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Author: Brent W. Laartz

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Go Un-Pro with Dr. Brent W. Laartz, MD FIDSA: Living an Unprocessed Life for Longevity and Healthspan

Have you ever known that something is SO good for you that you just can't wait, but life gets in front of you and prevents you from doing it? The inaction and procrastination could occur for a variety of reasons, and we will delve into my motivations and affirmations of a healthy life from this day forward. I am starting this series of videos and articles so that I can be accountable to myself regarding the changes in my diet that I REALLY NEED to survive into my 90s without heart disease, dementia, and arthritis. And hopefully, as you follow along, you can make your own improvements that will extend your life and prevent the horrible illnesses that are heart disease, dementia, and arthritis.

Can I introduce myself? I'm Dr Brent W. Laartz, and I am an Infectious Diseases physician with a Master's in Neuroscience, author, creator, and entrepreneur. I've been involved with medical education for almost all my life and have been sharing my knowledge, teaching students, patients, and other doctors as faculty of a medical school, in hospitals, and clinics around the world. I'm ashamed to admit that I have lived a life of processed foods despite knowing the facts that are stacked against me if I continue living this way. My most recent research into longevity and its connection to our diet, exercise, sleep, and mental health, all with help from our microbiome, the bacteria living in our body, has me wanting to shout this information to the masses from the rooftops! This is so important that I am going to communicate what I have learned in every forum possible. Simply put, I am not going to do it anymore, and I am going to stay accountable to myself so that I follow through with it this time.

Hence, the launch of this podcast, which I have been wanting to do for quite some time now. In addition, I am also launching publicly available Master courses that will delve incredibly deeply into the science behind diet and other interventions that will help me live well into my '90s and 100s, but not just live, but REALLY live! This is the concept of Healthspan. I know there are a lot of billionaires who are prominent in the media, trying to live forever, spending millions of dollars, but I am here to prove you can do it without spending a lot of money. The interventions I am doing will cost a little more money, but my budget is to only increase expenditures by a few $100 a month.

The thing is, we are so accustomed to our artificial products that we deep down believe they are good for us. Don't accept this BS from your food, expect better. Most physicians I know are not living a healthy life, and until the past 6 months, that generalization included me. If you think otherwise, let me paint the picture of a typical doctor's lounge in the hospital or the home kitchen of your local physician. Hospital kitchens use the cheapest oils, fried foods, and beef, butters with mashed potatoes, pre-manufactured eggs, mass-produced bacon, candy, and ice cream sandwiches. This is what I was eating day in and day out, working 26 days per month. My cholesterol was skyrocketing, and my weight had peaked at 165 pounds on a 5-foot-7-inch frame. Then I took stock of my life. And it was just in time, too, for my kids were graduating from high school. At least I didn't have the excuse of cleaning my kids' plates anymore.

I suspect that if you are listening to this podcast, reading this article, or taking this course, you are interested in living a more unprocessed life. If you are like me, you have reached a point in your life where you realize your health could be at a tipping point. I was lulled into thinking I was living a healthy life because I exercised and ate right some of the time. But that delusion could not have been further from the truth. I was drinking alcohol at least a few days per week, drank sodas at least a few days a week, and ate eggs, bacon, buffalo wings, cheeseburgers, candy half the week. As a physician, I should have known better. If you grew up similarly to me at the beginning of the downfall of America into the ultra-processed society, then your mother initially cooked dinners that contained whole foods most of the time. However, she also fell into the trap of the simpler life of the American family, spending less time cooking and more time eating macaroni and cheese, canned beef stew, box cereals with added sugar, and chocolate candy bars for dessert.



I found myself a few years ago at age 55. Double nickel! At 5'7", I was down from my peak height of probably 5'8" tall and 165 lb at the heaviest, and about 157 lb at the lightest. Calculate that. It is a BMI of 26 - barely, but in the overweight category. While I generally pictured myself as being relatively healthy and eating relatively healthy foods, I started to look at my pictures with a critical eye, and ooking at my friends was like looking in a mirror in both appearance and behavior. My girlfriend was a fantastic cook, but created delicious meals with heavy cream, the wrong types of oils, and sweet, sweet sugar.



Ten years previously. I loved to run and could run 6 miles easily and went to the gym periodically. I gradually decreased exercise and ate more, diminishing my ability to run as well. Essentially processed foods were making an increasing appearance in my household. Sure. I still had real maple syrup, organic bacon, organic eggs, beef, chicken, and was shopping at organic grocery stores, but I was tricked into thinking organic meant unequivocally healthy.

This journal documents the transformation of a wholeheartedly devoted consumer of processed products and the world that creates them to a more mindful utilization of organic, whole-food prebiotic and probiotic fruits and vegetables. There is no shortage of data showing that eating processed foods leads to diabetes, cardiac disease, and dementia. The possible culprits in these foods include sweeteners, preservatives, plastics, and processed cooking oils, such as canola oil. What do all these things have in common? Industrial manufacturing of products with long shelf lives in plastic bags that could be minimally cooked prior to eating. They contained preservatives, food colors, and high salt content. In 1976, the food industry invented the concept of high fructose corn syrup which provided a cheaper sweetener for products than sugar which was subject to price variation and the sugar industry.

In the meantime, Americans have become more obese and diabetes is now an epidemic where 20% of Americans have full-blown diabetes, defined by a Hemoglobin A1c level (a measure of the average blood sugar over 3 months) greater than or equal to 6.0, many of whom do not even know that they have it. Fully 38% of Americans have either diabetes or prediabetes, defined by a Hemoglobin A1c level above 5.6 to 5.9, which in itself is a metabolic syndrome with major consequences. If we lower the Hemoglobin A1c level that qualifies as pre-diabetes from 5.6 to 5.4. approximately 80% of Americans now have prediabetes or diabetes. Our medical system is rewarded by over medicating Americans when the real problem is the food we are eating. Doctors are also being rewarded for glossing over the real state of patients' health, telling them their heart disease or diabetes is under control when they clearly are not. Nutritional cohort studies have linked the modern processed diet to increasing rates of dementia, cardiovascular disease, cancer, mental illness, diabetes, and a whole host of other major medical problems that we as a society are spending billions of dollars with plastic bandages covering up the damage.

Some of you might think, I'm already in my 50s, it's too late! There is longevity research suggesting that diet and lifestyle changes that occur in middle age are almost as effective as if you begin at a younger age. The reality is, if you do it right, these modifications can be hearty, filling, tasty, and fun! Think of your lifestyle as an investment account. The sooner you start the better, but it is never too late to add to your IRA - your Individual Reinvigoration Account. Yet, you don't have to strictly adhere to a particular diet to live longer. There is a term for persons who abnormally adhere to a particular diet. It is called orthorexia. Behavioral research would suggest that most people do not have the discipline to adhere strictly to a single diet. It is not practical with modern society, going out to eat, work schedules, and other obstacles that would get in the way. I have found that the best way to begin a diet is gradually.

Have you ever made a major New Year's resolution to change your whole life, but after a month of small failures in that revolutionary change, you just gave up? Instead, a program that has small easily attainable goals spread out over time is a much better method for behavioral change. According to studies, the best path to high-stakes success is to split the process into smaller goals that are easier to achieve. I am here to tell you that it is going to take a year for you completely master these small goals on a weekly basis. Over just 6 months I have lost 20 lb and am in the best shape that I've been since I turned 30 years old.

Nobody is a robot, however, and I need a treat every once in a while, so I like to reward myself for my progress. If you reward yourself for every step you attain, the rewards become too commonplace to be effective. Random rewards are more effective, so I flip a coin and reward myself only if I win the toss. This unpredictable accolade then becomes a more powerful motivating tool. Another potent method of success is accountability. However, don't go out and shout out to the world the goal you have. Studies reveal that telling others your plan prematurely gives you a reward too early when they congratulate you
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Health & wellness podcast   Go Unpro · Week 22 of 52 Dr. Brent W. Laartz · A 52-Week Journey to an Unprocessed Life   The 7-Day Raw Food Road, and Why It Is Less Traveled   Framed by Robert Frost's "The Road Not Taken," this week trades ultra-processed convenience for a mostly raw, plant-based, whole-food challenge — layered with 5K training, a painting challenge, better sleep, and the next fabric swap.   The gamble: a dozen extra years of healthy life, and everyone who gets to see them.   The Unprocessed Road   Whole-food, mostly plant-based, 90/10   Resistance + cardio + 10–25k steps/day   Deep sleep, connection, generosity   Ditching plastics — fabrics next   +12 healthy years— the great-grandchild sees you active at 100.   +12healthy years is more than 10% of a life aimed at 110— the difference the road actually makes, not just a romanticized sigh.03:37   02 / WEEK PLAN Five pillars, one week   Week 22 stacks a food challenge on top of maintained work in movement, sleep, connection, and plastics. Addition, not subtraction — enjoyable healthy things naturally crowd out the rest.   Food   7-daywhole, uncooked, plant-based challenge for polyphenol density.   Cooked exceptions Beans · Oat-milk yogurt base   Movement   Final week of5K training— race is 8 days out, benefits a charity.   Daily steps10k → 25k12:41   Sleep   Target7.5 hr average; work on blackout & room temperature to lift deep sleep.   Sweet spot11 pm → 7–8 am13:35   Connection   7-day painting challenge— new easel, mix of emotional, nostalgic, landscape.   Target5–7 canvases16:01   Plastics   Shirts done; now research natural-fabric pants. Underwear, socks queued.   Focus this weekPants19:16   Five parallel tracks — each a small addition. Together they compose the road less traveled.   03 / THE CHALLENGE The 7-day raw food week, unpacked     — Dr. Brent W. Lartz10:58   04 / WARDROBE Plastic swap — the next front   Shirts have been largely converted to 100% cotton. This week the research moves to pants, which "are incredibly plastic, artificial." 🌱 Field trip next week — the backyard garden   Growing food starts as summer heat eases into Florida's rainier, milder season. A work in progress across the second half of the year.   Week 22 commitments to execute   To Do List   [ ] Run the 7-day whole, uncooked, plant-based food challenge (beans & oat-milk yogurt base cooked) 00:36   [ ] Complete the charity 5K — race in 8 days; finish the training taper this week 13:35   [ ] Buy a new easel and paints, then produce 5–7 paintings (emotional, nostalgic, landscape) and share on social 16:01   [ ] Hit a 7.5-hour average sleep and improve room blackout & temperature to lift deep sleep 13:35   [ ] Research and choose better natural-fabric pants to replace plastic-based ones 19:16   [ ] Shop Rolling Oats, Whole Foods, and Sprouts for the week's organic raw produce 22:21  
Can Diet Actually Reverse Heart Disease?   Three trials, one uncomfortable answer: the "standard American" advice given to most cardiac patients is not enough. Only intensive plant-based lifestyle change has been shown to shrink existing coronary plaque.   Ornish · Intensive   Vegetarian + Lifestyle   10% fat · exercise · stress mgmt   −7.9% Plaque change at 5 yrs (regression)   25 cardiac events Sustained 5 years   Henzel · DASH   DASH + Optimal Meds   mostly plant-based, lean meat OK   −1.7% Non-calcified plaque change   Total plaque held roughly flat   Fatty plaque reduced   Modest, achievable diet   CT angiography, 2021   Standard Care    Haskel "Usual" U.S. Regimen   generic advice + meds   +27.7% Plaque worsening at 5 yrs   45 cardiac events · 2.47× risk   Diseaseprogressed   Minimal real diet change   "Sad" advice, host argues   Source: Ornish Lifestyle Heart Trial (JAMA 1998, 5-yr follow-up) & Hensel DISCO trial (JACC 2021).   What "Intensive" Actually Meant   The Ornish arm was not a mild tweak. It rebuilt daily life on four pillars — and participants held the line for five years.   The Four Pillars     ~10% of calories from fat; dietary cholesterol markedly reduced.     Rose from 2.66 → ~5 sessions/week; still 4.34/wk at 5 years.   Meditation, relaxation, and group support built into weekly routine.   Adherence score more than doubled vs. baseline (0.62 increased  1.29 at 1 yr).     Three Trials, Compared Side-by-Side   Each study tests a different intensity of lifestyle change against usual care. The pattern is consistent: the deeper the change, the better the coronary anatomy behaves.   Study 01 · JAMA · 1998   Ornish — Lifestyle Heart Trial   Ornish et al., 5-year quantitative arteriography   Vegetarian, 10% fat, stress mgmt, exercise. 20/28 completed 5 yrs.   Plaque · 1 yr−4.5%   Plaque · 5 yr−7.9%   Cardiac events25 vs 45   Relative risk2.47× ↓   ✓ True regression of atherosclerosis   08:42   Study 02 · Circulation · 1994   Haskell — Stanford SCRIP   Multi-factor risk-reduction program   Low-fat/low-chol diet, exercise, weight loss, smoking cessation, lipid meds.   HDL+12%   LDL / apoB−22%   Triglycerides−20%   Narrowing rate47% slower   Hospitalizations25 vs 44 (−39%)   ↘ Slowed progression, no reversal   11:58   Study 03 · JACC · 2021   Henzel — DISCO Trial   CT angiography, n=92, non-obstructive CAD   DASH nutrition + optimal medical therapy vs. optimal medical therapy alone.   Non-calcified plaque−1.7%   Control non-calc plaque−0.7%   Total plaque (control)+1.1%   p-value (change)0.033    Fatty (modifiable) plaque shrank   The Host's Bottom Line   Dr. Laartz isn't demanding strict veganism — but he is arguing that the routine cardiology counseling most patients receive is dangerously understated.   If you already have coronary artery disease   Standard advice — "lower your cholesterol, exercise a little more" — allowed disease to progress and doubled cardiac events over 5 years. Intensive plant-forward change is currently the only lifestyle intervention shown to reverse plaque.   "If you really have coronary artery disease and you don't want an earlier death, don't listen to the standard American regimen. It needs to be intensive."   The host's personal target: mostly vegan, whole-food diet; when meat is eaten (a few times/week), only chicken, fish, or turkey — avoiding pork and beef.   Honest Caveats   Adherence is hard. The Ornish protocol has been criticized as difficult to sustain — though 20/28 did sustain it 5 years.   Not fully replicated at the same intensity in other trials.   Nutrient gaps on strict vegan diets:B12, vitamin D, omega-3. Supplements can close them without red meat.   Pescatarian diets have scored slightly better than pure vegetarian in prior mortality data — likely the omega-3 from fish.   Change gradually. Wholesale overnight diet swaps rarely stick; the host recommends a 52-week glide path.   Not medical advice .This summary reflects a podcast discussion of published studies. It does not create a doctor–patient relationship and is not diagnosis or treatment. Consult your own physician, therapist, or nutritionist before changing your diet, exercise, or medications.   Ornish D, Scherwitz LW, Billings JH, et al. Intensive Lifestyle Changes for Reversal of Coronary Heart Disease. JAMA. 1998;280(23):2001–2007. doi:10.1001/jama.280.23.2001    Haskell WL, Alderman EL, Fair JM, Maron DJ, Mackey SF, Superko HR, Williams PT, Johnstone IM, Champagne MA, Krauss RM, et al. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP). Circulation. 1994 Mar;89(3):975-90. doi: 10.1161/01.cir.89.3.975. PMID: 8124838.    Henzel, J, Kępka, C, Kruk, M. et al. High-Risk Coronary Plaque Regression After Intensive Lifestyle Intervention in Nonobstructive Coronary Disease: A Randomized Study. J Am Coll Cardiol Img. 2021 Jun, 14 (6) 1192–1202. https://doi.org/10.1016/j.jcmg.2020.10.019  
GO UNPRO · WEEK 21 / 52 Health & Wellness Podcast   Five Pillars, Twenty-Five Practices   Dr. Brent W. Laartz delineates every one of his five longevity pillars — diet, movement, sleep, connection, plastic-free living — now branches into five practices of its own. Week 21's focus lands squarely on a probiotic push paired with fermented meal prep, two-a-day workouts, and a wardrobe swap toward natural fibers.   1Diet   Whole food first   Mostly plant-based   Fish & beans as protein   Calorie restriction   No processed / fast food / alcohol   2Movement   Cardiovascular   Resistance training   Flexibility   Balance   Muscular endurance (12–24 reps)   3Sleep   Dark after 8 pm   Bright morning sunlight   Purpose & activity-driven day   Cool room + supportive diet   No alcohol / late food   4Connection   Family & friends   Creativity (art, music, writing)   Community & charity   Travel (not tour-resort)   Culture & history   5Plastic-Free   Cookware & storage   Work & electronics   Personal care items   Laundry & detergents   Clothes & fibers   5 pillars × 5 practices = 25 concrete levers reviewed each week for successes and failures.05:40   02   Week 21 — The Probiotic Push   The centerpiece this week is a coordinated microbiome experiment: powdered probiotic strains added to home-made oat-milk yogurt, layered on top of an ongoing fermentation push and a new two-a-day training pattern.   Diet   Probiotic Powders in Yogurt   Multiple strains stirred into homemade oat-milk yogurt for a daily microbial hit.   Movement   Two-a-Days, 1×/week   Training for a 5K in 2 weeks; buffers against forced rest days from work travel.   Plastics   Athletic Shirts Swap   Move toward linen, hemp, bamboo, Pima cotton — researching each fiber's real processing.   Inside the Probiotic Cascade   Why these strains, and why paired with fiber. Yogurt bacteria die in stomach acid and rarely colonize the gut — so the point is aconstant feedingthat reaches the colon and feeds the cells that feed you back.   The strain cascade — from lactose to fuel     L. plantarum   L. salivarius   L. acidophilus   L. rhamnosus   Bifidobacterium longum   Veillonella   Akkermansia   Feeds colonocytes   Short-chain fatty acids to muscle   Handles exercise-derived lactate   → colon & muscle fuel   The fiber rule.Because probiotics don't stick in the intestines, pair yogurt with oats, granola, or another fiber source so the bacteria and their fuel actually make it through.03:14   "Eat food, mostly plants, not too much."— Michael Pollan, quoted as the diet-pillar backbone09:04     Ferment chickpeasfirst, then cook & blend (cooking after fermenting kills the bacteria).       Bean · onion · tomato · pepper · cucumber · olives + fermented pickles.     Home oat-milk yogurt paired with oats or granola so probiotics reach the gut.   Rule:fermented + hummus + beans + yogurt-with-fiber— always in the same week.02:38     The Daily Operating System   Beneath the weekly push sits a stable rhythm — the daily defaults Dr. Lartz recaps each episode.   Hydration   25 oz water on the drive to work; another 25 oz at 11 am with psyllium-husk fiber.   Time-Restricted Feeding   Eating window closes 8–10 pm, opens noon–4 pm. Target 14–16 hours fasted daily.   Weekly Water Fast   One 36–48 hour water-only fast per week.   Daily Non-Negotiables   Berries, fermented foods, beans, leafy greens; 3+ fully vegan days per week.   Supplements   Acarbose, Ca + Vit D, B12, testosterone, vegan omega-3.   Sleep sits on the same rails: dark room after 8 pm, morning sunlight, cool bedroom, peppermint tea, lavender essential oil, 4-7-8 breath work, phone in another room, and screens set to amber and greyscale when they must be used.28:55   06   Connection & Culture, This Week   Connection isn't optional infrastructure — travel run clubs, a jazz club with family tonight, and cultural travel are all scheduled inputs.   1   Jazz club tonight with his daughter — a deliberate creativity + family + culture combo.   2   Travel run clubs wherever he lands; last week's example was Scottsdale, Arizona.   3   Purposeful travel ahead: potentially New Zealand this winter and Charleston, SC "in the books."   Travel-day survival tips   Steal the apple, orange, or nuts from the Marriott gym or Admirals Club — occasional jelly beans allowed. "It can't be all 100% draconian or monk life."   Hotel-room reality: tiny fridge, no stove — accept that whole-food prep will be harder and plan meals out at whole-food restaurants (last night: Lebanese).   Yesterday's travel day still delivered 8,000–9,000 steps. Small failures aren't the end — get back up.   07   The Wardrobe Swap   Week 21's plastic-free lever is athletic shirts. The broader pattern: replace plasticized fibers and cookware surfaces with natural materials — gradually, across all 52 weeks.     Plasticized athletic shirts & underwear   Fabric softeners & scented detergents   Non-stick pans, microwave cooking   Plastic phone cases & keyboards   Linen, hemp, bamboo, 100% Pima cotton   Minimal, unscented laundry care   Glass, steel, wood, copper cookware & storage   Wooden mouse, keyboard, phone case   Caveat: some "natural" fibers are actually processed into plastic — research each one before buying   What's Next   The upcoming Sunday Science, the training calendar, and the second-half format shift.   Scheduled next steps from this episode   Halfway through the 52-week experiment, the format shifts toward more field trips — kitchen, gym, home podcast studio, and travel destinations including a possible New Zealand winter trip and Charleston, SC.   The information herein is not intended as medical care, diagnosis, or treatment of any medical condition. No component of this content, including discussion or comments, shall be construed or implied as establishing a doctor-patient relationship. Before you translate or copy any of the information, diet, exercise, or products utilized herein to your own practice, consult your own research, physician, therapist, or nutritionist for your own health. Research any treatments, diet, exercise, or products thoroughly before trying for yourself.  
Health & Longevity Podcast   Week 20: The economic case for living healthier, longer   Dr. Brent Laartz reframes lifestyle change as capital: an extra decade of healthspan is money, freedom, and national savings. This week is not new rules — it's a root-cause analysis of where the plan slips, and doubling down on what already works.   National scale   $38T economic benefit if every American lives 1 more healthy year   $40T current U.S. national debt   Less Medicare/Medicaid use, later Social Security draw, more productive work years — the aggregate savings roughly cancels the country's debt.02:26   Personal scale   Live 10 more healthy years   2Work & earn ~$100K/yr longer   3Defer retirement drawdown; boost top-35 Social Security average   $$1.3M  $1.5M extra lifetime capital   Figure: Longevity as a return-on-investment — altruistic to self and to country.   Root cause analysis: why the plan slips   Before adding anything new, sit quietly (meditate, journal, or with a counselor) and drill into three questions every time you cheat on diet, movement, or alcohol.   Question 1     Exhaustion, poor sleep, ghrelin up & leptin down after short sleep hungrier, and hungrier for bad food. Look for the limiting belief or self-sabotage underneath.   Host's trigger: being run-down after travel.   Question 2     Environment enables the lapse. Identify the physical location  work, kitchen, cafeteria, airport  where the wrong choice is convenient.   Host's trigger: the hospital doctors' lounge and its free food.   Question 3     Who enables the bad situation and, just as importantly, who is present when things go right? Alcohol norms belong here too.   Host's trigger: girlfriend is a baker butter & cream in the kitchen.   Figure: The Feeling  Place  People diagnostic loop.   The 20-week protocol, at a glance   Five pillars, kept boring on purpose. Week 20 is doubling down, not redesigning.     Time-restricted 8 pm to 12–4 pm   36–48 h fast weekly (Sun to Tue)   3+ vegan days; fish before chicken before cheese , no red meat   Berries, ferments, beans daily   Whole foods; minimize protein (mTOR)   Acarbose, Ca+ and vit D, B12, T, vegan omega-3   VO₂ max & endurance   Resistance training   Muscular endurance   Balance   Run, bike, court sports   Dark room after 8 pm   Early morning sunlight   Cold room; no screens late   Purposeful, exhausting days   Family, friends, charity   Culture, travel, creativity   Sailing, sea & mountains   Strava run clubs   Glass containers, steel cookware   100% cotton, natural fibers   Wood/copper/steel drinkware   Beware "plasticized" naturals   139,000 unstudied chemicals   Figure: The five-pillar operating system carried forward into week 20.   A typical day, on the clock   Fast / sleep 25 oz water (fiber at 11 am) Eating window   Once weekly: 36–48 h fast, Sunday afternoon → Tuesday afternoon.15:37   Figure: A single day mapped against the time-restricted eating window.   Doubling down: week 20 focus   No new pillars this week. Fix the leaks in the ones already in place.   Miss   50-vegetable challenge: only 29 counted Travel and beach days broke the shopping rhythm. Fix: return to meal-prep and a Sprouts run.   Goal   30-day step average  12,000 (target 14,000) Kill the 3,000- and 8,000-step days; hold the 15–17k days from last week.   Goal   Sleep: reach 7 hours consistently Install blackout curtain (still outstanding on year's goal list); add meditation.   Goal   Connection: sea & mountains Sailing returns; mountains again this week after last week's trip.   Focus   Plastics month: continue household audit~50% of house done. Now: clothing (100% cotton polo, cautious merino), pens, car, work items.   Aim   Aspirational healthspan: 110 yearsWhole-food diet + resistance training + less meat + connection + better sleep + fewer plastics.   Open commitments from this episode   Not medical advice.This summary reproduces information shared in the episode and is not intended as medical care, diagnosis, or treatment. No doctor–patient relationship is established. Consult your own physician, therapist, or nutritionist before adopting any diet, exercise, product, or supplement discussed. Referral or affiliate fees may apply to the source material.   To Do List    Fly out today — travel for connection, culture, and exercise at destination    Record & upload the (late) Sunday Science episode by tomorrow    Install blackout curtain in the bedroom (year-goal, still outstanding)    Shop at Sprouts; restart meal-prep (yogurts, hummus, veg variety) to recover the 50-veg challenge    Research natural-fiber athletic wear (merino, cotton) that is not heavily chemically processed  
Sunday Science · Dr. Brent W. Laartz   Marijuana, Longevity & Cancer Medical Science Podcast Review   Fourteen studies, one honest verdict: on average, evidence points to accelerated biological aging and elevated hormone-sensitive cancer risk with chronic recreational cannabis — while therapeutic use in cancer care retains meaningful benefits. Read the balance, not the slogan.   Who is actually using — and how much   U.S. prevalence data (2021) shows cannabis use peaks in late adolescence and young adulthood, with roughly one in three high-school seniors and young adults reporting past-year use.   8%  13–14 yrs   16%  15–16 yrs   19%  15–16 yrs   30%  17–18 yrs   35%  15–29 yrs   17%  26Plus yrs   The Cancer Signal   Three converging lines of evidence — ecological trends, Mendelian randomization, and meta-analysis — point at hormone-sensitive cancers rising alongside cannabis legalization, particularly in younger people.   Incidence increases in legalized jurisdictions (2000–2019)   Testicular cancer — Canada (15–39) Plus  83%   Breast cancer — Canada  Plus35%   Breast cancer — US legalized (20–34)  Plus26%   Testicular cancer — US legalized (15–39)  Plus24%   Johnson et al., Academia Oncology . Non-legalized US states: incidence stable or decreasing.01:50   Meta-analysis · Song et al.   OR 1.71   Current cannabis use & testicular cancer — higherthan tobacco's OR 1.18 for the same outcome. 23 studies aggregated.   Odds ratio vs never-users   Mendelian randomization · Wang et al.   Causal signal   SNP-based causality analysis found  strong causal evidence  linking cannabis use to cervical, laryngeal, and breast cancer.     Biological Aging: three clocks, one direction   Independent aging biomarkers — phenotypic blood panels, alpha-Klotho protein, and epigenetic DNA-methylation clocks — all move in the same direction for current cannabis users.   Aging biomarkers · users vs never-users   Biomarker · Study      Polysubstance amplifier — Meyer et al.: Midlife recreational users showed composite age Plus0.7 yr, slower gait, older facial age, lower brain age, and reduced health/financial/social preparedness. After adjustment for tobacco, alcohol, and other drugs, the effect attributable to cannabis was greater than long-term ethanol use alone .   Hormones: why testicular & breast cancer?   Two clinical hormone studies suggest a mechanism: cannabis appears to disrupt the estradiol-testosterone-prolactin axis, offering a biological bridge to the hormone-sensitive cancers seen in the ecological data.   Texera et al. — 316 infertile men   Reproductive review — Lo et al.   Cannabis crosses the placenta and enters breast milk, with reported effects on:   Menstrual cyclicity & erectile dysfunction   Abnormal spermatogenesis, testicular atrophy   Gestational age & preterm birth   Brain, Age & Cognition   Two studies from the same group — Thayer, and Stapolsky & Thayer — produce a nuanced picture: moderate older-adult use looks neutral, but long-term use (≥19 years) is associated with real cognitive deficits.     The Benefits — Not Glossed Over   The scientific case for cannabis in cancer care and symptom relief is real and should be weighed alongside the risk signals above.   Confounders to keep in mind   Every association study inherits complications. Before reading these numbers as destiny, consider what the studies cannot fully separate:    Synthetic warning from the ER: Synthetic cannabinoids seen daily in emergency medicine can be hundreds of times more potent than natural compounds and are strongly linked to acute psychosis. Do not treat them as equivalent to plant cannabis.   Reader follow-through    Disclaimer. This summary and the referenced podcast are not medical advice, diagnosis, or treatment. No content herein establishes a doctor–patient relationship. Consult your own physician, therapist, or nutritionist before applying anything discussed. No warranties are made regarding benefits or risks of any treatment, diet, exercise, or product referenced.   To Do List Open the show-notes bibliography and read the 14 referenced studies yourself before forming a position 27:48 Weigh your own context — age, duration of use, therapeutic vs recreational purpose, family history of hormone-sensitive cancer 25:06 Consult your physician, therapist, or nutritionist before changing any use, treatment, or supplementation 28:46 Return next Sunday for the next Sunday Science expedition
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