. The conversation emphasizes trust-building, patience, and clear communication with both patients and their families as critical components of successful treatment.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode provides an in-depth discussion on the Sinclair Method (TSM) for reducing alcohol consumption, focusing on real-life challenges, coping mechanisms, and the psychological process involved in recovering from habitual drinking. Katie shares insights based on a comment from a viewer who has been practicing TSM for five years, highlighting common struggles and strategies to develop healthier habits alongside TSM.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Katie Lane, a Sinclair Method (TSM) success story, coach, and co-founder of Thrive Alcohol Recovery, shares her insights on the most common mistakes people make when following the Sinclair Method for alcohol use disorder. Drawing from her personal experience, coaching practice since 2018, and scientific literature—including The Cure for Alcoholism by Dr. Roy Eskapa—she outlines practical guidance to optimize success with TSM.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode provides an in-depth discussion on the use of Naltrexone in the Sinclair Method for treating alcohol dependence, emphasizing when and why the treatment might not work, common side effects, and practical advice for patients. The expert elaborates on the challenges of adherence, biological variability in drug metabolism, side effect profiles, and the psychological aspects of using Naltrexone. The conversation also touches on the evolving role of genetic testing to optimize dosing and the importance of balancing treatment with meaningful lifestyle changes.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This interview features Kent, a TSM (The Sinclair Method) user, sharing his personal journey with alcohol use, his experience with TSM, and insights on managing drinking habits. The conversation covers Kent’s drinking history, motivations to seek change, his discovery and application of TSM, and reflections on mental health, side effects of naltrexone (the medication used in TSM), mindfulness, and personal growth.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features an in-depth live Q&A session hosted by two experienced Sinclair Method (TSM) coaches, Samara and Katie. They address common questions, share personal experiences, and offer practical guidance about the Sinclair Method—a pharmacological treatment for alcohol use disorder (AUD) involving the medication naltrexone (referred to as “N treone” or “nrexone” in the transcript). The session aims to educate, support, and provide clarity for individuals at various stages of the TSM journey.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Katie Lane, founder of Thrive Alcohol Recovery and a Sinclair Method (TSM) success advocate, addresses a common challenge faced by many people using the Sinclair Method: the perception that the method has stopped working after an initial period of success. She explains why this experience occurs, breaks down the treatment into three phases, and emphasizes the importance of combining medication with mindful drinking practices, habit change, and cultivating coping skills to achieve sustainable results.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode features a live mindful drinking session centered on the Sinclair Method (TSM), a scientifically supported approach to reducing alcohol dependency using the medication naltrexone. The hosts engage with Eric, a long-time user of TSM, who shares his personal journey, insights into mindfulness, and practical guidance on how to integrate mindfulness with the Sinclair Method to optimize outcomes. The conversation addresses the challenges of habitual drinking, compliance with medication protocols, the role of intention, and how to apply mindfulness both during drinking sessions and in social contexts. The session also covers the importance of tracking drinks, managing cravings, and reshaping one’s relationship with alcohol.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features an in-depth conversation between Katie from Thrive and Richard, a filmmaker and podcast host of Glitch in the Code, who shares his unique and nuanced journey with alcoholism, alcohol use disorder (AUD), and various recovery methods. Richard’s story diverges from typical recovery narratives, particularly regarding his experience with the Sinclair Method and Alcoholics Anonymous (AA), offering valuable insights into the complexities of addiction, the limitations and potentials of treatment options, and the importance of individualized recovery paths.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Dr. Volpicelli answers some questions for us.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Q&A with Katie and Bruce
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Join me and guest Samara Boss, TSM Success Story and coach as we discuss life after AUD through TSM. Ready to get started or get supported on TSM?
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Q&A with Katie & Bruce
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode, Dr. Joseph Vachelli, a leading expert on naltrexone (Nxone), discusses how patients can determine if they need a higher dose of the medication when treating alcohol use disorder. He explains that the standard dose of 50 mg may not be effective for everyone, especially those who continue to experience the pleasurable effects of alcohol despite taking the medication. Dr. Vachelli highlights that the effectiveness of naltrexone can be assessed by the change in how alcohol feels—specifically, a reduced “high” or euphoria and diminished cravings after a few drinks are signs that the dose is working. However, if someone still experiences a “buzz” or pleasurable effects from drinking, it may indicate that a higher dose is necessary or that the person metabolizes the drug quickly, reducing its efficacy.
He emphasizes that different drinking habits, such as rapidly consuming high-concentration alcohol like shots, may require a higher naltrexone dose compared to slower consumption of beer. Dr. Vachelli also clarifies that naltrexone does not block all effects of alcohol, particularly its sedative effects, so feeling tired after drinking is not an indication of insufficient medication.
Importantly, Dr. Vachelli warns against misusing naltrexone to “game” the system—to continue drinking and still achieve a buzz. He stresses the need for using naltrexone as part of a structured recovery plan that includes psychosocial and behavioral support. Drawing from his clinical experience, he shares that medication alone is insufficient if patients are not genuinely motivated to recover. He developed a psychosocial program to enhance treatment adherence and motivation, which dramatically improved outcomes.
Finally, he underscores the critical role of social support, such as peer groups or coaching, in sustaining recovery. Whether patients use the Sinclair Method, daily oral dosing, or extended-release injections, coupling medication with behavioral support is essential for long-term success in overcoming alcohol addiction.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode it centers around a coaching call with a Thrive member who had been using the Sinclair Method (TSM) for three years but struggled to see meaningful progress. The individual was a daily drinker for 40 years prior to starting TSM and had been compliant with taking naltrexone (referred to as “nrex Zone” or “elrex Zone” in the transcript), yet did not experience alcohol-free days or significant change in their drinking habits. Eventually, they stopped the treatment but later restarted with a new mindset that led to better results. The core message is that success with the Sinclair Method requires more than just medication compliance; a fundamental mindset shift and intentional lifestyle changes are crucial. Specifically, having regular alcohol-free days and building new coping strategies and pleasures outside of alcohol play a vital role in achieving “extinction” — a state of indifference to alcohol where cravings are diminished, and drinking becomes a true choice rather than a compulsion.
The speaker highlights that many people on TSM remain stuck because, although they follow the protocol, they are not internally ready to change their relationship with alcohol. Often, alcohol is deeply intertwined with identity, habits, and emotional coping. Without confronting these beliefs and fears, and without consistent alcohol-free days to retrain the brain, progress stalls. The Sinclair Method’s effectiveness hinges on “meeting the medication halfway,” meaning that alongside taking naltrexone, individuals must actively cultivate new rewarding behaviors and coping mechanisms to replace alcohol. Over time, this rewiring helps the brain reduce the motivation to drink and ultimately achieve a balanced, controlled relationship with alcohol.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features a comprehensive Q&A session about the Sinclair Method (TSM) for addressing alcohol use disorder (AUD), hosted by Katie and Bruce, two experienced coaches working with individuals using this approach. The discussion centers on the unique, science-based mechanism of TSM, which uses the medication naltrexone (referred to as “nrexone” or “NTR”) to reduce alcohol cravings by targeting the brain’s endorphin addiction, rather than enforcing total abstinence. Bruce and Katie explain how alcohol triggers the release of endorphins—a natural brain chemical that produces pleasure and numbing effects—and how this neurochemical dependency fuels addiction. Unlike traditional abstinence-based treatments, which often fail due to intense cravings caused by removing alcohol (and thus endorphins) entirely, TSM allows controlled drinking while taking naltrexone to gradually “extinguish” the craving by breaking the endorphin-reward cycle.
They emphasize that TSM is a compassionate, forgiving, and flexible method that allows users to “press pause” during challenging life events, rather than forcing abstinence and self-denial. Naltrexone is taken about an hour before drinking to blunt the endorphin release, reducing the rewarding effects of alcohol and enabling gradual reduction or controlled drinking over time. The conversation also covers the importance of support structures, mindset work, counseling, and habit change alongside medication use. They discuss practical topics such as planning alcohol-free days, managing dosage timing, and differentiating between neurological addiction and psychological habit or emotional reliance on alcohol.
Bruce and Katie highlight that TSM success rates are around 78-80% when users are compliant with the medication protocol, and the program’s strength lies in combining neuroscience with behavioral change and emotional support. The dialogue also addresses common questions about supplements, the role of genetics in endorphin response, and how natural endorphin-producing activities (like exercise and social connection) can support recovery. The hosts encourage a kind, patient approach to recovery that includes self-compassion and realistic expectations, acknowledging that progress is gradual and nonlinear.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode, Dr. Joseph Vachelli, a leading expert on Naltrexone (referred to as “NRE Zone” or “naltrexone” in the transcript) and alcohol use disorder (AUD), discusses the practical applications of daily versus targeted naltrexone use, particularly in the context of the Sinclair Method. He explains who benefits most from each approach, the underlying brain mechanisms involved in alcohol cravings, and the importance of psychosocial support alongside medication. Dr. Vachelli highlights that targeted naltrexone is suitable for individuals who binge drink or are in early stages of problematic alcohol use, whereas daily dosing often suits severe, habitual drinkers. He also emphasizes the genetic and phenotypic factors influencing response to naltrexone, and clarifies why timing and adherence matter. He underscores the complex interaction between the logical (cognitive) brain and the emotional (limbic) brain in decision-making related to drinking and treatment adherence. Finally, Dr. Vachelli stresses the importance of combining medication with social and psychosocial support for effective recovery.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this video, Dr. Joseph Vachelli, a leading expert on Naltrexone and the Sinclair Method, addresses a common question among users: whether it is necessary to drink alcohol after taking Naltrexone (referred to as “Nxone” or “Nrex Zone”) or if one can choose not to drink and still benefit from the medication. Dr. Vachelli clarifies that it is perfectly acceptable—and often beneficial—for individuals to take Naltrexone without drinking. The medication reduces cravings and helps extinguish conditioned responses to alcohol-related cues, even when no drinking occurs. This means that people can regain control and freedom over their drinking habits, either by drinking in a controlled manner or abstaining altogether, without feeling pressured or wasting the medication.
Dr. Vachelli explains the mechanism behind this effect, highlighting how Naltrexone blocks the reinforcement of drinking behavior and also diminishes cravings triggered by environmental cues, such as being in a bar or watching Netflix at home. Over time, these cues lose their power, allowing individuals to be in high-risk drinking situations without temptation. Importantly, the medication also helps expand sources of pleasure beyond alcohol, such as enjoying a cup of hot cocoa or the company of a partner.
Furthermore, Dr. Vachelli emphasizes the importance of psychosocial support—including coaches, peers, or recovery groups—as a critical complement to medication. Such support systems provide accountability, encouragement, and hope, which are key to long-term recovery. Overall, the Sinclair Method, combined with Naltrexone and social support, offers people choice and freedom from addiction rather than strict abstinence or dogma.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode is a comprehensive Q&A session on the Sinclair Method (TSM), a treatment approach for alcohol dependence that involves taking the medication naltrexone (Nrexone) in relation to drinking. The hosts, Coach Samara and Katie, share their expertise, personal experiences, and insights from their coaching practice, addressing common questions and challenges faced by people on the method. Central themes include understanding the phases of TSM, managing hangovers while on naltrexone, the importance of foundational knowledge for success, strategies for gradual drink reduction, coping with emotional and psychological aspects of alcohol use, and the role of self-compassion and resilience in recovery. The conversation emphasizes that TSM is a gradual, personalized journey that meets individuals where they are, focusing on harm reduction, extinction of addictive pathways, and eventually developing healthier coping mechanisms and meaningful life habits. The hosts also explain practical tips about types of drinks, hydration, cold therapy, and the importance of working with the medication rather than against it. They highlight that sobriety or moderation is a personal choice, and success on TSM is measured by empowerment and improved control rather than strict abstinence.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/



