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Lab Rat Chat

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A podcast dedicated to providing facts and an alternate narrative to the public regarding the necessity of humane and ethical animal research. Lab Rat Chat was made possible through the Michael D. Hayre Fellowship in Public Outreach, which is sponsored by the biomedical research advocacy group Americans for Medical Progress.
16 Episodes
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Lab Rat Chat - Episode 16 with Lisa Roberts from the University of Connecticut Purchase Lab Rat Chat merch and help support our podcast and biomedical research!https://labratchat.myteespring.co/In this episode of Lab Rat Chat, Danielle and I talked with Lisa Roberts, RLATg, a veterinary technician at the University of Connecticut.  We had a very interesting conversation about the day-to-day operations and what life is like for those working within an animal research facility.  Lisa talked to us about the various positions within their animal care facility and the daily interactions that go on between them to ensure the animals are constantly receiving the best quality of care.Topics discussed in this episode:Lisa’s extensive background and experience throughout her education and career.The day-to-day responsibilities and what life is like working within an animal research facility.A few of Lisa’s favorite projects that she’s been a part of over the yearsAdvice for those who may be interested in pursuing a career in laboratory animal science.Notable quote:“The animal care techs...they are an advocate and a voice for the animals, they see and interact with them daily and they'll notice those subtle changes in their behavior...and it's so important to have people in those positions that are intuitive to that.  I feel that people who have a love for animals are the people that are drawn to this position, and they are very good at that job."Sign up for the Lab Rat Chat newsletter!https://www.amprogress.org/raising-voices/lab-rat-chat/Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat  https://www.facebook.com/labratchat  https://www.instagram.com/thelabratchat Resources & Links:Americans for Medical Progress (https://www.amprogress.org/) Americans for Medical Progress COVID-19 Resources (https://www.amprogress.org/covid-19-resources/)All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/  Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 15 with Angela Stoyanovitch, Founding Partner and Host of Legal Drugs Podcast.   Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat In this episode of Lab Rat Chat, Danielle and I had a chat with Angela Stoyanovitch, B.A., LATG, who is the Founding Partner and host of Legal Drugs Podcast, a production of Legal Drugs Agency, LLC.  Legal Drugs Agency is a consultancy and media agency dedicated to supporting both drug developers and the public in understanding what it takes to get a drug to market.  After graduating from Hope College with degrees in Biology and Neuroscience, Angela set out to understand more about biomedical research.  In her first job out of college she certified as a Laboratory Animal Technologist.  Leveraging her experience in the lab, Angela networked her way to supporting researchers as a sales representative for one of the largest contract research organizations in the world. Altogether, Angela brings twelve years of contract research, drug development and business development experience to her media platforms and show, Legal Drugs Podcast, where she interviews both scientific or industry experts and laypeople affected by disease.  Angela is interested in the human effect of the industry, preventative measures, curative drugs and a transparent tax-funded culture for all of biomedical research as it supports new legal drugs.Sign up for the Lab Rat Chat newsletter!https://www.amprogress.org/raising-voices/lab-rat-chat/Buy Lab Rat Chat merch and help support our podcast and biomedical research!https://labratchat.myteespring.co/Resources & Links:Legal Drugs Podcast (https://www.podpage.com/legal-drugs-podcast/)NAALAS Panel – Podcasting to the Public and the Art of Storytelling (https://issuu.com/aalasoffice/docs/2020_virtual_meeting_program/28)Listen to Lab Rat Chat co-host, Jeff, on Legal Drugs Podcast (https://www.podpage.com/legal-drugs-podcast/28-an-alternative-narrative-to-animal-research-in-biotechnology-the-journey-to-becoming-a-lab-animal-veterinarian-with-jeff-marshall/)Americans for Medical Progress (https://www.amprogress.org/) Americans for Medical Progress COVID-19 Resources (https://www.amprogress.org/covid-19-resources/)All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/ Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 14 with Dr. Christopher Chen from Texas Biomedical Research Institute Help us out by leaving us a rating or review on iTunes | Stitcher - we might even read your review on our next episode!In this episode of Lab Rat Chat, Danielle and I talked with Dr. Christopher Chen, Southwest National Primate Research Center Assistant Director for Research Support at Texas Biomedical Research Institute.  We had an interesting conversation about his lab’s recent development of a new incredible animal model in the squirrel monkey, for the purpose of studying Hepatitis B.  In this episode you’ll learn everything you need to know about Hepatitis B and the important ongoing research working toward cures and treatments for this disease.Topics discussed in this episode:Dr. Chen’s extensive background and experience throughout his education and career.Hepatitis B background information, including what it is, what it does to the body, how long the disease can last, and much more.The storied history of hepatitis B and C research, including the development of a vaccine for hepatitis B and a cure for hepatitis C, at Texas Biomedical Research Institute.The process of developing a squirrel monkey animal model for hepatitis B research and why the squirrel monkey makes for such a great model.Future directions for hepatitis B research now that the squirrel monkey model has been developed.Notable quotes:“The goal is to find some related monkey to wooly monkeys that would support the infection of this wooly monkey HBV chronically, so squirrel monkeys are closely related, and they have conserved residues of other receptors.”“Took the viral genome from wooly monkey HBV and inserted into another virus that infects the liver quite readily, it’s called adeno-associated virus…we essentially gutted the adeno-associated virus genome and replaced it with this wooly monkey HBV genome and that allowed us to get the virus to very readily infect the liver cells of the squirrel monkey, and once it was in the liver cells, it would naturally replicate and you would get wild-type wooly monkey HBV being produced.”Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat  https://www.facebook.com/labratchat  https://www.instagram.com/thelabratchat Sign up for the Lab Rat Chat newsletter!https://www.amprogress.org/raising-voices/lab-rat-chat/Resources & Links:Texas Biomedical Research Institute (https://www.txbiomed.org/)Texas Biomed Squirrel Monkey Animal Model for Hepatitis B article (https://www.txbiomed.org/news-press/news-releases/new-animal-model-identified-to-research-hepatitis-b-virus/)Americans for Medical Progress (https://www.amprogress.org/) Americans for Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 13 with Dr. Joanne Turner and Dr. Luis Martinez-Sobrido from Texas Biomedical Research Institute  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat In this episode of Lab Rat Chat, Danielle and I had the pleasure of talking to two guests, another first for us, with Dr. Joanne Turner and Dr. Luis Martinez-Sobrido from Texas Biomedical Research Institute.  We chatted about their recent development of humanized mice to help us understand some of the many complexities surrounding SARS-CoV-2, as well as simply talking about some general mysteries about this COVID-19 disease that we hear about in the media.  For a more in-depth read on their COVID-19 research, check out the link below in the 'Resources & Links' section.Topics discussed in this episode:Dr. Turner’s and Dr. Martinez-Sobrido’s extensive backgrounds and experiences throughout their education and careers.Details regarding the humanized mice they’ve developed and why they’re a good model to study COVID-19.Information about the infectious dose of COVID-19 and why children seem less susceptible, and how using this mouse model may help give clues on these mysteries.Ways to approach talking about animal research with the public and how the public should perceive the field of biomedical research.Notable quotes:“Altogether what we find is these transgenic mice pretty much represent a very nice and good small animal model to study COVID-19 pathogenesis and to study some of these approaches that we are trying to develop at Texas Biomed in terms of vaccine development and therapeutics for the treatment of these viral infections”“These transgenic mice will be a great model to study if you can get re-infected once you have primarily been infected with the virus.”“I think some of those apparent contradictions are because it’s a new virus, it’s unknown, and we’re working at it very quickly and we’re putting information out as we find it, so often our initial observation get modified when we learn more.  So that’s why it seems like, in science, we’re sometimes changing our minds, but that’s because we gathered new information in a robust way.”Sign up for the Lab Rat Chat newsletter!https://www.amprogress.org/raising-voices/lab-rat-chat/Resources & Links:Texas Biomedical Research Institute (https://www.txbiomed.org/)Texas Biomed Humanized Mice Press Release (https://www.txbiomed.org/news-press/news-releases/sars-cov-2-rodent-study/)Americans for Medical Progress (https://www.amprogress.org/) Americans for Medical Progress COVID-19 Resources (https://www.amprogress.org/covid-19-resources/)All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/  Support the show (https://www.amprogress.org/donate/)
12. All About BRAD

12. All About BRAD

2020-08-2733:02

Lab Rat Chat - Episode 12 with Dr. Logan France, board-certified laboratory animal veterinarian and Founder and Program Director of BRAD  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat In this episode of Lab Rat Chat, Danielle and I had a chance to catch up with Dr. Logan France to talk all about Biomedical Research Awareness Day (BRAD), officially planned for September 17, 2020.  If you don’t already know, BRAD is a truly amazing day that celebrates the use of animals in biomedical research that have contributed to both human and veterinary medicine.  Anyone and everyone can and should celebrate BRAD and help educate and inform not only the public but also themselves on the importance of animal research.  To get started, head to the BRAD webpage in the ‘Resources and Links’ section below and be sure to follow them on all their social media accounts!Topics discussed in this episode:Dr. France’s extensive background and experiences throughout her education and career.An overview of what Biomedical Research Awareness Day is and how it all started.How BRAD has grown over the years to become a worldwide celebration of laboratory animals and medical advancements.Ways to get involved and celebrate this annual tradition.Dr. France’s favorite laboratory animal and a couple of her favorite medical discoveries that have come from the use of animals in biomedical research.Notable quotes:“We also created BRAD challenges for this year…we’ve got 18 challenges for people to complete that are focused on showing support for animal research and educating others about the importance for animal research, and by participating they can earn entries for a raffle where we are giving away a bunch of neat prizes.”“The Principal Investigator (PI) for this lab was on the team of surgeons that completed the first bilateral forearm transplant at John’s Hopkins in a young man who survived a quadruple amputation after an injury in Iraq, and he lost all four limbs and was then able to have this transplant done and he now has two working arms…he’s able to do push-ups and pull-ups.”Sign up for the Lab Rat Chat newsletter!https://www.amprogress.org/raising-voices/lab-rat-chat/Resources & Links:BRAD's Webpage (https://www.bradglobal.org/)BRAD’s Facebook (https://www.facebook.com/BRADGlobal/)BRAD’s Instagram (https://www.instagram.com/brad_global/)BRAD’s Twitter (https://twitter.com/amp_brad)Americans for Medical Progress (https://www.amprogress.org/) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/  Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 11 with Dr. Dale Cooper, board-certified laboratory animal veterinarian  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat In this episode of Lab Rat Chat, Dr. Dale Cooper, speaks to us about some of the common misconceptions surrounding the use of animals in research.  We’ve all heard the argument that animals aren’t useful models for drug development, so take a minute and listen to Dr. Cooper break down the facts on this one and tell us why they are indeed the absolute best model for this and why they are still 100% necessary. Go check out Dr. Cooper’s guest article from a couple years back for Speaking of Research titled, “Predictability and Utility of Animal Models”.Topics discussed in this episode:Dr. Cooper’s extensive background and experiences throughout his education and career.A brief overview of the drug development process and alternatives that are utilized before ever testing a drug in an animal.The ability of animals to successfully predict potential toxicities and safety of a drug before testing it in humans.Whether or not the use of animals for drug development and testing could be skipped altogether, going straight into human testing instead.How a drug obtains approval to move from an animal model into human testing and ultimately on to the market.Notable quotes:“Some people will think about drug development in a particular animal research as if you one run study on one drug, and that gives you all your answers, and that couldn’t be further from the truth.”“The vast majority of people, even if they won’t admit that they’re okay with animal research, they are driving the demand that essentially is there asking us to develop drugs, develop within a certain timeframe, within a certain cost, and with a certain level of safety.”Sign up for the Lab Rat Chat newsletter!https://www.amprogress.org/raising-voices/lab-rat-chat/Resources & Links:Dr. Cooper’s Guest Post: Predictability and Utility of Animal Models (https://speakingofresearch.com/2017/07/25/predictability-and-utility-of-animal-models/)Americans for Medical Progress (https://www.amprogress.org/) PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/  Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 10 with Dr. Tara Martin, Director of the Refinement and Enrichment Laboratory at the University of Michigan  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat In this episode of Lab Rat Chat, Dr. Tara Martin from the Refinement and Enrichment Laboratory at the University of Michigan joins us to chat about the use of enrichment to stimulate and improve the lives of laboratory animals.  Dr. Martin and her team go to incredible lengths to ensure the enrichment they provide to every single animal are both safe and effective.Topics discussed in this episode:Dr. Martin’s extensive background and experiences throughout her education and career.The mission and vision of the Refinement and Enrichment Laboratory at the University of Michigan.What enrichment is and why it must (almost) always be used for laboratory animals.The process of testing and approving new enrichment items for use with the various animal species.Specific types of enrichment that may be used for animals based upon the type of study they’re involved in, such as studying cancer or cardiovascular diseases versus depression or anxiety.Notable quotes:“The reason we research enrichment is because there are a lot of toys and items available that seem like they would be really fun to us as humans, and then you give them to an animal and the animal is like ‘I have no interest in this item’, or they may even be afraid of the item.”“We filmed pigs with a bunch of different mats and then a bunch of different toys, and they ignored most of the items we put in, such as Kongs or balls, but the mats they would sleep on and then they would spend a lot of time pushing them around the cage, probably because pigs just love to root items on the ground and that’s just such a normal behavior for them.”Resources & Links:Refinement & Enrichment Advancements Laboratory (https://animalcare.umich.edu/animal-use/refinement-enrichment-advancements-laboratory)REAL Lab Animal Enrichment Database (https://az.research.umich.edu/animalcare/search/all?keys=&type=All&topic=18&category=All)Americans for Medical Progress (https://www.amprogress.org/) PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/  Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 09 with Dr. Javier Guillen from the European Animal Research Association  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat   In this ninth episode of Lab Rat Chat, Dr. Javier Guillen from the European Animal Research Association joins us all the way from Spain to chat about the similarities and differences in animal research regulations and laws in the European Union compared with those in the United States.   Topics discussed in this episode:Dr. Guillen's extensive background and experiences throughout his education and career.The mission and vision of the European Animal Research Association.Similarities and differences between United States and EU animal research regulations.The development of Transparency Agreements and how they may be contributing to increasing public trust.Notable quotes:“In these current times of COVID-19, EARA has put together an interactive map to display the biomedical research currently underway across the world to find a cure for coronavirus.”“Many people don’t really know when, why, and how animals are used.  When you explain to someone all the regulations and ethical oversight, they are really surprised.”Resources & Links:European Animal Research Association (www.eara.eu)EARA interactive COVID-19 map (https://www.eara.eu/post/how-animals-are-helping-in-covid-19-research-a-global-overview)Americans for Medical Progress (https://www.amprogress.org/) PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/ Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 08 with Dr. Ricardo Carrion, Jr., Professor at Texas Biomedical Research Institute   Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards! In this eighth episode of Lab Rat Chat, Dr. Ricardo Carrion, Jr., from Texas Biomedical Research Institute, talks to us about the research they are doing down at their institute in San Antonio, TX to help combat COVID-19. Topics discussed in this episode:Dr. Carrion’s journey through his education and career leading to his current position at Texas Biomedical Research Institute.The details behind various high containment laboratories that allow scientists to work safely with deadly pathogens.The use of various animal models to help understand and study SARS-CoV-2, the causative virus behind the COVID-19 disease.Notable quotes:"Individuals are actually suited into a space-suit type uniform, it's a single, continuous jump-suit, if you will, that has a zipper...they are tethered to a breathing air-supply line, and they work in the BSL-4 laboratory in that suit."“The level of collaborations seen in this outbreak, this pandemic, is greater than any other type of collaboration that I’ve seen in the 20 years that I’ve been doing science.”“If you look at vaccine development, if you look at Ebola for instance, as an example, it was about 7-10 years to license that vaccine.  So that in one year, we’re talking about possibly having an FDA licensed vaccine for COVID-19, it’s pretty remarkable”Resources & Links:Texas Biomedical Research Institute (www.txbiomed.org)Americans for Medical Progress (https://www.amprogress.org/)AMP's COVID-19 Resources (https://www.amprogress.org/covid-19-resources/)PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/  Support the show (https://www.amprogress.org/donate/)
7. Combating COVID-19

7. Combating COVID-19

2020-05-0431:12

Lab Rat Chat - Episode 07 with Dr. Mark Slifka, Professor at Oregon Health and Science University  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards! In this seventh episode of Lab Rat Chat, Dr. Mark Slifka from Oregon Health and Science University talks to us about his research involving developing antibody tests for detecting COVID-19.Check out the video version of this episode on YouTube (link below)! Be sure to comment and let us know if you want to see more of this in the future! And yes, I'm recording from my basement, which is one of the only, actually, it is the only, somewhat quiet place in my house.Video version of the episode - https://youtu.be/ArmVEja-AD0 Topics discussed in this episode:Dr. Slifka’s journey through his education and career leading to his current position at Oregon Health and Science University.Serological (antibody) tests for COVID-19 detection in people.Why developing these serological tests to be highly accurate is so important to help our country, and our entire world, move past this COVID-19 pandemic.The general role of animals in vaccine development.Potential treatment options for those suffering from COVID-19.Notable quotes:“We were the first study to demonstrate that immunity can be maintained for up to 75 years after a single vaccination against smallpox.”“A virus like measles is very very contagious, far more contagious than COVID-19, far more contagious than flu”“If we got herd immunity in the range of 50-60%, then there’s a good chance that the herd immunity itself would reduce that reproductive number to less than one and the virus would burn itself out”Resources & Links:Americans for Medical Progress (https://www.amprogress.org/) AMP's COVID-19 Resources (https://www.amprogress.org/covid-19-resources/)PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 06 with Dr. Rudolf Bohm, Associate Director and Chief Veterinary Medical Officer at the Tulane National Primate Research Center  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards! In this episode of Lab Rat Chat, Jeff and Danielle talk with Dr. Rudolf Bohm from the Tulane National Primate Research Center (TNPRC).  We cover a variety of topics in this one, including the basics of using monkeys in research, to TNPRC’s vaccine development work for the new coronavirus (COVID-19), to what the daily life of a monkey is like within the TNPRC.    Topics discussed in this episode:Dr. Bohm’s journey through veterinary school and beyond, leading to his current position at the Tulane National Primate Research Center.Why non-human primates (monkeys) are so critical to the field of biomedical research.Amazing contributions to medicine and technology attributed to the use of monkeys in research.TNPRC’s efforts in developing an animal model for the new coronavirus causing COVID-19 and the work to be done in discovering potential vaccine candidates for COVID-19.The daily life of a monkey living within the TNPRC facilities and the amazing level of care and compassion that goes in to caring for them in ways you’ve never imagined.Notable quotes:“We developed a much better test to detect Lyme disease in both humans and in pet dogs…so that one actually did benefit pets directly which was probably the first time we’ve seen that happen, something move from primates to dogs”Regarding coronavirus (COVID-19) - “Really there are a lot of unanswered questions, such as how is it transmitted and how long after infection is it transmitted, how much virus is excreted, and so those are the kinds of things we can answer in animal studies that you can’t answer in human studies because you don’t know when humans are infected…”“Our approach is not just to throw a toy in a cage or try something new because we think it’s going to work.  We do it in a limited fashion, and we collect data, and we assess the data because we want to do things that are going to improve their welfare…”Resources & Links:Tulane National Primate Research Center (https://tnprc.tulane.edu/)Americans for Medical Progress (https://www.amprogress.org/) PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/   Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 05 with Dr. Rick Born, Professor of Neurobiology at Harvard University and member of Society for Neuroscience  Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards! In this episode of Lab Rat Chat, Jeff and Danielle's conversation with Dr. Born delves into a variety of topics including amazing medical discoveries and even advances in everyday technology that have come from animal research.  Dr. Born talks about the role of The Society for Neuroscience in promoting responsible animal research as well as their resources to help protect their members facing opposition from animal rights groups.    Topics discussed in this episode:Dr. Rick Born’s journey through medical school and beyond, leading to his current position at Harvard University.Information on The Society for Neuroscience and their role in advancing science and promoting responsible animal researchAmazing contributions to medicine and technology attributed to the use of animals in researchThe basics of Dr. Born’s research of the visual system and why this requires the use of non-human primates in order to help us understand visionAn introduction to our listeners about some of the various levels of extremism researchers have faced from animal rights groupsWays the research community can continue to improve in furthering the trust of the publicNotable quotes:“It’s important for ordinary people to see that scientists are also ordinary people.  We have wives and children, and dogs for pets, and we live in your neighborhood.  We believe that what we’re doing is important and justified and humane.” “Again, it goes to show how deep and necessary animal research is to the entire biomedical enterprise, and not limited to humans, but including the benefits that go to our pets as well.”“All the software that recognizes you when you’re on Facebook, when you post a picture to Facebook…it recognizes you because it’s using algorithms that were directly patterned after what we’ve learned about vision from the Macaque [monkey] visual system.”Resources & Links:The Society for Neuroscience (https://www.sfn.org/)Americans for Medical Progress (https://www.amprogress.org/) Come See Our World (https://www.comeseeourworld.org/)PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 04 with Dr. Helen Diggs, Senior Director of AAALAC International Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards! In this fourth episode of Lab Rat Chat, Jeff and Danielle talk with Dr. Helen Diggs about why this organization has been so critical to the continued evolution of animal care and use standards. Listen and find out about some of the amazing efforts institutions put forth in order to obtain this voluntary accreditation.   Topics discussed in this episode:Dr. Helen Diggs' interesting background working in Alaska, which involved working with polar bears and wolves!The role of AAALAC International A brief overview of the process to obtain AAALAC International accreditation Common findings during AAALAC International triennial site visit assessmentsNotable quotes:“It was an amazing introduction to veterinary medicine, they cared for a wide variety of species - wolves, lemmings, a polar bear, arctic foxes, and they studied diseases that are widespread in the Alaskan animal population…”  “AAALAC International promotes the responsible treatment and care of animals used in science through a voluntary, rigorous assessment and accreditation program. ” “Accredited institutions understand that meritorious, reproducible science depends on superb, consistent animal care. ” Resources & Links:Americans for Medical Progress (https://www.amprogress.org/) AAALAC International (https://www.aaalac.org) PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)  Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/ Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 03 with Dr. Stephen Beebe, a cancer research scientist at Old Dominion University.Follow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards! In this third episode of Lab Rat Chat, Jeff and Danielle talk to a research scientist, Dr. Stephen, about his research and how and why it requires the use of animals.  Stephen conducts cancer research trying to find cures, and even vaccines, for various types of cancer.  This has real impacts for both humans and our beloved pets, and I think Stephen illustrates some really fascinating points regarding the use of animals in research that you’ve never thought about before. Topics discussed in this episode:Dr. Stephen’s extensive background in research and how he has used animals to conduct a wide variety of types of scienceHis role as both a research scientist and the Chair of the Institutional Animal Care and Use CommitteeThe type of research he is currently conducting and how bioelectrics may be a potential cure and vaccine to treat and prevent cancer, including breast cancer and melanomaThe importance of continuing to use animals in researchWhether or not there is potential to discontinue the use of research animals in our near or distant futureNotable quotes:“When we do euthanize an animal, we try to be sure that we get maximum use from the tissues.”“We place them in a cage with a heating pad under it so they stay warm…and we have treats in the cage and one thing I’ve always noticed when an animal comes out of anesthesia, the first thing they do is start chewing on those little treats.”“We actually began this with simulation and modeling…then we used cells in culture…and then the next step that needed to be taken was to go to animals.  So, we had a lot of information before we went to animals in terms of how to do this, so we minimized the number of animals needed.”Resources & Links:Americans for Medical Progress (https://www.amprogress.org/) AAALAC International (https://www.aaalac.org) PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm) Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act) All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 02 with Dr. Steve Shipley, a laboratory animal veterinarian from UNC Chapel Hill School of MedicineFollow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards!In this second episode of Lab Rat Chat, Jeff and Danielle speak with Dr. Shipley to continue to illustrate the importance of animals in research for the continued advancement of both human and veterinary medicine.That's right, there are actual veterinarians working in research laboratories all over the world who have taken an oath to oversee and protect the health and welfare of every single animal.Topics discussed in this episode:Dr. Shipley’s background and how he got involved in the field of laboratory animal medicineHis role within his current position as a veterinarian working in a research laboratoryHow research animals are cared for from a veterinary standpoint, including diagnosing, treating, and preventing disease and illnessThe importance of continuing to use animals in researchWhether or not there is potential to discontinue the use of animals in research in the near futureLaboratory animal medicine as a career choice for aspiring veterinarians as well as veterinary technicians, husbandry staff, administrators, etc.Notable quotes:“My job as a laboratory animal veterinarian is to manage, prevent and treat disease.  And my job as a veterinarian in private practice was to manage, prevent, and treat disease.”“You actually sign a contract, your institution signs a binding contract with the government saying, there are rules that have been set up and you say we will follow and abide by these rules”Resources & Links:Americans for Medical Progress (https://www.amprogress.org/)AAALAC International (https://www.aaalac.org)PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act)All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/Support the show (https://www.amprogress.org/donate/)
Lab Rat Chat - Episode 01 with Danielle and Jeff providing an introduction into the world of animal researchFollow us on Twitter! Facebook! Instagram! https://twitter.com/thelabratchat https://www.facebook.com/labratchat https://www.instagram.com/thelabratchat $100 Amazon Gift Card Giveaway! Simply rate and review the podcast to be entered to win one of FIVE $100 Amazon gift cards!Welcome to the very first episode of Lab Rat Chat podcast with Jeff & Danielle!In this podcast series, Danielle and Jeff will talk about animal research and why it’s important for the continued advancement of both human and veterinary medicine.  We aim to provide you with facts about this field and what’s really happening behind the scenes  We'll have some really exciting guests on this show who are doing great things in this field, so be sure you check out every episode to hear from all of them!In this very first episode, Danielle and I get the conversation started and talk about some basic things regarding the field of animal research, people and organizations involved in it, and a couple of common misconceptions surrounding the use of animals in research.Topics discussed in this episode:Jeff’s background in veterinary science and his experience in overseeing regulations related to animal researchDanielle’s story of getting into the world of lab animals and her past and current work in the fieldWhy it’s necessary to continue animal researchHow animals are housed and treatedClarifying the terms; “Animal Testing” & “Animal Research"Institutional Animal Care & Use Committee (IACUC) and its role in animal researchThe approval and monitoring process of protocols involved in animal researchRegulations and laws related to animal researchHow animal research is involved in developing and evolving human medical proceduresWhy it’s challenging for computer modeling or cell culture methods to replace animal researchNotable Quotes:“There are lots of things that we benefit on a daily basis that people don't even know require the use of animals.”“We have the USDA, the United States Department of Agriculture, and then we have Public Health Service policy, PHS policy. And between those two, they cover all the species that are using animal research.”“Out of 108 Nobel prizes that have been awarded in the field of medicine and physiology, 96 of those have included the use of animals.”Resources & Links:Americans for Medical Progress (https://www.amprogress.org/)AAALAC International (https://www.aaalac.org)PHS Policy on Humane Care and Use of Laboratory Animals (https://olaw.nih.gov/policies-laws/phs-policy.htm)Animal Welfare Act (https://www.nal.usda.gov/awic/animal-welfare-act)All Lab Rat Chat episodes are edited by Audionauts: https://audionauts.pro/Support the show (https://www.amprogress.org/donate/)
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