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a16z Podcast

a16z Podcast

Author: Andreessen Horowitz

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The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit for more details and to sign up for our newsletters and other content as well!
358 Episodes
Welcome to the first episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine.In this episode, we talk all about the science of aging. Once a fringe field, aging research is now entering a new phase with the first clinical trials of aging-related drugs. As the entire field shifts into this moment of translation, what have we learned? What are the basic approaches to developing aging-related drugs? How is studying aging helping us understand diseases like cancer and Alzheimer’s -- and increasing the amount of time we are healthy -- today? In this conversation, Laura Deming, founder of The Longevity Fund; Kristen Fortney, co-founder of BioAge, a clinical-stage company focused on finding drugs to extend healthspan; Vijay Pande, general partner at a16z; and host Hanne Winarsky discuss the entire arc of aging science from one genetic tweak in a tiny worm to changing a whole paradigm of healthcare delivery.Be sure to subscribe to 'Bio Eats World' if you want to keep getting it (and please feel free to rate it as well). To learn more about the expanding a16z Podcast network, please visit
With the U.S. tech partnership for TikTok being finalized, what happens if source code is excluded (and more specifically, the For You Page algorithm), given China’s revised export controls? But more broadly -- well beyond the specifics and politics of this deal -- what does the success of TikTok tell us about “creativity network effects”, where every additional creator makes the rest of the community more creative? How did "seeing like an algorithm" and the new age of algorithm-friendly product design enable the short video-sharing platform to grab massive marketshare in cultures and markets never experienced firsthand by the engineers and designers in China, beating out other dominant players and apps in the United States?In this episode of 16 Minutes -- our show where we discuss what's in the news, tease apart what's hype/ what's real, and  where we are on the long arc of innovation  with specific tech trends with top experts -- Eugene Wei (former head of product at Hulu, Flipboard, and video at Oculus) joins us. We also touch on the future of entertainment, education, and the power and future of video.full transcript here: content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see for additional important information.
Today’s episode, part two in our two-part series on the Creator Economy, focuses on the new potential revenue streams and fan-engagement models opened up by emerging decentralized technology. It's a new type of fan club, driven by crypto networks and aiming to give creators more power in the commercial sphere. Zoran Basich of a16z talked to two guests deeply immersed in these topics. Kayvon Tehranian is the founder and CEO of Foundation Labs, a platform for buying and selling limited edition goods. Think of it as a crypto marketplace that creates new revenue streams for creators, and financial incentives for buyers. Before that he was head of product at cryptocurrencies marketplace Dharma Labs, and he has long worked on making crypto more accessible to the mainstream. Jesse Walden is a former a16z partner who recently launched his own fund, Variant, which focuses on what he calls the ownership economy enabled by crypto. He also previously cofounded the startup Mediachain, which was acquired by Spotify, and is a former music promoter and manager whose focus was on helping artists stay independent. Kayvon and Jesse explain how the emerging crypto models differ from previous attempts to create new revenue streams for artists, and about the role of speculation and hype in creator markets. They also debate whether these new markets will largely be driven by financial motives, or whether cultural factors will be equally powerful in determining the growth of creator markets. And they offer advice to creators interested in exploring this new world, including important practical guidance on expectations and timelines.
This episode, part one in a two-part series on the Creator Economy, explores the process and economics behind creating an independent newsletter. In this candid conversation, host Lauren Murrow talks with four Substack writers—an artist, a technologist, a journalist, and a clinical researcher-turned-psychedelics scholar—about how to find and foster an audience, the calculus behind going paid versus unpaid, the pressure to produce, and financial benchmarks for making a living from newsletter writing.The pandemic has prompted a reckoning within traditional media  and, in parallel, a surge in the newsletter ecosystem. On Substack, readership and active writers both doubled from January through April. The newsletter hosting platform now has more than 100,000 paying subscribers.This episode reveals the behind-the-scenes experiences of four newsletter creators, all of whom launched roughly within the past year:Software engineer Lenny Rachitsky, most recently a growth product manager at Airbnb, whose tech-focused dispatch is called Lenny’s Newsletter.Artist and writer Edith Zimmerman, creator of the Drawing Links newsletter, which chronicles her life and musings through comic-style illustrations. Zach Haigney, an acupuncturist and researcher whose newsletter, The Trip Report, explores the science, policy, and business behind medicinal psychedelics.And Patrice Peck, a freelance journalist—previously a staff writer at BuzzFeed—whose newsletter, Coronavirus News for Black Folks, highlights the pandemic’s disproportionate impact on the black community.Listen to the end of the episode to hear more about Patrice, Zach, Edith, and Lenny's top newsletter recommendations:Patrice’s newsletter recs:The Intersection by Adriana LacyBeauty IRL by Darian Symone HarvinCarefree Black Girl by Zeba BlayMaybe Baby by Haley Nahman Zach’s newsletter recs:Stratechery by Ben ThompsonSinocism by Bill BishopA Media Operator by Jacob Cohen DonnellyOff the Chain by Anthony PomplianoThe Weekly Dish by Andrew Sullivan Edith’s newsletter recs:The Browser by Robert CottrellThe Ruffian by Ian LeslieRidgeline by Craig ModDearest by Monica McLaughlinWhy Is This Interesting? by Noah Brier and Colin Nagy Lenny’s newsletter recs:2PM by Webb Smith Li’s Newsletter by Li Jin Alex Danco’s Newsletter by Alex DancoTurner’s Blog by Turner NovakNext Big Thing by Nikhil Basu Trivedi Big Technology by Alex KantrowitzThe Profile by Polina MarinovaEverything by Nathan Baschez, Dan Shipper, Tiago Forte, and Adam KeeslingNot Boring by Packy McCormick  Illustration: Edith Zimmerman
Since Netflix started in the late 90s as a DVD-by-mail rental service competing with Blockbuster, it has completely reinvented itself... twice – first, when it went from DVD rental to video streaming platform, and then again when it went from licensing to producing original content.But what does it take to create an organization capable of reinventing itself?In this episode, originally recorded for the Commonwealth Club of California, Netflix CEO and co-founder Reed Hasting talks about his new book "No Rules Rules: Netflix and the Culture of Reinvention" with a16z co-founder and fellow author Ben Horowitz, who also wrote a bestselling book about culture last year. During the conversation, Reed tells the story of Netflix's evolution and his management philosophy, including the hard lesson he learned about what happens when you optimize for efficiency at the expense of creative talent. He also explains why sometimes a more narrow market focus is better for growth and shares the tactics that have helped Netflix expand globally and translate a culture of innovation across different countries, from Japan to Brazil to America.
"I'm in a movie, but it's the wrong movie."For better or for worse, we tell the story of entrepreneurs as one of the mythical hero's journey: that's there's a call, a test (multiple tests!), a destination... But nothing truly follows such a clean, linear, storytelling arc. Stories of success and resilience are messy and full of "sleepless nights, anxiety-ridden fears, moments of real despair and failure", observes Guy Raz -- who is the host, co-creator, and editorial director of three NPR programs, including the popular podcast "How I Built This" -- and has a new book (coming out this week) on How I Built This: The Unexpected Paths to Success from the World's Most Inspiring Entrepreneurs.But in sharing these stories, are we also indulging in "failure porn"? Where do (and don't) debates about optimism vs. pessimism come in; does this really squelch the appetite for building? What happens when "unexpected paths" are actually things like a once-in-a-lifetime pandemic? Editor in chief (and showrunner of the a16z podcasts) Sonal Chokshi probes Raz on these questions and more, while also pulling the threads of how storytelling IS business -- whether it's a company or a community or a product or a movement. So what's the difference between "building buzz" and "engineering word of mouth"? And how do the stories we tell ourselves, and others, actually move things?Raz is also an entrepreneur with his own production company; has won numerous awards and accolades; co-created a podcast for kids (Wow In The World); and is hosting a music interview show for Spotify, not to mention his NPR shows. So what's his best interview tip? And how does his story also thread into this broader sea of stories, along with the story of the podcasting industry, and even the story (and history) of the Bay Area? This episode is for anyone wanting to figure out how to rewrite their own story... it's really for everyone.
Monopoly, oligopoly, cartel. All three of those words can describe the (not so) modern education system today, given the cost structures, economics, and accreditation capture -- in everything from who can and can't start a new university (when was the last time a significant change happened there anyway?!) to where government funding really goes to the student loan and debt crisis.Yet degrees do matter, just not for the reasons we think. So what are the tradeoffs -- when it comes to the "right" school, making money, and assessing skills objectively -- between what's been called "hard" (B.S.) and "soft" (B.A.) degrees? What's the best book on career advice, and what advice does Marc Andreessen -- who went to a public university, worked on a revolutionary project there, and started a company right after -- have for students (and others contemplating change in their careers)... and especially for those considering dropping out, delaying, or skipping college altogether?Andreessen shares his thoughts on the purpose, past and present of education (briefly touching on the impact of the pandemic as well) with Dylan Field, CEO of Figma, which is free for students and educators. The Q&A was recorded in August 2020 and originally appeared as a video in their "Back to School?" interview series; it was actually inspired by the question of taking a gap year and questions about whether or not to go back to school this year that came up in their Virtual Campus community of students from across the world. image: Lyndsy Rommel / Flickr
This episode examines the potential for misuse and fraud among those applying for the Paycheck Protection Program (PPP)—and how fintech and software provide overlooked tools to stop it.  On March 27th, the government enacted a $2.2 trillion dollar stimulus package called the CARES Act, the largest aid measure in history. The act provides more than $500 billion for the Paycheck Protection Program, or PPP, a low-interest, forgivable loan program designed to help small businesses and self-employed individuals retain workers and stay afloat during the pandemic. Since March, the Small Business Administration has approved billions of dollars in PPP loans. But it is also estimated that U.S. losses from coronavirus-related fraud and identity theft have reached almost $100 million. According to the New York Times, the Small Business Administration’s fraud hotline has received 42,000 reports about coronavirus-related cheating and misuse; by comparison, last year it had less than 800.To date, the Department of Justice has charged more than 40 cases of PPP-related schemes, from claiming non-existent employees or non-existent businesses to identity theft, kickback schemes, fake tax documents, and multi-state fraud rings. Most of those cases have alleged fraud of more than a $1 million. But what about the countless others that may be cheating taxpayers out of smaller—but not insignificant—sums? How does the government decide who should get money and who shouldn’t among millions of applications from businesses of all industries and sizes—and what role do banks play? How does the program then distribute that money quickly and accurately—or not, in many cases? And what tools are at our disposal to catch those who cheat the system? Host Lauren Murrow is joined by Bharat Ramamurti, the original member of the COVID-19 Congressional Oversight Commission, which is tasked with evaluating the impact of coronavirus relief loans; Naftali Harris, the CEO of SentiLink, a software company that builds technology to detect synthetic fraud; and a16z fintech general partner Alex Rampell.
Okay, so we know community is important -- whether for developer relations for your product or other types of communities -- but how do we measure the success of community initiatives and even artifacts (like events or schwag), given how indirect and long-cycle so much of it is? How do we know we're even measuring the right things, and is there one key metric or KPI for measuring the health of a community? Where do "meta communities" or where does engaging key community leaders come in?And when it comes to developer relations specifically, where should devrel sit in an organization (product, sales, engineering)? Who should you hire first? How do you reconcile developer as customer vs. developer as community member? And what's the difference between evangelism and advocacy?Amir Shevat -- former VP of Product and Developer Experience at Twitch and former Director of Developer Relations at Slack who also previously worked at Google and Microsoft -- drew on his experiences to share insights and answers to these questions, as well as provides an overview of key concepts, followed by a Q&A with Mikeal Rogers, who works on Community Operations at Protocol Labs, and was formerly Community Manager of the Node.js foundation (and has shared insights on the changing culture and community of open source on a previous episode of the a16z Podcast).This episode is based on a conversation that took place at a portfolio workshop event from a couple years ago organized by former a16z crypto partner Jesse Walden, because crypto gives developers the ability to build on top of and extend any protocol or application in the space, and developer relations and community building is an important part of that being realized. You can find the latest on company building best practices for crypto at a16z Crypto Startup School and see other pieces in our ongoing community series at
There is no spoon. Or rather, “There is no such thing as ‘data’, there’s just frozen models”, argues Peter Wang, the co-founder and CEO of Anaconda — who also created the PyData conferences and grew the early data science community there, while on the frontlines of trying to make Python useful for business analytics. He views both models and data as fluid, more like metaphysics than typical data management… Or perhaps it’s that when it comes to data, those with a physics background just better appreciate the mind-bending complexity and challenges of reining in the natural world, and therefore get the unique challenges of AI/ML development, observes a16z general partner Martin Casado — whose first job after college involved computational physics simulation and high-performance computing in Python at Lawrence Livermore National Laboratory. (Wang, meanwhile, graduated in physics.)But this not just a philosophical question — the answer has real implications for the margins, organizational structures, and building of AI/ML businesses. Especially as we’re in a tricky time of transition, where customers don’t even know what they’re asking for, yet are looking for AI/ML help or know it’s the future. So what does this all mean for the software value chain; for open source collaboration and commodification; and for the future of software businesses? After all, it’s not written in stone that “All information systems must be deconstructed into hardware, and software, and data” and that “software must have these margins”… Will there be a new type of company? image: Pawel Loj / Wikimedia Commons
This episode is all about education and technology, a topic that’s especially top of mind this week as students in much of the country return to school—virtually. The intersection of learning and technology has been accelerated by the pandemic, but the debate around education's "disruption," and what that means for educators doing the hands-on work of teaching, has been swirling for years.In this episode, a16z general partner Connie Chan and host Lauren Murrow are joined by educators and experts Josh Kim, the Director of Online Programs and Strategy at  Dartmouth College (whose most recent book, Learning Innovation and the Future of Higher Education, was published earlier this year), and David Deming, Professor of Education and Economics at the Harvard Kennedy School and the Harvard Graduate School of Education.We explore the complicated issue of online education from a variety of angles: Can the quality of online learning stack up to an  in-person education? What improvements have we seen over the past decade and what improvements are we likely to see this fall, compared to the COVID scramble last spring? And might this moment be the push we need for educators and technologists—sometimes at odds—to collaborate more closely?We discuss and debate the research behind online learning, the dual impact of tech and COVID on the future of higher ed, and tech's potential in everything from curriculum to access to structural inequality.
WHEN are we going to have a COVID-19 vaccine, and how the heck are we going from (what’s been traditionally been up to) 12 years or so of vaccine development compressed into 12 months or so? What will and won’t be compromised here, and where do new technologies -- like mRNA or messenger RNA vaccines -- come in? Where will vaccines likely be distributed first, who will and won't get them initially, both across populations... and nations?Rajeev Venkayya, president of the Global Vaccine Business Unit at Takeda Pharmaceutical Company and former White House Special Assistant to the President for Biodefense (where, among other things, he was the principal author of the National Strategy for Pandemic Influenza) joins this special deep-dive episode of the a16z Podcast, in conversation with general partner Jorge Conde to discuss all things vaccines. Including where does manufacturing and scale-up come in -- is "plug and play" really here? -- and by the way, why have we traditionally used eggs in growing vaccines?Where and how can startups and others participate in vaccine development, given how competitive, time-consuming, capital intensive, and risky it is to develop (and sell) them? Can we decouple the question of how we reopen schools with when we have a vaccine? And how do we maintain not just safety and efficacy of vaccines but trust and transparency when it comes to mis/information? We may actually see the emergence of a "Neo Anti-Vaxxer" thanks to the rush... but we may also be entering a renaissance for vaccinology after this pandemic. So what changes, what doesn't? image: Jernej Furman / Flickr
In this episode, we continue our community series with a recent discussion that applies to many kinds of community building. Today’s topic: How do you create a platform that people not only use, but tell their friends about? One that goes beyond just being useful and actually connects deeply with the user? In this discussion, which was recorded at our Crypto Startup School in April 2020, a16z General Partner Chris Dixon talked about building communities — specifically, communities of open-source developers — with GitHub cofounder Tom Preston-Werner. They discussed how to engage early users, how to turn them into your biggest advocates, how to create superfans, and more. Today, GitHub is the leading community for open-source developers and others. They also discuss in-person communities vs. distributed communities, a topic that is very top of mind today.
CAR T therapy is a groundbreaking medicine that uses engineered T cells to attack cancer. But CAR T cells (that is, chimeric antigen receptor T cells) can be programmed to recognize a huge range of target proteins and cell types. So what other types of cells should we train CAR Ts to recognize and destroy to improve human health?On this episode of the a16z Journal Club, a16z General Partner Jorge Conde, bio deal team partner Andy Tran, and Lauren Richardson discuss new research published in Nature in which the authors engineer CAR T cells to recognize and kill senescent cells. Cellular senescence is a process where cells stop dividing (sort of go to sleep), and in many cases this can be protective, like its role in tumor suppression, but if too many cells become senescent of if they are not removed, they can trigger inflammation and cause disease, like in atherosclerosis and type 2 diabetes. Critically, senescent cells build up as we age and contribute to a whole host of age-related conditions. In this episode we cover how the authors created these senescence killing (aka senolytic) CAR T cells, the diseases that could be treated with senolytic CAR Ts, the hurdles to getting them into the clinic, and how they could potentially be used to treat aging and possibly improve longevity.“Senolytic CAR T cells reverse senescence-associated pathologies” in Nature (June 2020) by Corina Amor, Judith Feucht, Josef Leibold, Yu-Jui Ho, Changyu Zhu, Direna Alonso-Curbelo, Jorge Mansilla-Soto, Jacob A. Boyer, Xiang Li, Theodoros Giavridis, Amanda Kulick, Shauna Houlihan, Ellinor Peerschke, Scott L. Friedman, Vladimir Ponomarev, Alessandra Piersigilli, Michel Sadelain & Scott W. Lowea16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology. You can find all these episodes at
We're living in an unprecedented era of online collaboration, coordination, and creation. All kinds of people are coming together -- whether in an open source project or company, an R&D initiative, a department in a company, a club or special interest group, even a group of friends and family -- around some shared interest or activity. But the word "members" is faceless, and doesn't help us really understand, support (and better design for) these communities.So in this special book launch episode of the a16z Podcast, Nadia Eghbal -- author of the new book Working in Public: The Making and Maintenance of Open Source Software published by Stripe Press -- shares with a16z editor in chief Sonal Chokshi the latest research and insights from years of studying the health of open source communities (for Ford Foundation), working in developer experience (at GitHub), researching the economics and production of software (at Protocol Labs), and now focusing on writer experience at Substack.Eghbal offers a new taxonomy of communities -- including newer phenomena such as "stadiums" of open source developers, other creators, and really, influencers -- who are performing their work in massive spaces where the work is public (and not necessarily participatory). So what lessons of open source communities do and don't apply to the passion economy and creator communities? How does the evolution of online communities -- really, social networks -- shift the focus to reputation and status as a service? And what if working in public is also about sharing in private, given the "dark forest theory of the internet", the growing desire for more "high-shared context" groups and spaces (including even podcasts and newsletters)? All this and more in this episode.
In this episode -- cross posted from our 16 Minutes show feed -- we cover all the buzz around GPT-3, the pre-trained machine learning model from OpenAI that’s optimized to do a variety of natural-language processing tasks. It’s a commercial product, built on research; so what does this mean for both startups AND incumbents… and the future of “AI as a service”? And given that we’re seeing all kinds of (cherrypicked!) examples of output from OpenAI’s beta API being shared — how do we know how good it really is or isn’t? How do we know the difference between “looks like” a toy and “is” a toy when it comes to new innovations? And where are we, really, in terms of natural language processing and progress towards artificial general intelligence? Is it intelligent, does that matter, and how do we know (if not with a Turing Test)? Finally, what are the broader questions, considerations, and implications for jobs and more? Frank Chen explains what “it” actually is and isn’t and more in conversation with host Sonal Chokshi. The two help tease apart what’s hype/ what’s real here… as is the theme of 16 Minutes.
Many don’t realize we even need to think about the possibility of security hacks when it comes to things like pacemakers, insulin pumps, and more. But when bits and bytes meet flesh and blood, security becomes literally a life or death concern. So what are the issues and risks we need to be aware of in exposing security vulnerabilities in connected biomedical devices?This conversation—with Beau Woods, Cyber Safety Innovation Fellow with the Atlantic Council, part of the I Am The Cavalry grassroots security initiative, Founder/CEO of Stratigos Security; Andy Coravos, co-founder and CEO of Elektra Labs, advisor to the Biohacking Village at DEF CON (both of whom were formerly EIRs at the FDA); and a16z's Hanne Tidnam covers how we should begin to think about addressing these security issues in the biomedical device space. What are the frameworks that should guide our conversations, and how and when (and which!) stakeholders should be incentivized to address these challenges? How did the FDA begin to think about security as part of the safety of all medical devices, including software as a medical device, and how we should think about understanding, monitoring, and updating the security of these devices—from philosophical statements to on-the-ground practical fixes and updates?
Ever since the discovery of antibiotics, microbiologists have worried about and studied how bacteria acquire resistance to these drugs. Adding to the complexity of this problem is the fact that it is not always clear whether the conditions that drive the evolution of resistance in the lab occur in patients suffering from bacterial infections.This is where the work of Nathalie Balaban -- Professor at the Hebrew University, and our guest on this episode -- comes in. The article we discuss is based on a foundation of research done in her laboratory, but this study makes the important step into the clinic by using samples from a patient with a life-threatening bacterial (MRSA) infection. By analyzing these patient samples, Dr. Balaban and her team were able to understand the conditions that lead to multi-drug resistance in a hospital setting. The work reveals how the ability of bacteria to enter a state of dormancy, also known as tolerance, can act as a stepping stone to resistance and can interfere with the efficacy of drug combinations. Our conversation covers what tolerance is, the conditions that promote tolerance, how it can lead to resistance and impact drug combination therapies, and lastly, integrating this new understanding into clinical microbiology protocols."Effect of tolerance on the evolution of antibiotic resistance under drug combinations" in Science (January 2020) by Jiafeng Liu, Orit Gefen, Irine Ronin, Maskit Bar-Meir, Nathalie Q. Balaban.a16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). You can find all these episodes at
Cybercrime, Incorporated

Cybercrime, Incorporated


A dive into the sociological, operational, and tactical realities of this murky underworld, Lusthaus and de la Garza discuss who the players are, what they are motivated by, and specialize in—as well as how basic ideas like trust and anonymity function in a world where no one wants to get caught. How do criminal nicknames function as brand? Which countries tend to specialize in what kinds of crime, and why? And most of all, what changes when you begin to think of the business of cybercrime as an industry?
Dr. Marty Makary—surgical oncologist at Johns Hopkins University School of Medicine, and health policy and innovation expert—has long been a passionate advocate for transparent pricing in the healthcare system. We don’t talk enough (or really at all) about price in healthcare, says Makary (instead, we talk about cost). But shedding a light on prices in healthcare—from not just what those prices are but how prices are set and the value we all receive as consumers of the system overall—can help us measure quality in medicine, and be a driver for real behavioral change in the healthcare system, correcting many of the unintended consequences of a fee-for-service system like surprise billing or unnecessary medical procedures.In this conversation with a16z General Partner Julie Yoo, Makary and Yoo discuss what price transparency in the healthcare system could really do; how we can "steer" towards the good physicians who are not just highly skilled, but make the right judgment calls based on need and holistic health, not cost; how we might distinguish between high value and low value through medical appropriateness; and how we might gain clinical wisdom from other kinds of scientific discovery beyond randomized controls, especially during the wartime protocol of COVID-19.
Comments (16)

Kevin Schreder

With everything going on in the markets today, I would be interested in understanding how a cryptocurrency, driven by a private entity or open source, could influence the public markets, interest rates, and the dispersion of money. Depending on the economic ups and downs, wouldn't there need to be a governing entity, such as the federal reserve?

Apr 25th

Al Yaz

a very powerful and thought provoking episode. thank you. Buy American.

Feb 19th

Sara Jackson

This was a great episode! A lot of fun history to learn about.

Oct 20th
Reply (1)

AJF Nonprofit Podcast

That's why we in America need

Jun 16th

Connie Kwan

very informative. one of the best episodes!

May 30th


They really need to check out Castbox, we are working on a lot of the features they talked about, and some of the features are even available in other regions already. There will be lots of new monetization opportunities on Castbox for creators, keep an eye out in the near future!

Apr 7th

Cliffy B.

Even tho i had to slow down all the SPEED TAlKING this was enjoyable. Peeps be waaayyy Vata

Apr 4th

Luke H

A lot.of this does not reflect UK market

Mar 23rd

Pieter Haegeman

Let your guests speak and your audience make connections for themselves. The interviewers incessant hmms and rights are just distracting from the quality of your guests. Please think about the difference between showing your guests youre listening in the moment and letting your listeners still be able to experience the conversation for themselves.

Mar 17th


Really wish I could hear more from the CEO of Activision, he has some great stories!

Feb 22nd

Michael Bergman

Great podcast, please don't interrupt the subject so much next time.

Dec 26th

Marcin K

this is actually a really interesting talk...

Sep 18th

Melanie Matsuo

why are there only men in this interview? are there no women that have an opinion on hiring a vp of product???

Jul 13th
Reply (1)

Indrajit Rajtilak

- Idea meritocracy and believability weighted decision making - mission first people second - everything has precedent, understanding differences is important for good decision making - having 15 low correlated investments is great investing strategy - being early and being wrong are the same thing - ego barrier and blindspot - teacher vs peer vs student - Shaper : visualization to actualization - Simultaneous open mindedness and assertiveness - Open mindedness: having opinions but knowing that you might be wrong, and testing it

Apr 27th
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