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Thrive Alcohol Recovery
Thrive Alcohol Recovery
Author: Thrive Alcohol Recovery
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The Thrive Alcohol Recovery Podcast is your go-to resource for all things related to The Sinclair Method (TSM)—a groundbreaking treatment for alcohol use disorder with a clinically proven 78% success rate.
TSM uses the medication naltrexone to help people naturally reduce or stop drinking over time. What makes this method so unique is that abstinence isn’t required. Instead, it works on a deeper level—within the brain—to rewire habits and reduce cravings. This allows many people to return to moderate, safe drinking or choose an alcohol-free life without the fear of relapse. 🧠✨
In each weekly episode, we dive into inspiring Sinclair Method success stories, share expert tips and insights, explore the latest science and research, and cover so much more.
We’re so glad you’re here and part of our growing community of Thrivers.
✨ Change your drinking, change your life. ✨
TSM uses the medication naltrexone to help people naturally reduce or stop drinking over time. What makes this method so unique is that abstinence isn’t required. Instead, it works on a deeper level—within the brain—to rewire habits and reduce cravings. This allows many people to return to moderate, safe drinking or choose an alcohol-free life without the fear of relapse. 🧠✨
In each weekly episode, we dive into inspiring Sinclair Method success stories, share expert tips and insights, explore the latest science and research, and cover so much more.
We’re so glad you’re here and part of our growing community of Thrivers.
✨ Change your drinking, change your life. ✨
113 Episodes
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Katie Lane, founder of Thrive Alcohol Recovery and a Sinclair Method (TSM) success advocate, addresses a common challenge faced by many people using the Sinclair Method: the perception that the method has stopped working after an initial period of success. She explains why this experience occurs, breaks down the treatment into three phases, and emphasizes the importance of combining medication with mindful drinking practices, habit change, and cultivating coping skills to achieve sustainable results.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode features a live mindful drinking session centered on the Sinclair Method (TSM), a scientifically supported approach to reducing alcohol dependency using the medication naltrexone. The hosts engage with Eric, a long-time user of TSM, who shares his personal journey, insights into mindfulness, and practical guidance on how to integrate mindfulness with the Sinclair Method to optimize outcomes. The conversation addresses the challenges of habitual drinking, compliance with medication protocols, the role of intention, and how to apply mindfulness both during drinking sessions and in social contexts. The session also covers the importance of tracking drinks, managing cravings, and reshaping one’s relationship with alcohol.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features an in-depth conversation between Katie from Thrive and Richard, a filmmaker and podcast host of Glitch in the Code, who shares his unique and nuanced journey with alcoholism, alcohol use disorder (AUD), and various recovery methods. Richard’s story diverges from typical recovery narratives, particularly regarding his experience with the Sinclair Method and Alcoholics Anonymous (AA), offering valuable insights into the complexities of addiction, the limitations and potentials of treatment options, and the importance of individualized recovery paths.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Dr. Volpicelli answers some questions for us.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Q&A with Katie and Bruce
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Join me and guest Samara Boss, TSM Success Story and coach as we discuss life after AUD through TSM. Ready to get started or get supported on TSM?
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
Q&A with Katie & Bruce
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode, Dr. Joseph Vachelli, a leading expert on naltrexone (Nxone), discusses how patients can determine if they need a higher dose of the medication when treating alcohol use disorder. He explains that the standard dose of 50 mg may not be effective for everyone, especially those who continue to experience the pleasurable effects of alcohol despite taking the medication. Dr. Vachelli highlights that the effectiveness of naltrexone can be assessed by the change in how alcohol feels—specifically, a reduced “high” or euphoria and diminished cravings after a few drinks are signs that the dose is working. However, if someone still experiences a “buzz” or pleasurable effects from drinking, it may indicate that a higher dose is necessary or that the person metabolizes the drug quickly, reducing its efficacy.
He emphasizes that different drinking habits, such as rapidly consuming high-concentration alcohol like shots, may require a higher naltrexone dose compared to slower consumption of beer. Dr. Vachelli also clarifies that naltrexone does not block all effects of alcohol, particularly its sedative effects, so feeling tired after drinking is not an indication of insufficient medication.
Importantly, Dr. Vachelli warns against misusing naltrexone to “game” the system—to continue drinking and still achieve a buzz. He stresses the need for using naltrexone as part of a structured recovery plan that includes psychosocial and behavioral support. Drawing from his clinical experience, he shares that medication alone is insufficient if patients are not genuinely motivated to recover. He developed a psychosocial program to enhance treatment adherence and motivation, which dramatically improved outcomes.
Finally, he underscores the critical role of social support, such as peer groups or coaching, in sustaining recovery. Whether patients use the Sinclair Method, daily oral dosing, or extended-release injections, coupling medication with behavioral support is essential for long-term success in overcoming alcohol addiction.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode it centers around a coaching call with a Thrive member who had been using the Sinclair Method (TSM) for three years but struggled to see meaningful progress. The individual was a daily drinker for 40 years prior to starting TSM and had been compliant with taking naltrexone (referred to as “nrex Zone” or “elrex Zone” in the transcript), yet did not experience alcohol-free days or significant change in their drinking habits. Eventually, they stopped the treatment but later restarted with a new mindset that led to better results. The core message is that success with the Sinclair Method requires more than just medication compliance; a fundamental mindset shift and intentional lifestyle changes are crucial. Specifically, having regular alcohol-free days and building new coping strategies and pleasures outside of alcohol play a vital role in achieving “extinction” — a state of indifference to alcohol where cravings are diminished, and drinking becomes a true choice rather than a compulsion.
The speaker highlights that many people on TSM remain stuck because, although they follow the protocol, they are not internally ready to change their relationship with alcohol. Often, alcohol is deeply intertwined with identity, habits, and emotional coping. Without confronting these beliefs and fears, and without consistent alcohol-free days to retrain the brain, progress stalls. The Sinclair Method’s effectiveness hinges on “meeting the medication halfway,” meaning that alongside taking naltrexone, individuals must actively cultivate new rewarding behaviors and coping mechanisms to replace alcohol. Over time, this rewiring helps the brain reduce the motivation to drink and ultimately achieve a balanced, controlled relationship with alcohol.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features a comprehensive Q&A session about the Sinclair Method (TSM) for addressing alcohol use disorder (AUD), hosted by Katie and Bruce, two experienced coaches working with individuals using this approach. The discussion centers on the unique, science-based mechanism of TSM, which uses the medication naltrexone (referred to as “nrexone” or “NTR”) to reduce alcohol cravings by targeting the brain’s endorphin addiction, rather than enforcing total abstinence. Bruce and Katie explain how alcohol triggers the release of endorphins—a natural brain chemical that produces pleasure and numbing effects—and how this neurochemical dependency fuels addiction. Unlike traditional abstinence-based treatments, which often fail due to intense cravings caused by removing alcohol (and thus endorphins) entirely, TSM allows controlled drinking while taking naltrexone to gradually “extinguish” the craving by breaking the endorphin-reward cycle.
They emphasize that TSM is a compassionate, forgiving, and flexible method that allows users to “press pause” during challenging life events, rather than forcing abstinence and self-denial. Naltrexone is taken about an hour before drinking to blunt the endorphin release, reducing the rewarding effects of alcohol and enabling gradual reduction or controlled drinking over time. The conversation also covers the importance of support structures, mindset work, counseling, and habit change alongside medication use. They discuss practical topics such as planning alcohol-free days, managing dosage timing, and differentiating between neurological addiction and psychological habit or emotional reliance on alcohol.
Bruce and Katie highlight that TSM success rates are around 78-80% when users are compliant with the medication protocol, and the program’s strength lies in combining neuroscience with behavioral change and emotional support. The dialogue also addresses common questions about supplements, the role of genetics in endorphin response, and how natural endorphin-producing activities (like exercise and social connection) can support recovery. The hosts encourage a kind, patient approach to recovery that includes self-compassion and realistic expectations, acknowledging that progress is gradual and nonlinear.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode, Dr. Joseph Vachelli, a leading expert on Naltrexone (referred to as “NRE Zone” or “naltrexone” in the transcript) and alcohol use disorder (AUD), discusses the practical applications of daily versus targeted naltrexone use, particularly in the context of the Sinclair Method. He explains who benefits most from each approach, the underlying brain mechanisms involved in alcohol cravings, and the importance of psychosocial support alongside medication. Dr. Vachelli highlights that targeted naltrexone is suitable for individuals who binge drink or are in early stages of problematic alcohol use, whereas daily dosing often suits severe, habitual drinkers. He also emphasizes the genetic and phenotypic factors influencing response to naltrexone, and clarifies why timing and adherence matter. He underscores the complex interaction between the logical (cognitive) brain and the emotional (limbic) brain in decision-making related to drinking and treatment adherence. Finally, Dr. Vachelli stresses the importance of combining medication with social and psychosocial support for effective recovery.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this video, Dr. Joseph Vachelli, a leading expert on Naltrexone and the Sinclair Method, addresses a common question among users: whether it is necessary to drink alcohol after taking Naltrexone (referred to as “Nxone” or “Nrex Zone”) or if one can choose not to drink and still benefit from the medication. Dr. Vachelli clarifies that it is perfectly acceptable—and often beneficial—for individuals to take Naltrexone without drinking. The medication reduces cravings and helps extinguish conditioned responses to alcohol-related cues, even when no drinking occurs. This means that people can regain control and freedom over their drinking habits, either by drinking in a controlled manner or abstaining altogether, without feeling pressured or wasting the medication.
Dr. Vachelli explains the mechanism behind this effect, highlighting how Naltrexone blocks the reinforcement of drinking behavior and also diminishes cravings triggered by environmental cues, such as being in a bar or watching Netflix at home. Over time, these cues lose their power, allowing individuals to be in high-risk drinking situations without temptation. Importantly, the medication also helps expand sources of pleasure beyond alcohol, such as enjoying a cup of hot cocoa or the company of a partner.
Furthermore, Dr. Vachelli emphasizes the importance of psychosocial support—including coaches, peers, or recovery groups—as a critical complement to medication. Such support systems provide accountability, encouragement, and hope, which are key to long-term recovery. Overall, the Sinclair Method, combined with Naltrexone and social support, offers people choice and freedom from addiction rather than strict abstinence or dogma.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode is a comprehensive Q&A session on the Sinclair Method (TSM), a treatment approach for alcohol dependence that involves taking the medication naltrexone (Nrexone) in relation to drinking. The hosts, Coach Samara and Katie, share their expertise, personal experiences, and insights from their coaching practice, addressing common questions and challenges faced by people on the method. Central themes include understanding the phases of TSM, managing hangovers while on naltrexone, the importance of foundational knowledge for success, strategies for gradual drink reduction, coping with emotional and psychological aspects of alcohol use, and the role of self-compassion and resilience in recovery. The conversation emphasizes that TSM is a gradual, personalized journey that meets individuals where they are, focusing on harm reduction, extinction of addictive pathways, and eventually developing healthier coping mechanisms and meaningful life habits. The hosts also explain practical tips about types of drinks, hydration, cold therapy, and the importance of working with the medication rather than against it. They highlight that sobriety or moderation is a personal choice, and success on TSM is measured by empowerment and improved control rather than strict abstinence.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
In this episode, Dr. Joseph Vachelli, a leading expert on naltrexone and the Sinclair Method, addresses the common question of whether and when to redose naltrexone within the same day when using the Sinclair Method for managing alcohol consumption. He explains that there is limited direct research on redosing intervals but draws on pharmacokinetic principles to provide guidance. Rapid metabolizers of naltrexone may need to redose after about four to five hours, whereas slow metabolizers can be covered for up to 10 to 12 hours with a single 50 mg dose. Some individuals produce active metabolites with longer half-lives, potentially extending coverage for up to 24 hours.
Dr. Vachelli emphasizes the importance of individual variability in metabolism and response to naltrexone, recommending that patients work closely with knowledgeable healthcare providers to tailor dosing. He suggests personal experimentation by monitoring the return of alcohol’s euphoric effects as a practical indicator for when redosing may be necessary. Additionally, measuring metabolites in urine or blood can help determine how long naltrexone’s effects last for a particular person.
The discussion also touches on the extended-release injectable form of naltrexone, which is designed for monthly dosing but may require administration every three weeks for some individuals experiencing a return of alcohol effects sooner. Dr. Vachelli acknowledges a commonly recommended redosing window of six to eight hours as a practical average guideline, though individual needs vary.
Finally, he highlights the critical role of psychosocial support—such as peer groups, coaching, or counseling—in successful recovery alongside medication use. Support systems help maintain motivation and accountability, which are essential components of long-term success in reducing alcohol dependency.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features a live Q&A session hosted by Katie Lane and Samara, both certified coaches and success stories of the Sinclair Method (TSM), a scientifically supported treatment for alcohol use disorder centered around taking the medication naltrexone (referred to as “NRE Zone” or “nxone”) one hour before drinking to reduce alcohol cravings through a process called pharmacological extinction. Katie and Samara share their personal journeys, insights, and coaching experiences to help demystify the method, manage expectations, and offer practical advice to those struggling with alcohol. The discussion covers topics such as initial challenges with compliance, the importance of understanding the psychological reasons behind drinking, habit change, mindfulness, dealing with cravings, the “off switch” (regaining control over drinking), managing side effects, and strategies for sustaining progress on TSM. They emphasize that success with TSM requires both medication compliance and behavioral work, including self-inquiry, habit formation, and developing healthier coping mechanisms. The hosts also address common questions from viewers regarding alcohol-free days, handling cravings, pacing drinks, and how to approach social situations. Throughout the video, Katie and Samara encourage patience, self-compassion, and a mindset focused on incremental progress, supported by scientific research and personal anecdotes. They invite viewers to join their online support program for more personalized help.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features a comprehensive live Q&A session on the Sinclair Method (TSM) with Bruce Rose, a well-known coach and counselor in the field, alongside Katie, a TSM advocate and coach. The discussion delves into the science, practical application, challenges, and success stories related to TSM and the use of Naltrexone (Nxone), the medication central to this method. The Sinclair Method is a treatment for alcohol use disorder (AUD) that works by targeting the brain’s endorphin system to reduce cravings and rewire neurological addiction pathways.
Bruce and Katie emphasize that alcohol addiction is fundamentally driven by a neurological addiction to endorphins, not solely by psychological or emotional factors. Naltrexone blocks the endorphin receptors, thereby reducing the rewarding effects of alcohol and diminishing the compulsion to drink over time. The medication is taken about an hour before drinking, and with consistent use, it can lead to lasting changes in the brain’s response to alcohol, ultimately reducing or eliminating cravings.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features Dr. Joseph Vachelli, a leading expert on naltrexone (referred to as “Ntrex Zone” or “Nrex Zone” in the transcript) and its role in treating alcohol addiction through the Sinclair Method. Dr. Vachelli explains the different effects alcohol has on individuals, particularly emphasizing the distinction between the euphoric, energizing effects and the sedative effects of alcohol. He highlights how these effects influence addiction patterns and treatment outcomes. The discussion covers the mechanisms behind alcohol cravings, the role of endogenous opiates and dopamine in addiction, and the challenges some people face when drinking for sedation rather than for the “buzz” or euphoria. Dr. Vachelli also addresses practical aspects of alcohol detoxification, including outpatient options that can be safely managed with medications such as gabapentin and targeted benzodiazepines, debunking the myth that detox necessarily requires inpatient hospitalization. The video touches upon the importance of psychosocial support, counseling, and developing alternative coping strategies to replace alcohol use, particularly for individuals who rely on alcohol to manage anxiety or stress. Personal reflections from the interviewer illustrate the transformative potential of combining medication with lifestyle changes and therapy, reinforcing the message that recovery is achievable and life beyond alcohol can be fulfilling.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
The episode is a comprehensive Q&A session about the Sinclair Method (TSM), a treatment approach for alcohol use disorder (AUD) that leverages the medication naltrexone (referred to as “Nrexone” or “nxone” in the transcript) to help individuals regain control over their drinking habits. The hosts, Samara and Katie, are both coaches and personal success stories of TSM, sharing their experiences and insights alongside answering questions from participants. They discuss the neuroscience behind AUD, the role of naltrexone in extinguishing cravings and rewiring the brain, and common challenges faced during treatment. The session addresses stigma, strategies for managing social and familial resistance, dosage questions, and the importance of self-compassion and gradual habit change. They emphasize that TSM is a long-term journey focused on mindful drinking and eventual reduction or cessation of alcohol use, rather than immediate abstinence. The discussion also touches on parallels between alcohol addiction and other addictive behaviors, the significance of extinction sessions, and the psychological and physiological aspects of recovery. The hosts encourage patience, persistence, and meeting the medication halfway with lifestyle and habit adjustments.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/
This episode features an in-depth conversation between Katie and David Balancie (pronounced “Blankie”) about David’s personal journey with Alcohol Use Disorder (AUD) and his experience using the Sinclair Method (TSM) as an alternative approach to traditional recovery. David shares his background, including two and a half years in Alcoholics Anonymous (AA), his struggles with cravings and depression, and his eventual discovery of TSM. He details how TSM, which involves taking naltrexone to reduce cravings by rewiring the brain’s response to alcohol, gradually transformed his relationship with drinking over four years.
David explains the challenges he faced transitioning away from the abstinence-based mindset of AA, including feelings of guilt and shame for not adhering to traditional sobriety norms. He emphasizes the importance of combining TSM medication with behavioral support and recovery work to address the root causes of drinking, such as social anxiety and life stressors. The discussion also covers the realities of long-term management of AUD, the necessity of ongoing accountability, and the dangers of complacency—even after years on TSM.
Both Katie and David reflect on the limitations of the traditional recovery model and advocate for broader, more compassionate understandings of recovery that include medication-assisted approaches like TSM. They highlight the stigma and misunderstanding around TSM, especially from the sober community, and encourage people to seek individualized paths that work for them. The conversation concludes with advice for newcomers to TSM, emphasizing patience, compliance, support networks, and the recognition that recovery is a process, not an immediate fix.
About Katie Lain
Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder.
*Links*
https://www.thrivealcoholrecovery.com/
https://tiktok.com/@thrivealcoholrecovery
https://youtube.com/@thrivealcoholrecovery/
https://www.instagram.com/thrivealcoholrecovery/
https://www.facebook.com/groups/thrivewiththesinclairmethod
https://www.linkedin.com/company/thrive-alcohol-recovery/
https://twitter.com/thrivewithtsm/



