The Dr. Josh Axe Show

Exhausted in the morning but wired at night? Dr. Josh Axe explores how stress and disrupted cortisol rhythms may affect your energy, sleep, and hormones. He ranks seven strategies to support a healthier rhythm, discusses herbs studied for stress support, and shares the weekly habit he values more than any supplement.  

Dr. Josh Axe joins Dr. Will Cole to reveal how a stem-cell treatment led to a life-threatening spinal infection—and the protocol that helped him recover. They explore hyperbaric oxygen therapy, peptides, GLP-1 drugs, adaptogens, stem-cell safety, grief and the science of extending healthspan.

Your body makes its own master antioxidant — but after 40, production drops every year and most people never know it's low until something breaks. Dr. Axe walks through the clinical evidence, the exact blood marker hiding on your last lab panel, and a 4-step protocol to rebuild glutathione at the cellular level — without expensive IVs.

Dr. Gez Agolli has spent nearly 30 years using integrative medicine to treat cancer, autoimmune disease, and chronic illness — and what he's found challenges almost everything conventional medicine teaches about healing. Josh calls him one of his top two mentors in functional medicine, and this conversation covers the full protocol: terrain, toxicity, advanced therapies, and why testing matters more than guessing. In This Episode: - Why toxicity — not just genetics — is the #1 root cause of cancer right now, and what 3.3 billion pounds of environmental chemicals are doing to the body's terrain - How hyperthermia, high-dose vitamin C (the right kind), and hyperbaric oxygen work together — and which chemotherapy drugs make hyperbaric oxygen contraindicated - What insulin potentiation therapy (IPT) actually does: using fractionated chemo alongside glucose to target cancer cells directly - The circulating tumor cell tests and liquid biopsy markers (including Signatera and ctDNA) that can predict cancer recurrence 6–12 months before a scan shows anything - Why leaky gut is the root cause of autoimmune disease — and what Dr. Agolli's testing protocol reveals that most doctors never order - The glutathione, F2-isoprostane, and GGT markers that measure oxidative stress at the cellular level, and what happens when you address them Chapters: - "00:00:00" – Intro: Cancer Stats & Meeting Dr. Guez Agolli - "00:02:47" – His Origin Story & the Broken Healthcare System - "00:06:50" – What Cancer Is: Cell Biology & Root Causes - "00:13:46" – Sponsor Break: Heal Yourself Book - "00:14:31" – Parasites, Immune System & Terrain Theory - "00:19:57" – Advanced Cancer Testing: The RGCC (Greek) Test - "00:25:38" – Top Cancer Therapies: Hyperthermia, IPT & the 40-Day Protocol - "00:39:26" – Sponsor Break: Health Institute Bloodwork - "00:40:27" – Testing Philosophy: Micronutrients, Food Sensitivities & Glucose - "00:54:44" – Glutathione, Longevity & Reversing Autoimmune Disease - "01:05:12" – Mitochondria, Closing Thoughts & Closing Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! → http://mybloodwork.com *Disclaimer: The bloodwork our team runs at mybloodwork.com covers a handful of the biomarkers listed in the guide above — including critical thyroid and metabolic markers — plus a 1-hour consultation with a Senior Health Advisor, but does NOT cover all 25. You will want to consult your primary or functional doctor for the entire list. Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: / @drjoshaxe 🎧 Early Access! Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners → Spotify: https://bit.ly/DrJoshAxeSpotify Apple Podcast: https://apple.co/3JDvWcS Order my NEW BOOK, Heal Your Cells → www.healyourcellsbook.com Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com Discover practical steps you can take today to start healing your thyroid naturally → http://DrAxeThyroidClass.com If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com CONNECT WITH DR. JOSH AXE Instagram → / drjoshaxe Facebook → / drjoshaxe TikTok → / thedrjoshaxeshow X → https://x.com/drjoshaxe/ LinkedIn → / joshaxe Website → http://thehealthinstitute.com Sign up for my newsletter → https://bit.ly/4oE9Jf3 Ask Dr. Axe → http://speakpipe.com/drjoshaxe CONNECT WITH OUR GUEST Instagram → @progressivemedicalcenter TikTok → @progressivemedicalctr LinkedIn → Gez Agolli YouTube → Progressive Medical Center / Rethink My Health Website → Progressive Medical Center DISCLAIMER This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

Your hormones, your sleep, your stress, your diet — they may all be affecting your health at a much deeper level than you realize. Dr. Josh Axe sits down with functional medicine expert Dr. Will Cole and fitness and biohacking educator Dylan Gemelli for a no-holds-barred roundtable on what may actually be driving chronic disease, accelerated aging, hormonal dysfunction, and poor metabolic health — and why healing may need to start at the cellular level. In this episode, we learn why Dr. Axe and Dr. Cole believe cellular health could change how we approach chronic disease — and how to identify which systems in your body may be aging faster than others. Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism — plus a 1-hour consultation with a Senior Health Advisor! → http://mybloodwork.com Disclaimer: The bloodwork our team runs at mybloodwork.com covers a handful of the biomarkers listed in the guide above — including critical thyroid and metabolic markers — plus a 1-hour consultation with a Senior Health Advisor, but does NOT cover all 25. You will want to consult your primary or functional doctor for the entire list.   Thank you to our sponsors! Sunlighten Sauna → https://get.sunlighten.com/axepodcast Manukora Manuka Honey → https://manukora.com/axe Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube → https://www.youtube.com/@drjoshaxe?sub_confirmation=1 🎧 **Early Access!** Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners → Spotify → https://bit.ly/DrJoshAxeSpotify Apple Podcasts → https://apple.co/3JDvWcS Order our NEW BOOK, *Heal Your Cells* → healyourcellsbook.com Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com Discover practical steps you can take today to start healing your thyroid naturally → http://DrAxeThyroidClass.com If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com CONNECT WITH DR. JOSH AXE Instagram → https://www.instagram.com/drjoshaxe/ Facebook → https://www.facebook.com/DrJoshAxe/ TikTok → https://www.tiktok.com/@thedrjoshaxeshow/ X → https://x.com/drjoshaxe/ LinkedIn → https://www.linkedin.com/in/joshaxe Website → http://thehealthinstitute.com Sign up for my newsletter → https://bit.ly/4oE9Jf3 Ask Dr. Axe → http://speakpipe.com/drjoshaxe CONNECT WITH DR. WILL COLE Website → https://drwillcole.com Instagram → https://www.instagram.com/drwillcole/ Podcast → The Art of Being Well CONNECT WITH DYLAN GEMELLI Website → https://dylangemelli.com Instagram → https://www.instagram.com/dylangemelli/ YouTube → https://www.youtube.com/@DylanGemelliBiohacking Podcast → The Dylan Gemelli Podcast TIMESTAMPS: 00:00 — The Biggest Drivers of Chronic Disease 02:29 — Welcome to the Health & Longevity Roundtable 03:07 — Why Cellular Health May Be the Future of Medicine 06:10 — Is One of Your Organs Aging Faster Than the Rest? 08:22 — How Early Do Health Problems Really Begin? 12:30 — The Blood Markers That Could Reveal Heart Disease Risk 18:12 — What Insulin Resistance Actually Means 19:59 — The 2 Hormones That Can Throw Everything Off 22:58 — The Surprising Connection Between Sleep & Insulin Resistance 25:10 — “I’ll Sleep When I’m Dead” Is Destroying Your Health 31:32 — Waking Up at 3 A.M.? Cortisol May Be the Reason 32:43 — How to Lower Stress & Support Your Vagus Nerve 37:18 — How Your Mind & Nervous System Affect Your Health 41:32 — Can Childhood Trauma Keep You From Healing? 43:55 — Forgiveness, Faith & the Nervous System 48:11 — Why Dylan Believes Health Starts With “Mind, Body & God” 51:11 — Can Faith Actually Help You Live Longer? 58:35 — The Truth About Peptides & Where Medicine Is Headed 1:03:29 — Are Peptides Overhyped or the Future of Health? 1:05:31 — Conventional vs. Functional Medicine 1:10:14 — How to Increase Your Healthspan, Not Just Your Lifespan 1:11:01 — Why Gut Health Matters for Longevity 1:12:46 — The Best Exercise for Mitochondria & Healthy Aging 1:16:23 — Why Women Shouldn't Be Afraid of Strength Training 1:19:32 — Keto, Carnivore & Vegan: Why Extreme Diets Can Backfire 1:21:29 — Bio-Individuality: There Is No Perfect Diet for Everyone 1:27:30 — Is Health Advice Actually Making People More Stressed? 1:29:03 — Seed Oils vs. Saturated Fat: What's Actually Healthier? 1:39:12 — The 5 Foods Josh Axe & Will Cole Would Choose for Life 1:43:11 — Josh & Will Reveal Their Favorite Cheat Foods 1:45:29 — Are We Eating Too Much Protein? 1:50:01 — Do You Really Need Fiber? 1:55:12 — The #1 Health Lesson From Josh, Will & Dylan 1:57:16 — Dylan's Final Message: God First, Health Second