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We look at 5 recent publications in the field of toxicology.Polettini A, et al. LC–QTOF-MS Presumptive Identification of Synthetic Cannabinoids without Reference Chromatographic Retention/Mass Spectral Information. II. Evaluation of a Computational Approach for Predicting and Identifying Unknown High-Resolution Product Ion Mass Spectra. (2021) Journal of Analytical Toxicology, 45(5):440-61.Kuwayama, K. et al. Development of the “selective concentration” analytical method for drug-containing hair regions based on micro-segmental analysis to identify a trace amount of drug in hair: hair analysis following single-dose ingestion of midazolam. (2021) Forensic Toxicology, 39(1):156-66.Robin, T. First-Line Toxicological Screening with Fully Automated Extraction. (2021) Journal of Analytical Toxicology, 45(3):252-68.Kranenburg, R. Spotting isomer mixtures in forensic illicit drug casework with GC–VUV using automated coelution detection and spectral deconvolution. (2021) Journal of Chromatography B, 1173:122675.Elmsjö, A. Post-Mortem Metabolomics: A Novel Approach in Clinical Biomarker Discovery and a Potential Tool in Death Investigations. (2021) Chemical Research in Toxicology, 34(6):1496-1502.Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We chat with Alex Krotulski about his work with CFSRE and NPS Discovery. You can find out more about these initiatives, and access the many resources they produce, at https://www.npsdiscovery.org/Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
Modern forensic toxicologists are able to detect tiny amounts of drugs in a sample.  Is it possible we are now too sensitive?Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We chat with Jenny Button, Deputy Director of Chiron, about the use of reference standards in forensic toxicology.Jenny's written a book chapter about all this - it's really good! Here's a link. Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
Tim chats with Marthe Vandeputte about the current and potential uses of activity based assays in forensic toxicology. Links to a couple of Marthe's papers on the topic are below:Validation of activity-based screening for synthetic cannabinoid receptor agonists in a large set of serum samplesIn vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substancesContact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We look at 5 recent publications in the field of toxicology.Karoly, H. et al. Effects of high-potency cannabis on psychomotor performance in frequent cannabis users. (2020) Cannabis and Cannabinoid Research, X:X, 1-9Prado, E. et al. Metabolism of synthetic cathinones through the zebrafish water tank model: a promising tool for forensic toxicology laboratories. (2021) Forensic Toxicology, 39: 73-88Chu, M. et al. Time-dependent changes in THC concentrations in deceased persons. (2021) Journal of Analytical Toxicology, 45:1-7Van Schalkwyk, F. et al. Fatal pyrrolizidine alkaloid poisoning of infants caused by adulterated Senecio coronatus. (2021) Forensic Science International, 320:110680Norman, C. et al. Large-scale evaluation of ion mobility spectrometry for therapid detection of synthetic cannabinoid receptor agonists ininfused papers in prisons. (2021) Drug Testing and Analysis, 13:644–663Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We chat with Hilary Hamnett about the complex issue of cognitive bias in forensic toxicology.If you'd like to hear more from Hilary about cognitive bias, you can contact her at HHamnett@lincoln.ac.uk Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
Positively negative

Positively negative

2021-05-0431:58

How confident are you that your analytical methods won't miss a target analyte? In the first episode of season 4, we discuss the potential for false negative results in forensic toxicology.  Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We look at 5 recent publications in the field of toxicology.Costa, C. et al. Distinguishing between contact and administration of heroin from a single fingerprint using high resolution mass spectrometry. (2020) Journal of Analytical Toxicology. 44: 218-225Kaufmann, A. et al. Partially overlapping sequential window acquisition of all theoretical mass spectra: A methodology to improve the spectra quality of veterinary drugs present at low concentrations in highly complex biological matrices. (2020) Rapid Communications in Mass Spectrometry. 34: e8638Kraemer, M. et al. Detectability of various cannabinoids in plasma samples of cannabis users: Indicators of recent cannabis use? (2019) Drug Testing and Analysis. 11:1498-1506Margalho, C. et al. Determination of new psychoactive substances in whole blood using microwave fast derivatization and gas chromatography/mass spectrometry. (2020) Journal of Analytical Toxicology. 44:92-102Gundersen, P. et al. Retrospective screening of synthetic cannabinoids, synthetic opioids and designer benzodiazepines in data files from forensic post mortem samples analysed by UHPLC-QTOF-MS from 2014 to 2018. (2020) Forensic Science International. 311: 1-11Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
Tim chats with Alberto Salomone about workplace testing, hair analysis, and new psychoactive substances. Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
Peter chats with Richard Bade about the advantages and challenges of wastewater analysis.Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
Tim chats with Michelle Peace about her current research on vaping, and her experiences in the field of forensic toxicology.Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We channel our sports withdrawal into a toxicology related draft.Thanks to Michaela Kenneally and Stephen Trobbiani for participating in this episode.Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
CAT conference 2020

CAT conference 2020

2020-05-1239:35

The California Association of Toxicologists Spring meeting has been postponed due to COVID restrictions, but that won't stop us from chatting with some of the planned speakers! Thanks to Luke Rodda, Jarrad Wagner, Juliet Kinyua and Alan Wu for participating in this episode.Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We talk about synthetic cannabinoids (or is that SCRAs?) with medicinal chemist Samuel Banister. Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
We look at 5 recent publications in the field of toxicology.Blanckaert, P. et al. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene. (2020) Drug Testing and Analysis. 12: 422-430Reinstadler, V. et al. A validated workflow for drug detection in oral fluid by non-targeted liquid chromatography-tandem mass spectrometry. (2019) Analytical and Bioanalytical Chemistry. 411:867-876Benaglia, L. et al. Testing wastewater from a music festival in Switzerland to assess illicit drug use. (2020) Forensic Science International. 309:1-8Munoz-Munoz, A. et al. Characterization of an Amphetamine Interference from Gabapentin in an LC–HRMS Method. (2020) Journal of Analytical Toxicology. 44:36-40Darke, S. et al. Characteristics and circumstances of death related to gamma hydroxybutyrate (GHB). (2020) Clinical Toxicology. Published online 18 Feb 2020. Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
Season 3 preview

Season 3 preview

2020-04-2101:11

Season 3 drops on April 29. Subscribe now!
In our last episode of the season, we look at 5 recent publications in the field of toxicology.Steuer, A. et al. Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans. (2019) Drug Testing and Analysis. 11 (6):813-823Souza, R. et al. Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil. (2019) Journal of Chromatography B. 1124: 197-203 Snamina, M. et al. Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs. (2019) Talanta. 204:607-612Fabresse, N. et al. Development of a sensitive untargeted liquid chromatography-high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances. (2019) Drug Testing and Analysis. 11 (5):697-708Sitasuwan, P. et al. Comparison of purified beta-glucuronidases in patient urine samples indicates a lack of correlation between enzyme activity and drugs of abuse metabolite hydrolysis efficiencies leading to potential false negatives.(2019) Journal of Analytical Toxicology. 43 (3):221-227Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
In this episode, we dive into the techniques, practices, and guidelines used in forensic toxicology for drug identification. Do we have the balance right?Some of the available identification guidelines:World Anti-Doping Agency (WADA)European Workplace Drug Testing Society (EWDTS)Organisation of Scientific Area Committees (OSAC)Gesellschaft für Toxikologische und Forensische Chemie (GTFCh)That article Pete mentioned on amphetamine isomers:Brown, D. H., et al. (2016). "Beta-methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation." Drug Test Anal 8(3-4): 344-350.Contact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
During his recent trip to the TIAFT2019 conference in Birmingham, England, Peter caught up with a few toxicologists to discuss some of their recent work.Barry Logan's group has published their findings on kratomJoin the HighResNPS communityContact us at toxpod@tiaft.orgFind out more about TIAFT at www.tiaft.orgThe Toxpod is a production of The International Association of Forensic Toxicologists. The opinions expressed by the hosts are their own and do not necessarily reflect the views of TIAFT.
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