Xtalks Life Science Podcast

In this week’s episode of the Xtalks Life Science Podcast, host Soumya Shashikumar speaks with Anne-Cécile Chevrier, Global Head, Injectable Aesthetics at Galderma, about the science of skin quality and why the field is increasingly looking at “skin longevity” — keeping skin healthier, more functional and resilient for longer. Anne-Cécile explains that skin quality is about how skin looks, feels and functions, including hydration, firmness, radiance and texture. She also discusses how menopause and medication-driven weight loss can affect the skin. Tune in to hear Anne-Cécile explain the simple “pinch test” clinicians can use to assess skin laxity, why she believes more education is needed around menopause-related skin changes and how more personalized, data-informed approaches could shape the future of skin longevity. For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

In this week’s episode of the Xtalks Life Science Podcast, host Dr. Mohammad Ali speaks with Mike McCormick, President and CEO of Nuwellis, about fluid overload, the heart-kidney connection and what happens when diuretics stop working as expected. Mike explains that fluid overload is “not simply a cosmetic swelling.” Persistent congestion can make breathing difficult, reduce appetite and even make it hard for patients to lie flat. He also describes the cardiorenal balancing act, where worsening heart function can prompt the kidneys to retain more water and sodium, adding further strain on the heart. He discusses how clinicians recognize diuretic resistance and where ultrafiltration may fit as another “tool in the toolbox” for removing excess fluid when medications are no longer enough. Tune in to hear why Mike looks beyond the numbers to patient outcomes, why “How did the patient do?” remains a critical question and why pediatric patients are “not just small adults.” For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/   For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

In this week’s episode of the Xtalks Life Science Podcast, host Dr. Mohammad Ali speaks with James Hackworth, PhD, Cebranopadol Development Lead at Tris Pharma, about the clinical challenges of providing effective acute pain relief while limiting the treatment-related risks of traditional opioids. James explains that when severe pain is poorly treated, prolonged pain signaling can, in some cases, lead to lasting changes in the nervous system through neuroplasticity. He also describes how targeting the nociceptin (NOP) receptor system alongside traditional opioid pathways may act as a biological “brake,” helping reduce abuse potential, physical dependence and respiratory depression. James also discusses the use of bunionectomies and abdominoplasties as standardized surgical models that serve as proxies for hard-tissue and soft-tissue pain in clinical trials. Tune in to learn more about pain biology, clinical trial endpoints and early-stage tools that could help accelerate analgesic development. For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/   For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

In this week’s episode of the Xtalks Life Science Podcast, host Dr. Mohammad Ali, Life Science Writer and Knowledge Translation Specialist at Xtalks, spoke with Dr. Farideh Bischoff, Chief Medical Officer at HerAnova Lifesciences, about the challenges of diagnosing endometriosis and research into non-invasive testing. Dr. Bischoff explains that symptom severity does not always reflect disease extent, and symptoms can overlap with conditions such as irritable bowel syndrome and adenomyosis. Ultrasound and MRI can detect some forms of endometriosis, while smaller superficial lesions and early-stage disease may be more difficult to identify. She also discusses multiomic approaches, the use of AI and machine learning to analyze multiple biomarkers and the evidence needed to validate new diagnostic tests across different patient populations. Tune in to learn more about endometriosis diagnosis, biomarker research and efforts to shorten the path to diagnosis. For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/   For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

In this week’s episode of the Xtalks Life Science Podcast, host Soumya Shashikumar, Senior Life Sciences Journalist at Xtalks, spoke with James Mackay, CEO of Crystalys Therapeutics, about gout, persistent misconceptions surrounding the condition and current clinical research. Gout is often linked primarily to diet and alcohol. James explains that many patients instead have difficulty removing enough uric acid from the body, allowing crystals to accumulate in the joints and contribute to inflammation over time. The conversation examines the stigma this misunderstanding can create. James shares why some people may avoid discussing their condition or seeking care because they feel blamed for developing it. He also discusses difficult-to-treat gout, the limitations of current treatment options and how researchers are studying outcomes that may be more meaningful to patients. Tune in to learn more about why gout remains widely misunderstood, the gaps in current care and the challenges of developing treatments for patients with limited options. For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured