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The Toxpod

Author: Tim Scott & Peter Stockham

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Forensic Toxicology: It's a matter of half-life and death
28 Episodes
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We look at 5 recent publications in the field of toxicology.Costa, C. et al. Distinguishing between contact and administration of heroin from a single fingerprint using high resolution mass spectrometry. (2020) Journal of Analytical Toxicology. 44: 218-225Kaufmann, A. et al. Partially overlapping sequential window acquisition of all theoretical mass spectra: A methodology to improve the spectra quality of veterinary drugs present at low concentrations in highly complex biological matrices. (2020) Rapid Communications in Mass Spectrometry. 34: e8638Kraemer, M. et al. Detectability of various cannabinoids in plasma samples of cannabis users: Indicators of recent cannabis use? (2019) Drug Testing and Analysis. 11:1498-1506Margalho, C. et al. Determination of new psychoactive substances in whole blood using microwave fast derivatization and gas chromatography/mass spectrometry. (2020) Journal of Analytical Toxicology. 44:92-102Gundersen, P. et al. Retrospective screening of synthetic cannabinoids, synthetic opioids and designer benzodiazepines in data files from forensic post mortem samples analysed by UHPLC-QTOF-MS from 2014 to 2018. (2020) Forensic Science International. 311: 1-11Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
Tim chats with Alberto Salomone about workplace testing, hair analysis, and new psychoactive substances. Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
Peter chats with Richard Bade about the advantages and challenges of wastewater analysis.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
Tim chats with Michelle Peace about her current research on vaping, and her experiences in the field of forensic toxicology.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
We channel our sports withdrawal into a toxicology related draft.Thanks to Michaela Kenneally and Stephen Trobbiani for participating in this episode.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
CAT conference 2020

CAT conference 2020

2020-05-1239:35

The California Association of Toxicologists Spring meeting has been postponed due to COVID restrictions, but that won't stop us from chatting with some of the planned speakers! Thanks to Luke Rodda, Jarrad Wagner, Juliet Kinyua and Alan Wu for participating in this episode.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
We talk about synthetic cannabinoids (or is that SCRAs?) with medicinal chemist Samuel Banister. Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
We look at 5 recent publications in the field of toxicology.Blanckaert, P. et al. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene. (2020) Drug Testing and Analysis. 12: 422-430Reinstadler, V. et al. A validated workflow for drug detection in oral fluid by non-targeted liquid chromatography-tandem mass spectrometry. (2019) Analytical and Bioanalytical Chemistry. 411:867-876Benaglia, L. et al. Testing wastewater from a music festival in Switzerland to assess illicit drug use. (2020) Forensic Science International. 309:1-8Munoz-Munoz, A. et al. Characterization of an Amphetamine Interference from Gabapentin in an LC–HRMS Method. (2020) Journal of Analytical Toxicology. 44:36-40Darke, S. et al. Characteristics and circumstances of death related to gamma hydroxybutyrate (GHB). (2020) Clinical Toxicology. Published online 18 Feb 2020. Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
Season 3 preview

Season 3 preview

2020-04-2101:11

Season 3 drops on April 29. Subscribe now!
In our last episode of the season, we look at 5 recent publications in the field of toxicology.Steuer, A. et al. Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans. (2019) Drug Testing and Analysis. 11 (6):813-823Souza, R. et al. Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil. (2019) Journal of Chromatography B. 1124: 197-203 Snamina, M. et al. Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs. (2019) Talanta. 204:607-612Fabresse, N. et al. Development of a sensitive untargeted liquid chromatography-high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances. (2019) Drug Testing and Analysis. 11 (5):697-708Sitasuwan, P. et al. Comparison of purified beta-glucuronidases in patient urine samples indicates a lack of correlation between enzyme activity and drugs of abuse metabolite hydrolysis efficiencies leading to potential false negatives.(2019) Journal of Analytical Toxicology. 43 (3):221-227Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
In this episode, we dive into the techniques, practices, and guidelines used in forensic toxicology for drug identification. Do we have the balance right?Some of the available identification guidelines:World Anti-Doping Agency (WADA)European Workplace Drug Testing Society (EWDTS)Organisation of Scientific Area Committees (OSAC)Gesellschaft für Toxikologische und Forensische Chemie (GTFCh)That article Pete mentioned on amphetamine isomers:Brown, D. H., et al. (2016). "Beta-methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation." Drug Test Anal 8(3-4): 344-350.Contact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
During his recent trip to the TIAFT2019 conference in Birmingham, England, Peter caught up with a few toxicologists to discuss some of their recent work.Barry Logan's group has published their findings on kratomJoin the HighResNPS communityLearn more about The International Association of Forensic Toxicologists at www.tiaft.orgContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 
Peter is joined by toxicologists Sarah Wille (Belgium) and Luke Rodda (USA) to discuss how the field of toxicology is changing and where it will lead us. Recorded live at TIAFT2019 in Birmingham, England.Learn more about The International Association of Forensic Toxicologists at www.tiaft.orgContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 
The world of scientific publishing is a mysterious place - even to many who publish regularly! How does reviewing work? What are predatory journals? Why should scientists write?We are joined by Professor Roger Byard (forensic pathologist, prolific writer, and editor-in-chief of Forensic Science, Medicine and Pathology) as we peek behind the curtain of the publishing world. Roger's editorial - The forensic implications of predatory publishingABC Radio podcast on predatory publishingContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 
Dimitri Gerostamoulos

Dimitri Gerostamoulos

2019-09-0333:26

We are joined by Dimitri Gerostamoulos, Head of Forensic Science and Chief Toxicologist at the Victorian Institute of Forensic Medicine. Contact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 
Peter gets up close and personal with some delegates at the FACTA conference in Adelaide. Find out more about FACTA at www.facta.org.auContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 
TIAFT President Marc LeBeau joins The Toxpod for a special episode recorded live at the FACTA conference in Adelaide. We discuss some of the emerging risks in the field of toxicology.Find out more about FACTA at www.facta.org.auYou can read the available OSAC toxicology guidelines hereContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 
In this episode, we look at 5 recent publications in the field of toxicology.Oiestad, E. et al. Interpreting oral fluid drug results in prisoners: monitoring current drug intake and detection times for drugs self-administered prior to detention. (2019) Forensic Toxicology. 37 (1):59-74Erne, R. et al. Hair Analysis: Contamination versus incorporation from the circulatory system - Investigations on single hair samples using time-of-flight secondary ion mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry. (2019) Analytical Chemistry. 91 (6): 4132-4139Eckberg, M et al. Separation and identification of isomeric and structurally related synthetic cannabinoids using 2D liquid chromatography and high resolution mass spectrometry. (2019) Journal of Analytical Toxicology. 43 (3): 170-178Ivanov, I.D. et al. A case of 5F-ADB/FUB-AMB abuse: drug-induced or drug-related death? (2019) Forensic Science International. 297: 372-377Caspar A.T. et al. Blood plasma level determination using an automated LC-MSn screening system and electronically stored calibrations exemplified for 22 drugs and two active metabolites often requested in emergency toxicology.(2019) Drug Testing and Analysis. 11 (1): 102-111Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.
We're back and we're looking to bust some myths in forensic toxicology. No conventional idea is safe!Contact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 
Season 2 preview

Season 2 preview

2019-07-3001:13

Season 2 drops on August 7. Subscribe now!
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