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Start Disrupting

Author: Virginia Tech Corporate Research Center

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Everyone wants to be ahead of the game, and I talk to those who are… Join Brett Malone, Ph.D. President & CEO of the Virginia Tech Corporate Research Center, for Start Disrupting. Hear how industry disrupters are changing how we live and how we do business. Don’t miss an episode. Let’s start the conversation …
34 Episodes
Join us as we dig into Start Disrupting's archive and revisit Antarctica with guests James B. McClintock, Ph.D. (The University of Alabama at Birmingham, Author and Professor of Polar and Marine Biology) and Bill J. Baker, Ph.D. (The University of South Florida, Professor of Chemistry). In this episode, Brett takes a dive below Antarctica's ice with James and Bill as they discuss drug discovery, climate change, and some of their most profound research findings. - The Baker Research Group- James B. McClintock and UAB in Antarctica- Books by James B. McClintockHost: Brett MaloneEditor and Producer: Becca Halm 
Dr. Aileen Helsel is the current Interim Director for Carilion Clinic Innovation (CCI), a catalytic agent and resource for regional innovators and creatives within the Carilion healthcare system. Since beginning her role as Interim Director in April 2022, Dr. Helsel oversees the healthcare system’s efforts to develop and market disruptive Carilion inventions while also expanding the region’s biotech and entrepreneurial ecosystem. Dr. Helsel has an extensive biomedical research background and after spending years at the bench she started working with Washington State University (WSU), where she successfully licensed and commercialized life science innovations. Dr. Helsel then moved across the country to begin working with CCI in 2021, where she continues to guide disruptive ideas to the marketspace. About Carilion Clinic Innovation: Carilion physicians, nurses and staff make unique discoveries through their research, and continuous improvements to the care they provide our communities. Some of these discoveries are innovations with commercial potential. First and foremost, they can benefit patients in our community. When inventions are brought to market by an Industry partner or spun out as a startup, patients across the country and globe may benefit from our employees’ curiosity and commitment to innovation.Host: Brett MaloneEditor and Producer: Becca Halm 
James D. Harder is a Blockchain Ecosystem Catalyst. Currently Virginia Tech’s Blockchain Initiative Director, Harder is also an External Engagement Manager for VT’s Department of Computer Science. Harder has an interest in analyzing agricultural applications of blockchain, as well as other emerging technologies, such as AI and cybersecurity.Virginia Tech's Blockchain Certificate Program Wall Street Journal PodcastArchiveCoreTatiana MorozHost: Brett MaloneEditor and Producer: Becca Halm 
Amy White is Virginia Western Community College’s Dean for the science, technology, engineering, and mathematics department. White began at VWCC as a biology professor in 2003, and her passion for educating led her to her role as STEM dean. White focuses on educating and mentoring those who are interested in STEM careers, as well creating equal opportunities for all students wishing to make an impact on the healthcare system. In this episode Brett and Amy discuss the importance of young minds and how STEM is so much more than science, technology, engineering, and math.  Host: Brett MaloneEditor and Producer: Becca Halm 
Dr. Zac Doerzaph is the Executive Director of the Virginia Tech Transportation Institute (VTTI), a global leader in transportation research. Working alongside a talented team, Doerzaph focuses on creating a future of ubiquitous, safe, and effective mobility by conducting innovative and impactful research today. Also, a faculty member within the Department of Biomedical Engineering and Mechanics at Virginia Tech, Doerzaph works with fellow faculty to provide experiential learning opportunities to prepare the next generation workforce. Doerzaph is known for innovative and extensive transportation research and leadership projects. His work focuses on maximizing performance at the interface of driver, vehicle, and infrastructure systems through the application of advanced technologies.Host: Brett MaloneEditor and Producer: Becca Halm 
Learn more about 3-D printing, lab on a chip, and building your business products from Skyphos Technologies Founder and CEO, Elliot McAllister. Skyphos Technologies focuses on solving the manufacturing and technology gap for lab-on-a-chip technologies by bringing ultra-small resolutions and micro-3D printing to the biotech industry.  A Virginia Tech graduate, Elliot's career has been molded by engineering and management experiences. Elliot has experience in manufacturing, R&D, robotics, drug discovery, biomedical research, and more. Host: Brett MaloneEditor and Producer: Becca Halm 
Learn more about entrepreneurship and how to know you've hit traction with your startup from Active Capital Founder and CEO, Pat Matthews.Pat is the founder and general partner of Active Capital, a venture firm focused on leading seed rounds for B2B SaaS companies outside of Silicon Valley. Prior to Active Capital, Pat was an entrepreneur, operator, and angel investor.  Pat’s career started in 1999 when he dropped out of Virginia Tech to start a dot-com with some of his best friends and college roommates.  After the dot-com bubble burst, Pat and his team persevered through years of economic downturn before creating, a $10 million dollar software company that was recognized as one of the fastest-growing private companies in America by Inc. Magazine.  In 2007, was acquired by Rackspace where Pat worked as an executive on the senior leadership team until 2013.  Pat has personally invested in nearly 100 startups and is an active board member of the Virginia Tech Apex Center for Entrepreneurship, Venture for America in San Antonio, and several Active Capital portfolio companies.Host: Brett MaloneEditor and Producer: Becca Halm
Learn how Disney is utilizing technology to enhance the customer experience with new initiatives and how the Disney accelerator is creating new entertainment adventures and products. Kathy de Paolo, Vice President of Engineering at The Walt Disney Company, shares all this and entrepreneurial advice for all.Links:Kathy’s LinkedIn profileWalt Disney Imagineering: Accelerator: Brett MaloneEditor and Producer: Becca Halm 
Kenna Anderes Ph.D., RAC,  Vice President of Translational Medicine & Companion Diagnostics at Mirati Therapeutics, talks →  The art of partnering: How your small company can change the game for big companies; plus, “FIO” Figure it Out, how to follow the data, and navigate complex timelines and more. Dr. Anderes has been a scientific leader in oncology drug discovery, biomarker identification, and early clinical development in the pharmaceutical and biotech industries for over 20 years. She is trained as a pharmacologist and cancer biologist and has held a number of senior executive and scientific advisory positions at pharmaceutical, biotech, and in vitro diagnostic companies. As an early employee in several startup companies, Dr. Anderes acquired very broad, interdisciplinary technical and business skills, with breadth in science, clinical research, clinical operations, regulatory strategy, and product/medical device development. Achievements range from lead identification of novel small molecule or biological entities to characterization of clinical development candidates for several distinct first-in-class molecular targeted agents to treat cancer. She has extensive experience directing and designing studies to determine relationships to drug exposure, mechanism of action, efficacy, and biomarkers in the single-agent and combination settings in vitro and in vivo in classical xenografts and patient-derived tumor models. In parallel to drug discovery/development activities, Dr. Anderes has led equally diverse biomarker and in vitro diagnostic projects. She has evaluated numerous liquid biopsy approaches and served as an advisor on pharma-sponsored clinical trials to evaluate the clinical utility of CTCs and ctDNA. Delivery on the promise of personalized medicine requires strategic and tactical translational medicine expertise, Dr. Anderes formed Translational Medicine Partners, Inc. and co-founded Wild Type Advisors, LLC to provide bespoke consulting services for the life sciences, biotechnology and pharmaceutical industries.Host: Brett MaloneEditor and Producer: Becca Halm
DaSilva is the inaugural Executive Director of the Commonwealth Cyber Initiative (CCI), and the Bradley Professor of Cybersecurity at Virginia Tech.DaSilva previously held the chair of Telecommunications at Trinity College Dublin, where he served as the Director of CONNECT, a national telecommunications research center in Ireland.He has published two books and more than 300 peer-reviewed articles and chaired the Technical Program for ICC 2020, one of the flagship conferences of the IEEE Communications Society. He was an IEEE Communications Society Distinguished Lecturer (2015-2018), a Fellow of Trinity College Dublin, and is a Fellow of the IEEE, for contributions to cognitive networking and to resource management in wireless networks.The Commonwealth Cyber Initiative (CCI) is Virginia’s main access point for cybersecurity research, innovation, workforce development, and news. In this community, researchers find funding and collaboration, students discover diverse career possibilities, and new innovations come to life. Virginia is the ideal locale for CCI due to its strong base of research excellence and its diverse higher education system. These factors combined with the state’s ecosystem of venture capital investment and high-growth firms, along with its density of cybersecurity talent, bring a confluence of contributors to the future success of CCI.Host: Brett MaloneEditor and Producer: Becca Halm
Brian Sullivan is the anchor of CNBC’s “Worldwide Exchange” (M-F, 5AM-6AM ET), which broadcasts from CNBC Global Headquarters in Englewood Cliffs, N.J.  He is also Senior National Correspondent for the network, covering some of the nation’s biggest stories.Most recently, Sullivan was co-anchor of CNBC’s “Power Lunch”(M-F, 1PM-3PM ET).In his 25 years of financial journalism and television experience, Sullivan has reported from five continents. He has been twice nominated for the prestigious Loeb Award; one for being recognized as among the first financial journalists to highlight the risks of the housing bubble in 2007, and the other for the 2013 CNBC documentary “America’s Gun: The Rise of the AR-15.”Prior to CNBC, Sullivan served as an anchor at Fox Business News as well as a producer, reporter, and anchor for Bloomberg Television.Sullivan has a B.A. in political science from Virginia Tech, where he serves on the Alumni Board, as well as a law degree from Brooklyn Law School. In his free time, he is an avid race car driver with two SCCA divisional championships.Host: Brett MaloneEditor and Producer: Becca Halm 
Guests:Craig Meadows: Montgomery County AdministratorErin Burcham:  President, Verge and  Executive Director, Roanoke Blacksburg Technology CouncilMatthew Hull, Ph.D. : Research Scientist / President & Founder, Nanosafe, Inc.John Newby:  Chief Executive Officer,  Virginia Biotechnology Association Visit website |  Download flyerNew collaboration with Johnson & Johnson Innovation announced with the aim to accelerate life science sector growth in the New River and Roanoke Valleys by providing access to expert mentors, programming, and commercialization resources for startup companies  BLACKSBURG, Va. (Dec. 15, 2021) — The GO Virginia Coalition today approved a grant award to the Virginia Tech Corporate Research Center (VTCRC) to fund the expansion of laboratory space and facilities aimed at supporting the region’s growing life science industry. In addition to the construction of shared lab space by the VTCRC, this project will support the creation of 125 new biotech jobs over the next five years.  “Through collaborations, we aim to fill the demand from biotechnology companies and provide full access needed to support research to commercialization aspirations,” said Brett Malone, President & CEO of the Virginia Tech Corporate Research Center. “Our sophisticated infrastructure makes us a research destination across industries and for everyone from startups to enterprise companies.”Read full press release
Becca Halm, Communications Assistant and Virginia Tech media student, interviews Brett Malone. This episode takes a deeper dive into Brett’s vision for the Virginia Tech Corporate Research Center and how he is “enabling” the disrupters creating new opportunity. Listen and find out Brett’s entrepreneurial thoughts and how it takes a mindset of looking at a situation differently, having the conviction to try something new and tenancy to stick with it. Bio: Brett Malone, President and CEO of the Virginia Tech Corporate Research Center, has led multiple startups as a co-founder and CEO. He has a unique background that spans software, defense, biotech, and clinical markets. Brett has a Ph.D. in Aerospace Engineering from Virginia Tech and loves mentoring startups, building space with purpose, and getting involved in all things technology related.About us: Born out of a need to translate Virginia Tech research to commercial potential, the Virginia Tech Corporate Research Center  was established in Blacksburg in 1985. Since then, it has been home to over 750 premier organizations with a common goal to disrupt industries. Today, with operations across Virginia, the research park continues to be a destination for growth and a space with purpose. 
Daniel Smith is the co-founder and director of software at Entos.  Daniel holds a Bachelor of Science in Biochemistry and a Ph.D. in computational chemistry. With a passion for science, technology, and software engineering, Daniel has completed research for Georgia Institute of Technology and the Molecular Sciences Software Institute at the Virginia Tech Corporate Research Center, before beginning his journey with Entos. With a presence in our co-working community, COgro, they are working on AI-driven chemistry for medicine. 2015 - Graduated with a Doctor of Philosophy in Computational Chemistry from Auburn University.2010 - Graduated with a Bachelor of Science in biochemistry from the College of Charleston. Worked as a postdoctoral research associate for Georgia Institute of Technology, and worked as a software scientist at The Molecular Science Software institute in Blacksburg, VA. Started at Entos in April of 2020 as co-founder and principal software engineer and is now the director of software. Has a deep passion for computational chemistry, quantum chemistry, education, science, and technology.  
In this episode, Brett Malone, Ph.D., VTCRC President/CEO, talks with Michael about TORC, the region's strengths and how it has helped the company, his vision for autonomous trucking and more. Michael Fleming official bio Torc Robotics, a pioneer in self-driving vehicles {website}Torc Robotics, headquartered in Blacksburg, Virginia, is an independent subsidiary of Daimler Truck AG, the global leader and pioneer in trucking. Founded in 2005 at the birth of the self-driving vehicle revolution, Torc has 16 years of experience in pioneering safety-critical, self-driving applications. Torc offers a complete self-driving vehicle software and integration solution and is currently focusing on commercializing self-driving trucks. “Trucking is the backbone of the U.S. economy, delivering food and products to every community in the country,” said Torc CEO Michael Fleming. “Daimler has led innovation in trucking for more than a century, from the first truck to driver assist technology. Torc is working with Daimler Truck to commercialize self-driving trucks to make our roads safer and better fulfilling our mission of saving lives.” #self-driving #entrepreneur #virginiatech #hokies #vtcrc #torc
Webster discusses his research with drug discovery and therapeutic areas, and is co-founder of Flux Therapeutics, Inc.Webster Santos bio: Webster Santos received his BS and Ph.D.  from the University of Virginia under Prof. Timothy Macdonald.  Following his doctoral studies, he moved to Harvard University as a Ruth Kirschtein NIH fellow with Prof. Gregory Verdine. At Harvard, he performed chemical biology studies targeting RNA structures as well as HIV-1 integrase. In 2006, he started as an assistant professor of chemistry at Virginia Tech and was promoted to associate then full professor in 2018. He held a chaired position as the Blackwood Junior Faculty fellow of Life Science and is currently the Agnes and Cliff Lilly faculty fellow of drug discovery. He is a co-founder of three biotech companies and received the Schug Research Award as well as an Innovator’s award at Virginia Tech.  He is on the editorial advisory board of current topics in medicinal chemistry, medicinal research reviews as well as boron in the Americas.  His current research centers on developing drugs towards fatty liver disease, cancer, and multiple sclerosis, synthetic methodology of installing boron and silicon onto carbon bonds and chemical biology of targeting HIV-1 RNAs.
Words spoken by John Olver, President & CEO of Emisshield, during the #StartDisrupting podcast with Brett Malone, Ph.D. President & CEO of the Virginia Tech Corporate Research Center (VTCRC).Spotlight story: The 3,100°F ImpactHave you ever considered how many things we use in daily life here on earth that originated from NASA technology?  GPS, medical devices, audio conference bridge technology, among many, all got their start in space!In August 2021, Dr. John Olver, President and CEO of Emissield, Inc. became the 85th inductee into the Space Technology Hall of Fame for contributions to life-changing technologies emerging from global space programs. Emisshield Inc. and NASA Ames, also accepted the organizational award.  Read full story here.
Ryan King's research focuses on understanding how modest changes in electrolyte levels can have a profound impact on cardiac function, both electrically and mechanically. Through his work, he and fellow researchers are gaining a better understanding that there is no "one size fits all" electrolyte therapy in regards to cardiac function; rather, the intervention needs to be problem-specific. There are instances in which it is more important to preserve electrical function than mechanical function and vice-versa. When these instances arise it's crucial to understand what electrolyte modifications are necessary to achieve the desired results. 
Virginia Tech alumnus, Dave Lavery: LinkedInFor over a decade, David Lavery led the National Aeronautics and Space Administration (NASA) Telerobotics Technology Development Program, with responsibility for content and direction of robotics and planetary exploration research efforts. Under his leadership the program was transformed into a world-class robotics technology and systems development program impacting NASA flight programs, other government robotics projects, and the entire robotics industry. Among the major products of Lavery's research program were the Sojourner Mars rover, the first robotic rover ever successfully placed on another planet; a free-flying robotic camera used on the Space Shuttle; Dante I and II robotic volcano explorers; and the National Robotics Engineering Consortium (NREC), to transfer robotic technologies developed by NASA into the commercial robotics industry. As Program Executive for Solar System Exploration at NASA, Mr. Lavery is currently responsible for two Mars Exploration missions (2008 and 2009), the design and development oversight of the next generation of robotic Mars exploration spacecraft, the NASA Astrobiology Field Laboratory, and the Mars Advanced Technology Program. He has published more than 30 technical papers on robotic systems and technology. Lavery's current professional commitment and involvement includes the creation of the NASA Robotics Alliance Project (RAP) to inspire K-12 students in robotics, a Fellow of the National User Group Advisory Council and the KISS Institute for Practical Robotics, and National Executive Advisory Board member of FIRST Robotics.
Tony is a falconry expert, serial entrepreneur and developer of leadership and talent. Pictured is Tony and VTCRC President & CEO Brett Malone, Ph.D.Check out the latest book Tony is reading: Deep Survival: Who lives, who dies and why by Laurence Gonzales -- Tony says "It is about who panics and who stays calm in crisis situations. Very interesting and insightful book." 
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