Cryosphere Podcast

In this episode of The Cryosphere Podcast, hosts Max Marty and Rebecca Ziegler sit down with Mark Woodward, founder of Wake Bio, who's applying cutting-edge AI techniques to solve one of cryonics' most fundamental challenges: developing superior cryoprotectants. With a background in AI/ML at Google Brain and Stanford, Mark explains how he's now using machine learning to rapidly explore the chemical landscape in search of compounds that can protect biological tissue during freezing without the toxicity issues that plague current solutions. He's starting with Zebrafish, but his ultimate goal is full body human reanimation. Topics Discussed: -* How AI can accelerate cryoprotectant discovery by helping us navigate chemical combinations* The physics of vitrification and why current cryoprotectants struggle with larger organisms* Wake Bio's methodical approach: starting with zebrafish before progressing to mammals* Why warming tissue needs to happen faster than cooling to prevent ice crystal formation* The debate between biological reanimation versus mind uploading approaches* The practical challenges of transitioning from lab settings to real-world cryopreservation* How Wake Bio's research might eventually revolutionize organ preservation and transplantation* Mark's ambitious five-year goal of successfully preserving adult mice and ten-year vision for human cryopreservationLinks:* Wake Bio's Website: https://wake.bio* Contact: mark [at] wake.bio This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode of The Cryosphere podcast, hosts Max Marty and Rebecca Ziegler welcome Dan Held—a serial crypto entrepreneur and Bitcoin educator with over 850,000 followers on social media. As a General Partner at Asymmetric and former Head of Marketing at Kraken, Dan brings a wealth of experience in marketing disruptive technologies. He recently spoke at the Global Cryonics Summit in Miami about how cryonics can market itself and become more mainstream.Topics Discussed:•Dan's journey into bitcoin and how the 2008 financial crisis reshaped his worldview.•The role of open-mindedness in embracing new technologies•How Dan applies the concept of “return on stress” to choose his projects•The Japanese philosophy of Ikigai and its influence on his career decisions•Parallels between the early adoption of crypto and the current state of cryonics•Challenges in marketing cryonics and shifting the Overton Window•Strategies for targeting innovators and early adopters in the cryonics space•The potential synergy between the crypto community and cryonics enthusiasts•Philosophical discussions on immortality and the future of human experience•An “Overrated or Underrated” segment covering NFTs, AI existential risk, and university degreesPlus: Max & Becca's reflections on the conversation.Relevant Links:• Dan Held on X: https://x.com/danheld• Dan Held on the web: https://www.danheld.com/•Dan Held at the GCS in Miami 2024: https://www.youtube.com/watch?v=nAmXR9bQ5cwNote: We've recently changed the name of the podcast from The Cryonics Underground to Cryosphere Podcast. We also have a new host, Rebecca Ziegler, joining Daniel Walters and Max Marty. With that, more great episodes to come! This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

*(edit) We are officially sold out, but you can still add your email at the bottom of the website to get updates about future events.  In this quick update episode, Max and Daniel take a break from their usual guest format to update you on the Global Cryonics Summit in Miami this July 20th and 21st. Take a quick listen and then check out the show notes for details.   If you haven't purchased your tickets yet, you can grab them at GlobalCryonicsSummit.com. Show Notes:The event will be taking place at Ampersand Studios. We’ve secured a discounted room rate at the nearby Arlo Wynwood Hotel (you can use this discount link, but it will only work for a limited time so use it fast). If you want to extend your discount link booking to stay over on Sunday night as well, please click on Monday the 22nd as the checkout date even though it's X'd out, as that should make it work properly. That said, Miami is a major travel destination with many wonderful places to stay so feel free to shop around.If you’ve purchased our Patron Pass ticket, you’ll get a separate email with your pass to our Speaker/Sponsor dinner which will be Saturday evening after the day’s events. If you have already purchased a standard ticket but would like to upgrade to a Patron Pass and join us at Saturday’s Speaker and Sponsors Dinner, please reach out to us a globalcryonicssummit@gmail.com.Arlo Wynwood Full Link: https://be.synxis.com/?Hotel=38349&Chain=19470&arrive=2024-07-19&depart=2024-07-21&adult=1&child=0&group=PROTO This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

Important Note! Join your hosts Max and Daniel, plus luminaries from across the Cryonics industry, at the upcoming Global Cryonics Summit on July 20-21st in Miami, Florida. Go to globalcryonicssummit.com for early-bird tickets and more information.-----In this episode, Max and Daniel are joined by John Smart, the Vice President and Co-Founder of the Brain Preservation Foundation.  Our wide-ranging conversation delves into some of the lesser know alternatives to traditional cryopreservation.In this episode, we explore:John Smarts many roles as a futurist, foresight consultant and entrepreneur.The Brain Preservation Foundation: Brief History and MissionThe Brain Preservation Prize and its winnersAldehyde Stabilized Cryopreservation  (ASC)The many methods of brain preservation scienceQuestions about the true cost of brain preservationJohns famous article on "The Three Camps of Brain Preservation"Debates about the nature of identity and consciousness And much more! As always, you can find Max and Daniel over at the Cryosphere Cryonics discord server and the Cryonics Subreddit.Click here for the YouTube video version of this episode.You can also find the Cryonics Underground Podcast and host Max Marty on Twitter.Links:The Brain Preservation FoundationAspirational NeuroscienceForesight University This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this brief update episode, Max and Daniel take a break from their usual guest format to share some exciting announcements and milestones.In this update episode, we discuss:Cryosphere's Growth: Celebrating the big achievement of reaching 1,000 members in our community.Upcoming AMA: All about the "Ask Me Anything" session on Saturday, October 28th at 1PM CDT (UTC-5) at the Cryosphere cryonics discord server. Click here to learn about our esteemed panelists and how to participate.r/cryonics Subreddit Revamp: The cryonics subreddit is under new management. Get insights into what's new and what to expect in the future. Cryonics Conference Teaser: A sneak peek into our plans for an industry-wide Cryonics conference slated for next year and how interested parties can get involved. To get in touch with us about sponsorship, email us at cryonicsunderground@gmail.comNext Episode Preview: A hint at our next episode featuring Sayer Johanson, the chief operations officer at Suspended Animation Inc.Click here for the YouTube video version of this episode. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode, Max and Daniel are joined by James Arrowood, Alcor's new CO-CEO.  Our wide-ranging conversation delves into James's approach to leadership, his views on Alcor as a business and several of his upcoming strategic initiatives.In this captivating conversation, we explore:The upcoming strategic meeting taking place in Estes Park, CO on Aug 25th and 26th (see below for tickets and more info).How James views his role alongside Marji Klima as CO-CEO.How James separates his approach from his predecessors. The new in-house DART approach to SST at AlcorAlcor vs the competitionThe for-profit non-profit distinctions in the Cryonics industryManaging legal exposure and legal risk in this industryCommunity questionsAnd more! As always, you can find Max and Daniel over at the Cryosphere Cryonics discord server.Click here for the YouTube video version of this episode.For tickets to the upcoming strategic meeting in Estes Park, CO, check out this eventbrite page here. The event will be taking place at well known the Stanley Hotel, so be sure to call them for a special member discount on a room for the event.You can also find the Cryonics Underground Podcast and host Max Marty on Twitter. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode, Max and Daniel sit down with Michael Benjamin to discuss his meta-analysis of Alcor's case history. He is working on a comprehensive meta-analysis of all Alcor patient cases, an endeavor whose goal is to develop, experimentally validate, and refine a quantitative cryopreservation evaluation methodology. Michael brings with him 20 years of experience in physics, engineering and mathematics having worked at places such as NASA Goddard Space Flight Center, Brookhaven National Labs and Lockheed Martin.Topics include:Michael's experience in the space industry His unique health challenges and how they could affect his cryopreservationThe inception of Alcor's Meta-Analysis projectS-Mix score and why he values it as a primary metricConcerns and limitations with the S-Mix scoreSome surprising results of the meta-analysis The dangers of unattended death and suicideThe newly established Biostasis Technologies organization and what it means for the industryAnd much more...As always, you can find Max and Daniel over at the Cryosphere Cryonics discord server.Click here to check out our YouTube video version of the episode.Link to Biostasis Technologies and Michael and Aschwin de Wolf's S-Mix Paper This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode, Max and Daniel sit down with the renowned Aubrey de Grey to discuss the connection between life extension and cryonics. They cover a wide range of topics, diving into the latest breakthroughs and obstacles in both fields.In this captivating conversation, they explore:The current state of rejuvenation technologiesRecent advances in longevity research over the past decadeChallenges still facing life extension sciencePerspectives on achieving longevity escape velocityProgress in robust mouse rejuvenation experimentsAubrey de Grey's journey into the world of cryonicsTanya Jones's new cryonics venture, KeiniceInnovative cryopreservation techniques using helium persufflationThe importance of cryonics vs life extensionThe potential for cryonics to become mainstreamThe search for major donors to support cryonics researchAnd much more! As always, you can find Max and Daniel over at the Cryosphere Cryonics discord server.Click here for the YouTube video version of this episode.Check out the brand new: Longevity Escape Velocity Foundation Follow Aubrey de Grey on Twitter. You can also find the Cryonics Underground Podcast and host Max Marty on Twitter too. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode we’re speaking with Rebecca Ziegler - Product Manager at Tomorrow Bio, a member of the Berlin Standby Team, and the newest moderator on the Cryosphere.Why Rebecca chose business over politicsWhat it’s like to work at Tomorrow BioJob opportunities in European CryonicsWhy Tomorrow Bio is expanding to the USProfit vs Nonprofit corporate structures in the Cryonics spaceThe motivations of CryonicistsTomorrow Bio’s new “Brain Only” cryopreservationAlcor’s “Neuro” option vs TB’s “Brain Only” optionHow Tomorrow Bio views marketing cryonics to the publicWhy Tomorrow Biostasis changed their name to Tomorrow BioWhy female cryonicists are less common than male CryonicstsThe migration of the Biostasis Hub to the Cryosphere Discord ServerQuestions from the Cryosphere on R&DRebecca’s experience hosting a Ukrainian refugeeChat GPT and if cryonicists should be worried about runaway AGI?You can also check out our video version on YouTube.As can find Max and Daniel and Rebecca over at the Cryonics Underground Channel in the Cryosphere Cryonics discord server. And you can find out more about Tomorrow Bio at tomorrow.bio This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this special episode, Max Marty is speaking with return guest host Nikki Olson about the launch of the great Cryonics Survey of 2022. The Cryonics Survey is a large comprehensive survey of Cryonicists, the Cryocurious, and Cryocrastinators; intended to improve our understanding of the people most interested in this audacious endeavor.---> Please take the survey at http://bit.ly/cryosurvey2022 ! <---In this episode we discuss: Why does the Cryonics community need to better understand its members?What kind of data are we collecting with the survey?What can we do with this information? When will it be published, and what will that look like?You can also check out our new YouTube version of this episode, here. As always, you can find Max and Nikki over at the Cryonics Underground Channel in the Cryosphere Cryonics discord server. (but take the survey first)! This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode Max and Daniel speak with Kai Micah Mills. Kai is the Founder of Cryopets, the first company focused on pet cryopreservation. Before founding Cryopets, Kai founded and ran several entrepreneurial ventures the tech space. In this episode we discuss: Kai's history as a tech entrepreneurHis views on the value (or lack thereof) of traditional schoolingGrowing up religious, and the impact of a religious backgroundThe life extension tech treeWhy the life extension community doesn't embrace CryonicsCryopets - what it is, why work on this, where it is now, and where it's goingKai’s precise vision for how he intends to execute Kai's responses to major objections to his Cryopets planHow the Cryonics's industry’s existing views on pet cryopreservation have been detrimental to Cryonics as a wholeAnd more!You can also check out our new YouTube version of this episode, here.  As always, you can find Max and Daniel over at the Cryonics Underground Channel in the Cryosphere Cryonics discord server.- Find out more about Cryopets at Cryopets.comIf you would like a large first year discount when signing up for Alcor, feel free to use our code: CRYOCAST when registering. This will also help support the podcast.  This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode Max and Daniel speak with Carrie Radomski, President & Board Member of the Lifespan Society of British Columbia.Carrie is a geoscientist, writer, artist, crypto enthusiast, gold explorer (yes, the kind that goes looking for gold in the Yukon), and much more.In this episode we discuss: The Lifespan SocietyCarrie and her family's long legacy of contrarianism Her varied political leanings, past and presentCarries career as a gold explorer in the Yukon!  The legend of the Sour Toe whiskey...Life extension enthusiasts vs Cryonics enthusiastsGold vs Bitcoin as store of valueHow small planes are more dangerousThe Lifespan Societies legal challenge of the Crown The future of the Lifespan Society as an SST organization And much more...You can also check out our new YouTube version of the episode! As always, you can find Max and Daniel over at the Cryonics Underground Channel in the Cryosphere Cryonics discord chat server.Links: https://www.lifespansociety.com/If you would like a large first year discount when signing up for Alcor, feel free to use our code: CRYOCAST when registering. This will also help support the podcast.  This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

To celebrate coming back from our short hiatus, today we bring you our first bonus episode! This is the audio version of the new cryonics YouTube series: The Cryosphere Roundtable.The question we discuss today is: What books should every cryonicist read?The inaugural episode of a regularly occurring discussion amongst the mods of the The Cryosphere Discord channel. Every month we'll be discussing a different cryonics topic. Occasionally, we'll grab some unwitting members from the channel and force them to look at our faces for an extended period of time. And also talk with us. If you prefer a visual medium, we suggest you watch the funnier and more animated YouTube version, here. Lastly, don't forget to check out The Cryosphere community on Discord!  This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

On this episode of the podcast, Max is joined by special guest host and previous guest, Nikki Olson.For the first time, we're are also publishing the video of our full conversation over on Youtube! You can find it at : https://www.youtube.com/watch?v=acp6tBSJgE4 Today, Max and Nikki are speaking with long time Cryonicist Robin Hanson. Robin is an associate professor of Economics at George Mason University and a research associate at the Future of Humanity Institute. He's published several books and papers including the Age of Em, The Elephant in the Brain, and most recently a paper on what he calls "Grabby Aliens" a followup to his earlier line of inquiry around the fermi paradox and the possible great filter in front of us. He's also published on the subject of Cryonics for over a decade, much of which can be found on his popular blog, Overcoming Bias. Why aren’t more “contrarians”, like Robin, interested in Cryonics?The idea of offering to pay for (or defray the cost of) Cryonics for our friends?Max’s “GoFreezeMe” idea - to allow anyone to contribute to the cryopreservation of anyone else.Prediction markets & Cryonics.How could the Cryonics industry grow more quickly in the coming years?Theories on why there aren’t more women in Cryonics.Revival scenarios & bringing resources with you.Plastination and room temperature storage ideas.The “Uncanny Valley” problem with Cryonics?Brain uploading vs biological repair.Why are Cryonicists so… normal?Overrated or underrated including: Pet CryonicsThe Simulation Argument and moreYou can find both Max and Nikki over at the Cryosphere Discord server or email the pod at cryonicsunderground [at] G mail .com@makesmarty@robinhanson This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode, Max and Daniel speak with Patrick Harris, the CEO and President of Alcor. Patrick is speaking with us today on several major new initiatives he's been working on over the past several months. We'll be doing both a reveal of Patrick's new initiatives along with a deep dive into the thinking and goals behind them.Before his role at Alcor, Patrick was a healthcare executive, innovator, and business strategist with experience in the healthcare industry including McKesson and Safeway Corporate Pharmacy. Having experience in healthcare technology, products, and services, and managing a couple billion in revenue. He is a named inventor on more than 40 non-public patent applications.In this episode we discuss:Patrick's background and how he came to his position at AlcorThe obstacles that Alcor had historically struggled withAlcor's business model - Research, Education, and GrowthAlcor's new Enhanced Agreements and Online Signup processAlcor's new permanent prepay optionNew Member OptionsPet CryonicsAge Based Due StructuresThe new Independent Cryonics Educator (ICE) ProgramAlcor's future ambitionsAnd much more... As always, you can find Max and Daniel over at the Cryonics Underground Channel in the Cryosphere Cryonics discord chat server.Links:- Alcor's New Business Model PDF- Special Issue of Cryonics Magazine for Alcor’s 50th AnniversaryThe Cryonics Underground podcast Is hiring!  We're looking for a great audio engineer. Details here. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode Max and Daniel speak with the venerable Ralph Merkle. Among his numerous achievements Ralph is the leading expert on nanotechnology, the inventor of cryptographic hashing and the co-inventor of public key cryptography. He is currently a board member at Alcor.    In today's episode we discuss:What is Molecular Nanotechnology?How do different people use the phrase "Nano-Tech"The use cases for medical nanobotsHow we manipulate the world at the nano scaleWhat are the more difficult molecules to work with?The intersection of Cryonics and nanotechRalph Merkle's relationship with CryonicsRalph's views on other scientific fieldsRalphs opinions on cryptocurrency and BitcoinIs Ralph Merkle actually Satoshi Nakamoto? And much more... As always, you can find Max and Daniel over at the Cryonics Underground Channel in the Cryosphere Cryonics discord chat server.The Cryonics Underground podcast Is hiring!  We're looking for a great audio engineer. Details here.Links: Cryostasis Revival by Robert A. Freitas JR https://www.alcor.org/docs/CryostasisRevivalV2.11.pdfhttp://www.merkle.com/Nanofactory ExampleNanotechnology & Cryonics - Preserving ourselves for the futureThe Scale of the Universe - A simulation to understand just how big (and small) things are. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode, Max and Daniel speak with the legendary Ben Best. Among the numerous cryonics and life extension groups he has been associated with over the years, Ben is most known for being the former president of the Cryonics Institute from 2003 to 2012.He is a senior member of a cryonics Teens and Twenties group, and he’s currently the director of research and oversight at the biomedical research & longevity society, formerly known as the Life Extension Foundation.In today's episode we discuss:Ben's upbringingHis struggles to find his place within CryonicsBen's juggling of difficult personalities within the industryHis disagreements with Robert EttingerBen's tenure at the Cryonics InstituteHis pivot into life extensionThe differences between younger and older cryonicistsBen's thoughts on the state of the industryHis current endeavors in field And much more... As always, you can find Max and Daniel over at the Cryonics Underground Channel in the Cryosphere Cryonics discord chat server.Links: https://benbest.com/P.S. We are looking for a good podcast audio engineer. More info at https://bit.ly/3nqK6QW   This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode Max and Daniel speak with Lisa Harris. Lisa is an Alcor member and an advisor to the board of directors. She is also on Alcor's legal and regulatory committee as well as the research and development committee.  Lisa has a background as an attorney, and currently works in healthcare research technology. In today's conversation we discuss: Trusts and their usefulness to Cryoncists + Lisa and Patrick Harris's own efforts in this space! Patient Care Trusts Alcor Care Trusts Lisa's Personal Revival TrustHow to deal with long term risk Balancing asset-growth with risk mitigationWhen is the right time to be looking into this issue? How much by way of assets do you need before this makes sense? Incentivizing your future heirs to behave accordingly Should you bury your treasure like a pirate?Trust us... you don't wanna miss it!As always, you can find Max and Daniel over at the Cryonics Underground Channel in the Cryosphere Cryonics discord chat server.You can also find Lisa here and get in touch directly with any questions you may have for her.   This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

In this episode Max and Daniel speak with Eric Vogt. Eric is a veteran paramedic, a pilot and one of the two co-founders of I.C.E. - International Cryomedicine Experts. I.C.E is a highly experienced standby, stabilization and transportation company.In today's conversation we discuss:What I.C.E does, and how their organization benefits cryonics.Eric's background and how he came to work with Aaron DrakeA refresher on Standby, Stabilization and TransportWhy you may want to add private chartered flight to your cryo-plans. The challenges of bringing neuro patients through airport security.And much more... As always, you can find Max and Daniel over at the Cryonics Underground Channel in the Cryosphere Cryonics discord chat server.Links for I.C.E : www.cryomedics.org   This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com

Gennady Stolyarov II (G. Stolyarov II) became the second Chairman in the history of the Transhumanist Party in November 2016. Mr. Stolyarov is an actuary,  independent philosophical essayist, science-fiction novelist, poet, amateur mathematician, composer, and Editor-in-Chief of The Rational Argumentator, a magazine championing the principles of reason, rights, and progress. Mr. Stolyarov regularly produces YouTube Videos discussing life extension, politics, philosophy, and related subjects.In December 2013, Mr. Stolyarov published Death is Wrong, an ambitious children’s book on life extension. Death is Wrong can be found on Amazon in paperback and Kindle formats, and can also be freely downloaded in PDF format in the English, Russian, French, Spanish, and Portuguese languages.Mr. Stolyarov is the current chairman of the US Transhumanist Party and Chief Executive of the Nevada Transhumanist Party, established in August 2015.In today's episode we discuss: What is Transhumanism, and what does it have to do with Cryonics?The history of Transhumanism as a philosophical movement and as a political party.Gennady's personal journey towards Transhumanism.The political structure and political goals of the Transhumanist Party.Big umbrella vs small umbrella party politics and other political strategy.How Cryonics fits into the Transhumanist platform.And much more... As always, you can find us over at the Cryonics Underground Channel in the Cryosphere Cryonics discord chat server. You can also reach us directly by email at cryonicsunderground [at] the email service provided by everyone's favorite (or least favorite, as the case may be) search company.[Note, there are two small audio glitches at 25:00 to 26:00.]   This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cryospherepress.substack.com