Beyond the lab: PhDIBINEM - Unibo

This episode presents the splanchnic anti-inflammatory reflex as a neuroimmune pathway for the development of more precise and personalized therapies, individualized surveillance strategies for the early detection of hepatocellular carcinoma in patients with liver cirrhosis, patient-specific sagittal alignment targets for personalized pre-operative planning in adolescent spinal deformity surgery, and a further research perspective aimed at advancing innovation in spine surgery with particular focus on spinal deformities. We highlight how neuroimmune regulation, early risk prediction, anatomical modeling, and personalized surgical planning converge to drive innovation in patient care

What if we could read the brain, modulate its activity, and even generate new brain images with artificial intelligence? In this episode, we explore how emerging technologies are reshaping brain science and medicine: from brain–computer interfaces restoring movement, to chemogenetic approaches targeting sleep disorders, from AI-generated MRI to the neural networks behind pain and innovative strategies against brain tumors. Bringing together neuroscience, engineering, and clinical practice, this podcast offers a glimpse into the future of brain medicine and the power of collaboration driving it forward.

This episode focuses on Alzheimer’s disease in the context of IRCCS ISNB, presenting the main clinical features of the disease, its impact on memory and daily life, and the importance of early diagnosis and multidisciplinary care. We discuss how clinical evaluation, research, and patient support contribute to improving the understanding and management of neurodegenerative diseases.

This episode will present: the development of an innovative therapeutic platform for CDKL5 Deficiency Disorder as a non invasive, accessible oral treatment using engineered bacteria as a therapeutic vehicle; photobiomodulation as a potential new non invasive therapy for skeletal muscle tissue regeneration; a 3D model differentiated from perinatal stem cells as a potential therapy for type 1 diabetes; and a multidimensional approach to post transplant outcome assessment based on outcome indicators and interdisciplinary interventions.

In this episode, we examine how metabolic rewiring and genetic alterations drive cancer and neurological disease. We explore disrupted glycogen metabolism in rare neurodegenerative disorders, altered glucose utilization in leukemia, and the role of lipid metabolism in solid tumors. The conversation also highlights how key genetic mutations, such as those affecting TP53, reshape cellular pathways and disease progression. By examining these molecular changes across different diseases, we highlight how metabolism and genetics shape disease biology, revealing vulnerabilities that could be exploited for future therapeutic strategies."