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Mind & Matter

Author: Nick Jikomes

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Weekly science podcast by neuroscientist Nick Jikomes, PhD. Long-form interviews with researchers on the brain, nutrition, metabolism, drugs and aging. Not medical advice.


At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
316 Episodes
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Send us Fan Mail Keith Baar explains why tendons stop adapting after 10 minutes of loading, why long low-load holds beat fast reps for connective tissue, and how vitamin C, collagen, caffeine and mTOR shape training. SPONSOR: Brain Bean: Smart-roasted coffee with high polyphenol content, ultra-pure grass-fed colostrum, and more. Use code MINDMATTER15 for 15% off.TOPICS DISCUSSED: • Signal Architecture: The same total exercise split into two sessions spaced about six to eight hours apart gives...
Send us Fan Mail Dr. Stephen O'Rahilly explains GDF15, a stress hormone that makes us feel sick and eat less, and why morning sickness, and its severe form hyperemesis gravidarum (HG), comes from GDF15 made by the fetus. SPONSOR: Brain Bean: Smart-roasted coffee with high polyphenol content, ultra-pure grass-fed colostrum, and more. Use code MINDMATTER15 for 15% off.TOPICS DISCUSSED: • What GDF15 Is: A hormone made by stressed cells, sensed only in two small regions of the brainstem. • A Warn...
Send us Fan Mail Robin Carhart-Harris explains why his trial of psilocybin therapy vs. the SSRI escitalopram for depression missed one primary measure but favored psilocybin on almost everything else, and why SSRIs can blunt emotion. SPONSOR: Brain Bean: Smart-roasted coffee with high polyphenol content, ultra-pure grass-fed colostrum, and more. Use code MINDMATTER15 for 15% off.TOPICS DISCUSSED: • Consciousness Matters: Why the mind can drive biology, with placebo as the clearest example. • ...
Send us Fan Mail Nick talks with Prof. Gary Lewin (Max Delbrück Center, Berlin) about naked mole-rats, which in lab tests survived 18 minutes in pure nitrogen by shutting down brain activity, keeping the heart beating, and switching to fructose for fuel. TOPICS DISCUSSED: • From Pain Research to Mole-Rats: The work began when the animals turned out not to feel the burn of capsaicin. • Ecology & Eusociality: Colonies with a queen, one breeding male, workers, and soldiers, spread across sem...
Send us Fan Mail Nick talks with Prof. Lutz Schomburg about selenium biology in the endocrine system: selenoprotein P as the liver’s selenium transport protein and status biomarker, autoantibodies that can impair delivery despite normal blood selenium, thyroid autoimmunity (Hashimoto’s and Graves’), diabetes, aging, and what selenium supplementation trials show. TOPICS DISCUSSED: • Selenoprotein P: Liver-made transport protein that delivers selenium to tissues and serves as a status biomarker...
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