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The tangential flow filtration (TFF) unit operation in viral vector manufacturing is a critical step on the path to commercialization. In this episode, Merck viral vector experts Ratish Krishnan and Akshat Gupta discuss best practices – and common misconceptions – when establishing process conditions and utilizing different TFF device formats.  
Professor Dimitrios Mougiakakos is the director of the Hematology and Oncology department at the Otto-von-Guericke University in Magdeburg, Germany. In this episode, he joins us to discuss the exciting potential for CAR T cell therapy for autoimmune disease and how his team has approached GMP manufacturing in the clinical setting. He explains the challenges faced in setting up cell therapy for systemic lupus erythematosus (SLE), and the future of cell and gene therapy in different indications.
Cell and gene therapy scientists are under increasing pressure to achieve results faster and produce cells and cell products more cost-efficiently. Field applications scientists from their major suppliers can provide invaluable support, helping to optimize processes, utilize new platforms and technologies more effectively, and avoid costly errors. In this podcast, three veteran Field Applications Scientists from Corning Life Sciences - Austin Mogen, Catherine Siler, and Chris Suarez - share their expertise and lessons learned over decades of experience. 
Fatema Kazi works for the WHO, where she helps to assess the public health value of vaccine products and technologies in routine, campaign, and outbreak settings. We caught up with her to discuss how innovations in vaccine technology can help get vaccines to the people who need them.
In today’s challenging financial environment, it is more important than ever to get key biotech business decisions right first time. One of the most important and topical of these is the choice of CDMO partner. Dr Kim Watanabe, General Manager and Site Head for Patheon Translational Services, a part of the Thermo Fisher Scientific pharma services contract development and manufacturing organizational arm, joins BioInsights to share her advice and insights into optimizing outsourcing strategy.
Drug development is a costly and time-consuming process associated with a significant attrition rate in the clinic. Safety is an important factor in this, and is a particular issue for cell and gene therapies. A panel moderated by Dr John Maher of King’s College London and Leucid Bio, and featuring Dr Alastair King, Dr Francisca Neethling, and Dr Andrea Bisso, discuss this highly topical barrier to the further clinical and commercial success of the field.
What valuable experiences from first generation cell therapies can the industry carry forward and apply to other indications, such as solid tumors? In this episode, Sean Werner and Chris Brown explore the most important lessons the industry has gleaned from pediatrics, and how they can inform the future of cell therapy manufacturing.
Tom Foti (Vice President and General Manager of the Protein Business Unit, Aldevron) and Dr Kris Saha (Associate Professor of Biomedical Engineering and Medical History and Bioethics, University of Wisconsin-Madison) discuss ongoing work in Dr Saha’s lab to harness different types of HDR templates in order to build cutting-edge systems with the potential to enable point-of-care cell and gene therapy manufacture. 
The Maryland Stem Cell Research Fund (MSCRF) is a well-established US state fund aimed specifically at driving the development of new medical strategies for the prevention, diagnosis, treatment and cure of human diseases, injuries, and conditions through human stem cells. Here, we discuss the MSCRF’s specific activities and goals with Executive Director, Dr Amrithar Jaishankar, and get her take on how best to develop collaborative research programs and promote commercialization of stem cell technologies.
Transient transfection of plasmids into suspension HEK293 cells is still the most commonly used method for the production of recombinant adeno-associated virus (rAAV) gene therapies – in this episode, Diane Golebiowski and Marissa Stanvick discuss ways to optimize that process. 
Welcome to a 2-part series in which we identify and distill some key learnings for partnering success in today's life sciences sector.Perhaps one of the most valuable take-aways from the COVID-19 pandemic response is the sheer scale of what may be achieved through effective collaboration. Over the next three episodes, we'll talk to a range of different stakeholders from across BioInsights' fields of focus, asking them to pass on their tips for what works and what doesn't in this crucial aspect. Abi Pinchbeck, Assistant Editor, Immuno-oncology Insights, speaks to Arjun GoyalIn PART 2,  Arjun Goyal, co-founder and managing director of US-based life sciences venture capital firm Vida Ventures, provides a venture capitalist's perspective on licensing and partnering within immuno-oncology.
PART 1: The Big Pharma PerspectiveWelcome to a 2-part series in which we identify and distill some key learnings for partnering success in today's life sciences sector.Perhaps one of the most valuable take-aways from the COVID-19 pandemic response is the sheer scale of what may be achieved through effective collaboration. Over the next three episodes, we'll talk to a range of different stakeholders, asking them to pass on their tips for what works and what doesn't in this crucial aspect.In this first episode, Dr Marianne De Backer, a Member of the Executive Committee and Executive Vice President of Strategy, Business Development & Licensing, and Open Innovation at Bayer Pharmaceuticals, shares her experience as a driving force behind Bayer’s significant recent moves in the cell and gene therapy area. 
PART 4: Who are tomorrow’s cell and gene therapy workers?Welcome to a 4-part series exploring a question that the entire cell and gene therapy community is struggling with at the moment: “Where will tomorrow’s workforce come from?”The cell and gene therapy field has been advancing at a breakneck speed for the best part of a decade now, fuelled by long-awaited clinical successes, commercial breakthroughs, and a related startling increase in activity from both investors and big pharma. But with this relentless pace of growth and innovation comes the fundamental challenge of developing a sufficiently large and skilled workforce to support and maintain the sector. In this final episode, we look to the future of the cell and gene therapy workforce, exploring the motivations, skills, goals, and priorities of three individuals who are at various early stages of their careers in the sector – PhD student Tiffany Hood, recent Masters graduate Lihi Livne, and Sebastian Rudden, who is in his final year as an undergrad at University College London. 
PART 3: Innovation in staff sourcing, training and retention - what works and what doesn’t? Welcome to a 4-part series exploring a question that the entire cell and gene therapy community is struggling with at the moment: “Where will tomorrow’s workforce come from?”The cell and gene therapy field has been advancing at a breakneck speed for the best part of a decade now, fuelled by long-awaited clinical successes, commercial breakthroughs, and a related startling increase in activity from both investors and big pharma. But with this relentless pace of growth and innovation comes the fundamental challenge of developing a sufficiently large and skilled workforce to support and maintain the sector. In episode 2, we looked predominantly at how the educational system is evolving to meet the specific training and skills requirements of the burgeoning advanced therapies field. In this third episode, we turn the spotlight onto the cell and gene therapy industry and how it is approaching staff development and retention – a crucial area that has been made all the more challenging by the current high level of competition for talent in the field, as well as the evolving mindset of workers relating to their career development and pathway that has been wrought by the Covid-19 pandemic, amongst other things. So what are the keys to ensuring a cell or gene therapy company can keep hold of its brightest stars and help them to flourish and grow? Hear the thoughts of Sven Kili, James Miskin, Michael Lehmicke, Qasim Rafiq and Emily Hopewell.
Part 2: How is the educational system responding, and how can the cell and gene therapy community at large help?Welcome to a four-part series exploring a question that the entire cell and gene therapy community is struggling with at the moment: “Where will tomorrow’s workforce come from?” The cell and gene therapy field has been advancing at a breakneck speed for the best part of a decade, fuelled by long-awaited clinical successes, commercial breakthroughs, and a related startling increase in activity from both investors and big pharma. But with this relentless pace of growth and innovation comes the fundamental challenge of developing a sufficiently large and skilled workforce to support and maintain the sector. In this second episode, we look at some of the ways in which the academic and industry communities are responding today, as well as important focus areas for future initiatives, with Sven Kili, James Miskin, Michael Lehmicke, Qasim Rafiq, Emily Hopewell, Frank Barry and Parviz Shamlou.
Welcome to a 4-part series exploring a question that the entire cell and gene therapy community is struggling with at the moment: “Where will tomorrow’s workforce come from?”The cell and gene therapy field has been advancing at a breakneck speed for the best part of a decade, fuelled by long-awaited clinical successes, commercial breakthroughs, and a related startling increase in activity from both investors and big pharma. But with this relentless pace of growth and innovation comes the fundamental challenge of developing a sufficiently large and skilled workforce to support and maintain the sector.In this first episode of the series, we will frame the scale and nature of the issue through the eyes of cell and gene therapy leaders including Sven Kili, James Miskin, Michael Lehmicke, Qasim Rafiq, Emily Hopewell, Frank Barry and Parviz Shamlou.
Ratish Krishnan and Oliver Rammo share their thoughts on the need for a more nuanced understanding of AAV capture and empty–full separation, and the trends driving innovation in this area.
In this episode Ilaria Scarfone Field Application Specialist, Pharma Analytics, Thermo Fisher Scientific speaks to Mike Brewer, Director and Global Principal Consultant, BioProduction Division, Thermo Fisher Scientific about the challenges for residual DNA testing in viral vector manufacture.To read this interview and access lots more content, visit the Cell and Gene Therapy Insights website.
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