Claim OwnershipChris Masterjohn, PhD
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Short Answer: Measure this against whether it increases your likelihood of burning. If it does, it’s probably a bad thing, but if it doesn’t, or if it lowers your risk of burning, that’s a good thing. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of …
The post If glutathione whitens your skin, is that good or bad? | Masterjohn Q&A Files #294 appeared first on .
Short Answer: Vaccination shouldn’t change the vitamin D requirement. Quarterly testing makes sense for someone who has never tested before or who wants to make sure they stay in range during COVID, but generally testing yearly around the mid-point of seasonality for you, once you know your variation, is plenty. Watch the video or listen …
The post Vitamin D supplements, testing, and interactions with the vaccine. | Masterjohn Q&A Files #293 appeared first on .
Short Answer: BH4 is expensive and requires very high doses, so if the problem is modest it can much more easily be solved by taking tyrosine. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a …
The post BH4 vs tyrosine for low neurotransmitters and a high phenylalanine-to-tyrosine ratio. | Masterjohn Q&A Files #292 appeared first on .
Short Answer: While the body will tend to use TMG for methylation in the fasting state, it is normally found in food, so you should be able to absorb it with meals and hold on to it for later use, much as we do with folate. Watch the video or listen to the podcast with …
The post Does TMG have to be taken in the fasting state? | Masterjohn Q&A Files #291 appeared first on .
Short Answer: When I had a serious case of indoor mold-induced illness, I tested my urine and my apartment dust for mycotoxins. Both were high, but the classes of toxins were totally different between the two, making me think the mycotoxins in my urine came from food rather than my apartment. Symptoms going away when …
The post Is urinary mycotoxin testing useful for indoor mold exposure? | Masterjohn Q&A Files #290 appeared first on .
Short Answer: Even if genetics and other bloodwork don’t look like hemochromatosis, sky-high ferritin justifies trying to lower it with blood donation or phlebotomy if inflammation markers are low. If this doesn’t work, oxidative stress should be investigated. Watch the video or listen to the podcast with the links below. You can obtain a full …
The post Ferritin sky-high without hemochromatosis? | Masterjohn Q&A Files #289 appeared first on .
Short Answer: If optimizing for efficacy, the booster shot will likely be worth it for Pfizer, whereas other vaccines don’t have clear evidence of declining efficacy yet. If optimizing for safety, one should be skeptical of the booster since a 3-dose regiment hasn’t been tested in clinical trials. Watch the video or listen to the …
The post Will the booster shot be worth it? | Masterjohn Q&A Files #288 appeared first on .
Short Answer: To get adequate raw material for melatonin synthesis in the brain, carbs can come any time of day and are best if high-glycemic. To suppress brain histamine levels, carbs in the evening, with low protein and relatively low fat, is best. From among protein, collagen is best at night for the glycine. Watch …
The post How to use carbs and glycine for sleep. | Masterjohn Q&A Files #287 appeared first on .
Short Answer: It requires more frequent dosing and has some risk of hypercalcemia, and it would be best to make sure you have adequate D and magnesium and aren’t overdoing anything that could deplete D, such as other fat-soluble vitamins, first. Watch the video or listen to the podcast with the links below. You can …
The post What are the downsides to taking prescription calcitriol for bones? | Masterjohn Q&A Files #286 appeared first on .
Short Answer: B6 cannot be ruled out, though inflammation and estrogen could also be involved. While it is possibly a regulated means of increasing excitatory effects of quinolinate, it makes sense to assume it may respond to B6. Watch the video or listen to the podcast with the links below. You can obtain a full …
The post Does quinolinate sometimes indicate niacin or inflammation instead of B6? | Masterjohn Q&A Files #285 appeared first on .
Short Answer: While it is unclear, it could relate to vitamin K depletion, hypercalcemia, or compensation in acid-base balance. First and foremost, use the full testing algorithm in Testing Nutritional Status: The Ultimate Cheat Sheet (available at https://chrismasterjohnphd.com/cheatsheet) rather than just testing 25(OH)D to determine deficiency. Watch the video or listen to the podcast with …
The post Why would 5,000 IU vitamin D cause tooth sensitivity? | Masterjohn Q&A Files #284 appeared first on .
Short Answer: A half a gram to a gram of protein per pound of bodyweight, no more than 20-40 grams of that from protein powder, and whole foods supplying the targets for vitamins and minerals, erring on the side of overshooting them. Lentils and other legumes as primary carb foods and supply a portion of …
The post What’s the best and most affordable diet for a hungry teenage boy? | Masterjohn Q&A Files #283 appeared first on .
Short Answer: If the cause is nutritional, FIGlu cannot rule out folate deficiency as a cause because it reflects tetrahydrofolate rather than methylene-THF. So, increasing the dose of folate or switching from methylfolate to folinic acid could be tried. Otherwise the most likely nutritional solution would be copper. Watch the video or listen to the …
The post Why would MCV be elevated if MMA and FIGlu are normal? | Masterjohn Q&A Files #282 appeared first on .
Short answer: If inflammatory markers are low and Lp(a) is proportionally more elevated than LDL-P, then blood lipids probably account for part of the calcification, while factors impacting LDL oxidation come next and those impacting calcification directly come after that. For the latter two, the oxidative stress and calcium sections of the Cheat Sheet should …
The post How to further explore slightly high coronary calcium and Lp(a) and borderline high LDL-P? | Masterjohn Q&A Files #281 appeared first on .
Short answer: The science behind dietary AGEs being bad for us is very poor-quality. While food that is treated to excessively high heat, such as fried food, should not be the major portion of our diet, dietary tables of AGEs in foods are not accurate and dietary AGEs are probably not a major source of …
The post Is blackstrap molasses toxic because of AGEs? | Masterjohn Q&A Files #280 appeared first on .
Short answer: The second law of thermodynamics means that concentrations of specific chemicals or positive or negative charges will always “want” to disperse and randomly mix in their environment, making concentrations of ions such as sodium or potassium a form of potential energy. While the pump normally uses energy from ATP to invest into creating …
The post Why can the sodium-potassium pump work backwards? | Masterjohn Q&A Files #279 appeared first on .
Short answer: Alpha-GPC, ginkgo biloba, lion's mane, and a comprehensive analysis of your nutrient status as outlined in Testing Nutritional Status: The Ultimate Cheat Sheet to see if anything is missing. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up …
The post What can I take to improve my memory? | Masterjohn Q&A Files #278 appeared first on .
Short answer: Apart from well known acute risks such as fainting, hypoglycemia, or dehydration from a blood donation, there isn't anything to worry about except making sure you don't become deficient in iron. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by …
The post If you have high ferritin, are there any downsides to blood donation? | Masterjohn Q&A Files #277 appeared first on .
Short answer: 15 grams of psyllium husk should lower LDL-C over 6 weeks, and you may be able to get away with cutting the dose down to 5-10 grams if using a fine powder. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode …
The post What type and how much psyllium to lower LDL-cholesterol? | Masterjohn Q&A Files #276 appeared first on .
Short answer: When trying to stop the early progression of insulin resistance, it is best to use a combination of strength, power and muscle building, fat loss, and high-intensity exercise in 20-second to one-minute bouts; to institute a rhythmic fasting-feeding cycle; and not to use berberine or metformin unless absolutely needed. One good way to …
The post What is the most sustainable way to implement carb cycling? | Masterjohn Q&A Files #275 appeared first on .
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