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The Stem Cell Report with Martin Pera
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The Stem Cell Report with Martin Pera

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Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Martin Pera, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Pera goes “beyond the paper,” bringing authors together to draw new insights and explore the questions and creativity that drive new breakthroughs. Stem Cell Reports, published by the International Society for Stem Cell Research (ISSCR), is an open-access, peer reviewed journal that supports the field of stem cell research and regenerative medicine.
8 Episodes
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Mending a Broken Heart

Mending a Broken Heart

2021-10-1238:05

In this episode Drs. Charles Murry and Kenta Nakamura join the podcast to talk about “cardiac remuscularization therapy,” and the general approach of transplanting human pluripotent stem cell-derived cardiomyocytes to restore cardiac function after injury.GuestsCharles Murry, MD, PhD, University of Washington and Sana BiotechnologyKenta Nakamura, MD, University of Washington and VA Puget Sound Healthcare System HostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory Twitter: @martinperaJAXSupporting DocumentDrs. Murry and Nakamura are two of the authors of the recent paper ” Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes” in Stem Cell Reports.  About Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @StemCellReportsAbout ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCRWebsite: https://www.cell.com/stem-cell-reports/homeAcknowledgementISSCR StaffKeith Alm, Chief Executive OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Senior Manager of Scientific AffairsVoice WorkBen SnitkoffMusic@Konovalov
In this episode Drs. Peter Loskill and Christine Mummery join the podcast to talk about the intersection of stem cells, microphysiological systems and organs-on-a-chip technology in understanding disease, screening drugs and personalized medicine. Drs. Loskill and Mummery are guest editors of a special issue on this topic appearing now in Stem Cell Reports. GuestsPeter Loskill, PhD W3-Professor for Organ-on-Chip Research at the Eberhard Karls University Tübingen and the Natural and Medical Sciences Institute as well as Vice-Chair of the European-Organ-on-Chip-Society (EUROoCS). Twitter: @pe_loskChristine Mummery, PhD, Professor of Developmental Biology at Leiden University Medical Center and heads the iPSC & organ on a chip facility at the LUMC. She is also the recent past president of the ISSCR.HostMartin Pera, PhD, Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory Twitter: @martinperaJAXSupporting DocumentsSpecial Issue: Organs-on-ChipAbout Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @StemCellReportsAbout ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCRWebsite: https://www.cell.com/stem-cell-reports/homeAcknowledgementISSCR StaffKeith Alm, Chief Executive OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Senior Manager of Scientific AffairsVoice WorkBen SnitkoffMusic@Konovalov
In this episode, sponsored by Bio-Techne, Drs. Hans Clevers and Kai Kretschmar join the podcast to talk broadly about the role of adult stem cells in tissue maintenance and repair. Specifically, they will focus on the expression and function of Troy and stem cells in the development and homeostasis of the epidermis, the outermost layer of the skin, that functions as a protective mechanical and biological barrier against injuries, pathogens and the loss of heat and water.GuestsHans Clevers, MD, PhD, is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator. Both in the Netherlands. Kai Kretzschmar, PhD, is junior group leader at the MSNZ University Hospital Würzburg, Germany HostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryTwitter: @martinperaJAXSupporting DocumentsTroy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornificationAbout Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @StemCellReportsAbout ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCRAcknowledgementsISSCR StaffKeith Alm, Chief Executive OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Scientific AdvisorVoice WorkBen SnitkoffMusic@Konovalov
In this episode, sponsored by bit.bio,  Drs. Marius Wernig and Yi Han Ng join the podcast to talk about the directed differentiation of pluripotent stem cells into dopaminergic neurons. Their approach, which is based on the expression of specific transcription factors to drive cell fate directly to a specific neuronal identity, has been demonstrated to robust generalate functional dopaminergic neurons of midbrain character.GuestsMarius Wernig, MD, PhD, Associate Professor of Pathology at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford UniversityWebsite: https://www.werniglab.org/Yi Han Ng, PhD, Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine and Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, SingaporeSupporting DocumentsEfficient Generation of Dopaminergic Induced Neuronal Cells with Midbrain Characteristics HostMartin Pera, PhD: Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryTwitter: @martinperaJAX  About Stem Cell ReportsStem Cell Reports is the open access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @StemCellReportsAbout ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCR AcknowledgementsISSCR StaffKeith Alm, Chief Executive OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Senior Manager of Scientific AffairsVoice WorkJulie PerlinBen SnitkoffMusic@Konovalov
In this episode, Drs. Zubin Master, Kirstin Matthews, Mohamed Abou-el-Enein, and Sean Morrison join the podcast to talk about unproven stem cell-based interventions. These so-called “stem cell therapies” or “regenerative therapies” currently being marketed direct-to-consumers have insufficient evidence of safety and efficacy to justify their use and pose a potential risk to recipients. A recent paper from Masters, Mathews and Abou-el-Enein published in Stem Cell Reports discusses this global public health problem.GuestsMohamed Abou-El-Enein, MD, PhD, MSPH Keck School of Medicine, University of Southern California, USAZubin Master, PhD, Mayo Clinic, USAKirstin Matthews, PhD, Baker Institute for Public Policy, Rice University, USASean Morrison, PhD, Children’s Research Institute, UT Southwestern, USAHostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryWebsite: https://www.jax.org/research-and-faculty/faculty/martin-peraTwitter: @martinperaJAXSupporting DocumentsUnproven stem cell interventions: A global public health problem requiring global deliberation About Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.About ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCR AcknowledgementsISSCR StaffKeith Alm, Chief Executive OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Senior Manager of Scientific AffairsVoice WorkJulie PerlinMusic@Konovalov
In today’s episode, we will talk about new research on the use of an induced pluripotent stem cell-based vaccine to potentially protect against pancreatic cancer. This approach takes advantage of shared antigens between stem cells and pancreatic cancer cells and seeks to exploit them for clinical benefit. We will talk with the authors of this new research published in Stem Cell Reports on why they decided to pursue this approach, the background behind it, and whether this approach could work for other types of cancers. We also discuss some of Dr. Wu's other work, including research on stem cells in microgravity. Show NotesGuestsJoseph Wu, MD, PhD Director of the Stanford Cardiovascular Institute,  US Website: http://med.stanford.edu/wulab.htmlXiaoming Ouyang, PhD, Postdoctoral Scholar, Wu Laboratory, Stanford University, US Website: https://www.researchgate.net/profile/Xiaoming-OuyangHostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryWebsite: https://www.jax.org/research-and-faculty/faculty/martin-peraTwitter: @martinperaJAXSupporting DocumentsAnti-Tumor Effects of iPSC-Based Cancer Vaccine in Pancreatic Cancerhttps://www.cell.com/stem-cell-reports/fulltext/S2213-6711(21)00199-5About Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @stemcellreportsAbout ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCR AcknowledgementsISSCR StaffKeith Alm, Chief Operating OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Senior Manager of Scientific AffairsNancy Witty, Chief Executive OfficerVoice WorkJulie PerlinBen SnitkoffMusic@Konovalov
In this episode, we will talk about morphogenesis in embryo development, a process that in mammalians is known to show considerable plasticity. Understanding how this process is coordinated and how it responds to stress and physiological regulatory mechanisms provides us with a more complete picture of the regulation of mammalian development. We will talk with the authors of new research published in Stem Cell Reports on the regulation of embryo size and the timing of morphogenesis, critical early steps in embryonic development. Show NotesGuestsLorenzo Orietti, PhD – Medical Advisor, Onco-Hematology Unit,  Amgen, Inc, (Italy)Website: https://www.amgen.com/Marta Shahbazi, PhD – MRC Laboratory of Molecular Biology, Cambridge, UKWebsite: https://www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/marta-shahbazi/Twitter: @Marta_ShahbaziMagdalena Zernicka-Goetz, PhD – Mammalian Embryo and Stem Cell Group and The Centre for Trophoblast Research, University of Cambridge, UK and the California Institute of Technology, USWebsites: http://zernickagoetzlab.pdn.cam.ac.uk/, https://zernickagoetzlab.caltech.edu/ Twitter: @ZernickaGoetz and @MZG_LabHostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryWebsite: https://www.jax.org/research-and-faculty/faculty/martin-peraTwitter: @martinperaJAXPodcast Website: https://thestemcellreport.buzzsprout.com/Supporting ResourcesEmbryo Size Regulates the Timing and Mechanism of Pluripotent Tissue MorphogenesisDOI: https://doi.org/10.1016/j.stemcr.2020.09.004 About Stem Cell ReportsStem Cell Reports is the open access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @stemcellreportsAbout ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCR ISSCR StaffKeith Alm, Chief Operating OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director, Media and Strategic CommunicationsJack Mosher, Senior Manager, Scientific AffairsNancy Witty, Chief Executive OfficerVoice WorkJulie PerlinBen SnitkoffMusic@Konovalov
In this episode Drs. Janet Rossant and Patrick Tam, join the podcast. They are experts in early embryonic development and authors of new Perspective article in Stem Cell Reports,  Opportunities and Challenges with Stem Cell-Based Embryo Models. Embryo modeling is a rapidly emerging area of science which can help advance the understanding of early development, especially human development where insight has been limited due to technical and ethical issues. The article is online now and will appear in the May 2021 special issue of the journal.Show NotesGuestsJanet Rossant, PhD - Hospital for Sick Children, the University of Toronto and the Gairdner Foundation. Website: https://lab.research.sickkids.ca/rossant/Patrick Tam, PhD - University of Sydney, Australia Website: https://www.cmrijeansforgenes.org.au/researchers/patrick-tamHostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryWebsite: https://www.jax.org/research-and-faculty/faculty/martin-peraTwitter: @martinperaJAX (https://twitter.com/martinperajax) Podcast Website: https://thestemcellreport.buzzsprout.com/Supporting ResourcesOpportunities and Challenges with Stem Cell-Based Embryo ModelsWebsite: https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(21)00082-5 DOI: https://doi.org/10.1016/j.stemcr.2021.02.002NIH Blog Website: https://osp.od.nih.gov/2021/03/11/human-embryo-development/About Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Website: https://www.cell.com/stem-cell-reports/homeTwitter: @stemcellreports (https://twitter.com/stemcellreports)About ISSCRWith nearly 4,000 members from more than 60 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health. Website: International Society for Stem Cell ResearchTwitter: @ISSCR (https://twitter.com/isscr)AcknowledgementsISSCR StaffKeith Alm, Chief Operating OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director, Media and Strategic CommunicationsJack Mosher, Senior Manager, Scientific AffairsNancy Witty, Chief Executive OfficerVoice WorkBen SnitkoffMusicKonovalovMusic, @KonovalovMusic
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